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1.
Journal of Drug Delivery and Therapeutics ; 12(4-s):101-111, 2022.
Article in English | CAB Abstracts | ID: covidwho-2056786

ABSTRACT

In-silico Computer-Aided Drug Design (CADD) often comprehends virtual screening (VS) of datasets of natural pharmaco-active compounds for drug discovery protocols. Plant Based Natural Products (PBNPs) still, remains to be a prime source of pharmaco-active compounds due to their unique chemical structural scaffolds and functionalities with distinct chemical characteristic feature from natural source that are much acquiescent to drug metabolism and kinetics. In the Post-COVID-Era number of publications pertaining to PBNPs and publicly accessible plant based natural product databases (PBNPDBs) has significantly increased. Moreover, PBNPs are important sources of inspiration or starting points to develop novel therapeutic agents. However, a well-structured, indepth ADME/Tox profile of PBNPs has been limited or lacking for many of such compounds, this hampers the successful exploitation of PBNPs by pharma industries. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties play key roles in the discovery/ development of drugs, pesticides, food additives, consumer products, and industrial chemicals. In the present study, ADMET-informatics of Tetradecanoic Acid (Myristic Acid) from ethyl acetate fraction of Moringa oleifera leaves to predict drug metabolism and pharmacokinetics (DMPK) outcomes has been taken up. This work contributes to the deeper understanding of Myristic acid as major source of drug from commonly available medicinal plant - Moringa oleifera with immense therapeutic potential. The data generated herein could be useful for NP based lead generation programs.

2.
Journal of Xinyang Normal University Natural Science Edition ; 33(2):210-219, 2020.
Article in Chinese | CAB Abstracts | ID: covidwho-2055548

ABSTRACT

ADMEN prediction was used to perform the first round screening from Traditional Chinese Medicine Database and Analysis Platform(TCMSP). then VASARA and molecular docking were used to screen again based on targets spike glyoprotein and angiotensin converting enzyme 2. and finally the interaction between target and drug was analyzed. 425 candidate ingredients of traditional Chinese medicine were screened from TCMSP database. when targeted by Spike glycoprotein. 12 ingredients were screened. They were contained artemisia apiacea salvia miltiorrhiza bge. scutellaria baicalensis. pinellia ternate. liquorice. radixImplettri and other traditional Chinese medicine. With ACE2 as the target. 77 components of traditional Chinese medicine were screened out. including salvia miltiorrhiza bge scutellaria baicalensis. pinellia ternatc. Liquorice. radix bupleuri. ephedra and other traditional Chinese medicine. At last. salviolone and dihydrotanshinlactone were found to be the potential inhibitor.

3.
Journal of Food Processing and Preservation ; 46(9), 2022.
Article in English | CAB Abstracts | ID: covidwho-2052701

ABSTRACT

Virgin Coconut oil (VCO), owing to its functional properties (important in COVID-19), is costly and, therefore, susceptible to adulteration with other cheaper oils like coconut oil. An enzyme-based biosensor confirmative test of VCO was constructed by co-immobilizing enzymes onto a glassy carbon electrode. The performance of the biosensor was optimized at a potential of +0.5 V with 45 mg gelatin, 30 mg BSA coupled with 2.5% glutaraldehyde at pH 7.0 with an incubation time of 1 hr. Adulterated samples of VCO with coconut oil (CO) were analyzed. The concentration of diglyceride (DG) was estimated from the empirical relation, which showed a linear increase with the increase in adulteration. The developed biosensor was validated using high-performance liquid chromatography (HPLC) methods using a paired sample t test at a 5% significance level. The biosensor could detect adulteration in VCO with CO above 20% within 3-5 s and can be reused for 25 days.

4.
Journal of Drug and Alcohol Research ; 10(236120(2), 2021.
Article in English | CAB Abstracts | ID: covidwho-2045354

ABSTRACT

COVID-19 is an infectious disease caused by a newly discovered CORONAVIRUS. It's a type of Severe Acute Respiratory Syndrome. The symptoms of SARS-nCOV-2 cause dry cough, fever, Tiredness, and difficulty of breathing (severe cases). We can cure the symptoms and defects of the whole body (vata, pitta, kapha) caused by the system and its qualitative therapists.

