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1.
Journal of Ayub Medical College ; 33(Suppl. 1):721-726, 2021.
Article in English | GIM | ID: covidwho-1970851

ABSTRACT

Background: Despite the fact that much has been written on various aspects of COVID-19, literature lacks a detailed and accurate description of HRCT findings in relation to the duration of the disease. The aim of this study was to investigate the difference in HRCT scan findings depending on the time after onset of the disease. The objective of the study is to identify and compare findings of HRCT scan at different time points after onset of the disease.

2.
Journal of Travel Medicine ; 28(7), 2021.
Article in English | GIM | ID: covidwho-1961086

ABSTRACT

This paper presents 2 COVID-19 cases, one with severe pneumonia and another with sequenced Delta variant, despite two doses of vaccination. The first case is A 59-year-old Caucasian American male with Glucose-6-Phosphate-Dehydrogenase (G6PD) deficiency had received ChAdOx1 nCoV-19 vaccines. He presented to CIWEC on 9 May 2021 having completed his trek in the Everest area up to 5500 m with cough, shortness of breath, diarrhoea, fatigue and fevers for 6 days. On admission, he was febrile at 39 degrees C, pulse 108/min, with oxygen saturation of 86% in room air that declined rapidly. He had crepitations over bilateral lung fields. Chest X-ray showed COVID-19 pneumonia. RT-PCR and BioFire tests from nasopharyngeal and oropharyngeal swabs were positive. He required oxygen via high flow nasal cannula (HFNC) followed by Venturi mask due to HFNC intolerance. He received monoclonal antibody cocktail of Bamlanivimab and Etesevimab (personally acquired), Remdesivir, Dexamethasone, low molecular weight heparin (LMWH), antibiotics and paracetamol. After 9 days, he had an oxygen saturation of 94-95% in room air. The d-dimer was high at 16 000 ng/ml initially and stayed high till discharge. Doppler bilateral lower limbs showed acute thrombus in the right calf muscular vein. LMWH was continued at discharge followed by oral Rivaroxaban for 3 months. He was asymptomatic with normal d-dimer during follow up on June 17. The second case is a 61-year-old Caucasian American hypertensive male, aspiring Everest summiteer, with history of mRNA-1273 vaccinations on 12 January and 8 February 2021, in the USA presented to CIWEC on 12 May 2021 after helicopter evacuation from Everest Base Camp with headache and runny nose for 1 day. His COVID-19 antigen test and RT-PCR were positive. Vitals and systemic examination were normal apart from nasal and throat congestion. He was discharged for hotel self-isolation. He did well and flew back home on 25 May 2021 after testing negative. Whole genomic sequencing (Allpex Seegene Covid Multiplex Screening Assay) done at Intrepid Nepal laboratory in Kathmandu showed the Delta variant B.1.617.2.

3.
Journal of School of Public Health & Institute of Public Health Research ; 19(4):413-422, 2022.
Article in Persian | CAB Abstracts | ID: covidwho-1957775

ABSTRACT

Background and Aim: The objective of this study was to determine the seroepidemiological history of SARS-CoV-2 infection among asymptomatic children in Tehran. Materials and Methods: Blood samples of children younger than 14 years old were collected during the period autumn-winter 2020 and spring 2021 and tested for SARS-CoV-2 IgG antibody using the EUROIMMUN ELISA kit. In addition, questionnaires were used to collect demographic and infection status information in the participants. Data were analyzed using the SPSS software.

4.
Iran J Microbiol ; 14(1): 10-14, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1955203

ABSTRACT

Background and Objectives: Since the COVID-19 pandemic initiation, more than 28 million elective surgeries were postponed with a cancellation rate of 72.3%. However, studies suggested that the patient treatment should be conducted within 12 weeks of diagnosis because delay in treatment might have had adverse impacts on patients' health status, prognosis, and pathologic stage. Hence, the current study aimed to assess the importance of a pre-operative COVID-19 screening test for the patients were candidates for elective surgery. Materials and Methods: This cross-sectional study was conducted on 141 patients who were candidates for any type of elective surgeries or cesarean section at a tertiary university-based hospital, between June 2020, and September 2020. Results: The mean age of participants was 41.38 ± 11.66 years. Of them, 91.5% were women and 8.5% were men. The COVID-19 polymerase chain reaction (PCR) screening tests were positive in 12 (8.5%) patients. From whose PCR tests were positive, only five people (less than half) had symptoms of COVID-19 such as fever (three patients), a distinctive smell (two patients), and cough (one patient). Suspected exposure to COVID-19 was reported in four of them. Conclusion: In this study, we found that more than half of PCR positive COVID-19 patients were asymptomatic. Therefore, to have a safe hospital environment, and improve patient health outcomes, the COVID-19 screening test should be applied before any interventions.

