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1.
Food Bioscience ; 51:102348, 2023.
Article in English | ScienceDirect | ID: covidwho-2165299

ABSTRACT

The COVID-19 pandemic has substantially impacted the world health systems, causing public health concerns, and the search for new compounds with antiviral activity is of extreme interest. Natural molecules with bioactive potential are a trend, with essential oils (Eos) being the focus of recent studies. Thus, this study evaluates in chemico the d-limonene inhibitory activities in the viral genome of SARS-CoV-2 and analyzes the cytotoxic potential and safety profile of d-limonene and lime and orange EOs with a high content of d-limonene. The EOs were extracted and characterized, and the in chemico computational analysis for the determination as a potential anti-SARS-CoV-2 was performed with d-limonene, the major compound in EOs. The cytotoxicity analysis of EOs and d-limonene was carried out with MRC-5 and HaCaT, and the preliminary safety profile was also evaluated by the HET-CAM assay. d-limonene was suggested as a promising compound for anti-SARS-CoV-2 research, since the molecule does not provide mutagenic and cytotoxic fragments, and does not have irritating potential when diluted, in addition to having favorable pharmacokinetic characteristics, through in chemico analysis. Collectively, the results reveal the antiviral potential of lime and orange EOs, as well as their major compound. In this sense, further studies should be conducted to understand the antiviral mechanisms.

2.
AACN Adv Crit Care ; 33(4):312-318, 2022.
Article in English | PubMed | ID: covidwho-2155473

ABSTRACT

BACKGROUND: Intensive care unit (ICU) health care workers face increased burnout. The purpose of this project was to evaluate burnout after implementing lavender essential oils. OBJECTIVE: To assess the effectiveness of topical lavender essential oils in decreasing the instance of burnout in frontline ICU health care workers during the COVID-19 pandemic. METHODS: A predesign and postdesign evidence-based practice project was conducted to evaluate the implications of an 8-week topical lavender oil intervention on health care worker burnout. The Maslach Burnout Inventory, including subscales of emotional exhaustion, depersonalization, and personal accomplishment, was administered before and after the intervention. Health care workers' compliance and satisfaction with the intervention were also measured. RESULTS: Thirty-four ICU health care workers participated. Results showed significant improvements in the personal accomplishment subscale (mean [SD], 3.86 [0.81] before vs 4.14 [1.01] after intervention;P = .04). Improvements in depersonalization were not significant. Most participants were satisfied (n = 23 [67.6%]) and compliant (n = 23 [67.6%]) with the intervention. CONCLUSION: The use of topical lavender essential oils is a cost-effective intervention that can be used to decrease components of burnout in frontline ICU workers.

3.
International Journal of Professional Holistic Aromatherapy ; 11(3):3-3, 2022.
Article in English | CINAHL | ID: covidwho-2124739
4.
The Book of Flavonoids ; : 325-338, 2022.
Article in English | Scopus | ID: covidwho-2124512

ABSTRACT

Since ancient times, the different parts of the bitter orange of Seville have been used as food or for healing. One of its current main applications is the obtaining of a wide range of flavonoids which, after years of research and development, have proved to provide numerous benefits for human health including action against COVID-19, which is under research at laboratory level. Among the flavonoids found in the bitter orange of Seville naringin can be highlighted, which is very beneficial for human health. On the other hand, essential oils have been extracted and used since ancient times, from ritual and religious uses to the current uses in cosmetics, perfumery, food and health. This chapter overviews the history of the bitter oranges of Seville, the essential oils and naringin (a bioflavonoid) that can be extracted from them and their potential applications. © 2021 by Nova Science Publishers, Inc.

5.
Plants (Basel) ; 11(22)2022 Nov 08.
Article in English | MEDLINE | ID: covidwho-2143461

ABSTRACT

Aspergillus species consists of a group of opportunistic fungi that is virulent when the immunity of the host is compromised. Among the various species, Aspergillus fumigatus is the most prevalent species. However, the prevalence of fungal infections caused by non-fumigatus Aspergillus has been increasing. Polyenes, echinocandins and azoles are the three main classes of antifungal agents being used for the treatment of aspergillosis. Nevertheless, the incidence of resistance towards these three classes has been rising over the years among several Aspergillus spp. The side effects associated with these conventional antifungal agents have also limited their usage. This urges the need for the discovery of a safe and effective antifungal agent, which presents a major challenge in medicine today. Plants present a rich source of bioactive molecules which have been proven effective against a wide range of infections and conditions. Therefore, this present review intends to examine the current literature available regarding the efficacy and mechanism of action of plant extracts and their compounds against Aspergillus spp. In addition, novel drug delivery systems of plant extracts against Aspergillus spp. were also included in this review.