5.
Journal of Adolescent Health ; 70(4 Suppl):S1-S106, 2022.
Article in English | GIM | ID: covidwho-2044623

ABSTRACT

This journal issue includes 201 s of papers presented at the conference. Topics discussed include: association between cannabis use and COVID-19 and distress among adolescent patients;COVID-19 exposure and care-seeking behaviors among vulnerable urban adolescents and young adults;assessment of a poverty simulation in medical education;prevalence of chronic pelvic pain by sexual orientation in a large cohort of young women in the USA;confidentiality and patient satisfaction in adolescent telehealth visits;predictors of adolescent telemedicine visit no-shows during the COVID-19 pandemic;simulation of contraceptive access for adolescents using a pharmacist-staffed e-platform;foster caregivers and their role in contraception decision-making for adolescents in care.

6.
Journal of Henan Normal University Natural Science Edition ; 49(4):206-211, 2022.
Article in Chinese | CAB Abstracts | ID: covidwho-2040773

ABSTRACT

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease-19 (COVID-19), has become a global health issue. Spike proteins from the virus have a vital role in infection. Herbal medicines such as Lagerstroemia, Euphorbia hirta, and Kleinhovia hospita have several pharmacological functions such as anticancer, antiviral, and antioxidant because of their bioactive compound content. Based on an in silico study, this research was conducted on the possibility of phytochemicals from herbal Lagerstroemia, E. hirta, and K. hospita to inhibit spike protein SARS-CoV-2. A three-dimensional (3D) compound structure of each herbal medicine was docked with HR protein using AutoDock Vina software. The docking result, which has the best binding energy value, is continued with the analysis of molecular dynamics simulation. Lagerine, rutin, and nicotiflorin compounds might bind to proteins with lower binding energy. Protein was unstable when complexed with compounds compared with control, as seen from the root-mean-square deviation (RMSD) value. Therefore, this research is pre-experimental to inhibit SARS-CoV-2 spike proteins by herbal medicines.

7.
Iranian Journal of Field Crops Research ; 20(3), 2022.
Article in Persian | CAB Abstracts | ID: covidwho-2040588

ABSTRACT

Introduction: Most areas under spring sugar beet cultivation face severe water restrictions and increasing the area under cultivation of this crop in most of these areas is contrary to the principle of conservation of water and soil resources. The use of new areas for winter sugar beet cultivation should be the area under cultivation of this crop in hot and dry areas. Therefore, winter sowing (pending) of sugar beet with emphasis on the limitations of the country's water resources has been proposed as a solution. Materials and Methods: In this study, the quantitative and qualitative yield of 16 sugar beet genotypes in winter planting were studied as a randomized complete block design with four replications in the Torbat-e-Jam region in the two cropping years (2020-2021 and 2021-2022). The studied genotypes included F-20739, F-20837, F-21083, SBSI-5, SBSI-15, SVZA 2019-JD389, SVZA 2019-JD0402, SVZA 2019-JD0400, SVZA 2019-JD0401, FDIR 19 B 3021, FDIR 19 B 4028, F-20591, SBSI-6, SBSI-16, SBSI-7 and SBSI-17 are the breeding populations obtained from the gene bank of the Sugar Beet Seed Breeding Research Institute. In this research, traits such as root yield, sugar content, sugar yield, white sugar yield, Na, K, N, alkalinity, molasses sugar, white sugar content, and extraction coefficient of sugar were measured. Data were analyzed using SAS 9.1 software. The analysis of variance on test data and comparison to the middle of the Duncan test was performed at the 5% level. Factor analysis was calculated to identify the main factors using MINITAB software. Cluster analysis of the studied genotypes was obtained after standardizing the data by the Ward method and using Euclidean distance criterion with the help of SPSS software. Results and Discussion: The results of the combined analysis of variance showed that there was a significant difference between different genotypes of sugar beet at the level of 1% probability for all studied traits except for nitrogen content. The mean comparison showed that the SBSI-15 genotype had the highest root yield (60.66 ton.ha). It should be noted that this genotype in terms of yield index traits did not show significantly different from genotypes F-20739, SBSI-15, SVZA 2019-JD389, SVZA 2019-JD0402, SVZA 2019-JD0400, SVZA 2019-JD0401, and FDIR 19 B 4028. Also, the F-20739 genotype had the highest amounts of sugar content (19.5%), white sugar content (16.3%) and extraction coefficient of sugar (83.2%) and the lowest amount of potassium (4.24 meq .100 g-1 of root weight) and Molasses sugar (2.7%). In addition, the highest sugar yield (10.69 t/ha) and white sugar yield (8.68 t/ha) were in FDIR 19 B 3021 genotype. Investigating the correlation of traits showed the highest positive and significant correlation was between sugar yield and white sugar yield (0.99**) and the highest negative and significant correlation was between extraction coefficient of sugar and molasses sugar (-0.95**). Principal factor analysis based on the mean of the traits identified three factors that accounted for a total of 91% of the variability between the data. SBSI-15, SVZA 2019-JD0398, SVZA 2019-JD0402, SVZA 2019-JD0400, SVZA 2019-JD0401, FDIR 19 B 3021, and FDIR 19 B 4028 genotypes are distinguished different from other genotypes and they were as superior genotypes in terms of yield index traits. The dendrogram generated from the cluster analysis for white sugar yield classified genotypes into three main groups.