5.
Journal of Family Medicine and Primary Care ; 11(6):2274-2276, 2022.
Article in English | CAB Abstracts | ID: covidwho-1934374

ABSTRACT

The clinical spectrum of COVID-19 infection patients extends from being asymptomatic to mild, moderate and severe disease. This classification is largely based on oxygen saturation and respiratory rate. Asymptomatic/mild disease patients are managed in home isolation or COVID care centers. A subgroup of these patients will deteriorate and develop moderate to severe disease. Six-minute walk test is useful in identifying this group of patients by inducing hypoxia in normoxemia patients. This stage of the disease is labelled as 'pre-hypoxemia' phase in asymptomatic/mild disease. Identifying this stage in the course of illness of patients will help in intercepting further deterioration at the earliest by timely intervention.

6.
Science & Healthcare ; 24(2):93-102, 2022.
Article in English | GIM | ID: covidwho-1924995

ABSTRACT

Relevance. The outbreak of COVID-19 began in late 2019 in Hubei Province, China. Already in the first quarter of 2020, the disease spread around the world. On March 11, 2020, the WHO declared a COVID-19 pandemic. The first cases of the disease in Kazakhstan were registered in March 2020. The aim of the study: a systematic search for scientific information about the socially significant disease COVID-19 and its immunopathogenetic basis for the severity of the course. Search strategy: Research publications were searched in PubMed, ResearchGate, GoogleScholar databases. A total of 325 references were found, of which 89 were selected for analysis.

7.
Shanghai Journal of Preventive Medicine ; 33(4):287-290, 2021.
Article in Chinese | GIM | ID: covidwho-1924836

ABSTRACT

Objective: To model an outbreak of coronavirus disease 2019 (COVID-19) in Shijiazhuang and forecast its spread trend. Method: We collected confirmed COVID-19 cases from the Health Commission of Hebei Province during the period of January 2 to January 27, 2021. We built a new model (SEIaIcRK), including the contribution of asymptomatic cases, based on the traditional SEIR model to explore and analyze the transmission of COVID-19.

8.
Salud Publica de Mexico ; 64(3):243-248, 2022.
Article in English | CAB Abstracts | ID: covidwho-1904075

ABSTRACT

Objective. To describe the humoral response in a cohort with mild and asymptomatic SARS-CoV-2 infection previously identified in a community-based serological survey. Materials and methods. This study was an observational follow up of 193 subjects previously identified with positive anti-SARS-CoV-2 antibodies invited for a second test 112 daysafter the first sampling. All completed a standardized electronic questionnaire. IgM/IgG antibodies were determined using aqualitative IgM/IgG chemiluminescent immunoassay. Results. Among the 193 eligible subjects, a total of 174 (90%) attended the follow-up visit, and their serum samples were tested. Of the samples, 171 (98.3%) were still positive, and 3 (1.7%) were negative. Also, the cut-off index (COI) value of the immunoassay significantly increased from the first to the second test (P < 0.001). Conclusions. Our findings support a sustained humoral response in individuals with mild and asymptomatic SARS-CoV-2 infectionup to 112 days after a positive serologic baseline test, accompanied by increasing antibody titers.

9.
Salud Publica de Mexico ; 64(3):249-258, 2022.
Article in English | CAB Abstracts | ID: covidwho-1904073

ABSTRACT

Objective. To detect serum IgG anti-SARS-CoV-2 in pre-and post- Covid-19 pandemic in Mexican asymptomatic subjects in order to know the degree of viral dispersion. Materials and methods. Association of serum IgG antibodies (determined by ELISA) to sociodemographic and clinical data or contact with Covid-19 cases in three groups of subjects: (1) Covid-19 pre-pandemic blood donors (n= 538);(2) Covid-19 post-pandemic blood donors (n= 243);(3) Covid-19 post-pandemic neurological patients (n= 312). None of the subjects studied had been vaccinated. Results. The positive rate of IgG anti-SARS-CoV-2 was notably higher in participants recruited during the pandemic (donors, 29.6%;neurological patients, 15.7%) than in those recruited pre-pandemic (donors 0.6%) (p < 0.001). Other conditions associated to antibody positivity were being a worker in sales or services, or having had previous contact with people with Covid-19, for donnors and neurological patients, and having diabetes mellitus, for neurological patients. Higher positivity levels of anti-SARS-CoV-2 IgG were found in females than in males. The highest proportion of subjects with anti-SARS-CoV-2 antibodies was found in central Mexico. Conclusions. The dispersion of SARS-CoV-2 in asymptomatic, unvaccinated subjects (donors and neurological patients) recruited in a Mexican health institution, who work in sales or services or had previously had contact with Covid-19 patients is 16 to 30%. The level of positivity for anti-SARS-CoV-2 IgG is higher in females than in males. SARS-CoV-2 antibody seroprevalence follow-up studies must be favored among the general population, being mandatory for donors.

