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1.
Revista Chilena de Obstetricia y Ginecologia ; 87(4):261-265, 2022.
Article in Spanish | Scopus | ID: covidwho-2164573

ABSTRACT

Objective: The SARS-CoV-2 pandemic has forced a reorganization of face-to-face visits, for this reason they have been minimized to the point of reconsidering the completion of the third trimester visit. Our center eliminated the performance of this obstetric visit and obtained its own data to compare the perinatal results obtained with such management. Method: A retrospective cohort study was carried out in March 2020, with a cohort with a single face-to-face visit at 40th week of gestation (122 pregnant women), versus a cohort with conventional follow-up with face-to-face visit at 36th week of gestation (162 pregnant women). The following were evaluated: fetal growth restriction, gestational age at birth, neonatal weight, rate of inductions, of eutocic deliveries, and of urgent cesarean sections in labor. Results: Slight differences were found in the nulliparity rate (p < 0.04), without finding them in the rest of the maternal variables. There were no differences between the two cohorts in neonatal outcomes. Conclusions: There were no differences between the maternal-fetal results obtained in pregnant women with gestational follow-up with restriction of the third trimester visit compared to traditional follow-up, except in the diagnosis of alterations in fetal statics at the end of pregnancy. © 2022 Sociedad Chilena de Obstetricia y Ginecología. Publicado por Permanyer. Este es un artículo open access bajo la licencia CC BY-NC-ND (https://creativecommons.org/licenses/by-nc-nd/4.0/).

2.
Case Reports in Clinical Practice ; 7(2):61-64, 2022.
Article in English | EMBASE | ID: covidwho-2155946

ABSTRACT

After the Ministry of the health of Iran officially announced widespread of COVID-19 on 19 February 2020, our attention focused on novel coronavirus. In our case, a2-day- old neonate shows symptoms of sepsis. The main presentation was hypothermia and desaturation. The mother was COVID-19 positive with an active cough. The PCR of the neonate was negative. We don't claim that the neonate is affected by COVID-19, but this may be an atypical form of sepsis in neonates with positive mothers following COVID-19. A2-day- old female neonate with a gestational age of 40 weeks and a birth weight of 2370 grams was born via the cesarean route from a mother who was a 34-year-old primigravida woman without any history of disease during pregnancy. Two days before delivery, the mother had malaise and dry cough. She was diagnosed as a COVID-19 positive case based on RT-PCR after delivery. On the second day after birth, the parents brought the baby to the emergency room of the children's medical center hospital with complaints of poor feeding, poor sucking and decreased urination. Physical examination revealed the following signs;hypothermia;T=36C, diminished primitive reflexes, hypotonia, and oxygen desaturation until 85% without respiratory distress that increased to 98% with oxy hood. We admitted and treated her early-onset sepsis and discharged in excellent condition.Early-onset sepsis as defined is a clinical state that is transferred from mother. The presentations in our case maybe a new form of clinical sepsis following a mother with COVID-19. We don't claim that our case is COVID-19 positive but in neonates with affected mother's insidious symptoms should be in concern. Copyright © 2022 Tehran University of Medical Sciences.Published by Tehran University of Medical Sciences.

3.
European Psychiatry ; 65(Supplement 1):S103, 2022.
Article in English | EMBASE | ID: covidwho-2153814

ABSTRACT

Introduction: The consequences for the COVID-19 pandemic in the newborns of affected mothers remains unknown. Previous clinical experiences with other infections during pregnancy lead to considered pregnant women and their offspring especially vulnerable for SARS-COV-2. That is, the underlying physiopathological changes caused by the infection (e.g. storm of cytokines, micro-coagulation in placenta or vertical transmission) could clearly compromise fetal neurodevelopment. Objective(s): To analyze the impact of maternal SARS-COV-2 infection during pregnancy in early neurodevelopment of infants gestated during the COVID-19 pandemic period compared to those gestated immediately prior (2017-2021). Method(s): 212 pregnant women (14% infected) were followed throughout their pregnancy and postpartum, including newborn development. SARS-COV-2 infection was serologically confirmed during pregnancy. The Brazelton Neonatal Assessment Scale (NBAS) was administered at 6 weeks old by a trained neonatologist to evaluate neurological, social and behavioral aspects of newborn's functioning. Differences in NBAS scores between cases and controls were tested by ANOVAs. All the analysis were adjusted for maternal age, sociodemographic status, anxious-depressive symptomatology, infant's sex and gestational age at birth and NBAS, and for the period of gestation (previous or during COVID-19 pandemic). Result(s): NBAS social interactive dimension was significantly decreased in those infants exposed to prenatal SARS-COV-2 (F= 4.248, p=.043), particularly when the infection occurred before the week 20 of gestation. Gestation during COVID-19 pandemic did not alter NBAS subscales. Conclusion(s): SARS-COV-2 infection during pregnancy seems to be associated with lower NBAS scores on social dimension in 6 weeks old exposed newborns.

