Effect of facemasks on the tear film during the COVID-19 pandemic.

PURPOSE: To evaluate the effect of wearing facemasks on dry eye symptoms and on the tear film while comparing surgical face masks to N95 particulate respirators. METHODS: A prospective observational study was conducted at Ain Shams University Hospitals in the period from September 2020 to January 2021. Two hundred volunteers were recruited, and the daily number of hours spent by each participant wearing a facemask was recorded. Recruits were divided into two groups: 100 volunteers were allocated to Group A to use the surgical mask, and 100 participants to Group B to use the N95 particulate respirator. The tear film parameters were assessed at baseline by answering the Ocular Surface Disease Index (OSDI) questionnaire and performing tear break-up time (TBUT), corneal fluorescein staining, and Schirmer-I test Subjects then wore a facemask for 60 min and then the tear film parameters were reassessed by repeating TBUT, corneal staining and Schirmer-I test. RESULTS: Facemask use for 60 min significantly worsened all tear film parameters in both groups (P-value <0.0001). The deterioration was significantly larger in Group A subjects (P < 0.0001). The daily number of hours spent wearing a facemask correlated strongly with the OSDI and corneal staining. There was a strong negative correlation between the daily number of hours spent wearing a facemask and Schirmer test, and a weak negative correlation with TBUT. CONCLUSIONS: Wearing facemasks during the COVID-19 pandemic is a risk factor for worsening tear film parameters. This deterioration is significantly greater with surgical masks than with N95 particulate respirators and increases with the duration of facemask use.

Oculomotor, vestibular, reaction time, and cognitive tests as objective measures of neural deficits in patients post COVID-19 infection.

Objective: An alarming proportion (>30%) of patients affected by SARS-CoV-2 (COVID-19) continue to experience neurological symptoms, including headache, dizziness, smell and/or taste abnormalities, and impaired consciousness (brain fog), after recovery from the acute infection. These symptoms are self-reported and vary from patient to patient, making it difficult to accurately diagnose and initiate a proper treatment course. Objective measures to identify and quantify neural deficits underlying the symptom profiles are lacking. This study tested the hypothesis that oculomotor, vestibular, reaction time, and cognitive (OVRT-C) testing using eye-tracking can objectively identify and measure functional neural deficits post COVID-19 infection. Methods: Subjects diagnosed with COVID-19 (n = 77) were tested post-infection with a battery of 20 OVRT-C tests delivered on a portable eye-tracking device (Neurolign Dx100). Data from 14 tests were compared to previously collected normative data from subjects with similar demographics. Post-COVID subjects were also administered the Neurobehavioral Symptom Inventory (NSI) for symptom evaluation. Results: A significant percentage of post COVID-19 patients (up to 86%) scored outside the norms in 12 out of 14 tests, with smooth pursuit and optokinetic responses being most severely affected. A multivariate model constructed using stepwise logistic regression identified 6 metrics as significant indicators of post-COVID patients. The area under the receiver operating characteristic curve (AUC) was 0.89, the estimated specificity was 98% (with cutoff value of 0.5) and the sensitivity was 88%. There were moderate but significant correlations between NSI domain key variables and OVRT-C tests. Conclusions: This study demonstrates the feasibility of OVRT-C testing to provide objective measures of neural deficits in people recovering from COVID-19 infection. Such testing may serve as an efficient tool for identifying hidden neurological deficits post COVID-19, screening patients at risk of developing long COVID, and may help guide rehabilitation and treatment strategies.

