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1.
Journal of Pharmaceutical Sciences ; 2022.
Article in English | ScienceDirect | ID: covidwho-2165961

ABSTRACT

Delivery of messenger RNA (mRNA) using lipid nanoparticles (LNPs) is expected to be applied to various diseases following the successful clinical use of the mRNA COVID-19 vaccines. This study aimed to evaluate the effect of the cholesterol molar percentage of mRNA-LNPs on protein expression in hepatocellular carcinoma-derived cells and in the liver after intramuscular or subcutaneous administration of mRNA-LNPs in mice. For mRNA-LNPs with cholesterol molar percentages reduced to 10 mol% and 20 mol%, we formulated neutral charge particles with a diameter of approximately 100 nm and polydispersity index (PDI) <0.25. After the intramuscular or subcutaneous administration of mRNA-LNPs with different cholesterol molar percentages in mice, protein expression in the liver decreased as the cholesterol molar percentage in mRNA-LNPs decreased from 40 mol% to 20 mol% and 10 mol%, suggesting that reducing the cholesterol molar percentage in mRNA-LNPs decreases protein expression in the liver. Furthermore, in HepG2 cells, protein expression decreased as cholesterol in mRNA-LNPs was reduced by 40 mol%, 20 mol%, and 10 mol%. These results suggest that the downregulated expression of mRNA-LNPs with low cholesterol content in the liver involves degradation in systemic circulating blood and decreased protein expression after hepatocyte distribution.

2.
Journal of Financial Intermediation ; : 101017, 2023.
Article in English | ScienceDirect | ID: covidwho-2165539

ABSTRACT

We use Call Report data to examine the effects of the Paycheck Protection Program (PPP) and the PPP Liquidity Facility (PPPLF) on small business and farm lending by individual commercial banks. As program participation was associated with small business lending, we adopt an instrumental variables approach to identify causal implications based on historical bank relationships with the Small Business Administration and the Federal Reserve's discount window. Our results indicate that both programs encouraged lending growth over the first half of 2020. However, while the PPP encouraged greater lending across all banks, only small and medium-sized bank lending growth was significantly related to participation in the PPPLF.

3.
WHOIRIS; 2022.
Non-conventional in Russian | WHOIRIS | ID: grc-754916

ABSTRACT

Пандемия COVID-19 оказала беспрецедентное негативное воздействие на системы здравоохранения и экономики стран, при этом она особенно тяжело сказалась на положении 11 малых стран в Европейском регионе ВОЗ, поскольку для многих из них туризм был и остается весьма значительной частью их национальной экономики. В ходе Восьмого совещания высокого уровня Инициативы ЕРБ ВОЗ для малых стран министры здравоохранения и делегаты этих стран утвердили смелое перспективное видение, которое ляжет в основу процесса восстановления после пандемии COVID-19. В ходе этого двухдневного мероприятия, прошедшего 2–3 июня 2022 г. в Бечичи (Черногория), министры и их представители обсудили два ключевых вопроса: как малые страны могут успешно восстановиться после пандемии и как они могут сделать охрану здоровья одной из основных составляющих своих секторов туризма. В завершение совещания делегаты стран единогласно приняли “Черногорское заявление” – документ, в котором изложены ключевые обязательства в отношении дальнейших действий.

4.
WHOIRIS; 2022.
Non-conventional in English | WHOIRIS | ID: grc-754907

ABSTRACT

In May 2011 the Pandemic Influenza Preparedness (PIP) Framework was adopted by the 64th World Health Assembly to provide a foundation for countries WHO and key partners to improve the sharing of influenza viruses with pandemic potential and increase the access of developing countries to vaccines and other life-saving products during a pandemic. In WHO’s Eastern Mediterranean Region support provided to the nine PIP countries (Afghanistan Egypt Iraq Jordan Lebanon Morocco Sudan Syrian Arab Republic and Yemen) has enabled these countries to detect prepare for and respond to pandemic influenza. With PIP investment and building on existing influenza surveillance systems platforms capacities and also the structural concepts countries were able to leverage the assets for the COVID-19 pandemic response. This report which includes country profiles provides information on implementation of the PIP Framework in the Region from 2020 to 2021 utilization and implementation of funding and outlines plans for 2022–2023.

