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1.
Clinical and Experimental Rheumatology ; 39(6):S215-S222, 2022.
Article | EMBASE | ID: covidwho-1822803

ABSTRACT

Since the beginning of the COVID-19 disease pandemic causedby the new coronavirus SARS-CoV-2, the disease has claimed over 205M cases (205,338,159) and 4,333,094 deaths (WHO dashboard – accessed 15/08/2021). In addition to the overwhelming impact on healthcare systems treating acutely ill patients, the pandemic has had an impact on all other aspects of health care delivery, including the management of chronic diseases, the risk that is posed in patients with chronic conditions and the risk of the infection itself in those with chronic conditions. Autoimmune rheumatic diseases (ARDs), including primary Sjögren’s syndrome (pSS), characterised by immune dysregulation affecting several organs in variable severity, have been of particular interest given the accelerated phase of the immune response in the course of SARS-CoV-2 infection leading to the acute inflammatory response and respiratory distress syndrome or multi-organ failure. On the other hand, the effect of immunosuppressive drug therapies can represent a double edge sword on the course of the disease, either by increased susceptibility to and severity of the infection, or by preventing the accelerated inflammatory response induced by the infection. Additionally, the long-term impact of SARS-CoV-2 infection on the host immune system has led to the onset of novel complex clinical manifestations, comprised under the large umbrella of “long-COVID”, which we are only starting to understand. In this review we focus on two interrelated aspects: i) the impact of COVID-19 on patients with pSS and ii) the emerging evidence of long-term xerostomia after SARS-CoV-2 infection.

2.
Revue Medicale Suisse ; 17(751):1632, 2021.
Article in French | EMBASE | ID: covidwho-1822802
3.
Traditional Medicine Research ; 7(3), 2022.
Article in English | EMBASE | ID: covidwho-1822801

ABSTRACT

Coronaviruses exist widely in nature, can cause cross-species transmission, and pose serious threats to human and animal health. Over the past 20 years, coronaviruses have led to three major epidemics that have caused global panic, including severe acute respiratory syndrome, Middle East respiratory syndrome, and coronavirus disease-19. At present, coronavirus disease-19 not only spreads rapidly, but also mutates easily to escape host immune response, becoming more pathogenic. At present, there are no effective specific therapeutic drugs or vaccines. Drugs targeting severe acute respiratory syndrome coronavirus 2 and the host cell defense system that have been developed based on the structure and replication cycle of coronaviruses have a certain broad-spectrum antiviral effect;however, their efficacy still needs to be demonstrated in further clinical trials. Traditional Chinese medicine has an indispensable role in the ongoing response to coronavirus disease-19. Anti-virus treatment with traditional Chinese medicine has advantages such as broad-spectrum application, low toxicity and side effects, low susceptibility to drug resistance, and overall comprehensive regulation. Therefore, researches on effective components and mechanisms of action of the anti-viral effects of traditional Chinese medicine have increasingly gained attention. The present paper examines coronaviruses, specifically summarizing the genomes, replication mechanisms, and mutant strains. Afterward, the therapeutic effects and mechanisms of action of modern broad-spectrum anti-coronavirus drugs and traditional Chinese medicine are summarized. By considering the virus and the targets in the host comprehensively, in addition to the beneficial multi-target and multi-path antiviral effects of traditional Chinese medicines, this paper could guide the development of treatment strategies for broad-spectrum anti-coronavirus traditional Chinese medicines, and could facilitate the modernization and globalization of traditional Chinese medicine.

4.
Traditional Medicine Research ; 7(3), 2022.
Article in English | EMBASE | ID: covidwho-1822800
5.
Pakistan Journal of Medical and Health Sciences ; 16(3):837-839, 2022.
Article in English | EMBASE | ID: covidwho-1822799