A review of infection prevention and control guidelines for dental offices during the COVID-19 pandemic in mid-2020

Background: The COVID-19 pandemic was a challenge for all dental professionals who had to rapidly update infection prevention and control (IPAC) guidelines and protocols due to increased risk of SARS-CoV-2 transmission during common aerosol-generating procedures (AGPs), and a lack of consensus on how best to mitigate the risk of transmission in a dental office. Thus, the purpose of this descriptive study was to compare the variance in IPAC guidelines for dental offices that emerged, and to assess practice consistency from early to mid-2020. Methods: A comprehensive literature search was conducted from May 26 to July 8, 2020 for IPAC documentation specific to the dental office during the COVID-19 pandemic. Documents that met the inclusion criteria were independently reviewed. Data was extracted using a framework based on the following IPAC domains: pre-appointment, waiting room, personal protective equipment (PPE) selection, treatment room, and post-dismissal. Results: A total of 67 IPAC documents specific to dental offices were reviewed in this study. Included documents originated from 22 dental associations, 17 peer-reviewed articles, 13 dental regulators, 11 government bodies, two public health units, and two dental corporations. There was a great degree of variance with IPAC guidelines from the pre-appointment stage, during treatment, and post-treatment. Recommendations that emerged with some level of consistency involved pre-screening patients for COVID-19 symptoms (97%), staggering appointments (84%), social distancing, minimizing occupants in the waiting room, wearing a face shield over protective eyewear for AGPs (92%), and preprocedural rinses (84%). There was less consistency with recommendations for consolidating multiple appointments (36%), waiting room ventilation (46%), N95 masks (47%) versus FFP2/FFP3 masks (30%) use for AGPs, fit-testing respirators (37%), enclosing open operatories for AGPs (28%), prioritizing minimally invasive procedures (30%), and using third-party laundry companies (32%). Conclusions: The risk of SARS-CoV-2 transmission, lack of consensus on mode of spread, and need for rapid action resulted in a significant variation in most downstream IPAC interventions in the hierarchy of controls, including choice of PPE, treatment room, and post-dismissal domains. Upstream interventions, including pre-appointment and waiting room domains, were relatively consistent in practices in early to mid-2020.

Some observations on remote delivery of eye-movement desensitisation and reprocessing to people with intellectual disabilities

It is increasingly recognised that many people with intellectual disabilities suffer from post-traumatic stress disorder (PTSD). Eye-movement desensitisation and reprocessing (EMDR) has been proposed as a potentially helpful intervention that is less reliant on verbal skills than other effective treatments for PTSD and therefore could be more effective than verbal interventions for people with intellectual disabilities. The Trauma-AID project is a randomised clinical trial (RCT) evaluating the effectiveness of a bespoke EMDR protocol for adults with intellectual disability and PTSD, which incorporates a prolonged phase of Psycho-Education and Stabilisation (PES) prior to the trauma confrontation phase of EMDR. The COVID-19 pandemic struck during the feasibility phase of the Trauma-AID project, necessitating a second feasibility study to evaluate the acceptability and feasibility of remote or hybrid delivery of the PES + EMDR protocol. To this end, we conducted two online surveys of therapists followed by interviews with clients, carers and senior therapists. The surveys were analysed descriptively. Content analysis was used for client and carer interviews, and framework analysis for therapist interviews. All stakeholders reported positive experiences of EMDR;however, some challenges were identified. The majority of clients, carers and therapists interviewed reported that the intervention, whether PES alone or the full PES-EMDR package, had improved symptoms of PTSD and psychological well-being, and carers also reported decreases in challenging behaviour. A full account of the data is provided in four Supplementary Digital files. PES-EMDR therapy appears both feasible and acceptable for clients with intellectual disabilities and therapists, whether delivered face-to-face or in a remote or hybrid mode, though remote working appears easier for the PES phase than the EMDR phase of the intervention. © 2023 The Authors. Journal of Policy and Practice in Intellectual Disabilities published by International Association for the Scientific Study of Intellectual and Developmental Disabilities and Wiley Periodicals LLC.