5.
WHOIRIS; 2022.
Non-conventional in English | WHOIRIS | ID: grc-754898

ABSTRACT

The COVID-19 pandemic has had an unprecedented impact on countries’ health systems and economies, but its impact on the 11 smallest countries in the WHO European Region – many of which rely on tourism as a large part of their national economy – has been particularly severe. Meeting at the Eighth high-level meeting of the WHO/Europe Small Countries Initiative, the countries’ health ministers and delegates endorsed a bold vision to drive recovery in the post-COVID-19 era. The two-day event, held on 2–3 June 2022 in Bečići, Montenegro, saw the ministers and their representatives discuss two key issues: how small countries can successfully recover from the pandemic, and how they can place health at the heart of their tourism sectors. At the end of the meeting, the countries’ delegates unanimously adopted the Montenegro statement, which outlines key commitments for moving forward.

6.
WHOIRIS; 2022.
Non-conventional in German | WHOIRIS | ID: grc-754871

ABSTRACT

Die COVID-19-Pandemie hatte beispiellose Auswirkungen auf die Gesundheitssysteme und Volkswirtschaften der Länder, doch für die 11 kleinsten Länder in der Europäischen Region der WHO – von denen viele wirtschaftlich zu einem großen Teil vom Tourismus abhängig sind – waren die Folgen besonders schwerwiegend. Im Rahmen der Achten hochrangigen Tagung der Initiative kleiner Länder von WHO/Europa stimmten die Gesundheitsminister und Delegierten dieser Länder einer mutigen Zukunftsvision zu, um den Wiederaufbau nach der COVID-19-Pandemie voranzutreiben. Bei der zweitägigen Veranstaltung, die am 2. und 3. Juni 2022 in Bečići (Montenegro) abgehalten wurde, erörterten die Minister und ihre Vertreter zwei zentrale Themen: wie kleine Länder sich erfolgreich von der Pandemie erholen und wie sie das Thema Gesundheit in den Mittelpunkt ihrer Tourismuswirtschaft rücken können. Am Ende der Tagung nahmen die Delegierten der Länder einstimmig die Erklärung von Montenegro an, in der die zentralen Verpflichtungen für das künftige Vorgehen dargelegt werden.

8.
WHOIRIS; 2022.
Non-conventional in French | WHOIRIS | ID: grc-754865

ABSTRACT

Si la pandémie de COVID-19 a eu des effets sans précédents sur les économies et les systèmes de santé nationaux, son impact sur les 11 plus petits États de la Région européenne de l’OMS (l’économie de la majorité d’entre eux étant largement dépendante du tourisme) a été particulièrement grave. Rassemblés à l’occasion de la Huitième Réunion de haut niveau de l’Initiative des petits États de l’OMS/Europe, les ministres de la Santé et les délégués des pays concernés ont approuvé une vision audacieuse pour favoriser le relèvement post- COVID-19. Au cours de cet événement de deux jours organisé les 2 et 3 juin 2022 à Bečići (Monténégro), les ministres et leurs représentants se sont penchés sur deux questions essentielles : comment les petits États peuvent-ils réussir à se remettre de la pandémie, et comment peuvent-ils placer la santé au cœur de leur secteur touristique ? À la fin de la réunion, les délégués nationaux ont adopté à l’unanimité la Déclaration du Monténégro qui présente les principaux engagements pour aller de l’avant.

9.
International Journal of Applied Pharmaceutics ; 14(Special Issue 4):135-141, 2022.
Article in English | EMBASE | ID: covidwho-2164487

ABSTRACT

Objective: This study aims to predict a bioactive compound from Peronema canescens (PC) with mechanisms inhibitor interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) potential as an immunomodulatory using in silico approach. Method(s): Autodock 4 was used to accomplish computer-assisted drug design with molecular docking simulation to discover binding energy, inhibition constant, and interactions with an amino acid in bioactive compounds from PC against IL-6 and TNF-alpha receptors. Lipinski predicts the drug-likeness of a bioactive compound for the oral route of administration. ADMET profiling of bioactive compounds to predict pharmacokinetic properties with pkCSM ADMET. Result(s): The results showed that the best binding energy, inhibition constant, and interactions with an amino acid of peronemin C1 against IL-6 and TNF-alpha receptors were (-7.19 kcal/mol;5.39 nM;Arg 179, Arg 182, Gln 175), and (-8.86 kcal/mol;320.42 nM;Tyr 119, Tyr 59, and Gly 121), respectively. All bioactive compounds from PC met Lipinski's rule of five requirements for oral administration. ADMET prediction results all bioactive compounds from PC are non-mutagenic, except peronemin D1 is mutagenic. Conclusion(s): The peronemin C1 bioactive compounds from PC have good immunomodulatory potential, effectively inhibiting human IL-6 and TNF-alpha receptors using in silico approach. Copyright © 2022 The Authors. Published by Innovare Academic Sciences Pvt Ltd.

