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1.
Internal Medicine Alert ; 44(9), 2022.
Article in English | ProQuest Central | ID: covidwho-1824407
2.
Applied Radiology ; 51(2):28-32, 2022.
Article in English | ProQuest Central | ID: covidwho-1824329

ABSTRACT

Breast cancer is the leading cause of cancer death for women worldwide, and its incidence continues to increase, particularly in low- and middle-income countries (LMICs).3 There is relatively higher mortality from breast cancer in LMICs compared to high-income countries (HICs), which may be due to differences in tumor biology, limited awareness about breast cancer on the part of patients or healthcare providers, and lack of access to screening, diagnostic, and treatment services.1,5-8 Without structured screening programs or easily accessible imaging and intervention, breast cancer in LMICs is more commonly diagnosed at a late stage (stage III or IV) compared to HICs.3 While early-stage breast cancer is largely curable with appropriate surgical, oncologic, and radiation therapy, late-stage breast cancer has a much higher morbidity and mortality rate.4,9 Furthermore, late-stage breast cancer requires more advanced therapies, which are difficult to come by in the low-resource setting. The Breast Health Global Initiative (BHGI) and the National Comprehensive Cancer Network (NCCN) have published comprehensive guidelines suggesting how resources should be allocated toward various aspects of breast cancer care depending on resource availability.12,13 We also adhere to a phased implementation approach to build capacity gradually without overwhelming our partners.14 Our first step of program planning, therefore, is always a thorough assessment of our target population and the local availability of screening, diagnostic services (imaging, tissue sampling, and pathology) and treatment. [...]we plan with an eye toward sustainability to ensure our interventions lead to lasting improvement. There is also evidence that ultrasound may be a useful screening tool in areas where mammography is unfeasible.17 In the United States, RAD-AID launched a longitudinal collaboration with the Black Women's Health Imperative (BWHI), National Alliance of Hispanic Health, and Hologic Inc.'s Project Health Equality to bring awareness to and address long-standing healthcare disparities that affect women of color.18 In this initiative, we collaborate with and support primary care centers that are already serving medically underserved women of color as well as tertiary centers interested in improving access to specialty care for women who need it most.

3.
HEM/ONC Today ; 23(3):1-18, 2022.
Article in English | ProQuest Central | ID: covidwho-1824129

ABSTRACT

Healio ;HemOnc Today spoke with oncologists and leading communication experts in science and medicine about the prevalence of cancer misinformation on social media, important research into the issue, and possible strategies to improve communication platforms and disseminate trustworthy information more effectively. A problem 'across multiple health topics' Skyler B. Johnson, MD, physicianscientist at Huntsman Cancer Institute and assistant professor of radiation oncology at The University of Utah, discovered the scale and scope of cancer misinformation when his wife was diagnosed with cancer. In July, Johnson and colleagues published results of a study in Journal of the National Cancer Institute that showed one-third of the most popular cancer treatment articles on social media included inaccurate information. The researchers found that: * online search volume for cannabis and cancer increased at 10 times the rate of standard therapies (more in states where recreational or medical cannabis was legal);* cannabis as a cancer cure represented the largest category of social media content (23%) on alternative cancer treatments;* of the 40 high-impact new stories on social media referencing cannabis and cancer, 32 (80%) were false news that proposed cannabis as a cancer cure and only one (2.5%) was an accurate news story that debunked that claim;and * the top false news story claiming cannabis as a cancer cure generated 4.26 million engagements on social media;meanwhile, the top news story debunking this false news only received 36,000 engagements.

4.
HEM/ONC Today ; 23(5):24, 2022.
Article in English | ProQuest Central | ID: covidwho-1824128

ABSTRACT

"COVID-19 misinformation is a significant public health concern, and more vulnerable groups may be at increased risk of believing such types of misinformation - something their health care providers should be aware of and possibly address in relation to patients' concerns about the pandemic and how it relates to their treatment," Jeanine P.D. Guidry, PhD, assistant professor at Robertson School of Media and Culture and director of the media and health lab at Virginia Commonwealth University, told Healio ;HemOnc Today. Because patients undergoing treatment are particularly vulnerable to misinformation, the cancer care community must address patients' concerns on how the pandemic relates to their course of treatment, the researchers wrote. [...]we have no information on how the volunteers were selected - through online patient communities, online advertisement or other means - which means we cannot calculate the response rate.