4.
Journal of Agriculture and Food Research ; 11:100468, 2023.
Article in English | ScienceDirect | ID: covidwho-2149964

ABSTRACT

Globally, food insecurity is becoming a major public health concern, and has seriously been impacted by the COVID-19 pandemic. In the last decade, Rwanda has made significant improvement in terms of overall household food security. However, the magnitude of food insecurity among pregnant women is not well known. This study investigated the magnitude and factors associated with food insecurity among pregnant women during the COVID-19 pandemic. It was a cross-sectional study conducted in 30 health facilities across the country where a total of 1159 pregnant women in their first trimester of pregnancy were recruited during antenatal care visits (ANC). A pre-tested, standardized, and structured questionnaire was used to collect information on food insecurity based on household food insecurity access scale (HFIAS). Descriptive statistics were used to describe the basic characteristics of the study respondents and the status of household food insecurity. Logistic regression analysis was performed to estimate the predictors of food insecurity at a significance level of 5%. The majority (78.1%) of recruited pregnant women were aged 20 to 35 years and 70.3% were from rural areas. Overall, 53.1% of pregnant women were food insecure during COVID-19 pandemic. Pregnant women with low education level {AOR = 4.58;95%CI = 1.88–11.15} and from low social economic households {AOR = 2.45;95%CI = 1.59–3.76} were more likely to become food insecure during COVID-19 pandemic. In addition, women from households with farming as the main source of income had 64% more risk of food insecurity compared to women from household with other sources of monthly income. To achieve the sustainable development goals (SDGs) targets related to food security, there is urgent need to transform the agricultural sector from traditional farming to modern/technology farming. This will reduce the level of food insecurity in developing countries. There is also a need to provide social safety nets to pregnant women from families in lower socio-economic categories during pandemics.

5.
Journal of Experimental and Clinical Medicine (Turkey) ; 39(3):714-718, 2022.
Article in English | EMBASE | ID: covidwho-2146827

ABSTRACT

We aimed to investigate the change in hand washing habits of pregnant women before and during the COVID-19 pandemic. This study was designed prospectively and observationally. Two questionnaire forms were administered to each participant to determine their pre-pandemic and during pandemic habits relating to handwashing. The total score of handwashing attitude before and during the pandemic was calculated by summing the answers to the 25 questions in the survey. Independent t-tests were performed for data. P-values of <0.05 were considered statistically significant. The mean age of the 392 pregnant women participating in the study was 30.29+/-5.92. The values of gravidity, BMI and gestational age were estimated as 1.89+/-1.05, 27.08+/-4.26 kg/m2, 27.08+/-4.26 weeks, respectively. The frequency of the participants washing their hands more than 10 times a day increased from 32.2% before the pandemic to 75.8% during the pandemic. While the answer to the question "Is hand washing important in the prevention of diseases causing pandemics?" was 65.1% before the pandemic, it was 93.7% during the pandemic. Although the answer to the question on "How many seconds should the hand washing time be at least?" was 20 seconds at a rate of 42.9% before the pandemic, it was 84.1% during the pandemic. The total handwashing habit score was calculated as 79.25+/-11.92 before the COVID-19 pandemic and 94.42+/-5.58 during the pandemic (p<0.05). This study demonstrated that the pregnant population was affected by the COVID-19 pandemic and experienced a great change in hand hygiene. Copyright © 2022 Ondokuz Mayis Universitesi. All rights reserved.

6.
Journal of Experimental and Clinical Medicine (Turkey) ; 39(2):577-578, 2022.
Article in English | EMBASE | ID: covidwho-2146821

ABSTRACT

The case was a 32-year-old, nulliparous pregnant woman, after in-vitro fertilization (IVF) pregnancy. Her contractions started, and the amniotic fluid membrane ruptured at 38 gestational ages. The patient developed shortness of breath and lower oxygen saturation which started suddenly at the 8th hour after the cesarean section procedure under general anesthesia. Thrombotic conditions that may appear during the postpartum period should be diagnosed early and immediate treatment should be started to resolve the actual cause. Copyright © 2022 Ondokuz Mayis Universitesi. All rights reserved.