10.
Journal of the Society of Thoracic Carido-Vascular Anaesthesia & Intensive Care ; 28(4):345-356, 2022.
Article in Turkish | Academic Search Complete | ID: covidwho-2164317

ABSTRACT

Objectives: This study was planned to evaluate the perspectives, experiences, and methods followed by physicians on the treatment and management of COVID-19 infection, which affects the whole world. Methods: In this study, in which physicians were included in the study, a questionnaire consisting of 21 questions was conducted in the electronic environment. The questionnaire questions included the treatment methods applied by the physicians during the COVID-19 pandemic, the guidelines they followed and their own clinical experiences. Results: Our study was conducted with a total of 200 physicians, 72 (36.0%) men and 128 (64.0%) women. The mean age of the physicians was 36.54±7.40 years. In the management and treatment of COVID-19 patients, 78.5% of the participants preferred to use the Ministry of Health's COVID-19 Outbreak Management and Study Guide (MHCOMSG) and 60.5% preferred to use the current international guidelines. In the oxygen support management of hypoxemic patients, 53.5% of the participants preferred to follow their personal experience and experience, 52.5% of them preferred to follow the MHCOMSG, 51% of them preferred to follow the current international guidelines. There is a statistically significant relationship between the duration of professional experience, the institution where the employee is working and treatment management preferences. Conclusion: During the COVID-19 pandemic process, physicians preferred to follow the MHCOMSG in treatment and patient management. It is important for health-care professionals to follow new developments closely and to make updates on COVID-19 published online by official government health officials in terms of health workers' preferences in accessing information. (English) [ FROM AUTHOR]

11.
Pediatrics ; 150, 2022.
Article in English | ProQuest Central | ID: covidwho-2162666

ABSTRACT

PURPOSE OF THE STUDY: To evaluate if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection could promote the initial development or relapse of Juvenile Dermatomyositis (JDM). The secondary aim was to identify if SARS-CoV-2 played a role in triggering of JDM through induction of interferon-α (IFNα). STUDY POPULATION: This study included 10 patients with new disease onset (n = 6) or relapse (n = 4) of JDM at a single center in France between April 2020 and March 2021. All patients met diagnostic criteria for JDM according to the European Neuro Muscular Centre 2018 dermatomyositis classification criteria. METHODS: This was a cross-sectional analysis of IgG and IgM levels directed against 5 different portions of the SARS-CoV-2 virus in the plasma of 10 patients with new onset or relapse of JDM at the time of diagnosis. The point prevalence of a positive SARS-CoV-2 infection concomitantly among new onset or relapse of JDM was determined using basic data analysis. Descriptive statistical analysis was also performed comparing the level of interferon-α2 (IFNα2) protein among 2 patients with concomitant SARS-CoV-2 infection against median IFNα2 protein levels of 33 JDM patients with active disease followed in the same clinical center. RESULTS: Out of the 10 patients, this study identified 2 (20%) patients with high titers of both IgG and IgM antibodies directed against SARS-CoV-2 proteins. One patient had new onset JDM (P1) and the second patient had relapsing JDM (P2). The clinical presentation at relapse (isolated to skin) in P2 was similar to the lesions observed at diagnosis. Both had an asymptomatic SARS-CoV-2 infection. Two weeks after diagnosis, there was a 150-fold increase in the IFNα2 level in P1 (73 476 fg/mL) and a 9-fold increase in the IFNα2 level in P2 (4612 fg/mL) compared with the median IFNα2 level (491 fg/mL) in 33 patients with active JDM at same clinical center. For P2, following treatment with IVIG and corticosteroids, there was a progressive decrease in IFNα2 level (1466 fg/mL) seen at 10 weeks after symptom onset. CONCLUSIONS: The point prevalence was 20% for a concomitant SARS-CoV-2 infection among the 10 patients with new onset or relapse of JDM at a single clinical center in France. SARS-CoV-2 infection may trigger the development of JDM through induction of IFNα.

