Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 709
Filter
1.
Pediatria de Atencion Primaria ; 24(93):e81-e85, 2022.
Article in Spanish | Scopus | ID: covidwho-1837250

ABSTRACT

Introduction: the main objective of the study was to analyse the influenza vaccination coverage in years 2019 and 2020 and assess the impact of the COVID-19 pandemic on it. To do so, we compared the patients vaccinated in 2 primary care centres (PCCs) of similar characteristics but that differed in that one of them actively recruited patients for vaccination by sending a reminder to their home address. Material and methods: we conducted an observational study in a sample of 934 patients vaccinated in the first month of the influenza vaccination campaign in years 2019 and 2020. We did a descriptive analysis of the sample. Subsequently, we compared the percentage of vaccinated patients at the end of the first month of the campaign in 2019 and 2020 and in the 2 PCCs using the χ2 test. Results: the overall percentage of patients vaccinated after the first month of the campaign was 33.9% in 2020 and 19.9% in 2019 (p <0.001), with significant differences between PCCs as well. A greater percentage of patients received the vaccine in PCC 1, which had an active patient recruitment strategy (p <0.001). Conclusions: the vaccination coverage was higher in 2020 compared to 2019, which could be explained by the anxiety elicited in the population by coexistence of influenza virus and SARS-CoV-2. Active recruitment strategies help increase vaccination coverage in patients with asthma. © 2022, Spanish Association of Primary Care Pediatrics. All rights reserved.

2.
Cells ; 11(9):1478, 2022.
Article in English | ProQuest Central | ID: covidwho-1837174

ABSTRACT

Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two innate immune cell types are activated by bitter products, including those secreted by Pseudomonas aeruginosa, leading to Ca2+-dependent activation of endothelial nitric oxide (NO) synthase (eNOS). NO enhances mucociliary clearance and has direct antibacterial effects in ciliated epithelial cells. NO also increases phagocytosis by macrophages. Using biochemistry and live-cell imaging, we explored the role of heat shock protein 90 (HSP90) in regulating T2R-dependent NO pathways in primary sinonasal epithelial cells, primary monocyte-derived macrophages, and a human bronchiolar cell line (H441). Immunofluorescence showed that H441 cells express eNOS and T2Rs and that the bitter agonist denatonium benzoate activates NO production in a Ca2+- and HSP90-dependent manner in cells grown either as submerged cultures or at the air–liquid interface. In primary sinonasal epithelial cells, we determined that HSP90 inhibition reduces T2R-stimulated NO production and ciliary beating, which likely limits pathogen clearance. In primary monocyte-derived macrophages, we found that HSP-90 is integral to T2R-stimulated NO production and phagocytosis of FITC-labeled Escherichia coli and pHrodo-Staphylococcus aureus. Our study demonstrates that HSP90 serves as an innate immune modulator by regulating NO production downstream of T2R signaling by augmenting eNOS activation without impairing upstream Ca2+ signaling. These findings suggest that HSP90 plays an important role in airway antibacterial innate immunity and may be an important target in airway diseases such as chronic rhinosinusitis, asthma, or cystic fibrosis.

3.
Cells ; 11(9):1402, 2022.
Article in English | ProQuest Central | ID: covidwho-1837116

ABSTRACT

Cytomegaloviruses (CMVs) belong to the β-subfamily of herpesviruses. Their host-to-host transmission involves the airways. As primary infection of an immunocompetent host causes only mild feverish symptoms, human CMV (hCMV) is usually not considered in routine differential diagnostics of common airway infections. Medical relevance results from unrestricted tissue infection in an immunocompromised host. One risk group of concern are patients who receive hematopoietic cell transplantation (HCT) for immune reconstitution following hematoablative therapy of hematopoietic malignancies. In HCT patients, interstitial pneumonia is a frequent cause of death from hCMV strains that have developed resistance against antiviral drugs. Prevention of CMV pneumonia requires efficient reconstitution of antiviral CD8 T cells that infiltrate lung tissue. A role for mast cells (MC) in the immune control of lung infection by a CMV was discovered only recently in a mouse model. MC were shown to be susceptible for productive infection and to secrete the chemokine CCL-5, which recruits antiviral CD8 T cells to the lungs and thereby improves the immune control of pulmonary infection. Here, we review recent data on the mechanism of MC-CMV interaction, a field of science that is new for CMV virologists as well as for immunologists who have specialized in MC.