8.
Aroma Research ; 21(4):316-325, 2020.
Article in Japanese | CAB Abstracts | ID: covidwho-2034173

ABSTRACT

Stress such as uncertainty about the future, including the problem of new coronavirus infection, is a very serious problem not only for physical health but also for mental health. It is certain that stress is one of the risk factors for developing mental disorders. We have found stress-responsive biomarker (stress marker) candidates through studies on the process from stress to disease onset. Recently, we have been trying to prove the stress-suppressing effect of aroma with brain factors. We analyzed how aroma affects behavioral changes due to stress and the expression of stress marker candidates in the brain. In this article, the data on aroma that we have accumulated so far will be introduced. Specifically, we will describe changes happened in experimental animals when they smelled coffee beans, lavender, cypress, a-pinene, and thyme linalool. When considering the biological effects of aroma, it is inevitable that not only the olfactory pathway but also odor molecules act through the bloodstream by nasal and transdermal absorption. The brain transferability of odor molecules may be a bottleneck in analyzing the biological effects of volatile components. Thus, we would like to discuss on this issue.

9.
Revista de Politica Agricola ; 31(1):105-122, 2022.
Article in Portuguese | CAB Abstracts | ID: covidwho-2034170

ABSTRACT

The relationship between international trade and animal health is particularly important in the Agreement on the Application of Sanitary and Phytosanitary Measures (SPS) of the World Trade Organization - WTO. Supported by the World Organization for Animal Health (OIE), SPS measures are scientifically justified and play an important role in placing epidemiology at the center of decisions related to health and animal trade. The objective of this study was to discuss the interactions between the international meat trade and the epidemiology of zoonotic diseases of viral origin, in a debate on how the current Covid-19 pandemic could change the consumer behavior related to health and hygiene issues, and how the meat sector was affected by SPS measures, highlighting the relevance of Brazil in this context.

10.
Slovensky Veterinarsky Casopis ; 45(2):75-76, 2020.
Article in Slovak | CAB Abstracts | ID: covidwho-2034130

ABSTRACT

This article highlights information on the beneficial and pathogenic microorganisms of the oral cavity of dogs, effects of grass consumption, and the breeding and care of dogs.