12.
Pediatrics ; 150, 2022.
Article in English | ProQuest Central | ID: covidwho-2162663

ABSTRACT

PURPOSE OF STUDY: To summarize the evidence on treatments for multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children. STUDY POPULATION: Pediatric patients with suspected MIS-C or other inflammatory illness after SARS-CoV-2 infection between June 20th, 2020 and February 24th, 2021. METHODS: Pediatricians worldwide were invited to upload their data into a central database for any pediatric patient with suspected MIS-C or any inflammatory disease after SARS-CoV-2 infection. Deidentified data, including demographics, clinical features, laboratory results, treatments (including intravenous immunoglobulin [IVIG], glucocorticoid, and biologic medications), and hospital stay length were collected and analyzed. Three primary treatment groups were compared: IVIG alone, IVIG plus glucocorticoid, and glucocorticoid alone, with IVIG alone classified as primary treatment based upon prestudy acceptance of IVIG as a primary treatment. Day 0 was considered the first calendar day of treatment of each treatment modality. There were 2 primary outcomes: (1) inotropic or mechanical ventilation (invasive or noninvasive) by day 2 or later or death;(2) reduction in disease severity on a seven-point scale between day 0 and 2. A subgroup analysis of only those meeting World Health Organization (WHO) criteria for MIS-C were included. Secondary outcomes included trends in inflammatory markers, escalation of immunomodulators, time to decrease in disease severity by 1 point, left ventricular dysfunction on echocardiogram, coronary artery aneurysm after treatment and increase in cardiorespiratory support after day 0. RESULTS: A total of 614 patients, among 81 hospitals in 34 countries, had suspected MIS-C. Of these, 246 received primary treatment with IVIG, 208 with IVIG plus glucocorticoid, and 99 with glucocorticoid alone. An additional 22 patients received immunomodulators, and 39 patients received no immunomodulatory treatment. Troponin levels and percentage of patients on inotropic agents on day 0 were higher in the IVIG plus glucocorticoid group. The first primary outcome occurred in 56 patients with IVIG plus glucocorticoid (odds ratio [OR] 0.77 compared with IVIG alone;95% confidence interval [CI], 0.33 to 1.82) and in 17 patients on glucocorticoids alone (OR 0.54;95% CI, 0.22 to 1.33). In the subgroup analysis, 490 (80%) patients met WHO criteria for MIS-C and the first primary outcome occurred in 40 patients on IVIG and glucocorticoids (OR 0.95) and in 12 patients on glucocorticoids alone (OR 0.3). The second primary outcome occurred in 54 patients on IVIG plus glucocorticoids (OR 0.9) and in 20 patients on glucocorticoids alone (OR 0.93) among the entire group. In the subgroup that met MIS-C criteria, a second primary outcome event occurred in 52 patients on IVIG plus glucocorticoids (OR 1.09) and in 16 patients on glucocorticoids alone (OR 1.95). Regarding secondary outcomes, escalation of immunomodulatory treatment was less common in IVIG plus glucocorticoids (OR 0.18), though inconclusive in the glucocorticoid versus IVIG group (OR 1.31). There was no clear difference in inflammatory markers, inotropic support, or mechanical ventilation in groups who had escalation of care by day 2 versus those without escalation in care. CONCLUSIONS: There were no significant differences in the primary outcomes for patients receiving IVIG alone, IVIG plus glucocorticoids, or glucocorticoids alone. When restricted to only those who met WHO MIS-C criteria, there was modest evidence of benefit in use of glucocorticoids compared with IVIG alone. There were no major differences in secondary outcomes, with the exception of lower odds of immunomodulatory treatment escalation in patients in IVIG plus glucocorticoids.