5.
HEM/ONC Today ; 23(4):3, 2022.
Article in English | ProQuest Central | ID: covidwho-1824127

ABSTRACT

[...]COVID-19 affected all things in everybody's lives, but for patients with cancer it was really a much harder time," Antoni Ribas, MD, PhD, FAACR, professor of medicine, surgery and molecular and medical pharmacology at University of California, Los Angeles, director of the tumor immunology program at Jonsson Comprehensive Cancer Center, past AACR president, and chair of the report's steering committee, told Healio ;HemOnc Today. Building off the pandemic shining a light on the necessities of science and research, the AACR report included a call and action with recommendations for federal lawmakers to further support efforts to expand and enhance health care. The AACR called for: * at least $10 billion for the NIH and its grantees to offset pandemicrelated research costs as emergency supplemental funding, as proposed in the Research Investment to Spark the Economy (RISE) Act of2021;* funding increases of at least $3.5 billion for NIH and $1.1 billion for the NCI in fiscal year 2022, for total funding of $46.4 billion for NIH and $7.6 billion for NCI;* policies that broaden health care coverage and reduce inequities in access to health care, such as expanding Medicaid;and * increased diversity in clinical trials and efforts to alleviate the financial burden on prospective trial participants by reimbursing patients for ancillary trial-related costs, such as transportation and lodging, as established in the DIVN1 -https://media.proquest.com/media/hms/PFT/1/CaCpM?_a=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&_s=ASRlzCrgmzWR0jTNPlDJ055q%2FU4%3D ERSE Act.

6.
African Journal of Biomedical Research ; 25(1):1-11, 2022.
Article in English | CAB Abstracts | ID: covidwho-1823762

ABSTRACT

Spondias mombin is one of the species belonging to the (Family: Anacardiaceae), its ethnomedicinal uses may be justified through many studies that reported potential pharmacological properties due to its phytochemical compounds. This review aimed at examining the ethnomedicinal uses, phytochemical compounds and pharmacological properties of S. mombin leaf extracts on the African continent, to justify its use in the management and/ or treatment of viral infections and cancers. Electronic databases such as Google Scholar, SciHub, PubMed and Science Direct with search dates between 1999 and 2019 were used. Findings from this review confirm the ethnomedicinal uses, of decoctions and infusions of S. mombin leaf extracts for management diseases such as malaria, sore throat, and inflammation disorders;studies confirmed the presence of phytochemical compounds such as Geraniin, 2-O-Caffeoyl-(+)-allohydroxycitric acid, Quercetin-3-O-beta-D-glucopyranoside and pelandjuaic acid, responsible for the antiviral and chemotherapeutic properties. However, there is a need for bio-assay guided extractions, isolation, identification and characterization of phytochemical compound(s) in the leaf extracts of S. mombin that may be responsible for antiviral and anticancer activity. Investigations of the pharmacological action, in silico and in vitro studies of known and /or newly isolated compounds are warranted in the management and /or treatment of viral infections such as, Severe Acute Respiratory Syndrome Coronavirus 2, and cancers to justify the use of leaf extracts of S. mombin on the African continent for the management of viral infections and or cancer.

7.
HEM/ONC Today ; 23(3):16-17, 2022.
Article in English | ProQuest Central | ID: covidwho-1823699

ABSTRACT

The 21st century's primary communication channel has become such a part of everyday life that several members of the cancer care community formed Collaboration for Outcomes using Social Media in Oncology (COSMO), which held an inaugural, virtual 2-day meeting last year. COSMO began as a crowdsourced group of professionals interacting on Twitter regularly about 6 years ago, according to Don S. Dizon, MD, FACP, FASCO, head of community outreach and engagement at the Cancer Center at Brown University and head of the breast and pelvic malignancies program at Lifespan Cancer Institute. Attai, associate clinical professor of surgery at David Geffen School of Medicine at University of California, Los Angeles, said Twitter has evolved over the past decade from a novelty among health care providers for sharing information at meetings to an essential tool for a variety of reasons.