4.
International Journal of Environmental Research and Public Health ; 19(9):5036, 2022.
Article in English | ProQuest Central | ID: covidwho-1837115

ABSTRACT

Background: Tobacco smoke has been associated with negative health outcomes, including those with chronic respiratory illnesses, such as asthma. This study aimed to assess the relationship between exposure to environmental tobacco smoke (ETS), as well as tobacco use (cigarette and electronic cigarettes), on asthma severity among adults with current asthma, with stratification by sex to understand potential biological sex differences. Methods: The study population consisted of Californian adults 18 years or older with self-reported physician/health care diagnosis of asthma and still having current asthma from 2020 California Health Interview Survey. All descriptive statistics and analyses were sex-stratified and survey-weighted. Crosstabulations were used to understand the association between asthma attack and ETS or firsthand smoke exposure, while binary logistic regression models were used to assess the effect of ETS exposure, current smoking status, and control variables on asthma attack in the past 12 months, with a sub-analysis among non-smoking adults with asthma. Results: Among the primary variable of interest, 35% of males and 30% of females reported ETS exposure in the past 12 months, while 13% of males and 6% of females reported being a current smoker. Past year asthma attack was reported among 43% and 55% of males and females, respectively. Among males, after adjusting for all control variables, asthma attack was significantly higher among those with ETS exposure (OR: 1.75, 95% CI: 1.01–3.02) and among current smokers (OR: 3.82, 95% CI: 1.49, 9.81). Male non-smokers with ETS exposure had a 109% higher odds of asthma attack, compared to non-exposure individuals. Conclusion: Using a population-based survey, our results highlight the ongoing burden of tobacco use and exposure particularly among males with current asthma, further corroborate the literature on the relationship between tobacco and asthma, and highlight putative sex-specific outcomes.

5.
International Journal of Environmental Research and Public Health ; 19(9):5742, 2022.
Article in English | ProQuest Central | ID: covidwho-1837090

ABSTRACT

Phthalate esters (PAEs) are ubiquitous in indoor environments as plasticizers in indoor products. Residences are often exposed to indoor PAEs in the form of gas, particles, settled dust, and surface phases. To reveal the mechanism behind the accumulation of PAEs in different tissues or organs such as the liver and the lungs when a person exposed to indoor PAEs with different phases, a whole-body physiologically based pharmacokinetic model for PAEs is employed to characterize the dynamic process of phthalates by different intake pathways, including oral digestion, dermal adsorption, and inhalation. Among three different intake pathways, dermal penetration distributed the greatest accumulation of DEHP in most of the organs, while the accumulative concentration through oral ingestion was an order of magnitude lower than the other two doses. Based on the estimated parameters, the variation of di-ethylhexyl phthalate (DEHP) and mono (2-ethylhexyl) phthalate (MEHP) concentration in the venous blood, urine, the liver, the thymus, the pancreas, the spleen, the lungs, the brain, the heart, and the kidney for different intake scenarios was simulated. The simulated results showed a different accumulation profile of DEHP and MEHP in different organs and tissues and demonstrated that the different intake pathways will result in different accumulation distributions of DEHP and MEHP in organs and tissues and may lead to different detrimental health outcomes.

6.
Journal of the Dow University of Health Sciences ; 16(1):27-33, 2022.
Article in English | CAB Abstracts | ID: covidwho-1836604

ABSTRACT

Objective: To investigate the adverse events on skin with continuous practice of personal protective equipment (PPE) in COVID-19 management among healthcare workers (HCWs).

