Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 3.066
Filter
1.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-335102

ABSTRACT

Objective: To examine the relationship between young adults’ labor force participation and depression in the context of the COVID-19 pandemic. Design, Setting, Participants: Data come from the nationally-representative EPICOV cohort study set up in France, and were collected in 2020 and 2021 (3 waves of online or telephone interviews) among 2217 participants aged 18-30 years. Participants with prior mental health disorder (n=50) were excluded from the statistical analyses. Results: Using Generalized Estimating Equation (GEE) models controlled for participants’ socio-demographic and health characteristics and weighted to be nationally-representative, we found that compared to young adults who were employed, those who were studying or unemployed were significantly more likely to experience depression assessed using the PHQ-9 (multivariate ORs respectively: OR: 1.29, 95% CI 1.05-1.60 and OR: 1.50, 1.13-1.99). Stratifying the analyses by age, we observed than unemployment was more strongly associated with depression among participants 25-30 years than among those who were 18-24 years (multivariate ORs respectively 1.78, 95% CI 1.17-2.71 and 1.41, 95% CI 0.96-2.09). Being out of the labor force was, to the contrary, more significantly associated with depression among participants 18-24 years (multivariate OR: 1.71, 95% CI 1.04-2.82, vs. 1.00, 95% CI 0.53-1.87 among participants 25-30 years). Stratifying the analyses by sex, we found no significant differences in the relationships between labor market characteristics and depression (compared to participants who were employed, multivariate ORs associated with being a student: men: 1.33, 95% CI 1.01-1.76;women: 1.19, 95% CI 0.85-1.67, multivariate ORs associated with being unemployed: men: 1.60, 95% CI 1.04-2.45;women: 1.47, 95% CI 1.01-2.15). Conclusions and relevance: Our study shows that in addition to students, young adults who are unemployed also experience elevated levels of depression in the context of the COVID-19 pandemic. These two groups should be the focus of specific attention in terms of prevention and mental health treatment. Supporting employment could also be a propitious way of reducing the burden of the Covid-19 pandemic on the mental health of young adults.

2.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-335014

ABSTRACT

Background: The Omicron variant of SARS-CoV-2 led to a steep rise in transmissions. Recently, as public tolerance for isolation abated, CDC guidance on duration of at-home isolation of COVID-19 cases was shortened to five days if no symptoms, with no lab test requirement, despite more cautious approaches advocated by other federal experts. Methods: We conducted a decision tree analysis of alternative protocols for ending COVID-19 isolation, estimating net costs (direct and productivity), secondary infections, and incremental cost-effectiveness ratios. Sensitivity analyses assessed the impact of input uncertainty. Results: Per 100 individuals, five-day isolation had 23 predicted secondary infections and a net cost of $33,000. Symptom check on day five (CDC guidance) yielded a 23% decrease in secondary infections (to 17.8), with a net cost of $45,000. Antigen testing on day six yielded 2.9 secondary infections and $63,000 in net costs. This protocol, compared to the next best protocol of antigen testing on day five of a maximum eight-day isolation, cost an additional $1,300 per secondary infection averted. Antigen or polymerase chain reaction testing on day five were dominated (more expensive and less effective) versus antigen testing on day six. Results were qualitatively robust to uncertainty in key inputs. Conclusions: A six-day isolation with antigen testing to confirm the absence of contagious virus appears the most effective and cost-effective de-isolation protocol to shorten at-home isolation of individuals with COVID-19.