8.
Egyptian Journal of Hospital Medicine ; 87:1017-1023, 2022.
Article in English | Academic Search Complete | ID: covidwho-1823608

ABSTRACT

Background: The recent widespread of COVID-19 led to a marked increase in the number of CT chest examinations. This led to frequent encounters of associated incidental findings as thyroid nodules. Thyroid imaging reporting and data system (TI-RADS) using variable ultrasound feature-allowed systematic reproducible approach for diagnosis and management of thyroid nodules. Objective: This study aimed to detect the prevalence of incidental thyroid nodules in CT chest for COVID-19 cases as well as the percentage of malignant nodules among them and the concordance of TI-RADS classification with fineneedle aspiration cytology (FNAC) results. Patients and methods: This retrospective study included 895 patients with CT findings of COVID-19 pneumonia. 203 patients were excluded due to absent PCR confirmation of COVID-19, lack of ultrasound confirmation of thyroid nodules or lack of FNAC results, so our study included 692 patients with confirmed COVID-19 pneumonia. Results: A solitary thyroid nodule was discovered in 134 CT chest scans of 692 patients with confirmed COVID-19 pulmonary pneumonia, with a 19.4% incidence. These patients underwent ultrasound evaluation for the thyroid nodule. The nodules with TI-RADS 1-3 score were considered benign yet those with 4-5 score were classified as malignant. The results of the FNAC were compared to the thyroid TI-RADS classification, with nodules classified as Bethesda II-III being benign and those classified as Bethesda IV to VI being malignant. Conclusion: Incidental thyroid nodule discovered during CT chest examination is an important finding and should be investigated and categorized using the TI-RADS system as even though the incidence of malignancy is not high, early diagnosis of thyroid malignancy can have a huge effect on the patient outcome. [ FROM AUTHOR] Copyright of Egyptian Journal of Hospital Medicine is the property of Egyptian Journal of Hospital Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

9.
Akademik Acil Tip Olgu Sunumlari Dergisi ; 12(3):85-87, 2021.
Article in English | EMBASE | ID: covidwho-1822751

ABSTRACT

Introduction: Epistaxis and gingival bleeding are among the most common presentation to the emergency department for patients with thrombocytopenia. Here, we present a case who was admitted to the emergency department with thrombocytopenia and was diagnosed with metastatic cancer of unknown primary origin. Case Report: A 26-year-old male patient was admitted to the emergency department with gingival bleeding and epistaxis. The body temperature was 38.3 °C. Petechial rash, ecchymosis or organomegaly was not detected on physical examination. Laboratory results revealed thrombocytopenia as 31 × 103 (159-388 × 103/μL). Although hemoglobin and leukocyte counts were normal, no band or precursor cell was observed in the patient's peripheral blood smear. There was no history of weight loss, night sweats, arthritis, malar rash, photosensitivity, contact with ticks, animals, or a COVID-19 patient. Serological tests performed for infections such as HIV, EBV, HCV, Crimean-Congo hemorrhagic fever were negative. Bone marrow biopsy was performed due to the unexplained cytopenia, reported as "signet ring cell metastatic adenocarcinoma". Gastrointestinal system endoscopy was performed to detect primary cancer. A biopsy was taken from the antrum and corpus revealed gastritis. An FDG PET-CT was revealed heterogeneously pathologically increased FDG attitude in all axial and appendicular bones. Despite all the modalities of diagnosis, the origin was not found and the patient was transferred to the oncology department for treatment with a diagnosis of cancer of unknown origin with bone marrow infiltration. Conclusion: Bone marrow metastases should be kept in mind in patients presenting with thrombocytopenia.