Eye Strain Detection During Online Learning

The recent outbreak of the coronavirus disease of 2019 (Covid-19) has been causing many disruptions among the education systems worldwide, most of them due to the abrupt transition to online learning. The sudden upsurge in digital electronic devices usage, namely personal computers, laptops, tablets and smart-phones is unprecedented, which leads to a new wave of both mental and physical health problems among students, for example eye-related illnesses. The overexpo-sure to electronic devices, extended screen time usage and lack of outdoor sun-light have put a consequential strain on the student's ophthalmic health because of their young age and a relative lack of responsibility on their own health. Failure to take appropriate external measures to mitigate the negative effects of this process could lead to common ophthalmic illnesses such as myopia or more serious conditions. To remedy this situation, we propose a software solution that is able to track and capture images of its users' eyes to detect symptoms of eye illnesses while simultaneously giving them warnings and even offering treatments. To meet the requirements of a small and light model that is operable on low-end devices without information loss, we optimized the original MobileNetV2 model with depth-wise separable convolutions by altering the parameters in the last layers with an aim to minimize the resizing of the input image and obtained a new model which we call EyeNet. Combined with applying the knowledge distillation technique and ResNet-18 as a teacher model to train the student model, we have suc-cessfully increased the accuracy of the EyeNet model up to 87.16% and support the development of a model compatible with embedded systems with limited computing power, accessible to all students. © The Authors.

Keratoconus management: Lessons learned from an unusual time: Timely access to effective diagnosis and cross-linking are key to positive outcomes

The article discusses how the coronavirus disease 2019 (COVID-19) pandemic affected keratoconus (KC) diagnosis and management. Topics explored include the delay in the delivery of ophthalmic care during the early days of the pandemic due to service suspensions, the visual acuity lost by patients due to the delayed KC diagnosis and treatment, and the necessity of in-person evaluation of patients for KC to ensure accuracy of diagnosis.

Visual Servo Algorithm of Robot Arm Simulation for Dynamic Tracking and Grasping Application

Health pandemics such as Covid-19 have drastically shifted the world economics and boosted the development of automation technologies in the industries for continuous operation without human intervention. This paper elaborates on an approach to dynamically track and grasp moving objects using a robot arm. The robot arm has an eye-in-hand (EIH) configuration, where a camera is installed on the robot arm's end effector. The working principle of the robot arm in this paper is mainly dependent on the recognition of augmented reality markers, i.e., Aruco markers, placed on the dynamically moving target object with continuous tracking. Then, the proposed system updates the predicted location for the markers using the Kalman filter for performing grasping. The proposed approach identifies the Aruco marker on the target object and estimates the object's location using previous states, and performs grasping at the exact predicted location. When extracted information is updated, the vision system also implements a feedback control system for stability and reliability. The proposed approach is tested using simulation of the dynamic moving object with different speeds and directions. The robot arm with the Kalman filter can track and grasp the dynamic object at a speed of 0.2m/s with a 100% success rate while obtaining an 80% success rate at a speed of 0.3m/s. In conclusion, the moving object's speed is directly proportional to the grasping time until it reaches the threshold speed for the camera in identifying the Aruco markers. Future works are required to improve the dynamic visual servo algorithm with motion planning when obstacles are present in the path of robot grasping.

COVID-19 Pandemic is an Eye-Opener for Academicians to Use the Technology in the Teaching–Learning Process

Few things exist in life from the beginning but you don't realize until they become a habit. Education is also one of those things which cannot be exempted from this. The lockdown forced most of the academicians to take some determining decisions and new interests to revamp the teaching–learning process. The objective of this study is to analyze the impact of technology in teaching–learning process before and after a pandemic. This analysis is done by statistical tests using paired t-test and z-test by collecting data from students and teachers. Results show that this pandemic is an eye-opener for academicians to use the technology in teaching–learning process. © The Author(s) 2022.

