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1.
Kuei Suan Jen Hsueh Pao/Journal of the Chinese Ceramic Society ; 50(4):1143-1159, 2022.
Article in Chinese | Scopus | ID: covidwho-1835964

ABSTRACT

Scintillators as the core materials of radiation detection play an important role in industrial nondestructive testing, medical imaging, high energy physics and safety inspection, etc.. Theexisting scintillator research faces both opportunities and challenges, especially in the context of COVID-19 pandemic period. It is of great practical significance to develop cost-effective scintillators and optimize their overall performance. The nano-glass composites (i.e., glass ceramics) have some advantages like high emission efficiency of scintillator crystals, simple preparation and low cost as an effective star scintillator. Based on the different luminescence centers, such scintillators can be broadly divided into rare-earth element ions doped or rare-earth-free luminescent nanocrystals embedded materials. This review represented recent development on the preparation of these materials, the relationship between the types of nanocrystals and their luminescence properties, and the potential applications of these materials in high-energy X-ray and gamma-ray detection. In addition, the existing problems in the research were discussed and the future development direction of nano-glass composite scintillators was also prospected. © 2022, Editorial Department of Journal of the Chinese Ceramic Society. All right reserved.

2.
Marine Pollution Bulletin ; 174(52), 2022.
Article in English | CAB Abstracts | ID: covidwho-1829162

ABSTRACT

The study aimed to understand beach litter status at some of the world-famous beaches of Goa, West India, to comprehend the impact of the Covid-19 lockdown. We characterize litter in six categories (Nylon+Rubber, Plastics, Footwear, Glass, Metal, and Thermocol) for eight sampled beaches in the north and south Goa. All beaches show increased glass and decreased plastics (significant litter) during the lockdown period compared to the unlock period that marked the high tourist inflow. Beaches were classified and graded with colour codes using litter density exhibit light blue-green colour coding during the lockdown or unlock period, suggests clean maintenance. The Miramar beach located in the heart of the capital city showed relatively more litter density (yellow code) due to the combination of local people and tourist inflow. Morjim, Palolem, Velsao were littered the least during both periods.

3.
Journal of Advances in Medical and Biomedical Research ; 30(140):223-231, 2022.
Article in English | EMBASE | ID: covidwho-1822725

ABSTRACT

Background & Objective: Hospital readmissions are common and expensive. Identifying the patients who are at high risk of readmission can decrease readmission cases. Hence, in the present study, the clinical characteristics, biomarker results, and Computed Tomography (CT) criteria of all the readmitted patients were assessed. Materials & Methods: Data of 98 readmitted patients to the Baqiyatallah Hospital in Tehran were reviewed from December 22, 2019 through June 20, 2020. We classified the readmitted patients into three groups: patients (1) without COVID-19 symptoms, (2) with suspected COVID-19, and (3) with confirmed COVID-19 infection. Results: Our data revealed that the frequency of gender was significantly different between the groups (with higher frequency in men). The duration between the two admissions was significantly low in the confirmed COVID-19 group. Ischemic heart disease, hypertension, and diabetes mellitus were more common in confirmed COVID-19 group. High levels of CRP, and ESR were detected in the confirmed COVID-19 group. During the first admission, the WBC count was significantly lower in the confirmed COVID-19 group, the RBC count and hemoglobin level were significantly higher in both first and second admissions in the confirmed COVID-19 group. Most of the patients had bilateral lung lesions and ground glass opacities (GGO) in their CT Scans in the second admission. Conclusion: Our data suggested that the older men and ischemic heart disease, hypertension, and diabetes mellitus had a high risk of hospital readmission in COVID-19. The confirmed COVID-19 group showed a shorter time to be readmitted.

