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J Am Soc Nephrol ; 2022 Oct 27.
Article in English | MEDLINE | ID: covidwho-2234600


BACKGROUND: In March 2021, the United States implemented a new kidney allocation system (KAS250) for deceased donor kidney transplantation (DDKT), which eliminated the donation service area-based allocation and replaced it with a system on the basis of distance from donor hospital to transplant center within/outside a radius of 250 nautical miles. The effect of this policy on kidney discards and logistics is unknown. METHODS: We examined discards, donor-recipient characteristics, cold ischemia time (CIT), and delayed graft function (DGF) during the first 9 months of KAS250 compared with a pre-KAS250 cohort from the preceding 2 years. Changes in discards and CIT after the onset of COVID-19 and the implementation of KAS250 were evaluated using an interrupted time-series model. Changes in allocation practices (biopsy, machine perfusion, and virtual cross-match) were also evaluated. RESULTS: Post-KAS250 saw a two-fold increase in kidneys imported from nonlocal organ procurement organizations (OPO) and a higher proportion of recipients with calculated panel reactive antibody (cPRA) 81%-98% (12% versus 8%; P<0.001) and those with >5 years of pretransplant dialysis (35% versus 33%; P<0.001). CIT increased (mean 2 hours), including among local OPO kidneys. DGF was similar on adjusted analysis. Discards after KAS250 did not immediately change, but we observed a statistically significant increase over time that was independent of donor quality. Machine perfusion use decreased, whereas reliance on virtual cross-match increased, which was associated with shorter CIT. CONCLUSIONS: Early trends after KAS250 show an increase in transplant access to patients with cPRA>80% and those with longer dialysis duration, but this was accompanied by an increase in CIT and a suggestion of worsening kidney discards.

Journal of the American Society of Nephrology ; 33:45, 2022.
Article in English | EMBASE | ID: covidwho-2125490
Clin Transplant ; : e14847, 2022 Nov 02.
Article in English | MEDLINE | ID: covidwho-2097722


Changes in kidney allocation coupled with the COVID-19 pandemic have placed tremendous strain on current systems of organ distribution and logistics. Although the number of deceased donors continues to rise annually in the United States, the proportion of marginal deceased donors (MDDs) is disproportionately growing. Cold ischemia times and kidney discard rates are rising in part related to inadequate planning, resources, and shortages. Complexity in kidney allocation and distribution has contributed to this dilemma. Logistical issues and the ability to reperfuse the kidney within acceptable time constraints increasingly determine clinical decision-making for organ acceptance. We have a good understanding of the phenotype of "hard to place" MDD kidneys, yet continue to promote a "one size fits all" approach to organ allocation. Allocation and transportation systems need to be agile, mobile, and flexible in order to accommodate the expanding numbers of MDD organs. By identifying "hard to place" MDD kidneys early and implementing a "fast-track" or open offer policy to expedite placement, the utilization rate of MDDs would improve dramatically. Organ allocation and distribution based on location, motivation, and innovation must lead the way. In the absence of change, we are sacrificing utility for futility and discard rates will continue to escalate.

American Journal of Transplantation ; 22(Supplement 3):1087-1088, 2022.
Article in English | EMBASE | ID: covidwho-2063515
American Journal of Transplantation ; 22(Supplement 3):720, 2022.
Article in English | EMBASE | ID: covidwho-2063497
American Journal of Transplantation ; 22(Supplement 3):929, 2022.
Article in English | EMBASE | ID: covidwho-2063489
American Journal of Transplantation ; 22(Supplement 3):655, 2022.
Article in English | EMBASE | ID: covidwho-2063488
American Journal of Transplantation ; 22(Supplement 3):472-473, 2022.
Article in English | EMBASE | ID: covidwho-2063355
American Journal of Transplantation. Conference ; 22(Supplement 3), 2022.
Article in English | EMBASE | ID: covidwho-2057495
Nephrology Dialysis Transplantation ; 37(SUPPL 3):i723, 2022.
Article in English | EMBASE | ID: covidwho-1915799
International Journal of Surgery ; 100, 2022.
Article in English | EMBASE | ID: covidwho-1851286