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1.
FEBS Letters ; 597(1):3-5, 2023.
Article in English | EMBASE | ID: covidwho-2208848
2.
Clinical and Experimental Rheumatology ; 40(12):2201-2210, 2022.
Article in English | EMBASE | ID: covidwho-2218351
3.
Pharmacia ; 69(4):1047-1056, 2022.
Article in English | Web of Science | ID: covidwho-2217158

ABSTRACT

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) requires finding new drugs or repurposing drugs for clinical use. Molecular docking belongs to structure-based drug design providing a fast method for identifying the hit com-pounds with antiviral activity against SARS-Cov-2. However, the weakness of the docking method is compounded by the limited crystallographic information and comparison drugs due to the novelty of this virus can present challenges in identifying hits of anti-SARS-Cov-2. In the current review, we highlighted several aspects, especially those related to the target structure, docking validation, and virtual hit selection, that need to be considered to obtain reliable docking results. Here, we discussed several cases pertaining to the issue highlighted and approaches that could be used to solve them.

4.
Hormone Research in Paediatrics ; 95(Supplement 2):369-370, 2022.
Article in English | EMBASE | ID: covidwho-2214181

ABSTRACT

Introduction: Pituitary stalk thickening (PST) is a rare condition in pediatric patients. As there are few studies published in pediatric population, the definition has been difficult to establish. The etiologies involved in PST can be divided in neoplastic, congenital, inflammatory/infectious or autoimmune diseases. In children the most frequent causes are neoplastic, followed by congenital lesions. The inflammatory/infectious and autoimmune diseases are rare. Method(s): During the pandemic of COVID-19, we observed an increased incidence in the diagnosis of pediatric patients with PST in Chile, compared with previous years. A multicentric retrospective chart review of clinical, radiological and histological data was conducted on patients with confirmation of PST that presented during COVID-19 pandemic in Chile. The diagnosis of PST was made in patients with neuro-ophthalmic symptoms or pituitary dysfunction, who had a cerebral MRI with a pituitary stalk 3 mm or more at pituitary insertion or 4 mm or more at the optic chiasm, based on consensus guidelines. Result(s): A total of 11 patients were diagnosed with PST during the pandemic period, most of them were girls (82%). The mean age at the onset of symptoms was 10.1 years (range 1.1-18). The most common causes were neoplasms. Germinal cell tumors (GCT) were diagnosed in 10 patients and Langerhans cell histiocytosis in 1 patient. Tumor markers for GCT were negative in serum and cerebrospinal fluid in all patients (alpha-fetoprotein and chorionic gonadotropin). All patients presented with central diabetes insipidus and at least one anterior pituitary hormonal deficit. Thirty six percent had an abnormal campimetry. The diagnoses were confirmed by biopsy in all the patients and four patients required a second biopsy to confirm the diagnosis. Discussion(s): A surprisingly high frequency of PST presented during the COVID-19 pandemic among Chilean pediatric patients. The most frequent diagnosis was GCT. All had negative tumor markers, with a greater incidence in girls, opposed to data previously reported. The etiological diagnosis still remains challenging, and 36% of the patients required a second biopsy. It is important to establish new markers to assess patients with PST in order to make a prompt diagnosis.

5.
Oncology Research and Treatment ; 45(Supplement 3):137, 2022.
Article in English | EMBASE | ID: covidwho-2214118

ABSTRACT

Background: The COVID-19 pandemic has led to deviations in all sectors of cancer care. We present multidisciplinarily approved recommendations for ethically and empirically based prioritisation of procedures in times of scarce resources for patients with colorectal and pancreatic cancer. Method(s): The CancerCOVID consortium conducted qualitative and quantitative studies on ethical challenges and psychosocial stress of patients and health care professionals in cancer care. For empirical analyses we obtained data from AOK Plus, the main health insurance in Saxony, AIO (Arbeitsgemeinschaft internistische Onkologie) cancer centers, the institute of Pathology Bochum, the ColoPredict Registry and data of outpatient care from the BNHO (Berufsverband der Hamatologen und Onkologen) and Onkotrakt AG. A selective literature review of international data and guidelines focussing on the effects of the pandemic on cancer care and allocation of resources was conducted. Structured group discussions on justified criteria for prioritisation were held with experts from oncology, ethics, law and health research. Recommendations for prioritisation were formulated as S1 guideline with approval of 9 AWMF Medical Societies, 22 multidisciplinary experts and patient representatives. Result(s): The main principle for decisions on prioritisation in times of scarce resources is the minimisation of individual and aggregated harm. In case of relevant risk of harm from a possible low priority classification or postponement prioritization decisions should be made individually for the respective patients according to the multiple-eyes principle. Decision making should involve different disciplines and professions depending on local infrastructure. We concretised recommendations for 5 areas in cancer care. Conclusion(s): Guidelines based on a broad multidisciplinary consensus can give ethically and empirically based support in medical decision making when resources are scarce. This can provide relief for decision-makers and facilitate transparency and trust of patients and population.