Ocular manifestations of COVID-19

The Sars-Cov- 2 virus, the etiological agent of Covid-19, causes systemic and ocular manifestations in humans. Due to the global repercussion that the pandemic has had, the multisystemic damage it causes and the presence of ocular manifestations, which could be the presentation of the disease, it is decided to carry out the present work to offer a theoretical reference about the ocular manifestations of Covid- 19 and some therapeutic guidelines to consider. A bibliographic search was carried out in the Pubmed, Infomed, SciELO and academic Google databases, of articles in Spanish and English, which included new information related to the disease and its impact on eye health. Inflammatory and infectious processes of the visual apparatus, such as conjunctivitis and uveitis, are found with remarkable frequency. In the recovery stage, ocular findings associated with systemic immunosuppression, vasculitic and thromboembolic processes are presented. The indicated therapy does not usually differ from the conventional ones. First-line doctors play an essential role in the timely diagnosis of cases, since ocular manifestations can be the first sign of systemic disease.

COVID-19 and Eye Banking: Ongoing Impacts of the Pandemic

Purpose:The purpose of this study was to assess the impact of ongoing waves of the COVID-19 pandemic and resulting guidelines on the corneal donor pool with resumption of clinical operations.Methods:A retrospective analysis of donors deemed eligible for corneal transplantation at an eye bank from July 1, 2020, through December 31, 2021. Donors ineligible due to meeting Eye Bank Association of America (EBAA) COVID-19 guidelines or a positive postmortem COVID-19 testing were examined. The correlation between COVID-19 rule outs and state COVID positivity was calculated. The number of scheduled surgeries, suitable corneas, imports, and international exports was compared with a pre-COVID period. Postmortem testing was reduced for the final 5 months of the study, and numbers were compared before and after the policy change.Results:2.85% of referrals to the eye bank were ruled out because of EBAA guidelines. 3.2% of postmortem tests were positive or indeterminate resulting in an ineligible tissue donor (0.42% of referrals). Over the 18-month period, there was a 4.30% shortage of suitable corneas compared with transplantation procedures. There was a significant correlation between postmortem testing and state COVID-19 positivity (r = 0.37, P <0.01), but not with EBAA guidelines (r = 0.19, P = 0.07). When postmortem testing was reduced, significantly more corneas were exported internationally.Conclusions:Although corneal transplant procedures were back to normal levels, there was a shortage of suitable corneal tissue. The discontinuation of postmortem testing was associated with a significant increase in international exports of corneal donor tissue. © 2023 Lippincott Williams and Wilkins. All rights reserved.

Digital Eye Strain (DES) among children attending online classes during COVID-19 pandemic in Al-Madinah region, Saudi Arabia

Background: Digital eye strain is a group of eye disorders caused by usage of digital devices. Online learning has replaced the traditional methods during the COVID-19 pandemic. Objectives: To determine the prevalence, symptoms, frequency, and associated risk factors of Digital eye strain and the pattern of digital device usage among children attending online classes during the COVID-19 pandemic. Methods: A cross-sectional study was conducted using an online questionnaire distributed among parents of children. Results: Out of 443 participants, the majority were females (51.5%). Tablets (47.6%) and smart phones (40.6%) were the most commonly used for online classes. The commonest Digital eye strain symptoms were headache (27.5%), excessive blinking (25.6%), redness (25.3%) and itching (24.8%). Severe eye strain was reported among (14%) of children. Children's preference for smart phones and tablets and an increase in hours spent on digital devices were some of the risk factors of Digital eye strain in our study. Conclusions: A high prevalence of Digital eye strain has been reported among children who attended online classes during the COVID-19 pandemic.

Reactivation of Graves' Disease and Thyroid Eye Disease following COVID-19 Vaccination - A Case Report.