10.
China Tropical Medicine ; 22(4):359-364, 2022.
Article in Chinese | GIM | ID: covidwho-1903927

ABSTRACT

Objective: To compare the clinical features of patients with breakthrough infection after getting different kinds of COVID-19 vaccines, in order to provide reference for clinical diagnosis and treatment of such patients.

11.
China Tropical Medicine ; 22(4):320-323, 2022.
Article in Chinese | GIM | ID: covidwho-1903926

ABSTRACT

Objective: To analyze the epidemiological characteristics and effect of prevention on imported COVID-19 cases in Beijing, and provide scientific evidences for the prevention and control of imported COVID-19.

12.
Vestnik KAZNMU ; 3:337-342, 2021.
Article in Russian | GIM | ID: covidwho-1897535

ABSTRACT

A literature review on the features of residual phenomena and consequences of COVID-19 is analyzed on the basis of data published so far. By the beginning of January 2021, COVID-19, accompanied by severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2), led to more than 83 million confirmed cases and more than 1.8 million deaths. The clinical spectrum of SARS-CoV-2 infection is wide, including asymptomatic infection, fever, fatigue, myalgia, mild upper respiratory tract disease, severe and life-threatening viral pneumonia requiring hospitalization, and death. COVID-19 is a new disease, and uncertainty remains about possible long-term health consequences. To date, it is known that the majority of infected people, especially at a young age, have a mild course of the disease, compared with older people. In some patients, the disease progresses rapidly and various complications develop, including multiple organ failure. Therefore, early detection and timely treatment of critical cases is crucial.

13.
Revista Espanola de Salud Publica ; 95(e202110176), 2021.
Article in Spanish | GIM | ID: covidwho-1888083

ABSTRACT

Background: The impact of the first wave of the pandemic due to SARS-CoV-2 has been enormous in Spanish hospitals, being Madrid one of the most affected communities. The aim of this study was to analyze the impact of the pandemic on the workers of a hospital located in one of the most affected areas of Madrid (Alcala de Henares) using a chemiluminescence immunoassay (CLIA).

14.
International Journal of Public Health Research ; 11(2):1418-1424, 2021.
Article in English | CAB Abstracts | ID: covidwho-1887926

ABSTRACT

Introduction: The rapid spread of the COVID-19 worldwide has led the World Health Organization (WHO) to declare COVID-19 outbreak as a pandemic on March 11, 2020. This study aims to determine the factors associated with asymptomatic COVID-19 patients in Petaling District, Selangor, Malaysia.

15.
Revista Espanola de Salud Publica ; 94(e202009106), 2020.
Article in Spanish | GIM | ID: covidwho-1887775

ABSTRACT

Background: The Covid-19 pandemic is testing the resistance of health systems, the preservation of health professionals is a priority in processes of this type. The professionals' exposure to suspicious contacts often requires their confinement. The objective was to know the epidemiological characteristics of the primary care professionals who required confinement.

16.
Wiener Klinische Wochenschrift ; 133(23/24):1237-1317, 2021.
Article in English | GIM | ID: covidwho-1887503

ABSTRACT

This issue contains 12 articles discussing COVID-19 and other medical conditions. In particular, topics are: changes in characteristics and outcomes of critically ill COVID-19 patients in Tyrol, Austria, over 1 year;clinical characterization of hospitalized COVID-19 patients during the second wave of pandemic in the district of Rohrbach, Upper Austria;perspectives and needs of people at increased risk of severe illness from COVID-19;12-month SARS-CoV-2 antibody persistency in a Tyrolean COVID-19 cohort;prevalence of SARS-CoV-2 antibodies in healthy blood donors from Tyrol, Austria, in summer 2020;asymptomatic deep vein thromboses in prolonged hospitalized COVID-19 patients;direct cardiovascular complications and indirect collateral damage during the COVID-19 pandemic;point of care echocardiography and lung ultrasound in critically ill patients with COVID-19;management of hospitalized influenza A patients during the season 2018-19;CAR T-cell therapy and critical care;infectious diseases after medical conventions;and a case report of a frontal pulsating skin indentation with a central scar.