3.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-334938

ABSTRACT

Objective: We aimed to examine the mental health status and related factors among Vietnamese immigrants in Japan during the coronavirus disease 2019 (COVID-19) pandemic. Design: Online cross-sectional survey administered from September 21 to October 21, 2021 Setting: Online survey of Vietnamese immigrants in Japan Participants: The inclusion criteria for participation were 1) Vietnamese citizenship or Japanese citizenship in those of Vietnamese descent, current residence in Japan, and 2) age ≥18 years. Main Outcomes: Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder 7-item (GAD-7) scores were considered the main outcome measures. Multivariable logistic regression was used to identify factors related to symptoms of depression and anxiety, and the chosen variables were entered simultaneously in the survey. Results: Among 621 participants (age: 26.0±4.8 years;male: 347 [55.9%]) who completed the questionnaire, 73.7% reported a decrease in income when compared with the period before the COVID-19 pandemic, and 60.4% reported being recently affected by poor socioeconomic status. Moderate-to-severe symptoms of depression (PHQ-9 score ≥10 points) and mild-to-severe symptoms of anxiety (GAD-7 ≥5 points) were observed in 203 (32.7%) and 285 (45.9%) individuals, respectively. Factors related to depressive symptoms were age (odds ratio [OR]=0.94, p=0.043), medical or psychiatric co-morbidity (OR=2.46, p<0.001), and low socioeconomic status (OR=2.47, p<0.001). Factors related to anxiety symptoms were being single (OR=1.72, p=0.044), medical or psychiatric co-morbidity (OR=2.52, p<0.001), low socioeconomic status (OR=2.72, p<0.001), and absence of a partner with whom to discuss one’s health (OR=1.66, p=0.013). Conclusions: The current findings demonstrate that, when compared with Japanese citizens, Vietnamese immigrants experienced a decrease in income, worsening working conditions, and poor mental health status during the COVID-19 pandemic. These findings highlight the potential contribution of low socioeconomic status and social isolation to poor mental health status.

4.
Embase; 2021.
Preprint in English | EMBASE | ID: ppcovidwho-334661

ABSTRACT

The exponential scaling of scRNA-seq data represents an important hurdle for downstream analyses. Here we develop a coarse-graining framework where highly similar cells are merged into metacells. We demonstrate that metacells not only preserve but often improve the results of downstream analyses including visualization, clustering, differential expression, cell type annotation, gene correlation, imputation, RNA velocity and data integration. By capitalizing on the redundancy inherent to scRNA-seq data, metacells significantly facilitate and accelerate the construction and interpretation of single-cell atlases, as demonstrated by the integration of 1.46 million cells from COVID-19 patients in less than two hours on a standard desktop.

5.
Embase; 2021.
Preprint in English | EMBASE | ID: ppcovidwho-334645

ABSTRACT

Many large national and transnational studies have been dedicated to the analysis of SARS-CoV-2 genome, most of which focused on missense and nonsense mutations. However, approximately 30% of the SARS-CoV-2 variants are synonymous, therefore changing the target codon without affecting the corresponding protein sequence. By performing a large-scale analysis of sequencing data generated from almost 400,000 SARSCoV-2 samples, we show that silent mutations increasing the similarity of viral codons to the human ones tend to fixate in the viral genome over-time. This indicates that SARS-CoV-2 codon usage is adapting to the human host, likely improving its effectiveness in using the human aminoacyl-tRNA set through the accumulation of deceitfully neutral silent mutations.

6.
Clinical and Experimental Rheumatology ; 39(6):S215-S222, 2022.
Article in English | EMBASE | ID: covidwho-1822803

ABSTRACT

Since the beginning of the COVID-19 disease pandemic causedby the new coronavirus SARS-CoV-2, the disease has claimed over 205M cases (205,338,159) and 4,333,094 deaths (WHO dashboard – accessed 15/08/2021). In addition to the overwhelming impact on healthcare systems treating acutely ill patients, the pandemic has had an impact on all other aspects of health care delivery, including the management of chronic diseases, the risk that is posed in patients with chronic conditions and the risk of the infection itself in those with chronic conditions. Autoimmune rheumatic diseases (ARDs), including primary Sjögren’s syndrome (pSS), characterised by immune dysregulation affecting several organs in variable severity, have been of particular interest given the accelerated phase of the immune response in the course of SARS-CoV-2 infection leading to the acute inflammatory response and respiratory distress syndrome or multi-organ failure. On the other hand, the effect of immunosuppressive drug therapies can represent a double edge sword on the course of the disease, either by increased susceptibility to and severity of the infection, or by preventing the accelerated inflammatory response induced by the infection. Additionally, the long-term impact of SARS-CoV-2 infection on the host immune system has led to the onset of novel complex clinical manifestations, comprised under the large umbrella of “long-COVID”, which we are only starting to understand. In this review we focus on two interrelated aspects: i) the impact of COVID-19 on patients with pSS and ii) the emerging evidence of long-term xerostomia after SARS-CoV-2 infection.