A 51-year-old male had a history of well-controlled Graves' disease (GD) under regular follow-up, and thyroid eye disease (TED) with post bilateral orbital decompression. However, after COVID-19 vaccination, recrudescence of GD and moderate-to-severe TED were diagnosed by increased thyroxine levels and decreased thyrotropin levels in serum, and positive results of thyrotropin receptor antibody and thyroid peroxidase antibody. Weekly intravenous methylprednisolone was prescribed. Symptoms gradually improved accompanied with reduction in proptosis: 1.5 mm of the OD and 2.5 mm of the OS. Possible pathophysiological mechanisms discussed included molecular mimicry theory, autoimmune/inflammatory syndrome induced by adjuvants, and certain genetic predisposition of human leukocyte antigen. Physicians should remind patients to seek treatment if the symptoms and signs of TED recur following COVID-19 vaccination.

A multimodal facial cues based engagement detection system in e-learning context using deep learning approach.

Due to the COVID-19 crisis, the education sector has been shifted to a virtual environment. Monitoring the engagement level and providing regular feedback during e-classes is one of the major concerns, as this facility lacks in the e-learning environment due to no physical observation of the teacher. According to present study, an engagement detection system to ensure that the students get immediate feedback during e-Learning. Our proposed engagement system analyses the student's behaviour throughout the e-Learning session. The proposed novel approach evaluates three modalities based on the student's behaviour, such as facial expression, eye blink count, and head movement, from the live video streams to predict student engagement in e-learning. The proposed system is implemented based on deep-learning approaches such as VGG-19 and ResNet-50 for facial emotion recognition and the facial landmark approach for eye-blinking and head movement detection. The results from different modalities (for which the algorithms are proposed) are combined to determine the EI (engagement index). Based on EI value, an engaged or disengaged state is predicted. The present study suggests that the proposed facial cues-based multimodal system accurately determines student engagement in real time. The experimental research achieved an accuracy of 92.58% and showed that the proposed engagement detection approach significantly outperforms the existing approaches.

Update on Corneal Confocal Microscopy Imaging.

In vivo corneal confocal microscopy (IVCM) is a non-invasive ophthalmic imaging technique that provides images of the cornea at the cellular level. Despite the uses in ocular surface pathologies, in the last decades IVCM has been used to provide more knowledge in refractive surgery wound healing, in neuropathies diagnosis, etc. The observation of the corneal cells, both normal and inflammatory, and the possibility of quantification of the corneal nerve density with manual or automated tools, makes IVCM have a significant potential to improve the diagnosis and prognosis in several systemic and corneal conditions.

COVID-19 pandemic impact on ocular trauma in a tertiary hospital.

AIM: To analyze the impact of the coronavirus disease-2019 (COVID-19) pandemic on the presentation and characteristics of patients hospitalized for ocular trauma in a tertiary hospital in China between 2019 and 2020. METHODS: A retrospective case study was designed to collect information on all cases of ocular trauma in a tertiary hospital from 2019 to 2020 and compare differences in inpatients' data (age, sex, admission vision acuity, type of diagnosis, hospital stays, mechanism of injury and location of injury). RESULTS: The total number of patients admitted to the Ophthalmology Department was 883 (mean 73.58±11.25 patients per month) in 2019 and 714 (59.50±17.92 patients per month) in 2020. The injury number of in work was also the most within the four types of location in this two year (42.36% in 2019, 43.84% in 2020). The mean hospital stays were 12.66d in 2019 and 10.81d in 2020. The highest incidence of ocular trauma was the middle-aged (41-65y) groups in 2019 and 2020. The most common cause of ocular trauma was sharp object in 2019 (47.34%) and 2020 (47.58%). The mechanical ocular trauma reaches 98.98% in 2019 and 99.72% in 2020. CONCLUSION: The number of patients with ocular trauma decreased in 2020, but middle-aged (41-65y) are still high incident groups. Mechanical ocular trauma remains the leading cause of hospitalization for ocular trauma patients and the proportion of patients injured at home increases. It is necessary to arouse social attention and the public's awareness of eye trauma protection should be strengthened during the pandemic.