11.
Pakistan Journal of Science ; 73(5):539-545, 2021.
Article in English | CAB Abstracts | ID: covidwho-2034337

ABSTRACT

In this study eco-friendly antimicrobial finish was developed by Azadirachata indica, Butea monosperma and Litchi chinensis and then applied on 100% silk fabric. The effectiveness of antimicrobial finish was checked up to 25 washes. The antimicrobial finish was extracted from leaves of these plants and applied on silk fabric by using pad dry cure method. It is true experimental study with pre-test and post-test control group design. FTIR and SEM tests were used to observe the presence of antimicrobial finish on silk fabric. The antimicrobial finish was fixed on silk fabric by the use of poly urethane binder. The antimicrobial activity of treated and untreated fabric and durability to successive washes were assessed by using ASTEM E2149 shake flask method. The treated fabric with A. indica and B.monosperme showed 100% reduction in microorganism presence while L. chinensis revealed 60% reduction against microorganisms. The antimicrobial finish showed 100% reduction after successive laundring up to 25 washes. This fabric is beneficial for home furnishing, sportswear and footwear industry as well as in apparel sector such as in formal wear and making matching face mask against COVID-19 pandemic.

12.
Journal of Henan Normal University Natural Science Edition ; 49(4):212-219, 2022.
Article in Chinese | CAB Abstracts | ID: covidwho-2026896

ABSTRACT

The COVID-19 pandemic has changed consumer demands for food products due to the importance of eating functional foods capable of increasing the body's immune system, such as those containing natural bioactive compounds. Immune system enhancement through food intake is one of the top priorities for consumers globally. Hard candy products are ordinary foods consumed by people of all ages and social classes with numerous negative consumer perceptions due to their ability to cause dental caries. Therefore, it is imperative to develop hard candy as a functional food with antioxidant and antibacterial properties derived from natural ingredients. This research aims to innovate and design hard candy products that are acceptable to consumers with the addition of gambir catechins to its formulas. This research is considered novel for it provides innovation and design of hard candy products that are acceptable to consumers with the addition of gambir catechins. The result showed that all hard candy product formulas have Staphylococcus aureus with antimicrobial and antioxidant activities;hence, increased catechin concentration significantly affects these activities. Products in formulas 17, 8, 18, 4, and 7 with 4-5 ratings after organoleptic testing are standard products manufactured in accordance with SNI 3547.1:2018.

13.
Chinese Journal of Oil Crop Sciences ; 44(2):242-248, 2022.
Article in Chinese | CAB Abstracts | ID: covidwho-2026021

ABSTRACT

Low self-sufficiency rate and the higher foreign dependence rate of about 87% have seriously threatened the soybean safety in China. In recent years, with the changes of the international situation and the COVID-19 epidemic, soybean production, processing and consumption in China have attracted more attention at home and abroad. China unveiled "No. 1 central document" proposed a soybean revitalization plan in 2019, putting forward the goal of "one expansion and two improvements" to strengthen the competitiveness of China's soybean industry in the international agricultural market. This paper reviewed the current situation of soybean production, processing, trade and consumption in China in recent years, and upgraded strategies to enhance China's soybean industry and enhanced the self-sufficiency rate according to China's national conditions.

14.
Revista Colombiana de Ciencias Horticolas ; 16(1), 2022.
Article in English | CAB Abstracts | ID: covidwho-2025869

ABSTRACT

Cape gooseberry fruits have positioned in the world market due to their excellent nutritional characteristics, because they are an ideal food that contributes to raising the defenses of the human body and helps it to face diseases such as COVID-19, they are also a natural source of antioxidants and anticancer agents. In order to avoid the physiopathy of cracking in cape gooseberry fruits, these were characterized at harvest time, coming from greenhouse plants irrigated with different applications of water levels and irrigation frequencies, as well as different calcium doses, in a design of randomized complete blocks with 12 treatments. The blocks were the irrigation frequencies (4, 9 and 14 days), while the treatments were the combination of four irrigation coefficients (0.7, 0.9, 1.1 and 1.3 of the evaporation of the tank class A) and three doses of calcium (0, 50 and 100 kg ha-1). The plants were sown in 20 L pots with peat moss substrate. Fruits were harvested at the color stage 5 and 6 of the calyx, from 19 weeks after transplanting. The different water levels and irrigation frequencies did not significantly affect the firmness of the cape gooseberry fruits, but there was a strong tendency that cracked gooseberry fruits are less firm than healthy fruits. As the irrigation coefficient increased, the total soluble solids (TSS) increased while the total titratable acids (TTA) decreased. Irrigation frequency of 14 days generated fruits with higher TSS and pH values. The calcium doses did not affect the calcium concentration in the fruits or the TSS, TTA and pH values. Therefore, it can be concluded that incremented irrigation coefficients (up to 1.3) increase the quality of cape gooseberry fruits.