7.
Journal of Experimental and Clinical Medicine (Turkey) ; 39(2):409-413, 2022.
Article in English | EMBASE | ID: covidwho-2146810

ABSTRACT

Coronavirus Disease-19 (COVID-19) pandemic, affected pregnant women as well as many people. Aim of this study is to compare complete blood count (CBC) parameters of pregnant women infected with COVID-19 to that of healthy pregnant women and determine their prognostic features. 142 pregnant women infected with COVID-19 and 46 healthy pregnant women, included in this retrospective case-control study. Patients infected with COVID-19 were grouped as mild, moderate and severe, according to the findings of oxygen saturation and lung involvement. Age, gestational age, gravida, hospitalization length and CBC parameters of the participants were compared, according to the groups. CBC test revealed that uninfected pregnant women had statistically lower level of white blood cell count (WBC, p=0.001), platelet count (p=0,024), neutrophil count (p=0,001), lymphocytes (p=0,005), monocytes (p=0,001) and platelecrit (p=0.007) than from infected pregnant women. Evaluation of pregnant women with COVID-19 grouped into 3 categories as mild, moderate and severe showed that age, gravida and hospitalization length were comparable between groups, WBC (p=0.012) and neutrophile (p=0.001) counts of mild group were significantly lower than moderate group and there was no significant difference between moderate and severe groups regarding WBC and neutrophile counts (respectively p=0,281, p=0.542). CBC analysis is simple, applicable, widely used and cheap laboratory method. CBC parameters seem as a candidate for predicting COVID-19 clinical course. However, larger sample sized prospective studies supporting this idea are required. Copyright © 2022 Ondokuz Mayis Universitesi. All rights reserved.

8.
Journal of SAFOG ; 14(5):602-605, 2022.
Article in English | EMBASE | ID: covidwho-2144652

ABSTRACT

Objective: To analyze the risk factors associated with mortality in COVID-positive pregnant women. Material(s) and Method(s): The study was designed as a case-control study and was conducted at COVID-designated tertiary care hospital. It included 42 deceased and 96 RT-PCR-positive surviving pregnant women who developed severe forms of disease. All the affected patients were admitted and managed according to Indian national guidelines. Risk factors - age, residence, socioeconomic status, gestation age, parity, and comorbidities were evaluated for their association with mortality. Result(s): Advanced maternal age (>28 years), rural residence, diabetes, and comorbidities were found to be associated with increased risk of mortality among the COVID-affected pregnant women, the respective adjusted odds ratio was 15.45, 12.61, 2.65, and 4.77, respectively. Conclusion(s): Pregnant women are vulnerable to COVID infection. They were at higher risk of mortality with comorbidities, advanced age, and low access to healthcare in the rural areas. Copyright © The Author(s).

9.
Journal of SAFOG ; 14(5):592-595, 2022.
Article in English | Scopus | ID: covidwho-2144649

ABSTRACT

Introduction: With the rise in COVID-19 cases round the world, we have the problem of COVID-19 positive pregnancies at hand. Various case series and reports around the world have shown a high incidence of cesarian deliveries in these patients. We have attempted to study the factors predicting an increase in cesarean section (CS) rates in COVID-19 positive pregnancies admitted to our institution. Methods: Retrospective analysis of all deliveries of COVID-19 affected pregnancies in a tertiary care center in north Kerala from 15 April 2020 to 31 October 2020. There were 253 deliveries during this period with 183 cases of cesarean and 70 vaginal deliveries. The data were entered in Microsoft Excel and analyzed with appropriate statistical software. Results: There was 71.42% cesarean section rate in women below 35 years of age compared to 100% in those above 35 years. The rate was higher among nullipara (77.77%) compared to 67.32% among multipara. There was also a positive correlation between cesarean with obesity [prepregnancy body mass index (BMI) more than 30]. There were 70.22% term cesareans compared to 89.28% in preterm. Induction of labor also seemed to increase rate of cesarean. Fetal growth restriction (88.88%) contributed more to cesarean rates unlike those without (71.06%) preterm rupture of membranes (PROM) and meconium staining of amniotic fluid (MSAF) was also seen to increase the possibility of cesarean. Cardiotocogram abnormalities (13.83%) were another important contributing factor. A total of 100% of patients with abnormal cardiotocogram (CTG) underwent cesarean section when compared to only 67.88% in those with normal CTG. In patients delivered while still positive, the incidence of cesarean section was 77.63%, while this reduced to 63.04% in those whom delivery was delayed till seronegativity achieved. A total of 75.95% cases were done in the morning. There were 19.67% cases of fetal distress which added to the cesarean numbers. Conclusions: We found increased maternal age, obesity, nulliparity, fetal growth restriction, PROM, MSAF as factors which contributed to increased cesarean section rates in COVID-19 positive pregnancies. Hence these pregnancies need careful monitoring. © The Author(s).