Apple in My Eyes (AIME): Liveness Detection for Mobile Security Using Corneal Specular Reflections

The demand for contactless biometric authentication has significantly increased during the COVID-19 pandemic and beyond to prevent the spread of Coronavirus. The global pandemic unexpectedly affords a greater opportunity for contactless authentication, but iris and facial recognition biometrics have many usability, security, and privacy challenges, including mask-wearing and presentation attacks (PAs). Mainly, liveness detection against spoofing is notably a challenging task as various biometric authentication methods cannot efficiently assess the real user's physical presence in unsupervised environments. Although several face anti-spoofing methods have been proposed using add-on sensors, dynamic facial texture features, and 3-D mapping, most of them require expensive sensors and substantial computational resources, or fail to detect sophisticated 3-D face spoofing. This article presents a software-based facial liveness detection method named Apple in My Eyes (AIME). AIME is intended to detect the liveness against spoofing for mobile device security using challenge-response testing. AIME generates various screen patterns as authentication challenges, then passively detects corneal-specular reflection responses from human eyes using a frontal camera and analyzes the detected reflections using lightweight machine learning techniques. AIME system components include challenge and pattern detection, feature extraction and classification, and data augmentation and training. We have implemented AIME as a cross-platform application compatible with Android, iOS, and the Web. Our comprehensive experimental results reveal that AIME detects liveness with high accuracy at around 200-ms against different types of sophisticated PAs. AIME can also efficiently detect liveness in multiple contactless biometric authentications without any costly extra sensors nor involving users' active responses.

Branch Retinal Vein Occlusions as a Serious Complication of Covid 19 Infection

BACKGROUND: Branch retinal vein occlusion (BRVO) has an incidence of 0.5-1.2%. COVID-19 is associated with both venous and arterial thromboembolisms due to excessive inflammation, hypoxia, immobilization, and diffuse intravascular coagulation. AIM: The present study aims to describe our experience with BRVO in Egyptian COVID-19 patients. PATIENTS AND METHODS: The present retrospective study included 17 polymerase chain reaction (PCR)-proven COVID-19 patients with BRVO. Data obtained from the studied patients included detailed history taking. In addition, patients were diagnosed with BRVO based on a comprehensive ophthalmic evaluation, including logMAR Best-corrected visual acuity assessment, slit-lamp bio-microscopy, fundoscopy, fundus fluorescein angiography, and optical coherence tomography macular assessment. RESULT(S): The present study included 17 PCR-proven COVID-19 patients with BRVO. They comprised 9 males (52.9%) and 8 females (47.1%) with an age of 52.8 +/- 13.3 years. Fundus examination revealed BRVO as superior temporal in 9 patients (52.9%), inferior temporal in 5 patients (29.4%), superior nasal in 2 patients (11.8%), and inferior nasal in 1 patient (5.9%). The reported retinal thickness was 355.7 +/- 41.7 microm. In addition, fundus fluorescein angiography identified ischemic changes in 2 patients (11.8%). CONCLUSION(S): BRVO is a rare severe complication of COVID-19 infection. In patients with proven or suspected infection with a diminution of vision, there should be high suspicion of BRVO and prompt full-scale ophthalmological examination to exclude the condition. Copyright © 2022 Sanaa Ahmed Mohamed, Marwa Byomy, Eman El Sayed Mohamed El Sayed, Mostafa Osman Hussein, Marwa M. Abdulrehim, Ahmed Gomaa Elmahdy.