7.
Security and Communication Networks ; 2022, 2022.
Article in English | ProQuest Central | ID: covidwho-1832713

ABSTRACT

This paper presents the design and implementation of a health monitoring system using the Internet of Things (IoT). In present days, with the expansion of innovations, specialists are always looking for innovative electronic devices for easier identification of irregularities within the body. IoT-enabled technologies enable the possibility of developing novel and noninvasive clinical support systems. This paper presents a health care monitoring system. In particular, COVID-19 patients, high blood pressure patients, diabetic patients, etc., in a rural area in a developing country, such as Bangladesh, do not have instant access to health or emergency clinics for testing. Buying individual instruments or continuous visitation to hospitals is also expensive for the regular population. The system we developed will measure a patient’s body temperature, heartbeat, and oxygen saturation (SpO2) levels in the blood and send the data to a mobile application using Bluetooth. The mobile application was created via the Massachusetts Institute of Technology (MIT) inventor app and will receive the data from the device over Bluetooth. The physical, logical, and application layers are the three layers that make up the system. The logical layer processes the data collected by the sensors in the physical layer. Media access management and intersensor communications are handled by the logical layer. Depending on the logical layer’s processed data, the application layer makes decisions. The main objective is to increase affordability for regular people. Besides sustainability in the context of finance, patients will have easy access to personal healthcare. This paper presents an IoT-based system that will simplify the utilization of an otherwise complicated medical device at a minimum cost while sitting at home. A 95 percent confidence interval with a 5 percent maximum relative error is applied to all measurements related to determining the patient’s health parameters. The use of these devices as support tools by the general public in a certain situation could have a big impact on their own lives.

8.
Vaccine ; 40(23):3087-3088, 2022.
Article in English | ProQuest Central | ID: covidwho-1829618

ABSTRACT

Why are Influenza Vaccination Rates Low in Children with Asthma? A study by the Centers for Disease Control and Prevention (CDC) reported that flu vaccination rates among children with current asthma ranged from a low of 48.7% in Oregon to a high of 72.9% in New Jersey with a median rate of 63% for 24 reporting states. Other practitioner barriers included difficulty identifying at-risk children, keeping track of immunization schedules and contraindications, lack of appropriate influenza-related educational materials, and the absence of reminder systems for both providers and patients. A pediatric practice can use CA for outreach to caretakers of asthma patients in a specific zip code for instance, customizing language and recommendations, and providing culturally appropriate images.

9.
EClinicalMedicine ; 45(23), 2022.
Article in English | CAB Abstracts | ID: covidwho-1828405

ABSTRACT

Background: COVID-19 is typically characterised by a triad of symptoms: cough, fever and loss of taste and smell, however, this varies globally. This study examines variations in COVID-19 symptom profiles based on underlying chronic disease and geographical location. Methods Using a global online symptom survey of 78,299 responders in 190 countries between 09/04/2020 and 22/09/2020, we conducted an exploratory study to examine symptom profiles associated with a positive COVID-19 test result by country and underlying chronic disease (single, co- or multi-morbidities) using statistical and machine learning methods. Findings From the results of 7980 COVID-19 tested positive responders, we find that symptom patterns differ by country. For example, India reported a lower proportion of headache (22.8% vs 47.8%, p<1e-13) and itchy eyes (7.3% vs. 16.5%, p=2e-8) than other countries. As with geographic location, we find people differed in their reported symptoms if they suffered from specific chronic diseases. For example, COVID-19 positive responders with asthma (25.3% vs. 13.7%, p=7e-6) were more likely to report shortness of breath compared to those with no underlying chronic disease. Interpretation We have identified variation in COVID-19 symptom profiles depending on geographic location and underlying chronic disease. Failure to reflect this symptom variation in public health messaging may contribute to asymptomatic COVID-19 spread and put patients with chronic diseases at a greater risk of infection. Future work should focus on symptom profile variation in the emerging variants of the SARS-CoV-2 virus. This is crucial to speed up clinical diagnosis, predict prognostic outcomes and target treatment.

10.
Journal of the Dow University of Health Sciences ; 16(1):41-45, 2022.
Article in English | CAB Abstracts | ID: covidwho-1824381

ABSTRACT

The pandemic of CoronaVirus-19 (COVID-19) is an alarming situation worldwide as it poses a considerable threat to the healthcare system. Various study results suggested the effect of COVID-19 on non-communicable diseases (NCDs) including asthma. The present study aims to review, describe and assess the impact of COVID-19 on asthma patients. The results of the current review suggest a non-significant impact of asthma on COVID-19 outcomes. However, the impact of COVID-19 on asthmatics is complex that may vary according to the clinical severity, patient age, or genetics in different populations. Hence it is needed to conduct studies with a large number of cohorts in different populations that may provide us with conclusive results. The use of corticosteroids is not recommended, but some studies suggested that by monitoring certain factors corticosteroids can be used for COVID-19 patients suffering from asthma. The future care of asthmatic patients in COVID-19 should include self-management, remote interventions, and social distancing.

