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Journal of Experimental Biology and Agricultural Sciences ; 9(Suppl. 2):S202-S285, 2021.
Article in English | CAB Abstracts | ID: covidwho-1863785


This proceedings contains 13 papers focusing on the effect of green tea extract in modulating the antibacterial activity of standard antibiotics against clinical isolates of Acinetobacter baumannii, in silico screening of Ziziphus spina-christi and Strychnos ligustrine compounds as a proteinase inhibitor of SARS-COV-2, antioxidant and antifungal propterties of palu shallot (Allium ascalonicum var. aggregatum), probiotic properties and safety of lactic acid bactera isolated from South Sulawesi ethnic cheese, pharmacognostics of 2 Orthoshipon aristatus varieties and effect of honey consumption after physical exercises on electrolytes and blood sugar levels, among others.

Journal of Experimental Biology and Agricultural Sciences ; 9(Suppl. 2):S208-S214, 2021.
Article in English | CAB Abstracts | ID: covidwho-1818854


Diseases caused by the coronavirus have become an important concern in early 2020. The coronavirus is a new type of virus that is included in the SARS-CoV-2 group. One of the possible mechanisms of SARS-CoV-2 inhibition involves protease receptors inhibition. This research was aimed to in silico screening of Ziziphus spina-christi (L.) Desf., and Strychnos ligustrine active ingredients as the main protease inhibitors of SARS-CoV-2 by assessing the ligand-binding affinity in the binding pocket of SARS-CoV-2 main protease protein. The molecular docking method is generally used to predict the inhibitory site and bonds formation. In the current study, some generally used antiviral compounds from the PDB (Protein Data Bank) were also used to compare the affinity strength of the test compound against the protease receptor (code of 5R7Y). The inhibitory activity against the main protease receptor proven by the ChemPLP score is more negative than the receptor's native ligand and the comparison compounds. Jubanine B, a compound of Z. spina-christi has the most robust inhibition activity on the SARS-CoV-2 protease receptor. Results of this study can be concluded that this can be used to develop as a candidate for traditional medicine against SARS-CoV-2 but still it required some more in vitro and in vivo studies.

Biochemical and Cellular Archives ; 21(2):1-2, 2021.
Article in English | EMBASE | ID: covidwho-1812557