10.
Histopathology ; 81(Supplement 1):95, 2022.
Article in English | EMBASE | ID: covidwho-2114635

ABSTRACT

Background: The most common benign neoplasms of the placenta are non-trophoblastic tumours. They include chorioangioma, teratoma, leiomyoma and hepatocellular adenoma. Chorioangioma is the most common subtype. The incidence of chorangioma is 0.5-1.0%. Small chorangiomas are clinically insignificant. Giant chorioangioma is rare tumours, measuring more than 4 cm in diameter and seen in association with elderly primi, twin pregnancy, hypertension, diabetics, and female fetus. Giant chorioangioma is associated with complications that can affect the mother, fetus, or neonate. Aim(s): This is a retrospective study of chorangioma cases seen at Institute of Pathology, Medical faculty, Skopje during a 10-year period from 2012 to 2021. Method(s): Macroscopic findings, gestational weeks at delivery, maternal age and outcome of pregnancy were evaluated. Histological and immunochistochemical analyses of the placental chorangiomas were preformed. Results & Conclusion(s): In period of 10 years 6 causes of placental chorangioma were clinically identified and histopathologically confirmed. Four cases were giant chorangiomas measuring from 8 to 13 cm. One of the cases was identified as chorangioma of the umbilical cord. Three of the cases shows potential maternal risk factors like primary infertility, extreme obesity and post COVID status. The median gestational age of delivery was 33 + 6 weeks and 39.6 weeks, respectively. The maternal age range was between 25 to 34 years. Four of the pregnancies had favourable outcome with no complications during and after birth. One was with foetal distress and one with premature delivery. Microscopic examination of the mass showed numerous proliferative thin walled capillaries lined by flattened endothelium and separated by fibrous stroma. This was further confirmed by IHC for CD34, which showed strong reactivity of endothelial cells.

11.
International Journal of Pediatrics-Mashhad ; 10(10):16803-16810, 2022.
Article in English | Web of Science | ID: covidwho-2111336

ABSTRACT

Background: This study aimed to assess the symptoms and clinical laboratory data of pregnant women with COVID-19 in their second or third trimester of pregnancy as well as their maternal and neonatal outcomes.Methods: This retrospective observational study was conducted on 177 pregnant women with COVID-19 who were admitted to Yas hospital (affiliated with Tehran University of Medical Sciences), and Ali-ibn-Abi-Talib hospital (affiliated with Zahedan University of Medical Sciences).Results: There was significant higher complaints including fever (p-value=0.015), cough (p-value=0.028), fatigue (p-value=0.002), dyspnea (p-value=0.022), and lower hemoglobin level (p-value=0.009) in patients who were in their third trimester compared to those who were in their second trimester. 9.6% (n=17) of the patients had severe disease and needed ICU admission. There was a significant variation regarding gestational age (p-value=0.022) in pregnant women admitted to ICU compared to the other ones. During the study, delivery happened in 108 (61%) pregnant women. Fetal distress following meconium deification (p-value=0.041), need to MGSO4 (p-value=0.001), IUFD (p-value=0.006), need for blood transfusion (p-value=0.004), and neonatal death (p-value<0.001) were significantly higher in patients who needed ICU admission.Conclusion: Higher gestational weeks are the main risk factor for severe COVID-19 disease. Although vertical transmission is rare;due to the higher risk of perinatal outcomes, the delivery should be done in a center with a NICU department.

12.
Int J Gynaecol Obstet ; 2022 Oct 28.
Article in English | MEDLINE | ID: covidwho-2094198

ABSTRACT

OBJECTIVE: The current study investigated the immune response of maternal coronavirus disease 2019 (COVID-19) vaccination and vertical transmission of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) and nucleocapsid (N) proteins. STUDY DESIGN: This retrospective study included pregnant women in Bahrain Defense Force Hospital from March 2021 to September 2021 who were vaccinated with Sinopharm or Pfizer/BioNTech. Testing of anti-N and -S levels from paired samples of maternal and umbilical cord blood was performed at the time of delivery. The immune response to vaccination, association with maternal and fetal factors, and vertical transmission of antibodies were studied. RESULTS: The current study included 79 pregnant women. The median gestational age for those vaccinated with Sinopharm was 28 weeks and those vaccinated with Pfizer was 31 weeks, with 100% of the vaccinated population generating antibodies and showing vertical transmission. The anti-N and -S titers and interval frequencies varied in both vaccinations. The anti-N and -S and transfer ratio statistically correlated with maternal age, gestational age at delivery, latency period, and birth weight of the neonates differently in both vaccines. In addition, the peak level of antibodies and transfer ratios varied. CONCLUSION: Although variations are exhibited in both types of vaccination, the vaccinated pregnant population generated a significant level of anti-N and -S and showed vertical transmission.