4.
Egyptian Journal of Radiology and Nuclear Medicine ; 53(1), 2022.
Article in English | EMBASE | ID: covidwho-1822229

ABSTRACT

Background: The recent pandemic of COVID‐19 has thrown the world into chaos due to its high rate of transmissions. This study aimed to highlight the encountered CT findings in 910 patients with COVID-19 pneumonia in Egypt including the mean severity score and also correlation between the initial CT finding and the short-term prognosis in 320 patients. Results: All patients had confirmed COVID-19 infection. Non-contrast CT chest was performed for all cases;in addition, the correlation between each CT finding and disease severity or the short-term prognosis was reported. The mean age was higher for patients with unfavorable prognosis (P < 0.01). The patchy pattern was the most common, found in 532/910 patients (58.4%), the nodular pattern was the least common 123/910 (13.5%). The diffuse pattern was reported in 124 (13.6%). The ground glass density was the most common reported density in the study 512/910 (56.2%). The crazy pavement sign was reported more frequently in patients required hospitalization or ICU and was reported in 53 (56.9%) of patients required hospitalization and in 29 (40.2%) patients needed ICU, and it was reported in 11 (39.2%) deceased patients. Air bronchogram was reported more frequently in patients with poor prognosis than patients with good prognosis (16/100;26% Vs 12/220;5.4%). The mean CT severity score for patients with poor prognosis was 15.2. The mean CT severity score for patients with good prognosis 8.7., with statistically significant difference (P = 0.001). Conclusion: Our results confirm the important role of the initial CT findings in the prediction of clinical outcome and short-term prognosis. Some signs like subpleural lines, halo sign, reversed halo sign and nodular shape of the lesions predict mild disease and favorable prognosis. The crazy paving sign, dense vessel sign, consolidation, diffuse shape and high severity score predict more severe disease and probably warrant early hospitalization. The high severity score is most important in prediction of unfavorable prognosis. The nodular shape of the lesions is the most important predictor of good prognosis.

5.
Journal of Gastrointestinal and Liver Diseases ; 31(1):9, 2022.
Article in English | EMBASE | ID: covidwho-1818804
6.
Environmental Health and Toxicology ; 37(1), 2022.
Article in English | EMBASE | ID: covidwho-1818600

ABSTRACT

Sodium hypochlorite is widely used as the main component of cleaners and has an excellent bleaching and sterilizing effect in living and medical environments. In addition to bleaching, it is used for wastewater treatment and for sterilization in food factories, and also for disinfectants during the COVID-19 pandemic. This study analyzed reports of the health effects of sodium hypochlorite and classified them by toxicity along the exposure pathway. Most case reports described the health effects of acute high-concentration exposure, with a common case being dental exposure, mainly during treatment.

7.
Lung India ; 39(2):191-194, 2022.
Article in English | EMBASE | ID: covidwho-1818451

ABSTRACT

Pulmonary veno-occlusive disease (PVOD) is an important cause of pulmonary arterial hypertension (PAH) and is classified under idiopathic cause of PAH. Over a period of time, PVOD has been studied in detail in the western countries and various diagnostic criteria are formulated. Being a rapidly progressive disease, early diagnosis is of utmost importance which helps to initiate appropriate treatment. Recent studies suggest that PVOD has a genetic predisposition and has an autosomal recessive pattern of inheritance. Here, we discuss the case of siblings diagnosed with PVOD to have such genetic predisposition for this disease.

8.
Oral ; 1(3):190, 2021.
Article in English | ProQuest Central | ID: covidwho-1818186

ABSTRACT

Background: Nanoparticles such as multi-walled carbon nanotubes present resistance, resilience and biocompatibility with human tissues and could be incorporated into glass ionomer cement materials to improve their characteristics. Therefore, the aim of the present study was to evaluate the effect of multi-walled carbon nanotube (MWCNT) incorporation on different glass ionomer cements’ compressive (σc) and diametral tensile strengths (σt). Methods: Eighty (80) specimens were divided into four groups (N = 20/gr) according to the glass ionomer cement type (conventional and high-viscosity) and the presence or absence of multi-walled carbon nanotubes. Samples were kept in water for 24 h prior to the tests. Data were analyzed using two-way ANOVA and Tukey’s test (p = 0.05). Results: For both σc (p = 0.1739) and σt (p = 0.2183), the glass ionomer cements’ viscosity did not influence the results. The presence of MWCNTs decreased the mean compressive strength values (p = 0.0001) and increased the diametral tensile strength (p = 0.0059). For both conventional and high-viscosity glass ionomer cements, the compressive strength values were higher than the tensile strength data. Conclusions: Regardless of the cement viscosity, the multi-walled carbon nanotube incorporation reduced the compressive strength and increased the tensile strength values.