ABSTRACT

Aim: The knowledge of viral characteristics in addition immune reply to severe respiratory disorder (Sars Syndrome Coronavirus 2 (SARS-CoV-2) contamination still has significant gaps. Methods: In a retrospective longitudinal cohort analysis of 140 cases having PCR-established SARS-CoV-2 disease, researchers analyzed those parameters and demonstrated their correlation with symptom manifestations (mean age, 44 years;54 percent male;48 percent through comorbidities). Breathing models (n = 76) remained obtained for viral culture, serum specimens (n = 32) for IgM/IgG levels, and plasma samples (n = 82) for inflammatory cytokines and chemokines. The illness burden remained connected to the findings of viral culture, serologic tests, also immunological markers. Results: Fifty-eight (58%) cases established viral pneumonia, including 22 (18%) requiring supplementary oxygen and 14 (11%) requiring invasive mechanical ventilation. Twenty of the 77 individuals were positive for viral culture from respiratory samples (24 percent). When the PCR cycle threshold (Ct) value remained more than 31 or greater than 15 days following indication onset, no virus was recovered. Seroconversion happened at a median (IQR) of 13.6 (10-20) days for IgM and 16.1 (14-22) days for IgG;56/63 patients (88.2 percent) seroconverted on day 15 or later. Health hazard appeared linked to quicker seroconversion as well as greater peak IgM and IgG levels. Conclusion: Researchers discovered that viral viability significantly related having such a lower PCR Ct charge in the initial stages of disease. The seriousness of the illness was linked to a greater antibody level. Overcharged pro-inflammatory immune markers provide marks for host-directed immunotherapy, that would have been investigated in randomized precise studies.

6.
Pakistan Journal of Medical and Health Sciences ; 16(3):659-661, 2022.
Article in English | EMBASE | ID: covidwho-1822798

ABSTRACT

This article is investigating physiological childbirth statistics and obstetric service in Osh, Kyrgyzstan during the 2016 to 2021 years. Statistical analyses revealed several patients' admissions with their hospital stay days for the period from 2011 to 2020 in all departments. Growth in the population analyzed according to Kyrgyz Republic National Statistical Committee;due to spread of coronavirus infection COVID-19 pandemic and the government declared an emergency in certain territories in the Kyrgyz Republic, from March 31 to May 21, 2020, activities of public service centers and registry office by Government Registration Service were delayed. Conclusions: Quality provision in medical care is vital for both women and newborns and for a minority who experience complications in maternity service. Some statistical analyses revealed that average absolute birth number reduced by 92 births and births number variation analysis in Osh oblast for 2016 to 2021 years showed that in the 2021 year total birth number was 29902 and 31000 in 2020, which can be explained by COVID - 19 infection influence on the population. Number of births registered as 182.971 and the average annual number of births was 30.495.

7.
Pakistan Journal of Medical and Health Sciences ; 16(3):560-563, 2022.
Article in English | EMBASE | ID: covidwho-1822797

ABSTRACT

Objectives: The study aimed to examine COVID-19 knowledge among the general public in Pakistan, to review their attitudes and views regarding the fast epidemic. Study Design: Descriptive cross-sectional study. Duration of Study: June-July 2020. Methodology: A total of 679 respondents included. The questionnaires comprised of the following basic themes: basic demography, general & basic clinical/medical knowledge, attitudes, awareness, perceptions as well as a sense of prevention regarding COVID-19. Results: The majority (75.5%) of the respondents were from Punjab province. Around half (54.5%) of the respondents had heard about the COVID-19 infection through different social media. The majority were 28.4% medical students. The majority of the respondents (80-95%) selected correct answers from the given choices for the questions related to some clinical knowledge. More than half of people (59-64%) think positively that COVID-19 will successfully be controlled and Pakistan will be successful in winning this battle of the pandemic. 61% were afraid of COVID-19 as it is highly contagious disease (37.7%). Around 60% always covered their noses and mouths while sneezing and coughing. Conclusion: The people must have a thorough understanding of COVID-19 to successfully execute COVID-19 prevention strategies. Although we found enough knowledge, favorable perspectives, and readiness to follow SOPs, we believe that additional preventative and cautious attitudes, as well as awareness, are needed.