6.
2022 IEEE International Conference on Agents, ICA 2022 ; : 24-29, 2022.
Article in English | Scopus | ID: covidwho-2213207

ABSTRACT

In Web discussions, which have become mainstream with COVID-19, the amount of information possessed and the level of understanding of the discussion differ among participants. As a result, some participants may not be able to speak up satisfactorily, and this can hinder consensus building in the discussion as a whole. Therefore, we develop an agent that automatically recommends information related to the discussion as information that facilitates participants to speak up. The agent first obtains necessary discussion data from on-going Web discussions. The information to be recommended is determined by real-time search. Query words for the search are generated using a pre-trained query-term-generation model. When selecting information to recommend from the information obtained in the search, a model that classifies the acquired information according to the discussion phase is used. The results of a discussion experiment in which an agent intervened in a Web-based discussion showed many results indicating the effectiveness of the agent, although there are some points that need to be improved. However, since the scale of the discussion experiment was small, it will be necessary to validate the agent in large-scale discussions in the future. © 2022 IEEE.

7.
One Health ; 16 (no pagination), 2023.
Article in English | EMBASE | ID: covidwho-2211204

ABSTRACT

One Health is increasingly recognized as an optimal approach to address the global risk of health threats originating at the human, animal, and ecosystem interface, and their impact. Qatar has successfully practiced One Health approach for investigation and surveillance of zoonotic diseases such as MERS-CoV, and other health threats. However, the current gaps at institution and policy level hinder the sustainment of One Health. In this paper, we have assessed the potential for implementation of One Health Framework to reinforce and sustain One Health capacities in Qatar for 2022-2027. To implement One Health Framework in the country, Qatar Joint External Evaluation (JEE) report, lessons learnt during One Health experiences on zoonotic, vector-borne, and food borne diseases were used to present an outline for multisectoral coordination. In addition, technical capacities of One Health and factors that are required to operationalize it in the country were also assessed in series of meetings and workshops held at Ministry of Public Health on March 2022. Present health care infrastructure and resources were found to be conducive for effective management and response to shared health threats as evident during MERS-CoV, despite being more event based. Regardless, the need for more sustainable capacity development was unanimously emphasized. The consensus between all relevant stakeholders and partners was that there is a need for better communication channels, policies and protocols for data sharing, and the need to invest more resources for better sustainability. The proposed framework is expected to strengthen and facilitate multilateral coordination, enhanced laboratory capacity and network, improve active surveillance and response, risk communication, community engagement, maximize applied research, and build One Health technical work force. This would enable advancement and sustainment of One Health activities to prevent and control health threats shared between humans-animals-ecosystem interface. Copyright © 2023