9.
Egyptian Journal of Radiology and Nuclear Medicine ; 53(1), 2022.
Article in English | EMBASE | ID: covidwho-1817311

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was declared a pandemic by the World Health Organization on 11 March 2020 has been reported in most countries around the world since its origins in Wuhan, China. As of September 2021, there have been over 229 million cases of COVID-19 reported worldwide, with over 4.7 million COVID-19–associated deaths. Body: The devastating second wave of the COVID-19 pandemic in India has seen a rise in various extrapulmonary manifestations. One of key components in the pathogenesis of COVID-19 is downregulation of ACE-2, which is expressed on many organs and counterbalances the pro-inflammatory effects of ACE/angiotensin-II axis. This leads to influx of inflammatory cells into alveoli, increased vascular permeability and activation of prothrombotic mediators. Imaging findings such as ground glass opacities, interlobular septal thickening, vascular dilatation and pulmonary thrombosis correlate well with the pathogenesis. Conclusion: We hypothesize that the systemic complications of COVID-19 are caused by either direct viral invasion or effect of cytokine storm leading to inflammation and thrombosis or a combination of both. Gaining insights into pathobiology of SARS-CoV-2 will help understanding the various multisystemic manifestations of COVID-19. To date, only a few articles have been published that comprehensively describe the pathophysiology of COVID-19 along with its various multisystemic imaging manifestations.

10.
Insights into Imaging ; 13(SUPPL 1):8, 2022.
Article in English | EMBASE | ID: covidwho-1817265

ABSTRACT

An artificial intelligence (AI) tool designed to detect COVID-19 on chest CT can be used as a screening tool with high sensitivity but with low specificity. Additional training with supplementary artifact datasets should further improve diagnostic accuracy. Purpose/objectives: To evaluate the performance of an AI tool, for Covid-19 detection and lung injury quantification, on chest CT during a real-time clinical workflow. Materials & methods: We retrospectively collected a consecutive dataset of 264 Chest CTs performed to screen for Covid-19 at hospital admission. All axial images were pseudo-anonymized and sent to the AI tool Quibim Precision platform (QUIBIM S.L) to be analyzed by the Imaging COVID-19 Analyzer. The AI tool provided a probability score for COVID-19 infection. RT-PCR was considered the gold standard for COVID-19 diagnosis. Results: When the COVID-19 probability score cut-off value is set at 0.41 there is a sensitivity of 90.48% (95%CI: 82.09% to 95.80%), specificity of 30.00% (95%CI: 23.42% to 37.26%), PPV of 13.65% (95%CI: 12.32% to 15.11%) and NPV of 96.26 (95%CI: 92.77% to 98.10%) and an AUC of 0.75. Regarding the probabilities we suggest the following ranges with 95% sensitivity to exclude the disease and 95% specificity to include the disease: < 0.38: almost certain negative;0.39 - 0.62: indeterminate;> 0.63: almost certain positive. We chose a relatively low cut-off value in order to have a high sensitivity so it could be used as a screening test. However, this reduced the specificity and diagnostic accuracy. When using the suggested probability ranges, a substantial number of cases (69%) were labeled as indeterminate. False positive cases were partly explained by mislabeling of breathing artifacts, hypoventilation in dependent lung areas or linear atelectasis as ground glass opacities. Also, some clear-cut diagnoses for the radiologists (e.g., heart failure, bacterial pneumonia, interstitial lung disease, .) were often given a high probability by the AI tool. Conclusion: The AI tool can be used as a screening tool with a sensitivity of 90% when the cut-off value is set relatively low. Due to low specificity the AI tool on its own cannot be used as a diagnostic test but has the potential to serve as an adjunct for COVID-19 detection. Training with supplementary artifact datasets should further improve the AI accuracy.