6.
Molecules ; 27(22)2022 Nov 15.
Article in English | MEDLINE | ID: covidwho-2116027

ABSTRACT

Herbal products are a major source of herbal medicines and other medicines. Essential oils have shown various pharmacological activities, such as antiviral activity, and therefore are proposed to have potential activity against SARS-CoV-2. Due to their lipophilicity, essential oils can easily penetrate the viral membrane and cause the viral membrane to rupture. In addition, crude essential oils usually have many active constituents that can act on different parts of the virus including its cell entry, translation, transcription, and assembly. They have further beneficial pharmacological effects on the host's respiratory system, including anti-inflammatory, immune regulation, bronchiectasis, and mucolytics. This review reported potential essential oils which could be promising drugs for COVID-19 eradication. Essential oils have many advantages because they are promising volatile antiviral molecules, making them potential drug targets for the prevention and treatment of COVID-19, whether used alone or in combination with other chemotherapeutic drugs. The aim of the current review is to shed light on the potential essential oils against enveloped viruses and their proposed activity against SARS-CoV-2 which is also an enveloped virus. The objectives were to present all data reflecting the promising activities of diverse essential oils against enveloped viruses and how they could contribute to the eradication of COVID disease, especially in indoor places. The data collected for the current review were obtained through the SciFinder database, Google scholar, PubMed, and Mendeley database. The data of the current review focused on the most common essential oils which are available in the pharmaceutical market and showed noticeable activities against enveloped viruses such as HSV and influenza.


Subject(s)
COVID-19 , Oils, Volatile , Plants, Medicinal , Oils, Volatile/pharmacology , Oils, Volatile/therapeutic use , COVID-19/drug therapy , SARS-CoV-2 , Antiviral Agents/pharmacology , Antiviral Agents/therapeutic use
7.
Journal of the Chilean Chemical Society ; 67(3):5602-5614, 2022.
Article in English | Web of Science | ID: covidwho-2092449

ABSTRACT

Despite the social distancing and hygiene rules prescribed by the WHO, the novel Corona-virus is still on the way of a significant rapid rise in deaths. Therefore, identification of chemotherapeutic drugs against Corona Viral Infection all around the world is still requires. Some medicinal plants have a valuable therapeutic effect when mixt with honey, the obtained formulations are preliminary use in Cameroon against viral infection particularly respiratory infections. In this work, we looked for the potential anti-SARS-CoV-2 molecule throw execution of in silico computational studies of six Cameroonian plants intervening in the treatment respiratory infections in apiphytotherapy. AutoDock Vina was used for docking studies against SARS-CoV-2 main protease (Mpro) and spike (SP) proteins. We further conducted of pharmacokinetics properties and the safety profile of compounds with the top score in order to identify the best drug candidates. Totally 100 compounds were screened, of these, eighteen showed high binding affinity against SARS-CoV-2 Mpro and SP. The results suggest the effectiveness of compounds 10 and 17 obtained from Citrus Sinensis as potent drugs against SARS-CoV-2 as they tightly bind to its Mpro and SP with low binding energies. The stability of the two compounds complexed with Mpro and SP was validated through MD simulation. The availability of potent protein inhibitors and diverse of compounds from Cameroon flora scaffolds indicate the feasibility of developing potent Mpro and SP proteins inhibitors as antivirals for COVID-19. Based on further in vivo and in vitro experiments and clinical trials, some of these phytoconstituents could be proposed for effective inhibition of the replication of the SARS-CoV-2.

8.
Application of Natural Products in SARS-CoV-2 ; : 143-170, 2023.
Article in English | ScienceDirect | ID: covidwho-2085819

ABSTRACT

The coronavirus disease-2019 (COVID-19) pandemic is caused by a novel coronavirus;the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Millions of cases and deaths to date have resulted in a global challenge for healthcare systems. There are currently no effective therapeutic approaches for the prevention and treatment of COVID-19. Therefore, the identification of effective therapeutics is a necessity. Terpenes, meroterpenoids, and artemisinin are natural products that could serve as a source of new drugs or as prototypes to develop effective pharmacotherapeutic agents. This chapter deals with the biological properties and nutraceutical application of terpenes, meroterpenoids, and artemisinin and also finds out the possible interaction and discusses the mechanism of action of these natural products against SARs-CoV-2. The information reviewed here might provide useful clues and lay the foundation for developing new terpenes, meroterpenoid, and artemisinin-derived drugs.