Patterns of sclero‐uveitis in a referral center in Tunisia, North Africa

Purpose: To describe the demographics and clinical characteristics of anterior scleritis associated with uveitis in a referral center in Tunisia.Methods: The charts of twenty patients (20 eyes) diagnosed with sclero‐uveitis at Fattouma Bourguiba University Hospital, Monastir, Tunisia, presented between January 2015 and April 2022, were retrospectively reviewed. Detailed ophthalmic examination and fundus photography were performed in all patients. Mean follow‐up period was 28.4 months. Patients with keratitis or posterior scleritis were excluded.Results: There were eight women and 12 males patients with a mean age of 34.8 years. All patients presented with ocular pain. Mean initial best‐corrected visual acuity (BCVA) was 20/80 (range, 20/2000–20/25).There was an associated anterior uveitis in 80% of cases and panuveitis in 20%. Clinical findings at presentation included nodular scleritis in five eyes (25%) and scleromalacia perforans in four eyes (20%). Idiopathic sclero‐uveitis accounted for almost 55%. Identified causes of sclerouveitis included rheumatoid arthritis in four eyes (20%), tuberculosis in three eyes (15%), granulomatosis with polyangiitis in two eyes (10%), sarcoidosis in one eye (5%) and then one case after mRNA 1273 vaccine (5%). Ocular complications included pupillary seclusion in 25% of cases and vision loss in 10% of patients. Mean final BCVA was 20/100 (range, 20/4000–20/32). Treatment modalities of non‐infectious scleritis included indomethacine in 14 patients (82.3%), systemic corticosteroid in seven patients (41.1%) and immunosuppressant or biological agent in five patients (29.4%).Conclusions: Our results provide useful information about the patterns and etiologies of sclerouveitis. The leading causes of sclerouveitis include mainly rheumatoid arthritis and tuberculosis. An infectious cause should be always ruled out.

Rhino-Orbital Mucormycosis in a COVID-19 Patient: A Dreadful Challenge

Coronavirus disease 2019 (COVID-19) is a pandemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). COVID-19 infections may be associated with a wide range of bacterial and fungal co-infections. Recent studies are reporting invasive fungal infection associated with severe COVID-19. Herein, we report a case of COVID-19 rhino-orbital mucormycosis infection caused by Rhizopus sps in a 32 year old diabetic patient who was successfully managed with early aggressive debridement of infected tissue endoscopically with extended ethmoidectomy by modified Denker's approach along with orbital decompression and antifungal therapy with Liposomal Amphotericin B and Posaconazole. Serial diagnostic nasal endoscopy showed no evidence of progression of the infection. The patient was discharged on 21st day of hospitalization still on oral Posaconazole for a total of 3 months. Copyright © 2022, Kathmandu University. All rights reserved.

Could tear be an alternative specimen for SARS-CoV-2 detection?

Objectives: For a definitive diagnosis of COVID-19, respiratory tract samples are evaluated by polymerase chain reaction (PCR). In our study, PCR using a tear sample was used to diagnose COVID-19, and it was questioned whether it was a screening method. Unlike the general practice, Schirmer strips were used instead of a swab for tear sample collection in this study. In addition, the diagnostic values of serum procalcitonin (PCT), C-reactive protein (CRP), and Neutrophil (NEU) count in predicting COVID-19 disease from tears were also questioned. Method(s): A total of 94 patients who were positive for COVID-19 by PCR test were included in this study. Tear samples were obtained from patients with Schirmer strips, commonly used in eye examination, and studied with the PCR technique. CRP, PCT value, and NEU count were also compared between the positive and negative groups of the PCR. The obtained data were analyzed using the R Studio software, and the results were considered statistically significant for p<0.05. Result(s): Of these patients, 61 (64.9%) tear PCR was negative, and 33 (35.1%) tear PCR was positive. The mean age was 61.72 +/- 17.62 years. The patients were divided into two groups: tear PCR positive and negative. There was no significant age difference between these groups. As a result of ROC Analysis;When serum PCT, CRP, and NEU % values were examined in predicting COVID-19 disease from tears, it was seen that CRP (p=0.027) and especially PCT (p=0.003) values of patients with PCR-positive were significantly higher. Conclusion(s): PCR study on tears collected with Schirmer strips is a different and non-invasive method, but it was concluded that the proposed method could not be used as a screening test. In addition, significantly higher serum PCT values were found in patients with COVID-19 positivity in tears (p<0.05). Copyright © 2022 the author(s), published by De Gruyter.