11.
Blood Purification ; 50(SUPPL 1):31, 2021.
Article in English | EMBASE | ID: covidwho-1816955

ABSTRACT

Background: Rhabdomyolysis can occur as a rare complication of SARS-CoV-2 infection;acute kidney injury (AKI) with oliguria, resulting from rhabdomyolysis, is a serious syndrome and an accurate and timely diagnosis can be essential for patient survival. Methods: A 62-year-old man with Diabetes Mellitus and Hypertension, was hospitalized six days after the onset of fever and cough, tachycardia, tachypnea, hypotension, oliguria, despite maximal diuretic therapy, SpO2 91%. A picture of bilateral ground glass pulmonary opacities was evident on chest CT scan. He tested positive to the molecular swab for SARS-CoV-2. On admission, laboratory exams showed plasma concentration of: creatinine 4,5 mg/dL (eGFR 13 ml / min / 1.73m2), BUN 190 mg/dL, phosphate 9 mg/dl, GOT 3000 mg/dl, GPT 1000 mg/dl, LDH 1940 U/L, Myoglobin> 4000 U/L, CK 8000 U/ L. After right jugular catheter placement, a CVVHD session was started with high cut-off polysulfone 40000 dalton, Qb 150 ml / min, Qreinf. 2500 ml / hour. After seven days of CVVHD session, resumption of diuresis occurred. One month after, serum creatinine levels decreased to 1.2 mg/dl. Results: The differential diagnosis of rhabdomyolysis includes autoimmune myopathies, electrolyte imbalances, medications, drugs, alcohol abuse, and viral infections. In this specific case, the pathogenetic mechanism of rhabdomyolysis is likely triggered by the cytokine storm typical of Sars CoV-2 infection and by hypoxic damage. Conclusion: Acute kidney injury associated with rhabdomyolysis and sepsis has a high mortality rate. The treatment with a membrane with a high cut-off permeability allowed the removal of myoglobin and inflammatory cytokines with a marked improvement in hemodynamic stability and a complete recovery of renal function with suspension of the purification treatment.

12.
Clinical Cancer Research ; 27(6 SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1816910

ABSTRACT

INTRODUCTION: COVID-19 has been declared as a pandemic by the World Health Organisation (WHO)in December 2019, as it spread globally and confirmed cases approach 5,000 000 patients and will exceed 365000 deaths on the 25 May 2020 across over 160 countries. Cancer patients are one of the most vulnerable groups in the current (COVID-19) pandemic. To date, the clinical characteristics of COVID-19-infected cancer patients remain widely not well understood. Patients and methods A retrospective study was conducted in Royal Wolverhampton NHS Trust for COVID-19 Cancer patients. Hospitalised cancer patients diagnosed with COVID-19 infection were identified between 30th March 2020 to 30th June 2020. Patients already have been diagnosed with cancer and had a laboratory-confirmed SARS-CoV-2 infection were enrolled. Clinical retrospective data were collected from hospital medical records, including demographic features, clinical features, laboratory findings, and chest radiograph and chest computed tomography (CT) images. Statistical analysis was done to assess the risk factors associated with severe events which required admission to an intensive care unit, the use of mechanical ventilation, or death Results Forty Cancer patients with Covid 19 infection during the period from 30th March 2020 to 30th June 2020 were enrolled. (52.6%) 22 of patients were females. Median age was 65 years .All patients were local residents of Wolverhampton. Among the cancer patients, Breast cancer was the most frequent type of cancer (n= 9;21.1%), followed by Gl cancers (n= 8;21%) and lymphoma (n = 6;15.8%).Twenty two patients (52.6%) were diagnosed with stage I-III cancer.18 patients (47.4%) were on active chemotherapy, 3 patients were on target therapy and 3 patients(7.9%) were on active immunotherapy. In addition to cancer, 31 (81.6%) patients had at least one or more coexisting chronic diseases. The most common clinical features on admission were fever (92.1%), dry cough (86.8%), and fatigue (92%);29 (76.3%) patients developed dyspnoea along with lymphopaenia (n = 32, 84.2%), high level C-reactive protein (n = 40, 100%), anaemia (n = 22, 57.9 %), and hypoproteinaemia (n = 21, 55.3%). The common chest computed tomography (CT) findings were ground-glass opacity (n = 13) and patchy consolidation (n= 4) .It is important to note that CT chest not done in 17 patients. A total of 19 patients had severe events and the mortality rate was (44.7%) .Median days of hospital admission was (12.5).It is noted that all patients with active immunotherapy had recovered despite disease progression. Conclusions: Cancer patients have deteriorating conditions and worse outcomes from the COVID-19 infection. It is recommended that cancer patients receiving antitumour therapies should have regular screening for COVID-19 infection and should avoid treatments causing immunosuppression or have dose reduction during COVID-19 Pandemic in second wave .Covid 19 has different response with patients on active immunotherapy need to be highlighted.