7.
Pakistan Journal of Medical and Health Sciences ; 16(3):560-563, 2022.
Article in English | EMBASE | ID: covidwho-1822797

ABSTRACT

Objectives: The study aimed to examine COVID-19 knowledge among the general public in Pakistan, to review their attitudes and views regarding the fast epidemic. Study Design: Descriptive cross-sectional study. Duration of Study: June-July 2020. Methodology: A total of 679 respondents included. The questionnaires comprised of the following basic themes: basic demography, general & basic clinical/medical knowledge, attitudes, awareness, perceptions as well as a sense of prevention regarding COVID-19. Results: The majority (75.5%) of the respondents were from Punjab province. Around half (54.5%) of the respondents had heard about the COVID-19 infection through different social media. The majority were 28.4% medical students. The majority of the respondents (80-95%) selected correct answers from the given choices for the questions related to some clinical knowledge. More than half of people (59-64%) think positively that COVID-19 will successfully be controlled and Pakistan will be successful in winning this battle of the pandemic. 61% were afraid of COVID-19 as it is highly contagious disease (37.7%). Around 60% always covered their noses and mouths while sneezing and coughing. Conclusion: The people must have a thorough understanding of COVID-19 to successfully execute COVID-19 prevention strategies. Although we found enough knowledge, favorable perspectives, and readiness to follow SOPs, we believe that additional preventative and cautious attitudes, as well as awareness, are needed.

8.
Infektoloski Glasnik ; 41(3):87-92, 2021.
Article in English | EMBASE | ID: covidwho-1822781

ABSTRACT

Summary Originating with unexplained symptoms from Wuhan, city of China, COVID-19 being a global pandemic causing tremendous morbidity and mortality, has proved to be the biggest challenge of the 20th century. This study aimed to explore the functional impacts of COVID-19 upon those patients who were diagnosed with this disease and were admitted in hospitals. This cross-sectional survey included 183 COVID-19 diagnosed patients from COVID-19 isolation wards of public and private hospitals of Islamabad and Rawalpindi. After getting ethical permission from Institutional Review Board of Shifa International Hospital (Ref # 070-21), this survey was conducted for the time period of 6 months from December 2020 to May 2021. Through convenient sampling, 183 patients with the age range of 25 to 55 years with no already diagnosed psychological complaints were assessed for eligibility briefed regarding the study purpose and then were asked for their voluntary participation. The Functional Status Scale for the Intensive Care Unit (FSS-ICU) was used to assess the functional status impacted due to COVID-19 during hospitalization. Frequencies and percentages were calculated through SPSS-21. On FSS-ICU, out of 183 COVID-19, 11 (6%) patients reported that they were dependent, 18 (9.8%) required maximum assistance, 32 (17.5%) required moderate assistance, 27 (14.8%) required minimal, 24 (13.1%) required supervision to complete their tasks, 28 (15.3%) required assistive devices, whereas 43 (23.5%) were totally independent. Results indicated a temporal impact of COVID-19 upon functional status of hospitalized patients in intensive care units, therefore highlighting the need of physiotherapeutic and psychotherapeutic interventions.

9.
Journal of Critical and Intensive Care ; 13(1):12-17, 2022.
Article in English | EMBASE | ID: covidwho-1822779

ABSTRACT

Objective: Coronavirus Disease-2019 (COVID-2019), which originated in Wuhan, China in December 2019 and became a global pandemic in March 2020, is a viral infectious condition. This study was planned due to the novel character of the virus, unexpected clinical course of the disease as well as due to the relative lack of data on determinants of severe disease. Methods: This retrospective study was carried out with the inclusion of 80 patients admitted to the Intensive Care Unit (ICU), Medical Faculty of Erzincan Binali Yildirim University between 1st April 2020 and 1st October 2020 due to the diagnosis of COVID-19 pneumonia. Demographic, clinical, and laboratory data, as well as treatments complications, length of ICU stay and mortality rate were compared between patients who had survive or not. Results: Of the 80 patients, 18 were died, and 62 were discharged. The mean age was 69.7 ± 14.7 years, with a female to male ratio of approximately 1:2. Systolic blood pressure and mean arterial pressure on admission were significantly lower in non-survivors (p=0.002, and p=0.026, respectively). Also, non-survivors had significantly higher levels of CRP, procalcitonin, D-dimer, urea, LDH, INR, lactate, and neutrophil count and significantly lower lymphocyte counts as compared to survivors. The predictors of mortality were determined as the need for mechanical ventilation, presence of complications, higher CRP and urea levels in a multivariate regression analysis. Conclusion: Early estimation of patients with a high likelihood of severe illness, assessment of the intensive care unit admission, and convenient treatment strategies are important. This is a precious study that detects an early need for ICU admission and close follow-up of patients.