9.
J Funct Foods ; 97: 105225, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2049462

ABSTRACT

A broad range of evidence has confirmed that natural products and essential oils might have the potential to suppress COVID-19 infection. Therefore, this study aimed to develop an oral/throat spray formulation for prophylactic use in the oral cavity or help treatment modalities. Based on a reference survey, several essential oils, a cold-pressed oil, and propolis were selected, and cytotoxicity and antiviral activity of each component and the developed spray formulation were examined against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection using Vero E6 cells. Anti-inflammatory, antimicrobial, and analgesic activities as well as mutagenicity and anti-mutagenicity of the formulation were analysed. Forty-three phenolics were identified in both propolis extract and oral/throat spray. The spray with 1:640-fold dilution provided the highest efficacy and the cytopathic effect was delayed for 54 h at this dilution, and the antiviral activity rate was 85.3%. A combination of natural products with essential oils at the right concentrations can be used as a supplement for the prevention of SARS-CoV-2 infection.

10.
New Formations ; - (106):43-59, 2022.
Article in English | ProQuest Central | ID: covidwho-2024398

ABSTRACT

This article tracks the emergence of sleep discourse in the past ten years in the USA, illustrating a democratisation of this rhetoric insofar as it has begun to interpellate populations beyond midlife women. Despite the sociological and demographic inequities associated with sleep deficits in marginalised populations, the much vaunted 'sleep crisis' is more widely appreciated as a distinct self-care frontier. Such behavioural scripts resonate with exaltations of the self as resilient entrepreneurial problem-solver and are linked to the broader positioning of self-care as salve for the injuries of neoliberalism. Beginning with sleep's ties to women's wellness and consumerist culture writ large, we apprehend sleep as an economy, one with staggering new commercial dimensions. Sleep remedies tend to be focused narrowly on the acquisition of products and technologies (sleep sprays, essential oils and melatonin gummies, blackout curtains, premium bedding, sleep apps, sound machines, adult sleep coaches), all of which come under consideration here. The investigation then turns to the heightened attention paid to the experience of sleep during COVID-19, discusses how sleep discourse articulates to and with a sense of ambivalent dispossession from work regimes and, finally, argues that the sleep crisis has been leveraged to intensify neoliberal brutalities.

11.
Molecules ; 27(16)2022 Aug 11.
Article in English | MEDLINE | ID: covidwho-2023934

ABSTRACT

The flora of Kazakhstan is characterized by its wide variety of different types of medicinal plants, many of which can be used on an industrial scale. The Traditional Kazakh Medicine (TKM) was developed during centuries based on the six elements of ancient Kazakh theory, associating different fields such as pharmacology, anatomy, pathology, immunology and food nursing as well as disease prevention. The endemic Artemisia L. species are potential sources of unique and new natural products and new chemical structures, displaying diverse bioactivities and leading to the development of safe and effective phytomedicines against prevailing diseases in Kazakhstan and the Central Asia region. This review provides an overview of Artemisia species from Central Asia, particularly traditional uses in folk medicine and the recent numerous phytochemical and pharmacological studies. The review is done by the methods of literature searches in well-known scientific websites (Scifinder and Pubmed) and data collection in university libraries. Furthermore, our aim is to search for promising and potentially active Artemisia species candidates, encouraging us to analyze Protein Tyrosine Phosphatase 1B (PTP1B), α-glucosidase and bacterial neuraminidase (BNA) inhibition as well as the antioxidant potentials of Artemisia plant extracts, in which endemic species have not been explored for their secondary metabolites and biological activities so far. The main result of the study was that, for the first time, the species Artemisia scopiformis Ledeb. Artemisia albicerata Krasch., Artemisia transiliensis Poljakov, Artemisia schrenkiana Ledeb., Artemisia nitrosa Weber and Artemisia albida Willd. ex Ledeb. due to their special metabolites, showed a high potential for α-glucosidase, PTP1B and BNA inhibition, which is associated with diabetes, obesity and bacterial infections. In addition, we revealed that the methanol extracts of Artemisia were a potent source of polyphenolic compounds. The total polyphenolic contents of Artemisia extracts were correlated with antioxidant potential and varied according to plant origin, the solvent of extraction and the analytical method used. Consequently, oxidative stress caused by reactive oxygen species (ROS) may be managed by the dietary intake of current Artemisia species. The antioxidant potentials of the species A. schrenkiana, A. scopaeformis, A. transiliensis and Artemisia scoparia Waldst. & Kitam. were also promising. In conclusion, the examination of details between different Artemisia species in our research has shown that plant materials are good as an antioxidant and eznyme inhibitory functional natural source.