13.
Oxford Medical Case Reports ; 2022(3):110-111, 2022.
Article in English | EMBASE | ID: covidwho-1816226
14.
European Journal of Molecular and Clinical Medicine ; 9(3):1907-1915, 2022.
Article in English | EMBASE | ID: covidwho-1812734

ABSTRACT

Introduction:COVID-19 usually manifests clinically as pneumonia with predominant imaging findings of an atypical or organizing pneumonia. The standard technique for confirming COVID-19 is molecular testing by RT-PCR however chest imaging by CT scan can show signs of pneumonia in patients with negative RT-PCR and results can be achieved significantly faster, thus offering a potential role in supporting rapid decision making. CT scan has been shown to have more sensitivity than RT-PCR and Chest X-ray. CT Severity scoring also helps in better assessment of severity of disease. Aim:To estimate typical and atypical chest CT findings in COVID-19 RTPCR positive patients for better assessment of the role of chest CT in COVID-19 management. Materials andMethods:100 patients with confirmed COVID-19 were included in study. Findings like ground glass haze (GGO), reticulations, crazy paving appearance, consolidation, subpleural curvilinear line, bronchiectasis, subpleural transparent line, vascular enlargement, mediastinal lymphadenopathy, nodules, pleural effusion, Inverted halo sign, Halo sign and pericardial effusion were documented in them and analysis was done. Results:The typical Chest CT features present in our COVID-19 cases were GGO in 93 patients (93%), reticulations in 71 patients (71%), crazy paving appearance in 59 patients (59%), consolidation in 47 patients (47%), subpleural curvilinear line in 39 patients (39%), bronchiectasis in 37 patients (37%) and subpleural transparent line in 30 patients (30%). Most cases had bilateral (98%), peripheral (57%) and patchy involvement (86%) by GGO and lower lobe predominance (55%) by consolidation. Conclusion:GGO, reticulations, crazy paving and consolidation involving bilateral lung, in a peripheral and patchy distribution with lower lobe predilection are the typical findings on chest CT in COVID-19. Chest CT scan may act as a quick diagnostic tool with high sensitivity taking into consideration that almost all COVID-19 patients demonstrate typical features.

15.
Sage Open Medical Case Reports ; 10:4, 2022.
Article in English | Web of Science | ID: covidwho-1799154

ABSTRACT

Pneumocystis jiroveci pneumonia is a common pathology in HIV-infected but also in uninfected immunocompromised individuals. The pandemic coronavirus disease 2019 (COVID-2019) is a new type of coronavirus disease caused by SARS-COV-2, and the chest imaging is often used as complementary tool in patients' evaluation. The imaging finding is similar with many pulmonary pathologies. Chest computed tomography scan is gold standard imaging and shows a central and diffuse distribution, ground- glass pattern with septal thickening with "crazy paving pattern." We reported a case of 57-year-old man patient, followed in oncology for laryngeal cancer who presented of Pneumocystis jiroveci pneumonia during his follow-up. The diagnosis is confirmed by polymerase chain reaction with bronchoalveolar lavage fluid. Other immunochemical tests can be performed but are less specific. Both curative and preventive treatment in subjects at risk remains trimethoprim-sulfamethoxazole. Corticosteroid therapy may be associated depending on the case.

