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1.
PLoS Global Public Health ; 2(4), 2022.
Article in English | CAB Abstracts | ID: covidwho-1892274

ABSTRACT

The COVID-19 pandemic has affected many aspects of daily life worldwide, but the impact may be higher for impoverished populations. The main aim of this study is to describe the impact of the COVID-19 pandemic on different aspects of daily life in mothers in Nepal. We included 493 mothers of children aged 54-71 months participating in a randomized controlled trial on vitamin B12 supplementation. Mothers answered questions regarding the exposure and impact of the pandemic on their daily lives, and pandemic-related worries and sleep problems. We examined the extent to which worry, and sleep problems differed between mothers according to their exposure to COVID-19, socioeconomic status, and previous symptoms of depression. The mean age (SD) of the mothers was 32.3 (4.6) years and 54% had education below the secondary level. Of the mothers, 5.4% had either been exposed to someone who had tested positive or who had a family member with COVID-19. One-third of the participants responded that the pandemic had affected their economic situation, employment, and family life to a great deal. Both mothers and fathers with educational levels above 10 years or households with higher socioeconomic status had significantly higher average worry scores (maternal p = 0.020 and paternal p = 0.005). Mothers with a history of symptoms of depression had significantly more worry-related sleep problems during the pandemic (p = 0.020) than those without a history of depressive symptoms. Our study underlines the negative impact of the COVID-19 pandemic on diverse aspects of everyday life of mothers in Nepal.

2.
Natural Volatiles & Essential Oils ; 9(1):1086-1101, 2022.
Article in English | CAB Abstracts | ID: covidwho-1787334

ABSTRACT

COVID-19 is a new infectious disease, for which there is currently no treatment. It is therefore necessary to explore biomarkers to determine the extent of lung lesions and disease severity. Objective. The study aimed to assess the usefulness of procalcitonin levels in the COVID-19 and to correlate them with other biomarkers. Methods. the collected the data, prospectively, all COVID-19 cases admitted in lab private (30) cases with COVID-19 pneumonia and (30) control patients had Reverse Transcription Polymerase Chain Reaction (RT-PCR) positive. laboratory analysis of inflammatory indices and organ function was accomplished for the sum total of cases and controls measured procalcitonin, CRP, B12, LDH. Result. Procalcitonin,CRP, LDH, D-dimer levels in patients groups the higher than those in the controls highly significant. Conclusion. In the early stage of COVID-19 procalcitonin levels were positively correlated with CRP, D-dimer, ferritin, LDH and negative correlated with B12.

3.
Salud P..blica de M..xico ; 63(3):325-458, 2021.
Article in English | GIM | ID: covidwho-1716676

ABSTRACT

This special issue contains 23 articles that discusses the topic of diseases, nutrition, and malnutrition, especially in Mexico. Topics include the nutritional status of iron, vitamin B12, vitamin A, and anaemia in Mexican children, vitamin D status in Mexican women at reproductive age, prevalence of iron deficiency and anaemia during 2006-2018 in Mexican women 20-49 years of age, the increasing incidence of SARS-CoV- 2 in older adolescents and younger adults during the epidemic in Mexico, stakeholder analysis of the deliberation of an increase to the excise tax on sweetened beverages in Mexico, among others.

4.
Journal of Investigative Medicine ; 70(2):543-544, 2022.
Article in English | EMBASE | ID: covidwho-1707494

ABSTRACT

Case Report A 62-year-old male presented to our hospital with a few days of worsening dyspnea, associated with numbness in the left lower extremity, dizziness and transient brief chest pain that was described as a sharp intermittent pain. He denied any fever, chills, nausea, vomiting, diarrhea, headache, or recent ill contacts. The patient also denied any family history of blood or bone morrow disease. He had been released from incarceration 2 days prior to the presentation. Complete blood count revealed pancytopenia with hemoglobin of 6.8 g/dL, MCV of 112 fL, white blood cell count of 1.2 K/uL, and platelet count of 78 K/uL. The patient was transfused with packed red blood cells and then admitted to the inpatient medicine ward for further treatment and evaluation. Blood smear confirmed the pancytopenia with severe neutropenia, macrocytosis, and moderate thrombocytopenia. In addition, it showed erythrocytes with marked poikilocytosis including occasional schistocytes and teardrop cells. His lab investigations were notable for B12 level below 150 pg/mL (Normal range 211-911), fibrinogen of 144 mg/dL , haptoglobin less than 10 mg/dL, LDH of 1013 U/L. Other lab studies including troponin, ferritin, TIBC, serum iron, vitamin B1, PT/INR, PTT, SPEP, COVID-19, EBV, CMV, HIV, Hepatitis A, B, and C were all unrevealing. Abdominal ultrasound was significant for splenomegaly. CT head and chest xray were unremarkable. After starting treatment with cobalamin therapy, the patient has shown improvement in terms of cell counts, resolution of hemolysis. He also reported significant improvement in tingling and dizziness. All this confirms the diagnosis. Vitamin B12 deficiency manifestations can vary between asymptomatic, mild, and severe. In our case, the patient presented with pseudothrombotic microangiopathy and pancytopenia. Both are rare and serious manifestations of vitamin B12 deficiency. Physicians should be aware of cobalamin deficiency as one of the etiologies for pancytopenia and pseudothrombotic microangiopathy. Therefore, an early recognition and treatment is crucial. (Figure Presented).

5.
Nutr Rev ; 80(3): 561-578, 2022 02 10.
Article in English | MEDLINE | ID: covidwho-1522274

ABSTRACT

This comprehensive review establishes the role of vitamin B12 as adjunct therapy for viral infections in the treatment and persistent symptoms of COVID-19, focusing on symptoms related to the muscle-gut-brain axis. Vitamin B12 can help balance immune responses to better fight viral infections. Furthermore, data from randomized clinical trials and meta-analysis indicate that vitamin B12 in the forms of methylcobalamin and cyanocobalamin may increase serum vitamin B12 levels, and resulted in decreased serum methylmalonic acid and homocysteine concentrations, and decreased pain intensity, memory loss, and impaired concentration. Among studies, there is much variation in vitamin B12 doses, chemical forms, supplementation time, and administration routes. Larger randomized clinical trials of vitamin B12 supplementation and analysis of markers such as total vitamin B12, holotranscobalamin, total homocysteine and methylmalonic acid, total folic acid, and, if possible, polymorphisms and methylation of genes need to be conducted with people with and without COVID-19 or who have had COVID-19 to facilitate the proper vitamin B12 form to be administered in individual treatment.


Subject(s)
COVID-19 , Vitamin B 12 Deficiency , Dietary Supplements , Folic Acid , Homocysteine , Humans , Muscles , SARS-CoV-2 , Vitamin B 12 , Vitamin B 12 Deficiency/drug therapy
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