10.
Journal of the Nepal Medical Association ; 60(248):352-355, 2022.
Article in English | EMBASE | ID: covidwho-1822737

ABSTRACT

Introduction: The COVID-19 is caused by a coronavirus. COVID-19 patients present with lymphopenia, thrombocytopenia, and elevated inflammatory markers. This study aims to find out the prevalence of COVID-19 infection among patients attending the fever clinic of a tertiary care centre. Methods: This was a descriptive cross-sectional study conducted from 15th July, 2020 to 15th January, 2021 in the Department of Pathology at a tertiary care centre. The ethical clearance was obtained from the Institutional Review Committee of a tertiary care centre (Reference number: 2007021388). The patients who attended the fever clinic during the study period were subjected to the COVID-19 reverse transcriptase polymerase chain reaction test. A total of 1431 samples were taken using the convenience sampling method. All data were filled into a predesigned proforma and entered into Microsoft Excel. The data were analyzed using Statistical Package for the Social Sciences version 24.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data and mean and standard deviation for continuous data. Results: Among 1431 patients attending the fever clinic, the prevalence of COVID-19 was found in 277 (19.31%) (17.26-21.36 at 95% Confidence Interval). Most patients belonged to the age group of 20-29 years. There were 113 (40.79%) females and 164 (59.21%) males. Conclusions: The prevalence of COVID-19 infection in this study was higher than similar studies done in similar settings. Most cases had a low hematocrit with anemia. The total count, absolute neutrophil count, and absolute leukocyte count showed a wide range of variation.

11.
Journal of Advances in Medical and Biomedical Research ; 30(140):223-231, 2022.
Article in English | EMBASE | ID: covidwho-1822725

ABSTRACT

Background & Objective: Hospital readmissions are common and expensive. Identifying the patients who are at high risk of readmission can decrease readmission cases. Hence, in the present study, the clinical characteristics, biomarker results, and Computed Tomography (CT) criteria of all the readmitted patients were assessed. Materials & Methods: Data of 98 readmitted patients to the Baqiyatallah Hospital in Tehran were reviewed from December 22, 2019 through June 20, 2020. We classified the readmitted patients into three groups: patients (1) without COVID-19 symptoms, (2) with suspected COVID-19, and (3) with confirmed COVID-19 infection. Results: Our data revealed that the frequency of gender was significantly different between the groups (with higher frequency in men). The duration between the two admissions was significantly low in the confirmed COVID-19 group. Ischemic heart disease, hypertension, and diabetes mellitus were more common in confirmed COVID-19 group. High levels of CRP, and ESR were detected in the confirmed COVID-19 group. During the first admission, the WBC count was significantly lower in the confirmed COVID-19 group, the RBC count and hemoglobin level were significantly higher in both first and second admissions in the confirmed COVID-19 group. Most of the patients had bilateral lung lesions and ground glass opacities (GGO) in their CT Scans in the second admission. Conclusion: Our data suggested that the older men and ischemic heart disease, hypertension, and diabetes mellitus had a high risk of hospital readmission in COVID-19. The confirmed COVID-19 group showed a shorter time to be readmitted.