8.
Swiss Medical Weekly ; 151(506) (no pagination), 2021.
Article in English | EMBASE | ID: covidwho-2207246

ABSTRACT

OBJECTIVES: To develop and validate a screening tool designed to identify detained people at increased risk for COVID-19 mortality, the COVID-19 Inmate Risk Appraisal (CIRA). DESIGN: Cross-sectional study with a representative sample (development) and a case-control sample (validation). SETTING: The two largest Swiss prisons. PARTICIPANTS: (1) Development sample: all male persons detained in Poschwies, Zurich (n = 365);(2) Validation sample: case-control sample of male persons detained in Champ-Dollon, Geneva (n = 192, matching 1:3 for participants at risk for severe course of COVID-19 and participants without risk factors). MAIN OUTCOME MEASURES: The CIRA combined seven risk factors identified by the World Health Organization and the Swiss Federal Office of Public Health as predictive of severe COVID-19 to derive an absolute risk increase in mortality rate: Age >=60 years, cardiovascular disease, diabetes, hypertension, chronic respiratory disease, immunodeficiency and cancer. RESULT(S): Based on the development sample, we proposed a three-level classification: average (<3.7), elevated (3.7-5.7) and high (>5.7) risk. In the validation sample, the CIRA identified all individuals identified as vulnerable by national recommendations (having at least one risk factor). The category "elevated risk" maximised sensitivity (1) and specificity (0.97). The CIRA had even higher capacity in discriminating individuals vulnerable according to clinical evaluation (a four-level risk categorisation based on a consensus of medical staff). The category "elevated risk" maximised sensitivity and specificity (both 1). When considering the individuals classified as extremely high risk by medical staff, the category "high risk" had a high discriminatory capacity (sensitivity =0.89, specificity =0.97). CONCLUSION(S): The CIRA scores have a high discriminative ability and will be important in custodial settings to support decisions and prioritise actions using a standardised valid assessment method. However, as knowledge on risk factors for COVID-19 mortality is still limited, the CIRA may be considered preliminary. Underlying data will be updated regularly on the website (http://www.prison-research.com), where the CIRA algorithm is freely available. Copyright © 2021 EMH Swiss Medical Publishers Ltd.. All rights reserved.

9.
International Journal of Pharmaceutical Research and Allied Sciences ; 11(4):123-133, 2022.
Article in English | Web of Science | ID: covidwho-2206965

ABSTRACT

The elderly or geriatric patients represent a significant portion of emergency department (ED) admissions. Factors affecting poor outcome in these patients suspected or diagnosed with sepsis include shock, hyperlactatemia, and organ failure. Atypical presentations should be emphasized in the training of triage and ED personnel due to difficulties and pitfalls in diagnostic processes for sepsis. The vital organ functions of the elderly, who are among the highest risk groups in the management of sepsis, may deteriorate rapidly with very few precursors, and aggressive methods should be used rapidly when necessary. Interactions of drug doses in the elderly, problems in excretion and differences in metabolism should be considered in treatment regimens. Healthcare workers should try to eliminate colonization risks such as vascular catheterization, unnecessary vascular access and urinary catheters should be removed.In the long term after recovery from sepsis, heart failure, peripheral vascular disease, dementia, and diabetes are the most common entities recorded in the literature. This review was intended to provide an overview of the overall management and give some practical tips for this fragile group of patients in the post-pandemic era.

10.
Minerva Psychiatry ; 63(4):379-396, 2022.
Article in English | EMBASE | ID: covidwho-2205202

ABSTRACT

INTRODUCTION: Alexithymia brings negative consequences on the psycho-emotional well-being and health of an individual. This narrative review attempted to explore previous research at the objective to advance understanding of psychological essence and genesis on this phenomenon. EVIDENCE ACQUISITION: On the research topic, Web of Science, Scopus, PsycInfo and PubMed original articles, dissertations and monographs were found to be included in the overview (totally, 109 publications). We presented an analysis of numerous investigations and review works with the aim to fill the existing large gap in the psychological explanation of the emergence and functioning of alexithymia. EVIDENCE SYNTHESIS: The truth is that alexithymia is still predominantly studied at the clinical-medical level. Namely, psychological roots are not considered in research or reviews at all, and no consensus on alexithymia psychological origin exists. Evidence indicated that whilst the existing research findings establish multisided relationships between alexithymia and various risk-factors, extremely little is known about its psychological origin and mechanism. CONCLUSION(S): The present overview is the first attempt to elucidate psychological essence and genesis of alexithymic symptoms and delve into presenting a disclosure and adequate explanation of the psychological mechanism of alexithymia functioning. Moreover, for the first time an innovative definition of alexithymia is given within the framework of the explanatory-functional psychological paradigm. This article is a narrative review with less rigorous methodology;nevertheless, it is useful for coherent detailed highlighting the problem posed and in cases when too much research from different scientific fields and directions is analyzed. Copyright © 2022 Edizioni Minerva Medica. All right reserved.

11.
Infectio ; 24(3):1-2, 2020.
Article in Spanish | EMBASE | ID: covidwho-2205093

ABSTRACT

The "Asociacion Colombiana de Infectologia" (ACIN) and the "Instituto de Evaluacion de Nuevas Tecnologias de la Salud" (IETS) created a task force to develop recommendations for Covid 19 health care diagnosis, management and treatment informed, and based, on evidence. Theses reccomendations are addressed to the health personnel on the Colombian context of health services. Copyright © 2020 Asociacion Colombiana de Infectologia. All rights reserved.