13.
Open Access Macedonian Journal of Medical Sciences ; 10:1946-1949, 2022.
Article in English | EMBASE | ID: covidwho-2066707

ABSTRACT

Physiological changes during pregnancy and COVID-19 may affect one another. This report presents a 37-year-old female G4P10021 with gestational age 37+2 weeks infected with COVID-19 in Dr. Moewardi Hospital Surakarta, Central Java, Indonesia. The patient was diagnosed with antepartum hemorrhage due to total placenta previa with low-risk Morbidly Adherent Placenta score, a history of cesarean section, and ovarian cyst. The patient underwent conversion from spinal anesthesia to general anesthesia. Within 40 min after spinal anesthesia, the patient complained shortness of breath, which then worsened into decreased consciousness and inadequate spontaneous breathing. This may be complicated by the COVID-19 infection which has several effects on pregnancy.

14.
Obstetric Medicine ; 15(1 Supplement):33-34, 2022.
Article in English | EMBASE | ID: covidwho-2064395

ABSTRACT

Background: During the COVID-19 pandemic, the model of care for gestational diabetes mellitus (GDM)management at Bankstown-LidcombeHospital was adapted to include telehealth consultations to minimise unnecessary face to face interactions and mitigate contagion risk. Aim(s): Assessment of pregnancy outcomes before and during the COVID-19 pandemic. Method(s): We analysed prospectively collected data of singleton GDM pregnancies (International Association of the Diabetes and Pregnancy Study Groups (IADPSG)/WHO2013 criteria). The pre-COVID period defined as March 2016 to February 2020 and COVID period from March 2020 to March 2021. Baseline characteristics evaluated included age, ethnicity, pre-pregnancy body mass index (BMI), gestational age at GDM diagnosis, diagnosis of GDM <20 weeks, HbA1c and 75 g OGTT result. Outcomes assessed were need for insulin therapy, number of medical reviews, incidence of excessive weight gain (EGWG) during pregnancy (per IOM), pre-term delivery (<37 weeks) and caesarean section. Neonatal outcomes included infant gender, birthweight, small for gestational age (SGA, <10th percentile) and large gestational age (LGA, >90th percentile), shoulder dystocia, neonatal hypoglycaemia and jaundice. Independent sample t-tests and chi-square/Fisher's exact tests were used for continuous and categorical data, respectively. P < 0.05 indicated statistical significance. Result(s): A total of 1896 GDM women were included in this study, 292 (15.4%) during COVID and 1604 (84.6%) pre-COVID. During COVID, there was lower mean 1 h glucose (p < 0.0001), 2 h glucose (p < 0.001), HbA1c (p < 0.001), later diagnosis of GDM (p < 0.001) and a lower proportion diagnosed before 20 weeks (p < 0.05) compared to pre-COVID. There were no other differences in baseline characteristics. During the COVID period, there were similar rates of insulin use (48.6% vs. 43.0%), number of medical reviews (7.0 vs. 6.9 episodes), rates of EGWG (39.4% vs. 36.0%), pre-term delivery (6.2 vs. 6.1), caesarean section (37.0% vs. 34.6%), SGA (8.6% vs. 8.4%), LGA (14.4% vs. 11.4%), shoulder dystocia (1.0% vs. 0.2%), neonatal hypoglycaemia (9.2% vs. 10.2%) and neonatal jaundice (3.8% vs. 5.0%) compared to pre-COVID (all outcomes, p =NS). Conclusion(s): Increased use of teleconferencing during the initial 12 months of the COVID pandemic lead to similar pregnancy outcomes compared to the pre-COVID period. A model of care involving teleconferencing is likely to be retained as the 'new-normal' in a post-COVIDworld. Future audits will ascertain whether comparable outcomes are maintained.