Subject(s)
Artemisia , Antioxidants/pharmacology , Artemisia/chemistry , Ethnopharmacology , Humans , Phytochemicals/chemistry , Phytotherapy , Plant Extracts/chemistry , alpha-Glucosidases
12.
Antibiotics (Basel) ; 11(8)2022 Aug 12.
Article in English | MEDLINE | ID: covidwho-2023079

ABSTRACT

Plant-based natural compounds (PBCs) are comparatively explored in this study to identify the most effective and safe antibacterial agent/s against six World Health Organization concern pathogens. Based on a contained systematic review, 11 of the most potent PBCs as antibacterial agents are included in this study. The antibacterial and antibiofilm efficacy of the included PBCs are compared with each other as well as common antibiotics (ciprofloxacin and gentamicin). The whole plants of two different strains of Cannabis sativa are extracted to compare the results with sourced ultrapure components. Out of 15 PBCs, tetrahydrocannabinol, cannabidiol, cinnamaldehyde, and carvacrol show promising antibacterial and antibiofilm efficacy. The most common antibacterial mechanisms are explored, and all of our selected PBCs utilize the same pathway for their antibacterial effects. They mostly target the bacterial cell membrane in the initial step rather than the other mechanisms. Reactive oxygen species production and targeting [Fe-S] centres in the respiratory enzymes are not found to be significant, which could be part of the explanation as to why they are not toxic to eukaryotic cells. Toxicity and antioxidant tests show that they are not only nontoxic but also have antioxidant properties in Caenorhabditis elegans as an animal model.

13.
Biotechnol Bioprocess Eng ; 27(4): 543-555, 2022.
Article in English | MEDLINE | ID: covidwho-2007270

ABSTRACT

Antibiotic overuse has resulted in the microevolution of drug-tolerant bacteria. Understandably it has become one of the most significant obstacles of the current century for scientists and researchers to overcome. Bacteria have a tendency to form biofilm as a survival mechanism. Biofilm producing microorganism become far more resistant to antimicrobial agents and their tolerance to drugs also increases. Prevention of biofilm development and curbing the virulency factors of these multi drug resistant or tolerant bacterial pathogens is a newly recognised tactic for overcoming the challenges associated with such bacterial infections and has become a niche to be addressed. In order to inhibit virulence and biofilm from planktonic bacteria such as, Pseudomonas aeruginosa, Acinetobacter baumannii, and others, stable nanoemulsions (NEs) of essential oils (EOs) and their bioactive compounds prove to be an interesting solution. These NEs demonstrated significantly greater anti-biofilm and anti-virulence activity than commercial antibiotics. The EO reduces disease-causing gene expression, which is required for pathogenicity, biofilm formation and attachment to the surfaces. Essential NE and NE-loaded hydrogel surface coatings demonstrates superior antibiofilm activity which can be employed in healthcare-related equipments like glass, plastic, and metal chairs, hospital beds, ventilators, catheters, and tools used in intensive care units. Thus, anti-virulence and anti-biofilm forming strategies based on NEs-loaded hydrogel may be used as coatings to combat biofilm-mediated infection on solid surfaces.

14.
Acs Applied Polymer Materials ; 2022.
Article in English | Web of Science | ID: covidwho-2004744

ABSTRACT

The COVID-19 outbreak has seen the widespread use of personal protective equipment, especially antibacterial fibers. In this work, ionic liquid (IL) is used as a solvent to fabricate antibacterial fibers combining plant essential oils (PEOs) with cellulose. PEOs are buried in microcapsules first or mixed directly with IL-cellulose spinning dopes to prepare a series of composite fibers. The internal structures, surface and cross morphologies, thermal stability, mechanical properties, antibacterial activity, washing stability, and biocompatibility of these fibers are investigated and analyzed in-depth further. Artemisia microcapsule fiber (AMCRCF) with a break strength of 30.07 MPa is obtained. Besides, the antibacterial activity rates of AMC-RCF against Escherichia coli and Staphylococcus aureus are 89.8 and 97.8%, and the fibers still have a long-lasting antibacterial effect after 30 standard washes. Furthermore, the antibacterial fibers exhibit excellent biocompatibility. This research provides a green approach for the fabrication of the antibacterial fibers with long-lasting antibacterial activity and good biocompatibility.