13.
Pediatrics ; 150, 2022.
Article in English | ProQuest Central | ID: covidwho-2162661

ABSTRACT

PURPOSE OF STUDY: Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The authors describe outcomes of MIS-C in a multicenter cohort and assessed incidence nationally during the α, Δ, and ο variant waves. STUDY POPULATION: Israeli children admitted for treatment with MIS-C during the COVID-19 pandemic. METHODS: To assess cardiac involvement and admission to the ICU in patients with MIS-C, a prospective study was conducted in 12 Israeli hospitals over a 16-week period of each pandemic wave. These participating institutions account for approximately 70% of the admissions to PICUs in Israel. Data of all patients with MIS-C younger than 18 years from the α (December 20, 2020, to April 10, 2021), Δ (July 18, 2021, to November 13, 2021), and ο (November 21, 2021, to March 12, 2022) waves were prospectively collected. Vaccination status was determined by reviewing the SARS-CoV-2 digital vaccination record. The MIS-C definition was based on Centers for Disease Control and Prevention criteria. RESULTS: In the 12 participating hospitals, 171 patients with a median (interquartile range) age of 8 (5–12) years were diagnosed with MIS-C;59 during the α wave, 79 during the Δ wave, and 33 during the ο wave. Ninety-four patients (55%) were males. All patients were treated with intravenous immunoglobulins and steroids. In 5 of 79 patients (6.3%) during the Δ wave and 5 of 33 (15.1%) during the ο wave, a second SARS-CoV-2 vaccine dose had been administered at least 2 weeks before hospital admission. None of the vaccinated patients were admitted to the ICU or required treatment with vasopressors. Cardiac outcomes were more favorable during the ο wave. Admission to the ICU occurred in 34 participants (57.6%) during the α wave, 39 (49.4%) during Δ, and 7 (21.2%) during ο, and median hospital length of stay was 2 days shorter during ο than the α and Δ waves. Vasopressors were used in 22% of patients during α, 17.7% during Δ, and 6.0% during ο, and mechanical ventilation was used in 8.5% of patients during α, 8.9% during Δ, and in no patients during ο. One patient died during the Δ wave. Nationwide, in persons younger than 18 years, there were 188 800 SARS-CoV-2 infections and 103 patients with MIS-C during α, 233 585 SARS-CoV-2 infections and 115 patients with MIS-C during Δ, and 946 779 SARS-CoV-2 infections and 36 patients with MIS-C during ο. MIS-C incidences per 100 000 persons younger than 18 years were 54.5 during α, 49.2 during Δ, and 3.8 during ο. There was a higher incidence of MIS-C among patients during the α wave (incidence rate ratio, 14.34 [95% confidence interval, 9.81–20.96]) and Δ wave (incidence rate ratio, 12.94 [95% confidence interval, 8.90–18.81]) compared with the ο wave. CONCLUSIONS: This study suggests that MIS-C during the ο wave was less severe than during the α or Δ waves of the coronavirus disease 2019 pandemic. Possible explanations include the ο variant itself, previous infection with SARS-CoV-2, vaccination against SARS-CoV-2, and improvement in treatment over time. In addition, the incidence rate of MIS-C during the ο wave was lower than during the Δ and α waves. Limitations of the study include the small number of patients in the prospective cohort and the single-country data. Because MIS-C is a late-onset phenomenon of SARS-CoV-2 infection, cases that appeared after the 16-week period of each wave were not included.

14.
2022 Central and Eastern European eDem and eGov Days: Hate Speech and Fake News - Fate or Issue to Tackle?, CEEeGov 2022 ; : 31-37, 2022.
Article in English | Scopus | ID: covidwho-2162018

ABSTRACT

The COVID-19 challenged the everyday life as previously had been thought. Several restrictions were introduced on citizens and previous forecasts were turned upside down. The national governments should have adopted rapidly their performance to the changed circumstances. The resilience of public administration institutions is challenged. One of the priorities of the Hungarian public administration development was the spread and improvement of digital public administration services in the last decade. The infrastructural capabilities faced a sudden rise of users as a consequence of restriction imposed by the COVID-19. Public sector institutions can more efficiently implement new institutions if there is a common trust in institutions. This paper examines those factors of public administrations which can provide a successful adaptation to the new circumstances in the first wave of the COVID-19 pandemic in Hungary. © 2022 ACM.

15.
BMJ Open ; 12(12), 2022.
Article in English | ProQuest Central | ID: covidwho-2161869

ABSTRACT

IntroductionThe past decade has seen a rapid increase in the volume and proportion of testing for sexually transmitted infections that are accessed via online postal self-sampling services in the UK. ASSIST (Assessing the impact of online postal self-sampling for sexually transmitted infections on health inequalities, access to care and clinical outcomes in the UK) aims to assess the impact of these services on health inequalities, access to care, and clinical and economic outcomes, and to identify the factors that influence the implementation and sustainability of these services.Methods and analysisASSIST is a mixed-methods, realist evaluated, national study with an in-depth focus of three case study areas (Birmingham, London and Sheffield). An impact evaluation, economic evaluation and implementation evaluation will be conducted. Findings from these evaluations will be analysed together to develop programme theories that explain the outcomes. Data collection includes quantitative data (using national, clinic based and online datasets);qualitative interviews with service users, healthcare professionals and key stakeholders;contextual observations and documentary analysis. STATA 17 and NVivo will be used to conduct the quantitative and qualitative analysis, respectively.Ethics and disseminationThis study has been approved by South Central – Berkshire Research Ethics Committee (ref: 21/SC/0223). All quantitative data accessed and collected will be anonymous. Participants involved with qualitative interviews will be asked for informed consent, and data collected will be anonymised.Our dissemination strategy has been developed to access and engage key audiences in a timely manner and findings will be disseminated via the study website, social media, in peer-reviewed scientific journals, at research conferences, local meetings and seminars and at a concluding dissemination and networking event for stakeholders.