15.
Archives of Disease in Childhood ; 107(Supplement 2):A184, 2022.
Article in English | EMBASE | ID: covidwho-2064027

ABSTRACT

Aims Literature describes that most neonates with SARS-CoV-2 infection are asymptomatic or present with mild symptoWe describe an ex-preterm twin infant, born at 31+5 with birthweight 1600g, who deteriorated with COVID pneumonitis at 34 weeks corrected gestational age. They were an inpatient in a level 3 neonatal centre, with an uncomplicated stay prior to becoming unwell and had never been ventilated in their early neonatal course. Methods They acquired postnatal covid on day 24 of life, and deteriorated over the next 72 hours, escalating from high flow to CPAP then BiPAP, and finally requiring intubation. They were empirically commenced on antibiotics and required sedation and muscle relaxation to manage their worsening respiratory failure. Given their acute respiratory decompensation in the context of COVID, and with negative extended virology and bacterial testing otherwise, they were managed on a presumptive diagnosis of COVID pneumonitis. CXRs were consistent with this diagnosis. Despite further escalation in their ventilation strategies, including high frequency oscillatory ventilation and inhaled nitric oxide, they continued to deteriorate with severe hypoxic respiratory failure. Inotropic support was required to maintain cardiac stability. There was extensive MDT discussion between NICU, PICU and the Infectious Diseases teaDue to the severity of their condition, Remdesivir was commenced and the parents were fully informed of the trial nature of the drug and the guarded prognosis. Hydrocortisone was also commenced. Results Due to ongoing deterioration, the patient was transferred to PICU for ongoing care and consideration of ECMO. However, the infant stabilised and the hydrocortisone that had been commenced was switched to methylprednisolone. The Remdesivir was discontinued after 2 doses due to a worsening in LFTs. The situation was further complicated by COVID isolation guidelines while keeping family centred care at the heart of our approach, working within infection control policies and managing a relatively unfamiliar pathology in the neonatal population. Conclusion The infant progressed well and was extubated onto nasal cannula oxygen on day 40 of life and repatriated to our neonatal unit on day 41 at 37+4 corrected gestational age. They had an uneventful stay in our SCBU, establishing feeding, until discharge with home oxygen at 41+1 weeks corrected gestational age.

16.
International Journal of Pharmaceutical and Clinical Research ; 14(9):899-906, 2022.
Article in English | EMBASE | ID: covidwho-2057965

ABSTRACT

Introduction: COVID-19 pandemic has severe consequences for the whole world. Each age group has been affected. Both the pediatric and geriatric populations have been worst affected by COVID-19. Even pregnant females were affected much and especially the neonates of pregnant women with COVID-19. The vulnerability increases in neonates of mothers with COVID-19. There is less literature and guidelines available which discussed the outcomes of neonates of mothers who had COVID-19 during gestation. Aims and Objectives: To find out the effect on the fetus of mothers, who were infected with COVID-19 during gestation. Method(s): This is a retrospective study which considered 120 pregnant women, comprising 60 pregnant females with COVID-19 (study group) and another 60 pregnant females without COVID-19 (control group). The baseline characteristics were obtained from the hospital in both groups and the outcomes were evaluated and analyzed. Result(s): The study found that there are significant differences between the two groups in gestational age at the time of delivery, premature delivery occurred and neonatal death (p<0.05). Conclusion(s): The study has concluded that the presence of COVID-19 in pregnant females caused placental infection affecting the fetus significantly, as evidenced by premature birth and neonatal deaths among the COVID-19 group. Copyright © 2022, Dr Yashwant Research Labs Pvt Ltd. All rights reserved.

17.
Kondisi Kematian Ibu di Kabupaten Grobogan selama Pandemi COVID-19 Tahun 2020-2021: Studi Deskriptif. ; 10(3):256-264, 2022.
Article in English | Academic Search Complete | ID: covidwho-2056722

ABSTRACT

Background: Maternal mortality is one of the health statuses that is considered global. Central Java Province has the highest maternal mortality rate in Indonesia, and one of the regencies with a high MMR (Maternal Mortality Rate) is Grobogan. Purpose: This research wants to describe maternal mortality in Grobogan in 2020-2021. In further research, we can determine the relationship between risk factors that cause maternal death and use them to develop program decisions to reduce maternal mortality in Grobogan. Methods: This study used a descriptive-quantitative study using Maternal and Infant Mortality data from the Health Office of Grobogan in 2020-2021 and analyzed averages and proportions. Results: This study showed that 103 mothers died, 69% mothers at the age of 20-35 years, 46.60% mothers had Junior High School, 8% were in the Purwodadi 2 area, 73% with gestational age >28 weeks, 52% had 2-3 parity, 87.38% of mothers never abortion, 57% of mothers died during the puerperium, and 39% caused by being infected of COVID-19. Conclusion: Maternal mortality in Grobogan Regency during the 2020-2021 COVID-19 pandemic, most of the causes of death were due to COVID-19 infection, which mainly occurred in mothers aged 20-35 years, last educated at junior high school, at gestational age >28 weeks, parity 2-3, more common in mothers who have never had a history of abortion, and is currently experiencing the puerperium. This maternal death occurred in 28 of the 30 Puskesmas in Grobogan. (English) [ FROM AUTHOR] Latar Belakang: Kematian ibu merupakan salah satu status kesehatan yang dianggap global. Provinsi Jawa Tengah memiliki angka kematian ibu tertinggi di Indonesia, dan salah satu kabupaten dengan AKI (Angka Kematian Ibu) yang tinggi adalah Kabupaten Grobogan. Tujuan: Mendeskripsikan angka kematian ibu di Grobogan tahun 2020-2021. Pada penelitian selanjutnya, dapat diketahui hubungan antara faktor-faktor risiko penyebab kematian ibu dan menggunakannya untuk mengembangkan keputusan program penurunan angka kematian ibu di Grobogan. Metode: Penelitian ini menggunakan penelitian deskriptif-kuantitatif dengan menggunakan data Kematian Ibu dan Bayi dari Dinas Kesehatan Grobogan Tahun 2020-2021 dan dianalisis rata-rata dan proporsinya. Hasil: Penelitian ini menunjukkan 103 ibu meninggal, 69% ibu pada usia 20 tahun. -35 tahun, 46,60% ibu SLTP, 8% berada di wilayah Purwodadi 2, 73% dengan usia kehamilan >28 minggu, 52% memiliki paritas 2-3, 87,38% ibu tidak pernah aborsi, 57% ibu meninggal masa nifas, dan 39% disebabkan karena terinfeksi COVID-19. Kesimpulan: Kematian ibu di Kabupaten Grobogan pada masa pandemi COVID-19 2020-2021, sebagian besar penyebab kematian karena infeksi COVID-19, yang terutama terjadi pada ibu berusia 20-35 tahun, pendidikan terakhir di SMP, di usia kehamilan >28 minggu, paritas 2-3, lebih sering terjadi pada ibu yang tidak pernah memiliki riwayat abortus, dan sedang mengalami masa nifas. Kematian ibu ini terjadi di 28 dari 30 Puskesmas di Grobogan. (Indonesian) [ FROM AUTHOR] Copyright of Jurnal Berkala Epidemiologi is the property of Universitas Airlangga and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