17.
J Am Board Fam Med ; 35(3): 570-578, 2022.
Article in English | MEDLINE | ID: covidwho-1875332

ABSTRACT

INTRODUCTION: Universities are unique settings with large populations, congregate housing, and frequent attendance of events in large groups. However, the current prevalence of previous COVID-19 infection in university students, including symptomatic and asymptomatic disease, is unknown. Our goal therefore was to determine the prevalence of previous infection, risk factors for infection, and the prevalence of persistent symptoms following infection among university students. METHODS: This was a cross-sectional study set in a large public university between January 22 and March 22, 2021. We surveyed students about demographics, risk factors, and symptoms, and simultaneously tested their saliva for IgA antibodies to SARS-CoV-2. To estimate the prevalence of previous infection we adjusted our intentional sample of a diverse student population for year in school and age to resemble the composition of the entire student body and adjusted for the imperfect sensitivity and specificity of the antibody test. Univariate and multiple regression analysis was used to identify independent risk factors for infection, and the proportion of students with persistent symptoms following acute infection was determined. RESULTS: A total of 488 students completed the survey, 432 had a valid antibody result, and 428 had both. The estimated prevalence of previous infection for 432 participants with valid antibody results was 41%. Of 145 students in our sample with a positive antibody test, 41.4% denied having a previous positive polymerase chain reaction (PCR) test for SARS-CoV-2 and presumably had an asymptomatic infection; in our adjusted analysis we estimate that approximately 2-thirds of students had asymptomatic infections. Independent risk factors for infection included male sex, having a roommate with a known symptomatic infection, and having two or fewer roommates. More frequent attendance of parties and bars was a univariate risk factor, but not in the multiple regression analysis. Of 122 students reporting a previous symptomatic infection, 14 (11.4%) reported persistent symptoms consistent with postacute COVID-19 a median of 132 days later. CONCLUSIONS AND RELEVANCE: Previous COVID-19 infection, both symptomatic and asymptomatic, was common at a large university. Measures that could prevent resurgence of the infection when students return to campus include mandatory vaccination policies, mass surveillance testing, and testing of sewage for antigen to SARS-CoV-2.


Subject(s)
COVID-19 , SARS-CoV-2 , COVID-19/epidemiology , Cross-Sectional Studies , Humans , Male , Prevalence , Universities
18.
Revista Espanola de Salud Publica ; 94(e202009092), 2020.
Article in Spanish | GIM | ID: covidwho-1870888

ABSTRACT

Background: The Spanish registry of Covid-19 in Spanish pregnant women, made up of 100 centers, is created in response to the need to know the morbidity that Covid-19 generates in pregnant women and their newborns, to know the real incidence of the disease in this population group and to establish and monitor the package of measures to improve their care. The aim of this paper was the creation of a registry of pregnant women with Covid-19 infection in order to establish the interventions and measures necessary to improve the care of these patients during hospital admission.

19.
Travel Med Infect Dis ; 49: 102361, 2022 May 29.
Article in English | MEDLINE | ID: covidwho-1867827

ABSTRACT

INTRODUCTION: SARS-CoV-2 continues to have a high rate of contagion worldwide. The new variant of concern, Omicron, has mutations that decrease the effectiveness of vaccines and evade antibodies from previous infections resulting in a fourth wave of the pandemic. It was identified in Mexico in December 2021. METHODS: The Traveler's Preventive Care Clinic from the Faculty of Medicine UNAM at Mexico City International Airport has performed rapid antigen and PCR SARS CoV2 tests since January 2021 to comply with the new travel requirements. Demographic and clinical characteristics were collected from each passenger and the fourth wave of the pandemic in Mexico mainly caused by Omicron was analyzed in the travelers. RESULTS: A total of 5176 travelers attended the clinic between the second half of December 2021 and January 2022. Ten percent of all the tests performed were positive (13% of PCR and 9.3% of antigens, p = 0.001). Most of the SARS CoV2 positive cases were asymptomatic (78%), with a ratio of 3.5:1 over the symptomatic. By age groups, this ratio was higher for those under 20 years old (8.7:1). DISCUSSION: This study shows the rapid escalation of positivity that occurred in Mexico, detected in travelers, from the second half of December 2020 and throughout the month of January 2021. The incidence of COVID-19 was extremely high in travelers who were mostly asymptomatic for the period under study.

20.
Journal of Communicable Diseases ; 54(1):67-75, 2022.
Article in English | CAB Abstracts | ID: covidwho-1865705

ABSTRACT

Background: The daily cases and fatalities in the COVID-19 pandemic are still on the rise. This study aimed to examine the epidemiological trends of the COVID-19 patients at an early stage in the pandemic.

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