12.
Eurasian Journal of Pulmonology ; 24(3):185-192, 2022.
Article in English | Web of Science | ID: covidwho-2204013

ABSTRACT

BACKGROUND AND AIM: Coronavirus disease 2019 (COVID-19) has imposed a heavy burden on the intensive care unit and health care systems worldwide. Therefore, early detection of high-risk patients in terms of poor prognosis is crucial. We aimed to compare the diagnostic yield of the two most reliable scoring systems (National Early Warning Score 2 [NEWS 2] and quick Sepsis-related Organ Failure Assessment [qSOFA]) when repeatedly performed during the COVID-19 course. METHODS: The data of 403 COVID-19 patients admitted to our hospital between March 1, 2020, and November 30, 2020, were retrospectively reviewed. The demographic, comorbidity, and clinical data of the patients were recorded in the evaluation. NEWS2 and qSOFA score were retrospectively calculated at the time of admission, 24th hour, and 48th hour. We compared the effectiveness of qSOFA and NEWS2 for predicting the prognosis of COVID-19. RESULTS: The mean NEWS2 at the time of admission, 24th hour, and 48th hour was significantly higher in patients with poor outcomes than in patients with good outcomes. The 48th-hour NEWS2 was found to be the most successful score in predicting the poor outcome (AUC: 0.854;95% CI: 0.81-0.88;p<0.001). NEWS2 at 0th, 24th, and 48th hours were found to be superior to qSOFA scores at the same time points. CONCLUSIONS: NEWS2 was superior to qSOFA in determining the need for intensive care support and/or mortality. A high NEWS2 at the 48th hour seems to be more valuable to predict worse outcomes.

13.
Journal of the Medical Library Association : JMLA ; 110(3):348-357, 2022.
Article in English | EMBASE | ID: covidwho-2202616

ABSTRACT

Objective: The study purpose was to understand how early months of the COVID-19 pandemic altered interlibrary loan (ILL) and document delivery (DD) in North American health science libraries (HSLs), specifically the decision-making and workflow adjustments associated with accessing their own collections and obtaining content not available via ILL. Method(s): Researchers distributed an online 26-question survey through 24 health science library email lists from January 6-February 7, 2021. Respondents reported their library's ILL and DD activities from March-August 2020, including ILL/DD usage and policies, collection access, decision-making, and workflow adjustments. In addition to calculating frequencies, cross-tabulation and statistical tests were performed to test a priori potential associations. Two researchers independently and thematically analyzed responses to the 2 open-ended questions and reached consensus on themes. Result(s): Hospital libraries represented 52% (n=226/431) of respondents, along with 42% academic (n=179) and 6% (n=26) multi-type or other special. Only 1% (n=5) closed completely with no remote services, but many, 45% (n=194), ceased ILL of print materials. More than half (n=246/423;58%) agreed that ILL requests likely to be filled from print remained unfilled more than is typical. Open-ended questions yielded 5 themes on ILL/DD staffing, setup, and systems;6 on impacts for libraries and library users. Conclusion(s): Lack of communication regarding collection availability and staffing resulted in delayed or unfilled requests. Hospital and academic libraries made similar decisions about continuing services but reported different experiences in areas such as purchasing digital content. Hybrid ILL/DD workflows may continue for managing these services. Copyright © 2022 Jennifer K. Lloyd, Kristine M. Alpi, Margaret A. Hoogland, Priscilla L. Stephenson, Elizabeth Meyer.

14.
Journal of Phytomedicine and Therapeutics ; 21(2):783-785, 2022.
Article in English | EMBASE | ID: covidwho-2202277
15.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 34(12):1233-1237, 2022.
Article in Chinese | MEDLINE | ID: covidwho-2201089

