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1.
Ryan.
Farmers Weekly ; 2022(Jul 15):67-67, 2022.
Article in English | Africa Wide Information | ID: covidwho-2092957
2.
Journal of Pharmaceutical Negative Results ; 13:660-671, 2022.
Article in English | Web of Science | ID: covidwho-2072526

ABSTRACT

As concerns about the 2019 coronavirus disease (COVID-19) epidemic begin to dissipate, nations around the world are instead focusing on the outbreak of monkeypox in some areas. Once restricted to specific areas of Africa, the 2022 pandemic has primarily affected European countries and the rest of the western hemisphere. Although numerous groups are working on contact-tracing initiatives, the original cause of this epidemic remains a mystery. The monkeypox virus is a member of the Poxviridae family, which includes many other zoonotic viruses. After smallpox was eradicated worldwide, occurrences of monkeypox gained international attention in the 1970s. Cross-immunity against monkeypox was achieved through the use of the smallpox vaccine. A rise in the incidence of monkeypox followed the end of routine vaccination against smallpox. An outbreak in the United States in 2003 brought monkeypox to the forefront of public consciousness. Although it has been given the moniker "monkeypox," this particular virus did not initially manifest in these small mammals. To this day, the real origin of monkeypox remains a mystery, however it has been speculated that various rodents and tiny mammals are the carriers of the virus. The virus that causes monkeypox was originally observed in macaque monkeys, hence the name. Monkeypox is seldom spread from person to person, but when it does, it's usually through a person's mucocutaneous lesions or through airborne droplets. Although there is no successful treatment for those who have contracted the virus at this time, complimentary treatments can be given to alleviate symptoms;medications such tecovirimat may be given to those with extremely severe infections. There are no universally accepted standards for administering these medicines, making their efficacy open to debate.

3.
Economic and Political Weekly ; 55:16, 2020.
Article in English | GIM | ID: covidwho-1716597

ABSTRACT

Social distancing, regular handwashing, and self-isolation are being touted as preventive measures to tackle the spread of COVID-19. But, for the majority of Indians, complying with such norms are privileges that they cannot afford.

4.
10th IEEE International Conference on Healthcare Informatics, ICHI 2022 ; : 465-468, 2022.
Article in English | Scopus | ID: covidwho-2063253

ABSTRACT

The National Institute of Health (NIH) launches the RADx Radical research collaboratives (RADx-rad) to advance new, non-traditional approaches for COVID-19 testing. RADx-rad projects are required to adopt common data elements (CDEs) to collect data to increase data interoperability. To overcome the challenges in finding appropriate CDEs for a wide range of study variables, we create a web application - IMI-CDE to ease the burden of mapping study variables to CDEs from researchers. IMI-CDE can automatically recommend CDE candidates for a study variable based on its name and description. Together with interactive mapping interfaces, IMI-CDE allows researchers to perform variable-CDE mapping with one mouse click. In addition, the IMI-CDE application supports users with multiple roles to work collaboratively on the mapping tasks. We have piloted the IMI-CDE with RADx-rad projects. 22 researchers from 8 different projects have started to use the IMI-CDE system for variable-CDE mappings. The beta-testing evaluators reported the system is intuitive, effective, and easy to use. © 2022 IEEE.

5.
CAB Abstracts; 2022.
Preprint in English | CAB Abstracts | ID: ppcovidwho-345451

ABSTRACT

Background: Over 50 million cases of COVID-19 have been confirmed globally as of November 2020. Evidence is rapidly emerging on the epidemiology of COVID-19, and its impact on individuals and potential burden on health services and society. Between 10-35% of people with COVID-19 may experience post-acute long Covid. This currently equates to between 8,129 and 28,453 people in Scotland. Some of these people will require rehabilitation to support their recovery. Currently, we do not know how to optimally configure community rehabilitation services for people with long Covid.

6.
3rd International Conference on Machine Learning, Advances in Computing, Renewable Energy and Communication, MARC 2021 ; 915:701-706, 2022.
Article in English | Scopus | ID: covidwho-2059754

ABSTRACT

In medical domain, the accuracy of the data supplied is critical. Missing values, on the other hand, are a typical occurrence in this sector for a variety of reasons. Most current science concentrates on establishing novel data imputation procedures, but more research on conducting a comprehensive review of existing algorithms is highly desired. Authors have evaluated the performance of four mostly adopted data imputation techniques, i.e., MICE, EM, mean, and KNN on a real-world dataset of COVID-19. KNN is an imputation approach that, according to the findings of the studies, is expected to be a good fit for dealing with missing data in the healthcare industry. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

7.
Journal of Clinical and Basic Research ; 6(1):37-45, 2022.
Article in English | GIM | ID: covidwho-2057220

ABSTRACT

Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic is one of the most important healthcare and social challenges. The aim of this study was to evaluate the effect of acceptance and commitment therapy (ACT) on depression and quality of life among women with chronic pain during the COVID-19 pandemic lockdown.