10.
Surgical Neurology International ; 13, 2022.
Article in English | EMBASE | ID: covidwho-1822704

ABSTRACT

Background: Spondylodiscitis could be considered one of the most disturbing challenges that face neurosurgeons due to variety of management strategies. The lumbar region was highly affected then dorsal region with higher percentage for lesion in L4/5 (25%) followed by T11/12 and L5/S1 (15%). In our study, we discuss the efficacy of debridement and fixation in cases of spontaneous thoracic and lumbar spondylodiscitis. Methods: This retrospective study included 40 patients with spontaneous thoracic or lumbar spondylodiscitis indicated for surgical intervention in the period from March 2019 to February 2021. All patients were subjected to thorough history taking, neurological examination, and investigations. The patients were operated on through posterior approach by debridement and posterior transpedicular screws fixation and fusion. Results: Clinical assessment early postoperative revealed 75% of cases showed full motor power and 20% showed improvement in motor power, for sensory assessment, 85% showed improvement, the mean visual analog scale (VAS) score was of 3.65 ± 0.87. After 3 months postoperatively, 95% of cases were full motor power with sensory and autonomic (sphincteric) improvement. The mean VAS score was 2.5 ± 0.68. After 6 months postoperative, the clinical assessment revealed that 95% of cases were full motor power with sensory manifestation improvement, and 95% of them were continent. The mean VAS score was 1±0.85. Culture results showed that 65% of samples were negative culture, 15% had methicillin-resistant Staphylococcus aureus, and 10% had Escherichia coli with a single case of Pseudomonas and another one of fungal (Candida albicans). Postoperative 90% of cases showed improvement in erythrocyte sedimentation rate results and 95% of cases showed improvement in C-reactive protein results. Conclusion: Management of spontaneous thoracic and lumbar spondylodiscitis by surgical debridement and posterolateral open transpedicular fixation seems to be effective and safe method despite the presence of infection. We found that the clinical condition of our patients showed significant improvement with this addressed approach.

11.
Siberian Journal of Oncology ; 21(1):99-106, 2022.
Article in Russian | EMBASE | ID: covidwho-1822671

ABSTRACT

The aim of the study was to analyze the most significant studies representing the basic principles of diagnosis and treatment of patients with breast cancer (BC) during the CO VID -19 pandemic. Material and Methods. The search for relevant sources was carried out in PubMed, Cochrane Library, Web of Science systems, publications for 2019-2020 were studied, 48 of which were used to write this review. Results. During the CO VID -19 pandemic, it is necessary to suspend screening examinations for a certain period of time;patients with early and metastatic breast cancer should be transferred to outpatient treatment in the LU s located in their place of residence. Examinations and consultations of patients undergoing hormone therapy should be postponed or carried out using telemedicine technologies. Treatment of breast cancer patients during a pandemic should be carried out according to clinical guidelines and protocols, but minimizing the number of visits to the hospitals. Conclusion. The pandemic of the novel coronavirus infection (CO VID -19) is a serious problem for healthcare and professionals around the world. All treatment decisions must be based on risks and benefits in the context of each stage of the pandemic, on an individual basis and taking into account the preferences of patients.

12.
Siberian Journal of Oncology ; 21(1):29-36, 2022.
Article in Russian | EMBASE | ID: covidwho-1822670

ABSTRACT

The aim. To analyze the blood levels of endothelin-1 (ET - 1) and high molecular weight kininogen (HMWK) in patients with breast cancer (BC) previously infected with the new coronavirus. Material and methods. The study group included 20 patients with stage II - IV BC (invasive carcinoma). All patients were receiving chemotherapy at the time of their SA RS-CoV-2 infection. The comparison group included 19 women without breast cancer, who were matched for age. All women of both groups had an RT-PC R confirmed SA RS-Cov-2 infection. Blood levels of ET - 1 and HMWK were measured by ELISA 3-10 weeks after the positive antigen test results. The control group included 10 women of the same age without cancer and without CO VID - 19 symptoms and anti-SA RS-CoV-2 antibodies. Results. The ET - 1 levels in the comparison group were within the reference range, while HMWK levels were significantly higher than those in breast cancer patients. In BC patients with lung metastases, the ET - 1 levels were higher than those in the comparison group patients, while in others (no history of lung metastases, with mild infection course or pneumonia), the ET - 1 levels were similar to those in the comparison and control groups. The HMWK levels in the study and comparison groups were significantly higher than those in controls. Among BC patients, there were women who had significantly higher ET - 1 and HMWK levels compared to the reference levels, and the majority of these patients had lung metastases and previous CO VID - 19 pneumonia. Conclusion. The measurement of HMWK blood levels demonstrated that the plasma contact activation system and the kallikrein-kinin system were active for a long period after the infection both in BC patients and in women without cancer. A high level of ET - 1, the endothelial dysfunction marker, persisted for a long time in some BC patients. Our results were consistent with results of other studies supporting the hypothesis that SA RS-CoV-2 virus infection is a systemic vascular disease with long-term consequences, and its mechanisms require further study.