11.
Frontiers in Immunology ; 13, 2022.
Article in English | EMBASE | ID: covidwho-1822363

ABSTRACT

Acute inflammation is a localized and self-limited innate host-defense mechanism against invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in humans, play pivotal roles in host defense by eradicating invading pathogens and debris. Ideally, elimination of the offending insult prompts repair and return to homeostasis. However, the neutrophils` powerful weaponry to combat microbes can also cause tissue damage and neutrophil-driven inflammation is a unifying mechanism for many diseases. For timely resolution of inflammation, in addition to stopping neutrophil recruitment, emigrated neutrophils need to be disarmed and removed from the affected site. Accumulating evidence documents the phenotypic and functional versatility of neutrophils far beyond their antimicrobial functions. Hence, understanding the receptors that integrate opposing cues and checkpoints that determine the fate of neutrophils in inflamed tissues provides insight into the mechanisms that distinguish protective and dysregulated, excessive inflammation and govern resolution. This review aims to provide a brief overview and update with key points from recent advances on neutrophil heterogeneity, functional versatility and signaling, and discusses challenges and emerging therapeutic approaches that target neutrophils to enhance the resolution of inflammation.

12.
Journal of Thrombosis and Haemostasis ; 20(5):1056-1066, 2022.
Article in English | EMBASE | ID: covidwho-1822054

ABSTRACT

Venous thromboembolism is a very common and costly health problem worldwide. Anticoagulant treatment for VTE is imperfect: all have the potential for significant bleeding, and none prevent the development of post thrombotic syndrome after deep vein thrombosis or chronic thromboembolic pulmonary hypertension after pulmonary embolism. For these reasons, alternate forms of therapy with improved efficacy and decreased bleeding are needed. Selectins are a family (P-selectin, E-selectin, L-selectin) of glycoproteins that facilitate and augment thrombosis, modulating neutrophil, monocyte, and platelet activity. P- and E-selectin have been investigated as potential biomarkers for thrombosis. Inhibition of P-selectin and E-selectin decrease thrombosis and vein wall fibrosis, with no increase in bleeding. Selectin inhibition is a promising avenue of future study as either a stand-alone treatment for VTE or as an adjunct to standard anticoagulation therapies.

13.
Biomedicine & Pharmacotherapy ; 150:113041, 2022.
Article in English | ScienceDirect | ID: covidwho-1821148

ABSTRACT

Background Lung diseases including chronic obstructive pulmonary disease (COPD), infections like influenza, acute respiratory distress syndrome (ARDS), asthma and pneumonia lung cancer (LC) are common causes of sickness and death worldwide due to their remoteness, cold and harsh climatic conditions, and inaccessible health care facilities. Purpose Many drugs have already been proposed for the treatment of lung diseases. Few of them are in clinical trials and have the potential to cure infectious diseases. Plant extracts or herbal products have been extensively used as Traditional Chinese Medicine (TCM) and Indian Ayurveda. Moreover, it has been involved in the inhibition of certain genes/protiens effects to promote regulation of signaling pathways. Natural remedies have been scientifically proven with remarkable bioactivities and are considered a cheap and safe source for lung disease. Methods This comprehensive review highlighted the literature about traditional plants and their metabolites with their applications for the treatment of lung diseases through experimental models in humans. Natural drugs information and mode of mechanism have been studied through the literature retrieved by Google Scholar, ScienceDirect, SciFinder, Scopus and Medline PubMed resources against lung diseases. Results In vitro, in vivo and computational studies have been explained for natural metabolites derived from plants (like flavonoids, alkaloids, and terpenoids) against different types of lung diseases. Probiotics have also been biologically active therapeutics against cancer, anti-inflammation, antiplatelet, antiviral, and antioxidants associated with lung diseases. Conclusion The results of the mentioned natural metabolites repurposed for different lung diseases especially for SARS-CoV-2 should be evaluated more by advance computational applications, experimental models in the biological system, also need to be validated by clinical trials so that we may be able to retrieve potential drugs for most challenging lung diseases especially SARS-CoV-2.