12.
Journal of Advances in Medical and Biomedical Research ; 30(140):215-222, 2022.
Article in English | EMBASE | ID: covidwho-1822724

ABSTRACT

Background & Objective: Measurement of inflammatory markers and lactate dehydrogenase (LDH) may contribute to the evaluation of lung involvement severity. This study aimed to evaluate relationship between severity of primary lung involvement with highest level of erythrocyte sedimentation rate (ESR) and LDH in patients with COVID-19. Materials & Methods: This descriptive-analytical study was conducted on 123 patients with COVID-19 in Shahid Sadoughi Hospital. Data including age, gender, ESR (mm/h), LDH (U/L), and high-resolution Computed Tomography scan (HRCT) findings and hospitalization ward were extracted from medical records. The regression model was used to determine the relation between HRCT findings with LDH and ESR. Results: Mean LDH, ESR, and HRCT findings were 508.41±224.65, 52.23±29.56, and 37.17± 22.18 respectively. A significant relation was seen between HRCT findings with highest level of LDH and ESR (P=0.001). A significant relation was observed between the highest levels of ESR and HRCT findings, regarding age, gender, and hospitalization wards (P<0.01). There was a significant relation between the highest level of LDH and HRCT findings regarding age group and hospitalization wards (P<0.01). Conclusion: A significant relation was seen between HRCT findings and highest levels of ESR and LDH in patients with COVID-19. Therefore, it seems that assessment of laboratory findings such as LDH and ESR can be helpful as cost-effective markers instead of chest CT scan for predicting the severity of lung injury when the CT scan report is controversial. The relation between HRCT findings with LDH and ESR were affected by age and hospitalization ward. However, more studies should be conducted in this regard.

13.
Revista de la Facultad de Medicina Humana ; 22(2):401-411, 2022.
Article in English | EMBASE | ID: covidwho-1822699

ABSTRACT

Introduction: The pandemic caused by COVID-19 has affected the way of life of people, and particularly relationships. The aim of the present study was to evaluate the psychometric properties of the Quality of Relationship of Couple Scale (CRP-ASO) within the context of compulsory social isolation due to COVID-19, in Peru. Methods: The CRP-ASO scale was applied to 499 adults (60% women;Mage = 41,54 years, Sage = 13,48). The internal structure of the instrument was evaluated by exploratory factor analysis (AFE) and confirmatory factor analysis (AFC). Reliability was also estimated by calculating Cronbach’s alpha (α) and McDonald’s omega (coefficients. Results: The item-test correlations indicated that all items should be kept (iHC > 0,2). According to the EFA (KMO = 0,956;Bartlett sphericity test p < 0,01) the emergent factor structure yielded 4 factors, confirmed through the CFA (SRMR = 0,059;R-CFI = 0,921;R-TLI = 0,913;R-RMSEA = 0,077). The factors were called consensus, complicity-intimacy, satisfaction in the relationship and stability in the relationship, with high indicators of internal consistency. Conclusion: It is concluded that the instrument has satisfactory psychometric properties and can be used in similar samples.

14.
Revista de la Facultad de Medicina Humana ; 22(2):412-419, 2022.
Article in English | EMBASE | ID: covidwho-1822697

ABSTRACT

The mortality rate from COVID-19 in Peru continues to increase, considered by January 24, 2022, as the third country with the most cases and deaths in all of South America. Confinement favors an extremely sedentary lifestyle, physical inactivity, and poor eating practices causing serious health risks. Objectives: Describe the eating habits and lifestyles of medical students during the CoVID-19 quarantine. Materials and Methods: Multicenter Descriptive Cross-sectional Study. Results: A total of 886 medical students participated. The female gender prevailed with 81.49% (n = 722) compared to the male gender with 18.51% (n = 164). Regarding the perception of health, only 4.51% (n= 40) rated it as low and the remaining 95.49% rated it as satisfactory (n= 111), good (n= 495), very good (n= =200) and excellent (n=40). The predominant healthy habits were not smoking 91.08% (n= 807) and doing physical activity 78.78% (n= 698);During the pandemic, physical activity was reduced, reaching 53.95% of students. Conclusions: Medical students during the COVID-19 confinement stage, medical students opted for regular healthy eating habits and preventive behaviors. However, daily physical activity was predominantly low.