16.
BMJ Open ; 12(12), 2022.
Article in English | ProQuest Central | ID: covidwho-2161860

ABSTRACT

ObjectiveWe analyse the impact of different vaccination strategies on the propagation of COVID-19 within the Madrid metropolitan area, starting on 27 December 2020 and ending in Summer of 2021.Materials and methodsThe predictions are based on simulation using EpiGraph, an agent-based COVID-19 simulator. We first summarise the different models implemented in the simulator, then provide a comprehensive description of the vaccination model and define different vaccination strategies. The simulator—including the vaccination model—is validated by comparing its results with real data from the metropolitan area of Madrid during the third COVID-19 wave. This work considers different COVID-19 propagation scenarios for a simulated population of about 5 million.ResultsThe main result shows that the best strategy is to vaccinate first the elderly with the two doses spaced 56 days apart;this approach reduces the final infection rate by an additional 6% and the number of deaths by an additional 3% with respect to vaccinating first the elderly at the interval recommended by the vaccine producer. The reason is the increase in the number of vaccinated individuals at any time during the simulation.ConclusionThe existing level of detail and maturity of EpiGraph allowed us to evaluate complex scenarios and thus use it successfully to help guide the strategy for the COVID-19 vaccination campaign of the Spanish health authorities.

17.
Criminology & Public Policy ; 21(4):811-837, 2022.
Article in English | ProQuest Central | ID: covidwho-2161497

ABSTRACT

Research SummaryGun violence was declared a "public health crisis” after shootings increased in many U.S. cities during the course of the COVID‐19 pandemic. The public health approach to gun violence prevention offers many advantages such as an applied research model, the mobilization of a wider range of stakeholders, and a commitment to harm reduction. Too often, however, the public health community seems unaware of criminological research on gun violence and avoids including criminal justice interventions in their comprehensive plans.Policy ImplicationsCommunities need immediate relief from the persistent trauma of repeated shootings. Criminal justice interventions represent important responses to outbreaks of gun violence that should be included among recommended public health programs intended to address proximate and upstream causes of gun violence. Gun violence prevention policy and practice would be strengthened by more deliberate attempts to foster complementary public health and criminology research and development collaborations. More applied criminologists need to become engaged in gun violence research to meet this call.

18.
Am J Health Syst Pharm ; 2022.
Article in English | Web of Science | ID: covidwho-2160914

ABSTRACT

In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.

19.
Australian Health Review ; 46(6):710-712, 2022.
Article in English | ProQuest Central | ID: covidwho-2160437

ABSTRACT

The United Nations Convention on the Rights of Persons with Disabilities and the Sendai Framework for Disaster Risk Management establish the importance of ensuring the equitable protection of human rights in disaster planning, relief, and recovery. However, internationally and within Australia, the reality is one of indignity, human rights violations, and corruption. Australia is living in a perpetual state of crisis, following 3years of environmental and health disaster events. Vulnerable Australian citizens, especially people with disability, are at a great risk of human rights violations and may have restricted access to resilience-building resources that would enable them to recover. Embedding dignity into disaster management and recovery can safeguard human rights and improve outcomes for people with disability.

20.
The Lancet Neurology ; 22(1):9-10, 2023.
Article in English | ProQuest Central | ID: covidwho-2159969

ABSTRACT

The CHOICE trial6 investigated whether, in patients with endovascular thrombectomy and successful angiographic reperfusion, intra-arterial alteplase can improve rates of excellent functional outcome (mRS 0–1). Because of enrolment problems related to the COVID-19 pandemic and no placebo being available, this randomised, double-blind, placebo-controlled trial was stopped before completion of planned enrolment. Furthermore, the approved dose of alteplase in Japan (0·6 mg/kg) was used for intravenous thrombolysis, which differs from the approved dose in North America (0·9 mg/kg). [...]these results might have been different if CT would have been used as the imaging modality, whereas the use of a low alteplase dose might have led to an underestimation of the risk of intracranial haemorrhage. During the enrolment period (2014–16), most centres started to use antiplatelet and statin therapy immediately after stroke, especially in patients with intracranial atherosclerotic disease. [...]although the findings provide valuable guidance for clinicians and guideline committees, the question remains as to whether the results are applicable to patients nowadays, because they often receive a more aggressive medical treatment than for patients in 2016.

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