18.
Cureus ; 14(8): e28328, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-2056307

ABSTRACT

Aim This study aimed to evaluate the immune response and vertical transmission of anti-severe acute respiratory syndrome (SARS) antibodies in vaccinated, expectant mothers infected with coronavirus disease 2019 (COVID-19) and to study the sequelae. Study design This was a retrospective study of pregnant women conducted at Bahrain Defense Force Hospital from March 2021 to September 2021. The study population was divided into two groups: group 1 was vaccinated with Sinopharm or Pfizer/BioNTech during pregnancy and never infected with COVID-19. Group 2 was unvaccinated and had been infected with COVID-19. Immune responses such as anti-nucleocapsid (anti-N) and anti-spike (anti-S) from paired samples of maternal and umbilical cord blood were measured with Elecsys immunoassay (Roche Holding AG: Basel, Switzerland) at the time of delivery. Obstetric complications such as preterm labor, preeclampsia, and stillbirth were assessed. Analysis was performed using SPSS version 26.0 (IBM Corp: Armonk, NY) and Minitab version 18 (Minitab, LLC: State College, PA). A p-value of less than 0.05 was considered statistically significant. Results The study included 90 vaccinated and 90 COVID-19-recovered pregnant women. Matched samples were available for 80 vaccinated and 74 COVID-19-recovered women. Group 1 had significantly higher levels of anti-S for both the mother and the cord blood and a significantly higher transfer ratio of anti-S. Group 2 had higher levels of anti-N. In group 1, the paired sample titer of anti-S had a weak negative correlation with maternal age whereas, in group 2, the mother's anti-N had a weak positive correlation with age. Antibodies of COVID-19-recovered mothers and cord blood had a moderate negative correlation with gestational age, except for the mother's anti-N. In group 1, the transfer ratio of anti-N and anti-S had a statistically significant association with gestational age. Preterm delivery had a high prevalence of anti-transfer ratios of <1, and delivery at >37 weeks had a high prevalence of ≥1. In group 2, 90% of preterm deliveries had transfer ratios of anti-S <1. The latency period of the COVID-19 group had a statistically significant association with the antibody transfer ratio. An interval of less than 100 days had a high prevalence in the ratio of <1. An interval of more than 100 days had a high prevalence in the ratio of ≥1. There was no significant latency period in group 1. Group 1 had a 75% prevalence of an anti-S transfer ratio ≥1 with a birth weight of >3500 g; group 2 had no significance in birth weight. We did not find significance in the sequelae of morbidities in either group. Conclusion The production of the antibody N in the COVID-19-infected and antibody S in the vaccinated pregnant women as well as the vertical transmission of antibodies was efficacious. Significant variation was found regarding maternal age in both groups. The transfer ratio of the antibodies in the vaccinated and COVID-19-recovered women was significantly higher in terms of babies of the vaccinated and the infected population. The transfer ratios were distinct according to the latency period and birth weight of the infants.