8.
Journal of Clinical and Basic Research ; 6(1):11-27, 2022.
Article in English | CAB Abstracts | ID: covidwho-2057219

ABSTRACT

Coronavirus disease 2019 (COVID-19) is a severe acute respiratory disease with a high prevalence. According to the research and statistical data, in January 2021, there have been 92,262,621 confirmed cases of COVID-19 and more than two million deaths. Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the main cause of this disease. In addition to the respiratory system, the disease affects the gastrointestinal tract, central-peripheral nervous system, circulatory system, and kidneys. Therefore, any therapeutic action to reduce COVID-19-related symptoms and complications is essential. In this study, we conducted a systematic review of the published literature and preprints on the efficacy of erythropoietin (EPO) and recombinant human EPO as a safe stimulant and tissue protector in the treatment of COVID-19. We also briefly described the structure of coronavirus, its pathogenesis, and the structure of EPO and recombinant human EPO. All relevant articles published in the Science Direct, PubMed, and Google Scholar databases were searched. According to the results, EPO is a cytoprotective cytokine induced by hypoxia. The pleiotropic effects of EPO are associated with its erythrocyte-forming, anti-apoptotic, anti-inflammatory activities. It also exerts protective effects on the heart, lungs, kidneys, arteries, and central and peripheral nervous systems. It has been demonstrated that EPO can increase hemoglobin levels, thereby increasing oxygen delivery to the tissues. Therefore, recombinant human EPO therapy can be used for counteracting the adverse effects of COVID-19 including hypoxic myocarditis, acute renal failure, pulmonary edema, and brain-spinal cord ischemic injury. Overall, the use of EPO and recombinant human EPO therapy increases blood coagulation, tumor growth, thromboembolism, and purification of red blood cells, which must be accompanied by anticoagulants such as heparin.

9.
Journal of Guilan University of Medical Sciences ; 30(2), 2021.
Article in Persian | CAB Abstracts | ID: covidwho-2057029

ABSTRACT

The current study sought to examine the clinical, laboratory, and imaging aspects of COVID-19-positive critically sick patients who were admitted to the intensive care units (ICUs) at three hospitals in Rash City, Iran. The goal of this retrospective study was to examine 138 COVID-19 patients who had been hospitalized to the intensive care unit. Data on the study participants' demographics, underlying diseases, laboratory and imaging results, and prognosis of the diseases were taken from their medical records. 138 COVID-19 patients who were hospitalised to the intensive care unit were the subject of this retrospective analysis. Patient records were used to extract information about the patient, including demographic details, underlying diseases, laboratory and imaging results, and disease outcomes. The majority of the patients in this study were male and between the ages of 55 and 69. The most prevalent underlying conditions were diabetes mellitus, hypertension, and chronic heart disease;the most prevalent symptoms were shortness of breath, fever, and cough. The most prevalent lung Computer Tomography (CT) scan finding was ground glass opacities, and the most frequent laboratory findings in the study participants were an increase in LDH, ESR, CRP, neutrophil percentage, and lymphopenia. A 90.58% fatality rate was recorded. This study showed that the majority of patients with severe disease presentations were older, had a history of underlying disease, symptoms of shortness of breath, cough, and fever, substantial lung involvement in imaging, and altered laboratory findings. Despite medical treatment and mechanical ventilation, mortality remained high.

10.
Molekuliarnaia Biologiia ; 56(5):774-782, 2022.
Article in Russian | MEDLINE | ID: covidwho-2057017

ABSTRACT

One of the most important steps in the development of drugs and vaccines against a new coronavirus infection is their testing on a relevant animal model. The laboratory mouse, with well-studied immunology, is the preferred mammalian model in experimental medicine. However, mice are not susceptible to infection with SARS-CoV-2 due to the lack of human angiotensin-converting enzyme (hACE2), which is the cell receptor of SARS-CoV-2 and necessary for the entry of the virus into the cell. In present work, it was shown that intranasal administration of the adeno-associated vectors AAV9 and AAV-DJ encoding the hACE2 provided a high level of expression of ACE2 gene in the lungs of mice. In contrast, the introduction of the AAV6 vector led to a low level ACE2 expression. Infection with SARS-CoV-2 of mice expressing hACE2 in the lungs led to virus replication and development of bronchopneumonia on the 7th day after infection. Thus, a simple method for delivering the human ACE2 gene to mouse lungs by intranasal administration of the AAV vector has been proposed. This approach enabled rapid generation of mouse model for studying coronavirus infection.