15.
Applied Sciences ; 12(15):7500, 2022.
Article in English | ProQuest Central | ID: covidwho-1993920

ABSTRACT

(1) Background: Essential oil from Vitex negundo is known to have repellent and insecticidal properties toward the Anopheles gambiae and this is linked to its monoterpene and sesquiterpene content. In this work, an effort is made to delineate the constitution of V. negundo essential oil (VNEO) and their interaction with odorant-binding proteins (OBPs) of A. gambiae and hence access its repellent efficiency as cost-effective and safer malaria vector control alternatives. (2) Methods: Anopheles species authentication was performed by genomic DNA analysis and was subjected to behavioral analysis. GC-MS profiling was used to identify individual components of VNEO. Anopheles OBPs were obtained from the RCSB protein data bank and used for docking studies. Determination of ligand efficiency metrics and QSAR studies were performed using Hyper Chem Professional 8.0.3, and molecular dynamics simulations were performed using the Desmond module. (3) Results: GC-MS analysis of VNEO showed 28 compounds (monoterpenes, 80.16%;sesquiterpenes, 7.63%;and unknown constituents, 10.88%). The ligand efficiency metrics of all four ligands against the OBP 7 were within acceptable ranges. β-selinene (−12.2 kcal/mol), β-caryophellene (−9.5 kcal/mol), sulcatone (−10.9 kcal/mol), and α-ylangene (−9.3 kcal/mol) showed the strongest binding affinities for the target proteins. The most stable hydrophobic interactions were observed between β-selinene (Phe111 and Phe120), Sulcatone (Phe54 and Phe120), and α-ylangene (Phe111), while only sulcatone (Tyr49) presented H-bond interactions in the simulated environment. (4) Conclusions: Sulcatone and β-caryophyllene presented the best log p values, 6.45 and 5.20, respectively. These lead phytocompounds can be used in their purest as repellent supplement or as a natural anti-mosquito agent in product formulations.

16.
All Life ; 14(1):147-158, 2021.
Article in English | Web of Science | ID: covidwho-1396587

ABSTRACT

Respiratory infection is one of the leading causes of death in the world. The outbreaks of influenza and the Middle East respiratory syndrome have added to the miseries of human beings. Interventions such as the use of masks, social distancing, hand washing, and the use of personal protective equipment by health care professionals have minimized the transmission of pathogens from infected to healthy individuals. Another intervention is gargling which is most commonly performed by the Japanese to avoid respiratory infections. PubMed was used to search articles on gargling in respiratory infections published in the last three decades. Gargling is effective in upper respiratory infections (URTIs). URTI precedes lower respiratory tract infection;early intervention could prevent complications. The gargling agents in this review are classified as synthetic and natural gargling agents. The mouthwashes or gargling agents reviewed in this article have proven efficacy in reducing either bacterial or viral (or both) respiratory infections. The mouthwashes available over the counter may also have side effects. The use of mouthwash should be based on the potential benefit of oral and systemic conditions.

17.
J Biomol Struct Dyn ; : 1-19, 2022 Aug 09.
Article in English | MEDLINE | ID: covidwho-1978100

ABSTRACT

Coronavirus disease (COVID-19) has the virus that causes the SARS-CoV-2 severe acute respiratory syndrome, which has reached a pandemic proportion, with thousands of deaths worldwide already registered. It has no standardized effective clinical treatment, arousing the urgent need for the discovery of bioactive compounds for the treatment of symptoms of COVID-19. In this context, the present study aimed to evaluate the influence of seasonality on the yield and chemical composition of the essential oils of Piper cernuum and Piper rivinoides as well as to evaluate the anti-SARS-CoV-2 potential of the major components of each oil by molecular docking and quantum chemical calculation (Density Functional Theory method), being possible indicate that the winter and autumn periods, the seasons of the year where it is possible to obtain the highest percentage of Piper cernuum and Piper rivinoides oils, respectively. Regarding the anti-SARS-Cov-2 potential, the present work showed that the dihydroagarofuran present in Piper cernuum, presented a strong interaction with amino acid residues from Mpro, presenting a potential similar to Remdesivir, a drug for clinical use. Regarding methyltransferase, dihydroagarofuran (Piper cernuum) and myristicin (Piper rivinoids) showed better affinity, with important interactions at the active site of the inhibitor Sinefugin, suggesting a potential inhibitory effect of the heterodimer methyltransferase complex NSP16-NSP10 SARS Cov-2. Molecular docking and molecular dynamics studies represent an initial step, being indicative for future in vitro studies of dihydroagarofuran and myristicin, as possible pharmacological tools for COVID-19.