13.
Palliative Medicine in Practice ; 15(4):267-269, 2021.
Article in English | EMBASE | ID: covidwho-1822566
14.
Canadian Urological Association Journal ; 16(2):13-14, 2022.
Article in English | EMBASE | ID: covidwho-1822560

ABSTRACT

The CUA has introduced a webinar series called Practice- Changing Publications (PCP series), which features Canadian experts discussing recent data that have impacted their field. CUAJ is proud to present summaries of these talks and the important research discussed in this series.

15.
Vaccines ; 10(4), 2022.
Article in English | EMBASE | ID: covidwho-1822468

ABSTRACT

A unique case of multiple metastatic melanoma skin nodules regression in a heavily pretreated, 72-year-old Caucasian female, after administering the second dose of the SARS-CoV-2 mRNA Pfizer-BioNTech vaccine, is presented. Two days after vaccination, all her melanoma skin nodules became painful and were significantly reduced in size. Physical examination and ultrasound imaging confirmed the patient’s observation. The effect was sustained, and further reduction of the nodules occurred after the third vaccine dose. One of the reduced nodules was removed, histologically examined, and its histopathology was compared to that of another such nodule removed and examined earlier. Distinct differences were observed between the two histopathologies, with the most notable the unexpected finding of the absence of infiltrating lymphocytes in the reducer nodule’s melanoma tissue. Based on this observation, the possible immunological mechanism(s) leading to the vaccine’s effect are speculated. More possible is the vaccine’s antitumor and apoptotic activity via stimulation of the Tol Like Receptors 3, 7, and 8, and (downstream) the nuclear factor kappa-light-chain-enhancer of the activated B cells pathway of the non-lymphocytic immune effector cells.

16.
Cells ; 11(9), 2022.
Article in English | EMBASE | ID: covidwho-1822413

ABSTRACT

Background: Polyphenols are the largest class of bioactive compounds in plants, which are synthesized as secondary metabolites. In the last few years, interesting studies have demonstrated the efficacy of polyphenols against coronavirus infections. Methods: we conducted a phase II multicentric clinical trial (TAEROVID‐19) during the first wave of the COVID‐19 pandemic in order to assess the safety and feasibility of Taurisolo® aerosol formulation in hospitalized patients suffering from SARS‐CoV‐2 pneumonia. Results: we observed a rapid decline of symptoms and a low rate of intensive care in patients treated with Taurisolo®, with a faster decline of symptoms. Conclusions: This is the first trial assessing the safety and feasibility of Taurisolo® aerosol formulation. We could argue that this treatment could act as an add‐on therapy in the treatment of COVID‐ 19 patients, owing to both its anti‐inflammatory and antioxidant effects. Further controlled trials are needed, which may be of interest to evaluate the compound’s efficacy.

17.
Frontiers in Psychiatry ; 13, 2022.
Article in English | EMBASE | ID: covidwho-1822404

ABSTRACT

Introduction: The study aimed to explore the psychometric properties of the Stress and Anxiety to Viral Epidemics-6 (SAVE-6) scale among patients with cancer who are in serious situations in the current COVID-19 pandemic. Methods: The survey included questions on the participants' demographic information, clinical history of cancer (including cancer type, stage, current treatment or diagnosis of complete remission), and scores on rating scales, including the SAVE-6 scale, Coronavirus Anxiety Scale (CAS), and the Patient Health Questionnaire-9 (PHQ-9). Results: The confirmatory factor analysis (CFA) results determined that the model fits the single factor structure of the SAVE-6 scale among patients with cancer. The multi-group CFA showed that SAVE-6 can measure the anxiety response in a similar way across multiple variables, such as sex, presence of clinical depression, being in a state of complete remission, or currently undergoing cancer treatment. The SAVE-6 scale showed good reliability (Cronbach's alpha = 0.819) and convergent validity with the rating scales, such as CAS [r = 0.348 (95% CI, 0.273–0.419), p < 0.001] and PHQ-9 items score [r = 0.251 (95% CI, 0.172–0.328), p < 0.001]. Conclusions: This study confirms SAVE-6 as a reliable and valid rating scale for measuring the anxiety response of patients with cancer during the current COVID-19 pandemic.