16.
The Journal of Allergy and Clinical Immunology: In Practice ; 2022.
Article in English | ScienceDirect | ID: covidwho-1819517

ABSTRACT

Structured : Background Inconsistent and unequal access to medical care is an issue that predates the COVID19 pandemic, which only worsened the problem. Limited access to care from asthma specialists and other specialists treating comorbid diseases may adversely affect asthma. Objective The purpose of this review is to identify health disparities associated with access to care for asthma, and cost-effectiveness of therapies and interventions addressing this health disparity. Methods A narrative systematic review was undertaken using MeSH searches of English language articles published in CINAHL, Scopus or PubMed. Results 725 articles were identified. Barriers recognized from the literature included access to diagnostic spirometry, access to specialists, medication formulary restrictions and issues leading to medical non-adherence. Telemedicine, school-based health care interventions, digital applications and non-office based digital spirometry could be used to address these gaps in access to asthma care while potentially being cost-effective. Conclusion With the widespread adoption of telemedicine because of the pandemic, and adoption of other mobile services, we now have potential tools that can increase access to asthma care, which can help address this healthcare inequity. Evidence is limited, but favorable, that some of these tools may be cost-effective.

17.
Pediatric Pulmonology ; n/a(n/a), 2022.
Article in English | Wiley | ID: covidwho-1819388

ABSTRACT

IntroductionIt is not clear whether asthma, the most frequent chronic disease in childhood, is a risk for severe SARS-CoV-2 infection in the pediatric population and how SARS-CoV-2 infection affects the lung functions in these patients.PurposeWe aimed to investigate the course and the consequences of SARS-CoV-2 infection among children with asthma and determine the risk factors for the decline in lung function testsMethodsIn this retrospective study, asthmatic children with Coronavirus disease 2019 (COVID-19) were compared with a random control group of asthmatic patients without COVID-19. In addition, the clinical course and the effect on lung function tests of COVID-19 among children with asthma were also evaluated.ResultsOne hundred eighty-nine patients who had COVID-19, and 792 who did not were included in the study. Fever, fatigue, and cough were the most frequent symptoms during COVID-19. Regarding the severity of COVID-19, 163 patients (87.6%) had a mild clinical condition, 13 (7%) had moderate disease, one (0.5%) had severe disease and two had (1.1%) critically ill disease. Two patients were diagnosed with multisystem inflammatory syndrome in children (MIS-C), one patient suffered from pneumothorax. Lung function tests of the patients before and after COVID-19 infection were analyzed;no significant differences were found in FEV1 % (91.7% vs 90.9%, p=0.513), FVC% (89.8% vs 90.8%, p=0.502) and FEV1/FVC (103.1% vs 100.6%, p=0.056), while FEF25-75% values (107.6% vs 98.4%, p<0.001) were significantly lower after the COVID-19 infection. Obesity [OR: 3.785, 95%CI: 1.152-12.429, P =0.028] and having a family history of atopy [OR:3.359, 95%CI:1.168-9.657, P = 0.025] were found to be the independent risk factors for ≥25% decrease in FEF25-75 after COVID-19 infection.ConclusionCOVID-19 infection leads to dysfunction of the small airways in asthmatic children and obesity is an independent risk factor for ≥25% decrease in FEF25-75. The long-term effects of COVID-19 infection especially on small airways require close monitoring in children with asthma.This article is protected by copyright. All rights reserved.

18.
Asia Pacific Allergy ; 12, 2022.
Article in English | EMBASE | ID: covidwho-1818572

ABSTRACT

Background: Allergen-specific immunotherapy (AIT) is accepted as the only disease-modifying therapy for IgE-mediated allergic airway diseases and hymenoptera venom allergy. AIT requires repeated contact between patient and physician or nurse in the hospital. Because it is a long-term treatment, compliance is essential issue to obtain maximal efficacy. Coronavirus disease 2019 (COVID-19) pandemic reshaped doctor-patient interaction and pattern of hospital admissions. Objective: We aimed to determine the possible changes in the administration of AIT and associated factors, in addition to the characteristics of patients diagnosed with COVID-19 infection. Methods: Adult patients who underwent AIT for hymenoptera venom allergy, allergic rhinitis or allergic asthma between 11 March 2020 and 31 January 2021 were included in our retrospective study. Perennial and preseasonal AIT practices were evaluated. We identified patients with COVID-19 infection among the ones who received AIT. Results: The mean age of 215 patients was 37.8±11.9 years and 52.1% of the patients were female. In our study, 35.4% of perennial AIT patients did not continue treatment after the COVID-19 pandemic, and the cause was patient-related in 66.7% of the cases. Compliance was 70.7% in patients receiving perennial AIT. The highest compliance rate for AIT was for venom allergy (86.5%). Thirty-four patients (15.8%) were diagnosed with COVID-19 infection. No mortality due to COVID-19 infection was observed in those who underwent AIT. Conclusion: COVID-19 pandemic has reduced compliance to AIT. Compliance was higher in venom immunotherapy than in aeroallergens. Severe COVID-19 infection and COVID-19 related death were not observed in patients receiving AIT.