ABSTRACT

In order to more actively respond to the new situation of prevention and control of coronavirus disease 2019 (COVID-19), and to guide home health management for adults who are asymptomatic carriers or exhibit mild symptoms, the World Federation of Chinese Medical Societies Emergency Committee, World Federation of Chinese Medical Societies Respiratory Diseases, World Federation of Chinese Medical Societies Heat Disease Committee, Chinese Association of Chinese Medicine Pulmonary Disease Chapter, the First Aid Group of Integrated Traditional Chinese and Western Medicine of the Emergency Branch of the Chinese Medical Doctor Association, the First Aid Group of Integrated Traditional Chinese and Western Medicine of the Emergency Branch of the Emergency Physician Branch of the Chinese Medical Association, the Emergency Branch of the Shanghai Chinese Medical Association, the Institute of Emergency and Critical Care of the Shanghai University of Traditional Chinese Medicine, National Health Commission's Key Laboratory of Critical Care Medicine and other academic institutions have organized the medical experts at treating COVID-19 front line in China to investigate and discuss the traditional Chinese medicine (TCM) health management at home for adults infected with SARS-CoV-2 variants, and concluded the "Expert consensus on traditional Chinese medicine health management at home for adults infected with SARS-CoV-2 variants", in combination with "Guideline on SARS-CoV-2 variant infection recover at home" issued by the Joint Prevention and Control Mechanism of the State Council. The expert consensus included home environment, asymptomatic infection, infection with mild symptoms, recovery period, and TCM non-drug therapy intervention, which will provide a guidance to TCM intervention at home to adults infected with SARS-CoV-2 variants.

16.
Vaccines ; 10(12) (no pagination), 2022.
Article in English | EMBASE | ID: covidwho-2200928

ABSTRACT

Vaccination against pertussis in pregnancy is safe for pregnant women and newborns. Vaccination against pertussis during the second or early third trimester of pregnancy is highly protective against pertussis in young infants. Vaccination early in the third trimester versus vaccination late in the third trimester is associated with higher newborn anti-B. pertussis antibody levels. Infants whose mothers were vaccinated in pregnancy have less boosting of anti-B. pertussis antibody concentrations after their own vaccination, but this is not clinically significant. More immunogenicity and vaccine effectiveness studies are needed in countries using whole-cell pertussis vaccines. Vaccination in pregnancy induces anti-B. pertussis antibodies in breast milk. COVID-19 mitigation strategies have resulted in a significant decrease in B. pertussis circulation, which could negatively affect population immunity against B. pertussis. Highlights: Infants are at high risk for severe morbidity and mortality from pertussis disease during early infancy. Vaccination against pertussis in pregnancy has emerged as the ideal strategy to protect infants during these early, vulnerable, first months of life. On 30 November and 1 December 2021, the Global Pertussis Initiative held a meeting that aimed to discuss and review the most up-to-date scientific literature supporting vaccination against pertussis in pregnancy and outstanding scientific questions. Herein, we review the current and historically published literature and summarize the findings as consensus statements on vaccination against pertussis in pregnancy on behalf of the Global Pertussis Initiative. Copyright © 2022 by the authors.

17.
Journal of Cardiovascular Magnetic Resonance ; 24(1):73, 2022.
Article in English | MEDLINE | ID: covidwho-2196336

ABSTRACT

The global pandemic of coronavirus disease 2019 (COVID-19) caused by infection with severe acute respiratory suyndrome coronavirus 2 (SARS-CoV-2) is now entering its 4th year with little evidence of abatement. As of December 2022, the World Health Organization Coronavirus (COVID-19) Dashboard reported 643 million cumulative confirmed cases of COVID-19 worldwide and 98 million in the United States alone as the country with the highest number of cases. While pneumonia with lung injury has been the manifestation of COVID-19 principally responsible for morbidity and mortality, myocardial inflammation and systolic dysfunction though uncommon are well-recognized features that also associate with adverse prognosis. Given the broad swath of the population infected with COVID-19, the large number of affected professional, collegiate, and amateur athletes raises concern regarding the safe resumption of athletic activity (return to play, RTP) following resolution of infection. A variety of different testing combinations that leverage the electrocardiogram, echocardiography, circulating cardiac biomarkers, and cardiovascular magnetic resonance (CMR) imaging have been proposed and implemented to mitigate risk. CMR in particular affords high sensitivity for myocarditis but has been employed and interpreted non-uniformly in the context of COVID-19 thereby raising uncertainty as to the generalizability and clinical relevance of findings with respect to RTP. This consensus document synthesizes available evidence to contextualize the appropriate utilization of CMR in the RTP assessment of athletes with prior COVID-19 infection to facilitate informed, evidence-based decisions, while identifying knowledge gaps that merit further investigation.