15.
Journal of Cotton Research and Development ; 36(2):244-251, 2022.
Article in English | CAB Abstracts | ID: covidwho-2010741

ABSTRACT

The impact of COVID 19 on the economy in general is no doubt ravaging and its impact on agriculture is complex and varied across diverse segments that form the agricultural value chain. Cotton has a complex supply chain that stretch from input suppliers, farmers, traders, ginning factories, spinning mills, textile companies and oil processors. The study was designed to capture the panoramic view of world and national cotton economy during the pandemic period and its impact on cotton fanning in India. Cotton prices declined in the initial months for January to April, 2020 and later recouped once the lock down restrictions were phased out. As such from the study during the year 2020-2021, it was noticed in general, as per CAB estimates, cotton fanning in India was not Effected in its area and production excepting in north zone which was not due to lock down but for the pest attack and lack of irrigation facilities. Districtwise analysis confirmed that labour availability for loading and unloading and its transport was the major impediment especially in the southern zone while it was market uncertainty in the other zones. During the COVID 19 pandemic year, the cotton value chain, like others, had faced unprecedented disruptions. Cotton farmers and supply chain actors should work together to make sure that the farmers have secured acquaintance to sell their cotton. Farmers' protection should be considered a priority in getting the minimal requirements regarding the input supply, logistics and remuneration for their produce.

16.
Pharmacognosy Reviews ; 16(32):62-69, 2022.
Article in English | CAB Abstracts | ID: covidwho-2002632

ABSTRACT

Edible vaccines are created from transgenic plants and animals and contain immunostimulant. Edible vaccines, to put it simply, are medications generated from plants or animals. In underdeveloped countries, oral vaccines are less expensive and more widely available. Researchers came up with the idea of edible vaccines, in which edible plant pieces are employed as a vaccine factory. To make edible vaccinations, scientists put desired genes into plants and then force the plants to generate the proteins expressed in the genes. Transgenic plants are the result of transformation, whereas transformation is the act of converting plants. The edible vaccination promotes mucosal immunity. Dendritic cells in the gut can assist native T cells activate and differentiate into follicular T-helpers (Tfh). T and B cells will respond precisely to a reliable, digestible immunization. Potato, tomato, banana, carrots, tobacco, papaya, algae, and a variety of other plants are utilised as alternative agents for standard vaccinations. Malaria, cholera, hepatitis, rabies, measles, rotavirus, diarrhoea cancer treatments and treatment of covid-19 are among the illnesses for which plant-based vaccines have been created. It takes time and dedication to develop and sell edible vaccinations. Many edible vaccines for animal and human ailments have been developed and have gone through various levels of clinical testing. The importance of plant-based vaccinations is emphasized in this article.

17.
Nutrition Research and Practice ; 16(4):450-463, 2022.
Article in English | CAB Abstracts | ID: covidwho-2002594

ABSTRACT

BACKGROUND/OBJECTIVES: Adolescents who skip breakfast have an increased prevalence of chronic diseases. Thus, we aimed to evaluate whether the intake of rice-based breakfast had positive effects on blood glucose indices and to determine the possibility of diabetes prevalence in Korean youths who habitually skip breakfast. SUBJECTS/METHODS: In this randomized parallel-group controlled trial, 81 subjects who were suitable for compliance among 105 middle-and high-school students aged 12-18 years who usually skipped breakfast were included in this study (rice-meal group [RMG], n = 26;wheat-meal group [WMG], n = 29;general-meal group [GMG], n = 26). The RMG and WMG received a rice-based breakfast and a wheat-based breakfast for 12 weeks, respectively. The anthropometric indices, blood glucose indices, and metabolites were measured at baseline and the endpoint, respectively. RESULTS: The mean body weights in the RMG, WMG, and GMG groups at the endpoint were 62.44 kg, 61.80 kg, and 60.28 kg, respectively, and the mean body weights of the WMG and GMG groups at the endpoint were significantly higher than that at baseline (P < 0.05). The levels of fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) values were significantly decreased in the RMG group at the endpoint compared to baseline (P < 0.05, P < 0.05, respectively). The levels of tryptophan and tyrosine in the WMG group at the endpoint were significantly higher than that those at baseline (P < 0.01, P < 0.05, respectively). CONCLUSIONS: Rice-based breakfast has positive effects on fasting insulin levels and HOMA-IR in Korean adolescents who skip breakfast. Additionally, it was found that a skipping breakfast could increase the prevalence of diabetes in adolescents who skip breakfast. Therefore, in addition to reducing breakfast skipping, it is vital to develop a rice-based menu that fits teenage preferences to prevent chronic diseases such as diabetes.