19.
Eur J Obstet Gynecol Reprod Biol ; 274: 238-242, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-2049150

ABSTRACT

OBJECTIVE: The effect of severe maternal infectious morbidity on fetal growth during the second half of pregnancy is under debate. Preliminary evidence suggests that such association may be plausible. The objectives of this study were to determine: 1) The association between severe maternal infectious morbidity and adverse pregnancy outcome; and 2) The effect of maternal infection during pregnancy on fetal growth. STUDY DESIGN: This retrospective population - based cohort study included 4771 women who gave birth at our medical center during the study period. Parturients were allocated into two groups: 1) patients with severe maternal infection during the second half of pregnancy (n = 368); and 2) control group comprised of normal pregnant women who were matched to the study group by maternal age, gravidity and parity (n = 4403). RESULTS: The severe maternal infection group included women with pneumonia (n = 198), pyelonephritis (n = 131), and viral pneumonitis (n = 39). In comparison to the normal patients group: 1) having had pneumonia during the second half of pregnancy was associated with increased rates of fetal growth restriction, placental abruption, fetal demise (P < 0.001, for all comparisons) and preeclampsia (P = 0.041); 2) Pyelonephritis during the second half of gestation was associated with higher rates of fetal growth restriction (P < 0.001), placental abruption (P = 0.006) and labor induction (P = 0.039). As a group, women with severe maternal infection had higher rates of small for gestational age neonates compared to normal parturients (P < 0.001). Among women with infections, only those who had pyelonephritis (P = 0.032) or pneumonia (P = 0.008), had a higher rate of small for gestational age neonates than those in the control group. After adjustment to confounding factors, maternal infection (OR = 1.42, 95% CI 1.085-1.85) and previous delivery of a small for gestational age neonate (OR = 2.54, 95% CI 2.02-3.19), were independent risk factors for the delivery of a small for gestational age neonate. CONCLUSION: Severe maternal infectious morbidity during the second half of pregnancy is an independent risk factor for the delivery of a small for gestational age neonate and is associated with adverse pregnancy outcomes. Both, pneumonia and pyelonephritis, during the second half of gestation affect fetal growth and are related to higher rates of small for gestational age neonates.


Subject(s)
Abruptio Placentae , Pyelonephritis , Cohort Studies , Female , Fetal Growth Retardation/epidemiology , Gestational Age , Humans , Infant, Newborn , Infant, Small for Gestational Age , Morbidity , Placenta , Pregnancy , Pregnancy Outcome , Retrospective Studies , Risk Factors
20.
Voprosy Ginekologii, Akusherstva i Perinatologii ; 21(3):28-35, 2022.
Article in Russian | EMBASE | ID: covidwho-2033519

ABSTRACT

Objective. To assess the effectiveness of different preventive measures for novel coronavirus infection in pregnant women. Patients and Methods. This study included 125 pregnant women hospitalized with moderate to severe laboratory-confirmed SARS-CoV-2 infection between September and November 2021 (the fourth pandemic wave), and 175 pregnant women who were not infected with COVID-19 during the same period. All women in these two groups were comparable for gestational age (II–III trimesters, 24–39 weeks), age (20–40 years), social status, parity, body mass index, and had no known COVID-19 risk factors. Results. Our findings revealed that vaccination 3-5 months before pregnancy (OR = 4.12;95% CI 1.28–13.27;χ2 = 0.022), inconsistent use and/or non-timely replacement of face masks (OR = 5.71;95% CI 2.83–11.51) were associated with the increased risk of COVID-19 in the second and third trimesters of gestation. It was showed that systematic (once in the morning at 24–48-hour intervals) intranasal administration of recombinant interferon alpha-2b (IFN-α;Grippferon) as compared with a single application after exposure to COVID-19 reduced the disease incidence rate and there was no evident risk of illness (OR = 0.08;95% CI 0.05–0.14;19.2% vs 74,3%, p < 0.001). This can be explained by the fact that women were mostly infected in unpredictable conditions (e.g., 29.2% of pregnant women were infected from family members, 23.9% had unknown source of exposure). The use of umifenovir, not currently authorised for the medication-assisted prevention of COVID-19 in pregnant women, and rectal administration of IFN-α suppositories did not reduce the disease incidence rate. Rectal use of IFN-α suppositories by pregnant women off-label increased the incidence (32.0 vs 15.4%, p = 0.001) and risk of developing novel coronavirus infection (OR = 2.58;95% CI 1.48–4.50). Conclusion. There is a need to improve awareness among pregnant women about the mandatory and timely vaccination against COVID-19 during pregnancy and the importance of strict adherence to wearing face masks. Increased efforts should be made to monitor and inform pregnant women about the use of only authorised medication-assisted preventive measures of SARS-CoV-2 infection, such as intranasal administration of recombinant IFN α-2b (Grippferon). During the epidemic rise in COVID-19 cases, the systematic intranasal administration of recombinant interferon-based medication Grippferon (once in the morning at 24–48-hour intervals) is recommended for pregnant women.

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