19.
Cardiogenetics ; 12(2):133-141, 2022.
Article in English | EMBASE | ID: covidwho-1818054

ABSTRACT

Eosinophilic pancarditis (EP) is a rare, often unrecognized condition caused by endomyocardial infiltration of eosinophil granulocytes (referred as eosinophilic myocarditis, EM) associated with pericardial involvement. EM has a variable clinical presentation, ranging from asymptomatic cases to acute cardiogenic shock requiring mechanical circulatory support (MCS) or chronic restrictive cardiomyopathy at high risk of progression to dilated cardiomyopathy (DCM). EP is associated with high in‐hospital mortality, particularly when associated to endomyocardial thrombosis, coronary arteries vasculitis or severe left ventricular systolic dysfunction. To date, there is a lack of consensus about the optimal diagnostic algorithm and clinical management of patients with biopsy‐proven EP. The differential diagnosis includes hypersensitivity myocarditis, eosinophil granulomatosis with polyangiitis (EGPA), hypereosinophilic syndrome, parasitic infections, pregnancy‐related hypereosinophilia, malignancies, drug overdose (particularly clozapine) and Omenn syndrome (OMIM 603554). To our knowledge, we report the first case of pancarditis associated to eosinophilic granulomatosis with polyangiitis (EGPA) with negative anti‐neutrophil cytoplasmic antibodies (ANCA). Treatment with steroids and azathioprine was promptly started. Six months later, the patient developed a relapse: treatment with subcutaneous mepolizumab was added on the top of standard therapy, with prompt disease activity remission. This case highlights the role of a multimodality approach for the diagnosis of cardiac involvement associated to systemic immune disorders.

20.
Allergy, Asthma and Clinical Immunology ; 18(SUPPL 1), 2022.
Article in English | EMBASE | ID: covidwho-1817260

ABSTRACT

Background: Mast cells are tissue-resident sentinels that regulate responses to pathogens and allergens. They are critical for hypersensitivity reactions and typically activated in Th2 cytokine-rich environments during allergic disease. Mast cells respond to viruses by producing chemokines and type I and III interferons (IFNs). Clinical studies have investigated Th2 cytokine inhibitors, including IL-5 inhibitors, in asthma therapy1- 3. However, the influence of IL-5 inhibition on mast cell responses to virus infection remains unclear. The effects of IL-5 or IL-5 inhibition on mast cell antiviral responses may be important in virus-associated exacerbation of asthma. Methods: Human cord-blood-derived mast cells from anonymized donors (n = 14;12 donors) were isolated and pre-treated in culture medium with or without 10 ng/mL IL-5 for 48 hours. Cells were infected with OC43 coronavirus at 1.0 MOI, treated with poly(I:C), or left in culture medium (mock) for 24 hours. qPCR and Luminex analysis were performed to assess mRNA and protein levels for type I and III IFNs. Statistical analysis was performed using mixed-effects analysis with Sidak's multiple comparisons test. Results: Coronavirus infection or poly(I:C) treatment of mast cells resulted in significantly higher levels of IFNA2, IFNB1, and IFNL1 mRNA compared to respective mock treatments (p < 0.01-0.0001). Luminex analysis revealed that IFNα2 production was increased in IL-5-pretreated and non-pre-treated cells following poly(I:C) stimulation and following coronavirus infection of IL-5-pre-treated cells compared to controls (p < 0.001-0.0001). Interestingly, the enhancement of mRNA and protein expression following coronavirus infection or poly(I:C) treatment was significantly greater in IL-5-pre-treated compared to non-pre-treated mast cells for all targets (p < 0.05-0.001). Conclusions: IL-5-pre-treatment enhances the expression of type I and III IFN mRNAs by mast cells in response to coronavirus or poly(I:C), suggesting IL-5 may have an important role in mast cell antiviral responses. The mechanism by which IL-5 enhances mast cell IFN expression will be investigated further.

SELECTION OF CITATIONS
SEARCH DETAIL