18.
Genetics & Applications ; 5(2):1-9, 2021.
Article in English | CAB Abstracts | ID: covidwho-1994923

ABSTRACT

The genus Artemisia (fam. Asteraceae) is one of the largest and widely distributed with around 500 species, majority used as aromatic and medicinal plants. Artemisia annua L. is widely used as a dietary spice, herbal tea, as a supplement, and in a non-pharmaceutical form for treatment of malaria and fever. It is orally consumed as capsules, extracts and tinctures and topically applied as an essential oil diluted in lotions and ointments. Artemisinin is the main constituent of Artemisia annua L. extracts. Since the discovery that the artemisinin is efficient in malaria treatment, there is also a growth in consumption of A. annua extracts for antitumour and even recently for antiviral treatments against SARS-CoV-2 infections. This study aimed to investigate genotoxic effect in peripheral blood culture and cytotoxic effects in cancer and normal cell lines, of commercially available A. annua L. tincture in series of dilutions. Both comet and neutral red uptake assays revealed dose-dependent genotoxicity and cytotoxicity of A. annua tincture dilutions. Comet assay revealed significantly increased DNA damage in peripheral blood cells while neutral-red assays showed increase in cytotoxicity (p<0.001) in both normal and cancer cell cultures treated with the lowest extract dilution compared to the highest one applied. Obtained results indicate caution needed in A. annua L. tincture use, especially when poorly diluted.

19.
Entomologia Experimentalis et Applicata ; 170(8), 2022.
Article in English | CAB Abstracts | ID: covidwho-1961565

ABSTRACT

Originally, the 17th Symposium on Insect-Plant Relationships (SIP-17) was scheduled to take place in Leiden, The Netherlands, in July 2020. However, due to the COVID-19 pandemic, the symposium was postponed to July 2021 and held in an exclusively online format. This exceptional edition has resulted in four strong contributions to the journal. It is with great pleasure that we now present a themed issue including the proceedings of SIP-17, supplemented with eight regular articles within the subject of insect-plant relationships.

20.
Revista Latinoamericana de Estudios Rurales ; 7(13), 2022.
Article in Spanish | CAB Abstracts | ID: covidwho-1958302

ABSTRACT

In this paper, we analyze the effects of the COVID-19 pandemic and the preventive and compulsory social isolation, called ASPO in Argentina (Decree 297/2020), on the temporary and cyclical mobility of agricultural workers towards different productive areas of the country. On the one hand, we observe the effects on workers of Salta province who were involved in harvesting and packing tasks in the viniculture sector in Mendoza and the fruit growing sector in Rio Negro when the ASPO was declared by the government. On the other hand, we inquiry about the impact on Bolivian workers that were doing different works in tobacco and horticulture farms in Salta province at the beginning of the pandemic and the isolation measures. Moreover, we observe some effects on Bolivian people that were permanently (residents) or temporarily in Salta at the time when the ASPO and the closing of the border between Argentina and Bolivia began. The findings are based on interviews to agricultural workers, leaders of social organizations both from Bolivia and Salta origin, and civil servants of the Bolivian consulate in Salta carried out during 2020 and 2021. We incorporate in our analysis the collection of national and provincial news articles, web portals, decrees and official resolutions. We also include the findings of our previous research conducted before the pandemic about Bolivian mobility associated to tobacco and horticulture labor market in Salta province.

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