15.
Revista de la Facultad de Medicina Humana ; 22(2):338-345, 2022.
Article in English | EMBASE | ID: covidwho-1822696

ABSTRACT

Objective: The objective of this research was to determine the relationship between the level of knowledge and attitudes towards the COVID-19 vaccine in the inhabitants of the province of Trujillo in the year 2021. Materials and methods: The type of study was applied, non experimental desing, with a quantitative approach, cross-sectional, and correlational level;a questionnaire for knowledge and attitudes was administered to a total of 500 adults in the province of Trujillo. Results: The results show that 88% of the population has a good level of knowledge about the vaccine, and 91% of them have an adequate attitude to be vaccinated. Conclusions: In this way, it is concluded that there is a signicant relationship between the level of knowledge and attitudes towards the vaccine against COVID-19 (p value<0.05). The level of knowledge is a protective factor (OR: 0.43;CI: 0.2318-0.8053) for an adequate attitude to be vaccinated.

16.
Revista de la Facultad de Medicina Humana ; 22(2):446-451, 2022.
Article in English | EMBASE | ID: covidwho-1822695

ABSTRACT

Introduction: The epidemic that had its beginning in the city of Wuhan in December 2019, has become a public health problem that is advancing at dizzying steps. Objective: To determine the clinical and epidemiological profile in Covid-19 patients attended at the HASA-I - Utcubamba, 2020. Methods: The type of research was observational, descriptive and retrospective cross-sectional. The population consisted of 312 patients from which a sample of 173 patients was extracted that met the conditions of being representative and adequate. All data processing and statistical calculations were performed using Microsoft Excel 2019 software. Results: Regarding the results, it was determined that the epidemiological profile: male gender a total of 102 and female gender 71, representing 59,0% and 41,0% respectively;average age of 45 years;most affected place of origin, the city of Bagua Grande, with a frequency of 162, which represents 93,6%. Regarding the clinical profile: diabetes mellitus presented a total of 7 cases, representing 4,1%;cardiovascular diseases with a frequency of 6, representing 3,5%;general malaise with a total of 75 cases, representing 43,4%;fever with a frequency of 66 cases, representing 38,2%;cough with a frequency of 56 cases, representing 32,4%;headaches with a frequency of 50 cases, representing 28,9%;and dyspnea with a frequency of 34, representing 19,7%. Conclusion: The male gender was predominant with comorbidities such as diabetes mellitus, general malaise and elevated CRP.

17.
ARYA Atherosclerosis ; 17(1), 2021.
Article in English | EMBASE | ID: covidwho-1822676

ABSTRACT

BACKGROUND: During ongoing coronavirus disease 2019 (COVID-19) pandemic, social isolation and lockdown measures were implemented to prevent spread of virus which created enormous challenges to patient healthcare. In order to overcome these challenges, teleconsultation (telecardiology) was initiated. Objective of this study was to assess outcome of telecardiology using audio/visual/audio-visual consultation among patients with implantable cardiac devices. METHODS: Telecardiology was performed (either physician-initiated or patient-initiated) among 1200 patients over a five-month period (July 13 to December 13, 2020) to review health status of patients to decide further course of treatment and to access their satisfaction level with telecardiology. RESULTS: Teleconsultation was cardiologist-and patient-initiated in 1042 (86.8%) and 158 (13.2%) cases, respectively. 1117 (93.2%) patients were stable, while scheduled admission, urgent hospitalization, and death were noted in 20 (1.8%), 45 (3.9%), and 18 (1.5%) patients, respectively. Next visit was rescheduled in 986 (82.2%), while 127 (10.6%) were called earlier because of battery depletion. Majority (n = 1077, 89.8%) were satisfied. CONCLUSION: Telecardiolgy is an effective option during COVID-19 to minimize interpersonal contact, spread of disease, psychological stress, and burden on already stretched healthcare.