8.
Pakistan Journal of Medical and Health Sciences ; 16(3):546-551, 2022.
Article in English | EMBASE | ID: covidwho-1822796

ABSTRACT

Vaccines function via a variety of methods to provide disease protection;nevertheless, the process of establishing immunity may create side effects. As a result, the goal of this research was to investigate the COVID-19 vaccination's acute side effects among oral health care professionals. In order to investigate the pictured objectives the research was conducted in a explorative manner. The data was collected from the oral health care workers using survey analysis to bring insights into the study objectives. Study followed by the descriptive and frequency analysis of the reported side effects in the selected population. The analytical procedures found that persons who have been vaccinated may display a variety of symptoms, and it is important to examine which vaccination is most cost-effective or has the fewest side effects for a certain age range. Classification should be based on these factors. There are many more aspects to consider when making vaccination decisions, including cost-effectiveness, minimal or zero adverse effects, and efforts to protect socioeconomically disadvantaged populations, as well as the urgent need to restore economic and social normality.

9.
Research Journal of Pharmacy and Technology ; 15(3):1348-1352, 2022.
Article in English | EMBASE | ID: covidwho-1822794

ABSTRACT

This review highlights the regulatory status of herbal medicines in India and in specific countries. The herbal medicines are being used in different system of medicines like the Ayurveda, siddha, homeopathy, unani and Chinese system of medicine. The regulatory authorities and WHO are making efforts to collaborate in order to for a harmonized herbal medicine regulation. The Drugs and Cosmetics Act 1940 and Rules 1945 consist of the regulatory guidance and guidelines for Ayurveda, Unani, Siddha medicine. The herbal medicines are being categorized as Complimentary medicines, Natural health products, Prescription medicines, over the counter medicines, Supplements, Traditional herbal medicines globally.

10.
Pharmacophore ; 13(1):48-55, 2022.
Article in English | Web of Science | ID: covidwho-1822791

ABSTRACT

At the current time, obesity itself can be a pandemic for many risk factors such as what is occurring in western countries were quickly comforted by the increase in the frequency of obesity, whose effects on health were soon manifested by a significant increase in cardiovascular disease in the general population. Inflammatory proteins can be classified according to their functions into different categories, although they are mainly involved in the response of the acute phase of inflammation, among which is the C-reactive protein (CRP). This study aimed to provide the effects of obesity according to the inflammatory analysis with CRP test on obese patients having a high-frequency inflammation which is one of several causes lead toward the infection and catching by Coronavirus COVID-19 disease because the influence of the obesity on the immunity system, according to sex, ethnicity, and age. We focused that obese patients must avoid any high-level CRP concentration to prevent them from any risk factors of contamination by COVID-19 pandemic. Copyright (C) 2013 - All Rights Reserved - Pharmacophore

11.
Tijdschrift voor Geneeskunde en Gezondheidszorg ; 77(10), 2021.
Article in Dutch | EMBASE | ID: covidwho-1822790

ABSTRACT

Public health ethics is guided by a core value: the defense of the common good, which may, in certain circumstances, conflict with the respect for individual freedom. The management of contagious infectious diseases in general, and the management of the COVID-19 pandemic in particular offer many examples of this ethical clash. Both victim and vector of the disease, the contagious patient must benefit from the best possible care and at the same time accept a duty of solidarity towards those he may infect. If, however, in certain circumstances, health constraints can be imposed on citizens in order to protect the common good, these coercive measures should be guided by clear ethical benchmarks. First of all, the threat for which we seek protection, must be significant and realistic. Secondly, the coercive measures put in place must have proven their effectiveness. Thirdly, the inconveniences linked to these measures must be proportional to the expected benefits and the targeted threat. Finally, the measures must be as least restrictive as possible.

12.
Tijdschrift voor Geneeskunde en Gezondheidszorg ; 77(11), 2021.
Article in Dutch | EMBASE | ID: covidwho-1822789
14.
Tijdschrift voor Geneeskunde en Gezondheidszorg ; 77(4), 2021.
Article in Dutch | EMBASE | ID: covidwho-1822787
15.
Tijdschrift voor Geneeskunde en Gezondheidszorg ; 77(4), 2021.
Article in Dutch | EMBASE | ID: covidwho-1822786

ABSTRACT

Healthcare providers, patients, policymakers and the public at large face unseen challenges due to the Covid-19 pandemic, including ethical questions that cover the entire healthcare landscape: from the citizen who is subjected to specific prevention measures, primary care and residential care, and intensive care in specialized hospital wards. By consequence, prioritization decisions are made in different places in the healthcare landscape and by various actors. Moreover, different domains within the healthcare landscape may act as communicating vessels. For example, patients who are denied access to Intensive Care Units have to be cared for elsewhere, and the centralization of resources and manpower in hospitals may complicate access to tests, protective equipment or oxygen in primary care and residential care. Furthermore, the postponement of non-urgent care to create capacity for the care for covid patients has a significant impact on non-covid related care. Against this background, the Belgian Advisory Committee on Bio-ethics provides the current recommendations, in which four decision areas are considered: the organization of care, the patient, medical professionals, and care institutions and primary care. The recommendations were endorsed by the Order of Physicians and the Superior Health Council.

