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Journal of Pediatric Surgery Case Reports ; 88, 2023.
Article in English | Scopus | ID: covidwho-2244314


Spitzoid melanoma is very rare tumour in the pediatric population, with clinical and non-uniform behaviour, different from adult melanoma [1]. It can be difficult to differentiate an atypical Spitz nevus from a Spitzoid melanoma, resulting in diagnostic problems. In addition, in our clinical case, the COVID-19pandemiccaused significant delays both in the diagnosis and in the surgical treatment of our patient. We present the clinical case of a 4-year-old child suffering from a localized polypoid cutaneous neoformation on the dorsum of the left hand, which started immediately before the lockdown and steadily increased during the COVID-19 pandemic. After a general clinical framing, the child underwent an excisional biopsy at our Department of Plastic and Reconstructive Surgery, at the Policlinico of Foggia. Subsequently, two independent anatomic pathology groups examined the specimen. Definitive diagnosis was made only after careful genetic analysis in combination with supporting histological and immunohistochemical examinations. This clinical case shows how during the pandemic we have been facing advanced forms of tumours, compared to the previous period and highlight show an interdisciplinary and multicenter collaboration allowed a quick diagnosis of certainty, demonstrating the utility of molecular pathology as a fundamental aid in clinical/surgical practice. © 2022 The Authors

British Journal of Dermatology ; 186(6):e245, 2022.
Article in English | EMBASE | ID: covidwho-1956713
British Journal of Dermatology ; 186(6):e252, 2022.
Article in English | EMBASE | ID: covidwho-1956690
Journal of Investigative Dermatology ; 142(8):S105, 2022.
Article in English | EMBASE | ID: covidwho-1956223
Critical Reviews in Environmental Science and Technology ; 2022.
Article in English | EMBASE | ID: covidwho-1895682
"Analele Stiintifice ale Universitatii ""Al. I. Cuza"" din Iasi" ; 67:17-22, 2021.
Article in English | ProQuest Central | ID: covidwho-1801643
Current Topics in Peptide & Protein Research ; 22:67, 2021.
Article in English | ProQuest Central | ID: covidwho-1762621
Biomedical and Biopharmaceutical Research ; 18(2), 2021.
Article in English | EMBASE | ID: covidwho-1744006
Journal of Pharmacognosy and Phytotherapy ; 13(4):91-107, 2021.
Article in English | EMBASE | ID: covidwho-1629413
Mol Cell Endocrinol ; 529: 111260, 2021 06 01.
Article in English | MEDLINE | ID: covidwho-1157602


Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), has been identified as the receptor for the SARS-CoV-2. Several RAS components including ACE2 and its substrate Ang II are present in both eye and skin, two stratified squamous epithelial tissues that isolate organisms from external environment. Our recent findings in cornea and others in both skin and eye suggest contribution of this system, and specifically of ACE2 in variety of physiological and pathological responses of these organ systems. This review will focus on the role RAS system plays in both skin and cornea, and will specifically discuss our recent findings on ACE2 in corneal epithelial inflammation, as well as potential implications of ACE2 in patients with COVID-19.

Angiotensin-Converting Enzyme 2/metabolism , Epithelium, Corneal/enzymology , Receptors, Coronavirus/metabolism , Skin/enzymology , Autophagy , COVID-19/enzymology , COVID-19/virology , Humans , Inflammation/enzymology , Renin-Angiotensin System/physiology , Wound Healing