18.
ARYA Atherosclerosis ; 17(2), 2022.
Article in English | EMBASE | ID: covidwho-1822674

ABSTRACT

BACKGROUND: COVID-19 was introduced by the World Health Organization (WHO) as a global pandemic. The disease manifestations ranges from a mild common cold to severe disease and death. It has a higher mortality rate in people with a history of comorbidities, including cardiovascular disease (CVD) and can also contribute to cardiac injury. This study was conducted to evaluate the relationship between troponin levels as a cardiac marker and adverse outcomes in this disease. METHODS: The study sample included 438 patients hospitalized with COVID-19;however, the troponin data of 6 patients were not available. The need to be admitted to the intensive care unit (ICU), and death were considered the adverse outcome in patients with COVID-19. Troponin levels were checked in all patients on day 1 and day 3 of hospitalization. Multiple logistic regression analysis was performed to determine whether there was an independent association between the adverse outcomes and troponin enzyme in hospitalized patients with COVID-19. RESULTS: The mean age of patients was 61.29 ± 15.84 years. Among the 432 patients tested on day 1 of hospitalization, 24 patients (5.6%) tested positive (Troponin 1), and among the 303 patients tested on day 3, 13 patients (4.3%) tested positive (Troponin 2). Based on our results, Troponin 1 showed an independent association with both death (3.008 [95%CI = 1.091-8.290];P = 0.033) and need for ICU admission (8.499 [95%CI = 3.316-21.788];P < 0.001) in multiple logistic regression analysis. Moreover, the status of Troponin 2 had an independent significant association with both death (4.159 [95%CI = 1.156-14.961];P = 0.029) and ICU admission (7.796 [95%CI = 1.954-31.097];P = 0.004). CONCLUSION: Troponin showed a significant association with adverse outcomes in people who were hospitalized with COVID-19. The periodical assessment of this enzyme from the time of hospitalization may improve the clinical decision making of clinicians.

19.
Revista Medica Herediana ; 33(1):15-23, 2022.
Article in Spanish | EMBASE | ID: covidwho-1822664

ABSTRACT

In Peru, one of the first interventions to flattened the epidemiologic curve of the pandemic was quarantine that changed eating behavior, physical activity and mental health of the population. Objective: to determine modifications in eating behavior, physical activity and mental health in young adults before and after the quarantine. Methods: cohort study involving 384 adults from 18 to 24 years of age that were subjected to a virtual interview and application of an international questionnaire to evaluate changings in eating behavior, physical activity and mental health contrasted by Chi square. Results: an increase in the distribution of daily foods [breakfast (p<0.001), morning snack (p<0.05), lunch (p<0.001), afternoon snack (p<0.001), dinner (p<0.05)] and an increase in ingestion of fruits (p=0.005) and reduction in the ingestion of fast food (p<0.05) and candies (p=0.03). Physical activity decreases specially in males vs females (28.4% vs. 25.3%) and there was a reduction in the total number of sleep hours, mental health was severely affected. Conclusions: quarantine induced variations in eating behavior, reduction in physical activity and increase in mental health disorders. These modifications put the population at risk for weight gain or obesity and eventually to non-transmissible diseases.

20.
Chinese Journal of Disease Control and Prevention ; 26(2):193-199, 2022.
Article in Chinese | EMBASE | ID: covidwho-1822639

ABSTRACT

Objective To investigate the willingness and influencing factors with novel coronavirus vaccines(COVID-19 vaccines) among college students in Shanghai. Methods From February 23 to March 15, 2021, a web based questionnaire survey was conducted among students from four colleges to analyze the willingness rate of COVID-19 vaccines. Multivariate Logistic regression was used to analyze influencing factors of the willingness to receive vaccines. Results Of 4 462 subjects, 78.04% were willing to receive COVID-19 vaccines. Logistic regression analysis showed that students from the technology university and the vocational school had higher willingness to vaccinate (OR=1.53, 1.50), compared with those from medical college. Respondents did not agree that vaccines are important for protecting health (OR=0.11) and did not agree that all vaccines marketed through National Medical Products Administration are safe (OR=0.42) were less willing to be vaccinated. Those who had no one nearby to vaccinate against COVID-19 were less willing to be vaccinated (OR=0.68). The main reasons for refusing or hesitating to be vaccinated were concerned about the safety(73.88%) and efficacy(55.61%) of the vaccine. Further investigation showed that 37.86%, 48.27% and 35.31% of respondents who had previously chosen not to vaccinate or were unsure about vaccinating against COVID-19 were willing to vaccinate if recommended by the government, doctors, relatives and friends, respectively. Conclusion The willingness rate of COVID-19 vaccination among college students was high in Shanghai. The relevant departments should do a good job in the coordination of vaccination so that the vaccination work can be carried out effectively.

SELECTION OF CITATIONS
SEARCH DETAIL