18.
Journal of Cosmetic Science ; 73(2):96-113, 2022.
Article in English | Web of Science | ID: covidwho-1976021

ABSTRACT

The global beauty industry has been shocked by the COVID-19 pandemic. Currently, with increased hygiene habits, the choice of preservatives can be impacted by consumers opting for safe products. Products without preservation system could quickly become contaminated with mold, fungi, and bacteria, resulting in spoilage and increased risk of infection. This review explores the possible impacts of COVID-19 in the preservation of cosmetics from the perspective of effectiveness and safety. The preservatives included benzalkonium chloride, propylparaben, butylparaben, phenoxyethanol, sorbic acid, potassium sorbate, as well as the multifunctional/booster agents ethylhexylglycerin, caprylyl glycol, and natural antimicrobials. First, we highlight the current scenario of cosmetic preservation, the mode of action, and the maximum concentration allowed for preservatives;then examines overexposure to preservatives. Unexpectedly, the COVID-19 pandemic paralyzed the world market, and cosmetic industries had to adapt to a new reality. Due to the widespread use of cosmetic products, the prevalence of allergies, microbiological resistance, the need for proper prevention of product contamination, and concerns over the safety of preservatives, further investigations into the modes of action of traditional or alternative preservatives are needed to create successful safety products.

19.
J Drug Deliv Sci Technol ; 74: 103430, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1945537

ABSTRACT

The current COVID-19 epidemic is a sobering reminder that human susceptibility to infectious diseases remains even in our modern civilization. After all, infectious diseases are still the major reason of death globally. Healthcare authorities have often underestimated and ignored the threat posed by "microbial dangers," although they put millions of lives at risk every year. Overlooked developing diseases including fungal infections (FIs) contribute to roughly 1.7 million fatalities per year. As many as 150 million cases of severe and potentially life-threatening FIs are reported each year. In the last few years, the number of instances has steadily increased. Most of them are invasive fungal infections that require specialized treatment and hospital care. In recent years herbal antifungal compounds have been explored to acquire effective and safe therapy against fungal infections. However, potential therapeutic effects are hampered by the poor solubility, stability, and bioavailability of these important chemicals as well as the gastric degradation that occurs in the gastrointestinal tract. To get around this issue, researchers have turned to novel drug delivery systems such as nanoemulsions, ethosomes, metallic nanoparticles, liposomes, lipid nanoparticles, transferosomes, etc by improving their limits, nanocarriers can enhance the medicinal effects of herbal oils and extracts. The present review article focuses on the available antifungal agents and their characteristics, mechanism of antifungal drugs resistance, herbal oils and extract as antifungal agents, challenges in the delivery of herbal drugs, and application of nano-drug delivery systems for effective delivery of antifungal herbal compounds.

20.
Food Science and Human Wellness ; 11(5):1134-1142, 2022.
Article in English | Web of Science | ID: covidwho-1926460

ABSTRACT

Coronavirus pandemic infection is the most important health issue worldwide. Coronavirus disease 2019 is a contagious disease characterized by severe acute respiratory syndrome coronavirus 2. To date, excluding the possibility of vaccination, against SARS-CoV-2 infection it is possible to act only with supportive care and non-virus-specific treatments in order to improve the patient's symptoms. Pharmaceutical industry is investigating effects of medicinal plants, phytochemical extracts and aromatic herbs to find out natural substances which may act as antiviral drugs. Several studies have revealed how these substances may interfere with the viral life cycle, viral entry, replication, assembly or discharge, as well as virus-specific host targets or stimulating the host immune system, reducing oxidative stress and inflammatory response. A natural compound can be used as a prophylaxis by people professionally exposed to the risk of contagion and/or positive patients not in intensive care. The aim of this paper is to perform a narrative review of current literature in order to summarize the most studied natural compounds and their modes of action. (c) 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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