16.
Tijdschrift voor Geneeskunde en Gezondheidszorg ; 77(1), 2021.
Article in Dutch | EMBASE | ID: covidwho-1822785
17.
Tijdschrift voor Geneeskunde en Gezondheidszorg ; 77(4), 2021.
Article in Dutch | EMBASE | ID: covidwho-1822784
18.
19.
Infektoloski Glasnik ; 41(3):87-92, 2021.
Article in English | EMBASE | ID: covidwho-1822781

ABSTRACT

Summary Originating with unexplained symptoms from Wuhan, city of China, COVID-19 being a global pandemic causing tremendous morbidity and mortality, has proved to be the biggest challenge of the 20th century. This study aimed to explore the functional impacts of COVID-19 upon those patients who were diagnosed with this disease and were admitted in hospitals. This cross-sectional survey included 183 COVID-19 diagnosed patients from COVID-19 isolation wards of public and private hospitals of Islamabad and Rawalpindi. After getting ethical permission from Institutional Review Board of Shifa International Hospital (Ref # 070-21), this survey was conducted for the time period of 6 months from December 2020 to May 2021. Through convenient sampling, 183 patients with the age range of 25 to 55 years with no already diagnosed psychological complaints were assessed for eligibility briefed regarding the study purpose and then were asked for their voluntary participation. The Functional Status Scale for the Intensive Care Unit (FSS-ICU) was used to assess the functional status impacted due to COVID-19 during hospitalization. Frequencies and percentages were calculated through SPSS-21. On FSS-ICU, out of 183 COVID-19, 11 (6%) patients reported that they were dependent, 18 (9.8%) required maximum assistance, 32 (17.5%) required moderate assistance, 27 (14.8%) required minimal, 24 (13.1%) required supervision to complete their tasks, 28 (15.3%) required assistive devices, whereas 43 (23.5%) were totally independent. Results indicated a temporal impact of COVID-19 upon functional status of hospitalized patients in intensive care units, therefore highlighting the need of physiotherapeutic and psychotherapeutic interventions.

20.
Journal of Critical and Intensive Care ; 13(1):12-17, 2022.
Article in English | EMBASE | ID: covidwho-1822779

ABSTRACT

Objective: Coronavirus Disease-2019 (COVID-2019), which originated in Wuhan, China in December 2019 and became a global pandemic in March 2020, is a viral infectious condition. This study was planned due to the novel character of the virus, unexpected clinical course of the disease as well as due to the relative lack of data on determinants of severe disease. Methods: This retrospective study was carried out with the inclusion of 80 patients admitted to the Intensive Care Unit (ICU), Medical Faculty of Erzincan Binali Yildirim University between 1st April 2020 and 1st October 2020 due to the diagnosis of COVID-19 pneumonia. Demographic, clinical, and laboratory data, as well as treatments complications, length of ICU stay and mortality rate were compared between patients who had survive or not. Results: Of the 80 patients, 18 were died, and 62 were discharged. The mean age was 69.7 ± 14.7 years, with a female to male ratio of approximately 1:2. Systolic blood pressure and mean arterial pressure on admission were significantly lower in non-survivors (p=0.002, and p=0.026, respectively). Also, non-survivors had significantly higher levels of CRP, procalcitonin, D-dimer, urea, LDH, INR, lactate, and neutrophil count and significantly lower lymphocyte counts as compared to survivors. The predictors of mortality were determined as the need for mechanical ventilation, presence of complications, higher CRP and urea levels in a multivariate regression analysis. Conclusion: Early estimation of patients with a high likelihood of severe illness, assessment of the intensive care unit admission, and convenient treatment strategies are important. This is a precious study that detects an early need for ICU admission and close follow-up of patients.

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