16.
Egyptian Journal of Radiology and Nuclear Medicine ; 53(1), 2022.
Article in English | EMBASE | ID: covidwho-1799083

ABSTRACT

Background: The occurrence of invasive fungal infections in COVID-19 patients is on surge in countries like India. Several reports related to rhino-nasal-sinus mucormycosis in COVID patients have been published in recent times;however, very less has been reported about invasive pulmonary fungal infections caused mainly by mucor, aspergillus or invasive candida species. We aimed to present 6 sputum culture proved cases of invasive pulmonary fungal infection (four mucormycosis and two invasive candidiasis) in COVID patients, the clues for the diagnosis of fungal invasion as well as difficulties in diagnosing it due to superimposed COVID imaging features. Case presentation: The HRCT imaging features of the all 6 patients showed signs of fungal invasion in the form of cavities formation in the pre-existing reverse halo lesions or development of new irregular margined soft tissue attenuating growth within the pre-existing or in newly formed cavities. Five out of six patients were diabetics. Cavities in cases 1, 2, 3 and 4 of mucormycosis were aggressive and relatively larger and showed relatively faster progression into cavities in comparison with cases 5 and 6 of invasive candidiasis. Conclusion: In poorly managed diabetics or with other immunosuppressed conditions, invasive fungal infection (mucormycosis, invasive aspergillosis and invasive candidiasis) should be considered in the differential diagnosis of cavitary lung lesions.

17.
Journal of Clinical and Diagnostic Research ; 16(SUPPL 2):16, 2022.
Article in English | EMBASE | ID: covidwho-1798714

ABSTRACT

Introduction: Anatomy Museum is an indispensable part of a medical college since it gives complete knowledge of the human body in its four walls. It not just displays meticulously and painstakingly prepared prosections of different body parts and organs but also includes many other teaching aids. Aim: The aim of the study is to use epoxy resin to mount specimens for anatomy museum and also to overcome the difficulty in traditional mounting methods. Materials and Methods: Epoxy resin mixture with hardener, fresh goat kidney, and liver plastic mould and Perspex/glass jar was used. Introduction: In 2019, COVID-19 originated from China and rapid spread throughout globe. Transmission of SARS-CoV-2 is high as a result;WHO and countries worldwide have imposed rigorous public health concern, such as lockdown and social distancing. This results the closure of educational institutes globally. Since the outbreak of COVID-19, paramedical institutes have sought ways to shift from traditional teaching to virtual teaching. Aim: The aim of this study was to determine the perception of 1st year paramedical students and to analyze the merits and demerits of virtual learning during the COVID-19 pandemic. Materials and Methods: A descriptive cross-sectional study was conducted at Sri Ramachandra Medical College and Research Institute, Chennai for Paramedical courses Microbiology, BSc sports science and BSc Speech therapy courses. Phase -I students participated in this study with a sample size of 400. A self-designed The fresh specimens were mounted using epoxy resin and allowed for curing. Result: The result obtained was a crystal-clear epoxy resin mounted specimen. The demonstrator as well as the students may feel comfortable and easy to handle as well as to teach and learn. Conclusion: The greatest advantage of this technique was it can be stored and maintained for a long time in the museum without forming any discolouration and dusting of the mounted specimens.

18.
Journal of Optoelectronic and Biomedical Materials ; 14(1):19-28, 2022.
Article in English | Web of Science | ID: covidwho-1798318

ABSTRACT

Silver nanoparticles have a wide range of anti-bacterial, anti-fungal, and anti-viral effects due to their unique properties. In this work, citrate reduction has been employed to fabricate silver colloidal nanoparticles with 12 nm. The plasmon resonance spectra of nanoscopic silver particles adsorbed onto transparent electrodes in contact with various electrolyte solutions and concentrations of NaClO4, KPF6, and NaCl were studied. Potentials were controlled with a galvanostat, and UV/visible spectrophotometer was employed to obtain the optical spectra. The results showed the electrolyte identity, potential-induced redshifts, and damping is most pronounced for NaCl, whereas spectral changes are weaker in the cases of NaClO4 and KPF6 solutions. Hence, due to the noble physical and biological properties of silver colloid nanoparticles, it becomes a great candidate and promising in the future to be used as an anti-coronavirus surface.