18.
Frontiers in Psychology ; 13:10, 2022.
Article in English | Web of Science | ID: covidwho-1822403

ABSTRACT

IntroductionAn individual's level of mindfulness can predict his/her level of general health, anxiety, and anger. If we have a valuable tool for measuring mindfulness, we can predict such factors more concisely. Therefore, the aim of this study was to compare a narrowband and a broadband mindfulness scale in predicting the level of general health, anxiety, and anger in a general population. Materials and MethodsThis was a cross-sectional study on an Iranian general population (all citizens living in Kerman) from September 22, 2020 to April 14, 2021. The convenience sampling method was used. Data were collated via electronic and paper forms of the Relaxation/Meditation/Mindfulness Tracker t-Persian version (RMMt-P), the Freiburg Mindfulness Inventory- Short-Form-Persian version (FMI-P), the General Health Questionnaire, the trait anxiety section of the State-Trait Anxiety Inventory, and the trait anger section of the State-Trait Anger Expression Inventory-2. ResultsThe FMI-P predicted 0.05% of GHQ variance while the first and third levels of RMMt-P predicted 0.145%. The FMI-P predicted 0.19% of anxiety variance, while the first and third levels of RMMt-P predicted 0.195%. The FMI-P predicted 0.0% of anger variance, while the first, second, and third levels of RMMt-P predicted 0.08%. RMMt-P Level 1 was a better predictor of general health, anger, and anxiety. ConclusionThe current study found that the RMMt-P was a better predictor of general health and anger than the FMI-P. These findings suggest that the type of questionnaire used in the study of mindfulness is important, but more research is needed to determine the extent of these relationships.

19.
Frontiers in Oncology ; 12, 2022.
Article in English | EMBASE | ID: covidwho-1822387

ABSTRACT

Background: A study conducted in China on patients with coronavirus disease 2019 (COVID-19) showed that cancer conferred a five times increased risk for needing intensive care admission and mortality;No data has yet been collected and published from the Philippines. Thus, the investigators conducted this substudy to determine the association of having a history of cancer with clinical outcomes among patients included in the Philippine CORONA Study. Methodology: Multi-center, retrospective cohort design Results: A total of 244 patients had a history of cancer, out of 10,881 COVID-19 hospital admissions. After adjusting for different confounding variables of interest, having cancer was significantly associated with a 75% increased odds of having severe/critical COVID-19 at nadir (CI 95% 1.32, 2.33;p < 0.001). After adjusting for different confounding variables of interest, having cancer was significantly associated with the following time-to-event outcomes: 72% increase in hazard of in-hospital mortality (CI 95% 1.37, 2.16;p < 0.001), 65% increase in hazard of respiratory failure (CI 95% 1.31, 2.08;p < 0.001), and 57% increase in hazard of being admitted to ICU (CI 95% 1.24, 1.97;p < 0.001). Conclusion: A history of cancer conferred poorer clinical outcomes on adult, hospitalized COVID-19 patients.

20.
Frontiers in Endocrinology ; 13, 2022.
Article in English | EMBASE | ID: covidwho-1822360

ABSTRACT

Aim: To determine the efficacy and safety of inactivated SARS-CoV-2 vaccine (BBIBP-CorV) in patients with breast cancer. Methods: In this multi- institutional cohort study, a total of 160 breast cancer patients (mean age of 50.01 ± 11.5 years old) were assessed for the SARS-CoV-2 Anti-Spike IgG and SARS-CoV2 Anti RBD IgG by ELISA after two doses of 0.5 mL inactivated, COVID-19 vaccine (BBIBP-CorV). All patients were followed up for three months for clinical COVID-19 infection based on either PCR results or imaging findings. Common Terminology Criteria for Adverse Events were used to assess the side effects. Results: The presence of SARS-CoV-2 anti-spike IgG, SARS-CoV2 anti-RBD IgG, or either of these antibodies was 85.7%, 87.4%, and 93.3%. The prevalence of COVID-19 infection after vaccination was 0.7%, 0% and 0% for the first, second and third months of the follow-up period. The most common local and systemic side-effects were injection site pain and fever which were presented in 22.3% and 24.3% of patients, respectively. Discussion: The inactivated SARS-CoV-2 vaccine (BBIBP-CorV) is a tolerable and effective method to prevent COVID-19.

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