18.
Political Psychology ; 2022.
Article in English | Web of Science | ID: covidwho-2193186

ABSTRACT

This article explores constructions of consensus and unity and their potential implications on partisan politics and democratic decision making in parliamentary discourse on the management of the COVID-19 pandemic in Greece. The analytic corpus consists of transcripts of three debates on COVID-19 management in the Greek parliament, conducted in the period from April 2020 to October 2021. Analysis using tools and concepts of rhetorical and discursive psychology indicated that consensus was constructed as agreement on hard data, as compliance with health experts, and as national unity, and it was counterposed to partisan politics. Nevertheless, at the same time, appeals to consensus constituted a resource mobilized in the service of partisan politics, as both government and opposition parties appealed to the need of agreement in order to warrant their position and to ward off the position of opponents. The rhetoric of consensus, however, included the seeds of disagreement, since while its necessity was collaboratively accomplished, its parameters and boundaries were challenged. The implications of these findings for democratic governance and political decision making are pinpointed.

19.
Geriatrics and Gerontology International ; 23(1):5-15, 2023.
Article in English | EMBASE | ID: covidwho-2192597

ABSTRACT

We defined respiratory sarcopenia as a coexistence of respiratory muscle weakness and decreased respiratory muscle mass. Although respiratory muscle function is indispensable for life support, its evaluation has not been included in the regular assessment of respiratory function or adequately evaluated in clinical practice. Considering this situation, we prepared a position paper outlining basic knowledge, diagnostic and assessment methods, mechanisms, involvement in respiratory diseases, intervention and treatment methods, and future perspectives on respiratory sarcopenia, and summarized the current consensus on respiratory sarcopenia. Respiratory sarcopenia is diagnosed when respiratory muscle weakness and decreased respiratory muscle mass are observed. If respiratory muscle mass is difficult to measure, we can use appendicular skeletal muscle mass as a surrogate. Probable respiratory sarcopenia is defined when respiratory muscle weakness and decreased appendicular skeletal muscle mass are observed. If only respiratory muscle strength is decreased without a decrease in respiratory function, the patient is diagnosed with possible respiratory sarcopenia. Respiratory muscle strength is assessed using maximum inspiratory pressure and maximum expiratory pressure. Ultrasonography and computed tomography are commonly used to assess respiratory muscle mass;however, there are insufficient data to propose the cutoff values for defining decreased respiratory muscle mass. It was jointly prepared by the representative authors and authorized by the Japanese Society for Respiratory Care and Rehabilitation, Japanese Association on Sarcopenia and Frailty, Japanese Society of Respiratory Physical Therapy and Japanese Association of Rehabilitation Nutrition. Geriatr Gerontol Int 2023;23: 5-15. Copyright © 2022 Japan Geriatrics Society.

20.
Pediatric Critical Care Medicine Conference: 11th Congress of the World Federation of Pediatric Intensive and Critical Care Societies, WFPICCS ; 23(11 Supplement 1), 2022.
Article in English | EMBASE | ID: covidwho-2190775

ABSTRACT

BACKGROUND AND AIM: Paediatric inflammatory multisystem syndrome temporally related with COVID-19 (PIMS-TS) has considerable overlap in presentation with Kawasaki disease, sepsis, toxic shock syndrome, and surgical abdominal pathology. National consensus guidelines were published in the United Kingdom in September 2020, detailing investigations that should be undertaken to exclude other diagnoses. This retrospective audit aimed to assess referrals to our regional critical care transport service to ascertain whether alternative diagnoses are being excluded in children with suspected PIMS-TS. METHOD(S): 66 referrals were made to the transport service from September 2020 to 2021 with a provisional diagnosis of COVID-19, PIMS-TS, atypical Kawasaki disease, acute abdomen or cardiac disease. Referral documentation was examined and excluded if PIMS-TS was not suspected, leaving a total of 41 referrals for audit. Documentation was examined for evidence of completion by the referring team of sepsis screen and abdominal imaging. RESULT(S): 24 (59%) patients had a sepsis screen already completed prior to referral. Of the remaining 17 referrals, 16 (94%) did not have a sepsis screen recommended by the transport service. 27 (66%) referrals had abdominal symptoms on referral. Of these, 9 (33%) had received abdominal imaging, 6 (22%) were recommended to receive imaging by the transport service, and 12 (44%) were not recommended to receive imaging. CONCLUSION(S): The majority of patients referred to the regional transport service had received a sepsis screen prior to referral. However the majority of patients with abdominal symptoms did not receive imaging. A referral proforma for suspected PIMS-TS patients has been developed to improve exclusion of alternative diagnoses.

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