19.
Journal of Heart and Lung Transplantation ; 41(4):S295, 2022.
Article in English | EMBASE | ID: covidwho-1796810

ABSTRACT

Introduction: Acute pericarditis is frequently encountered in the immediate post-operative period following lung transplant, however when seen following recovery it is often in the context of infection. We present a case of a patient 12 years out from lung transplant who presented with findings compatible with acute pericarditis, ultimately diagnosed with acute cellular rejection (ACR). Case Report: A 60 year old man 12 years post bilateral lung transplant for smoking related COPD with CLAD, stage I, BOS phenotype and prior history of probable antibody-mediated rejection (AMR), presented to the emergency department with acute onset dyspnea (<24h), pleurisy, and a leukocytosis. CT angiogram of his chest revealed no evidence of pulmonary embolism, but new bilateral ground glass and consolidative opacities. Infectious studies, including COVID-19, were negative. Multiple EKGs demonstrated diffuse ST elevations without reciprocal changes. Serial high sensitivity troponin assays were negative, and transthoracic echocardiogram did not reveal any findings compatible with myocardial injury. Once ischemia was excluded he underwent bronchoscopy with biopsies, which demonstrated A2 ACR. Screening for donor specific antibodies indicated new C1q-binding class II HLA antibodies. He was treated for acute pericarditis with colchicine and prednisone. He also received high dose methylprednisolone for ACR, as well as IVIG and rituximab for possible AMR. His chest pain and pleurisy dramatically improved after the first dose of methylprednisolone. The initial insult was thought to be an interruption of immunosuppression coupled with cigarette use. This case represents a novel presentation of ACR with concurrent findings of acute pericarditis. Symptoms of pericarditis and rejection can overlap and this case highlights that the two entities can present simultaneously.

20.
Journal of Xi'an Jiaotong University (Medical Sciences) ; 43(2):273-277, 2022.
Article in Chinese | EMBASE | ID: covidwho-1791918

ABSTRACT

Objective: To evaluate the ability of different disinfection methods to remove nucleic acid pollution in 2019-nCoV so as to obtain the best removal scheme. Methods: 2019-nCoV positive quality control nucleic acid of 50 μL was applied to plastic, metal and glass with medical cotton swabs, respectively. After drying, we dropped 50 μL of 750 mL/L alcohol (ethanol), chlorine-containing disinfectant (2 000 mg/L and 5 500 mg/L), and PCR Cleaner, respectively. After 1 min, the contaminated area was wiped with medical cotton swabs and soaked in 300 μL of pure water. After shaking and mixing, 5 μL was taken as a template. The Ct values of ORF1ab and N genes and IC genes of internal standard fragment in the amplified target area of 2019-nCoV after wiping with different disinfection methods were compared to evaluate the effect of eliminating nucleic acid pollution, and each experiment was repeated for three times. Similarly, the effects of ultraviolet irradiation for 0, 1, 2, 3, 4, and 5 hours on the removal of nucleic acid pollution were compared. Results: After 2 000 mg/L and 5 500 mg/L chlorine-containing disinfectant wiped the contaminated area, the Ct values of ORF1ab and N genes and IC genes of internal standard fragment in the amplified target area in 2019-nCoV were all 0, and the Ct values of all genes in the contaminated area in groups 3, 4 and 5 h after UV irradiation were all 0, which completely cleared the pollution and had a strong effect. The effect of PCR Cleaner was second, and 750 mL/L ethanol was the worst. Conclusion: 2 000 mg/L and 5 500 mg/L chlorine-containing disinfectant and ultraviolet irradiation for 3 hours have the best effect of eliminating nucleic acid pollution, which is worth popularizing under appropriate conditions.

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