11.
Revista de Investigacion en Agroproduccion Sustentable ; 6(1):1-9, 2022.
Article in Spanish | CAB Abstracts | ID: covidwho-2056879

ABSTRACT

Efficiency in shrimp farming is due to the use of an extensive system that includes fewer larvae per pool, which increases productivity, improves financial results, and even the environmental impacts generated during these operations. The objective of this study was to identify the factors that affect supply in the Ecuadorian shrimp sector. To this end, some statistical techniques such as linear regression and hypothesis testing were used. A bibliographic study was carried out regarding shrimp production in Ecuador, taking as reference the data provided by the National Chamber of Aquaculture and public control entities and reviewing the unprecedented impact on the current COVID19 sanitary crisis and the reduction of shrimp demand affecting Ecuador's income. Finally, it was observed that the research variables considered directly impact crustacean production, and a mathematical model was established.

12.
Dermatologia, Revista Mexicana ; 66(2):196-204, 2022.
Article in Spanish | GIM | ID: covidwho-2056850

ABSTRACT

OBJECTIVE: To evaluate the frequency of skin manifestations in a period of 3 months after COVID-19. MATERIALS AND METHODS: Prospective and longitudinal study done from October 1st to November 30th, 2020, in which patients older than 18 years, recovered from COVID-19, were evaluated from day 14 to day 90 after the infectious process. RESULTS: There were included 204 patients (113 women and 91 men);51% of patients developed symptoms and hair loss was the most frequent of them, followed by itching and xerosis. Telogen effluvium was the most frequent diagnosis (29.4%), with a mean disease onset of 39.15 days;11.6% developed rash, the most common was the morbilliform and papulosquamous rash. CONCLUSIONS: The most frequent form of cutaneous affection in postinfectious period of COVID-19 is telogen effluvium;however, it is possible to find other manifestations, such as xerosis cutis and rash.

13.
Dermatologia, Revista Mexicana ; 66(1):16-24, 2022.
Article in Spanish | GIM | ID: covidwho-2056849

ABSTRACT

BACKGROUND: During the pandemic, the use of multiple products for disinfection and prevention of COVID-19 transmission was widespread, many of them topically administered. OBJECTIVE: To determine the prevalence and factors associated with the perception and use of topical products for the prevention of COVID-19 in Peruvian populations., MATERIALS AND METHODS: Analytical cross-sectional study of secondary data analysis was done applying a survey to Peruvian adults, who were asked about the belief or use of different products, according to whether they believed in or used at least one of them. In addition, the association was sought according to socio-educational and occupational characteristics. RESULTS: There were included 3509 participants. The product that they perceived the most that could prevent COVID-19 was the mixture of 4% sodium hypochlorite, vinegar and alcohol (37%), but the one they used the most was 4% sodium hypochlorite (11%). In the multivariate analysis, it was found that women were those who had a positive perception of the topical use of these products (p value < 0.001), adjusted for the marital status of the respondents. However, when the use was analyzed, women were the ones who used these products the least (p value = 0.028), those who were working used these products the most (p value = 0.010). CONCLUSIONS: The results show that the Peruvian population does not perceive or use topical products to prevent COVID-19.

14.
African Journal of Infectious Diseases ; 16(2):80-96, 2022.
Article in English | CAB Abstracts | ID: covidwho-2056737

ABSTRACT

Background: The 2'-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and consequently the evasion of the host's immune system. This study aims at identifying prospective natural inhibitors of the active site of SARS-CoV-2 2'O-methyltransferase (2'-OMT) through an in silico approach. Materials and Method: The target was docked against a library of natural compounds obtained from edible African plants using PyRx - virtual screening software. The antiviral agent, Dolutegravir which has a binding affinity score of -8.5 kcal mol-1 with the SARS-CoV-2 2'-OMT was used as a standard. Compounds were screened for bioavailability through the SWISSADME web server using their molecular descriptors. Screenings for pharmacokinetic properties and bioactivity were performed with PKCSM and Molinspiration web servers respectively. The PLIP and Fpocket webservers were used for the binding site analyses. The Galaxy webserver was used for simulating the time-resolved motions of the apo and holo forms of the target while the MDWeb web server was used for the analyses of the trajectory data.

15.
African Journal of Infectious Diseases ; 16(2):55-62, 2022.
Article in English | CAB Abstracts | ID: covidwho-2056736

ABSTRACT

Background: Healthcare providers have been at the frontline of the response to the COVID-19 disease. Many of them have contracted the disease, and some of them already dead. This study assessed the knowledge, compliance with preventive measures and determined the relationship between knowledge and practice of preventive strategies to COVID-19 among nurses working in a selected hospital in South-South Nigeria. Materials and methods: A cross-sectional descriptive design guided the study. Census method guided the recruitment of all the 378 nurses in the hospital who met the study's inclusion criteria.

16.
Saude e Pesquisa ; 14(2):333-340, 2021.
Article in Portuguese, English | CAB Abstracts | ID: covidwho-2056619

ABSTRACT

The aim of this study was to identify the incidence of COVID-19 according to the positivity of the rapid tests and the associated factors in the population of the state of Para. This is a cross-sectional, analytical, retrospective study, developed with cases of COVID-19 in individuals notified and residing in the state of Para. Information was collected on the State Transparency Portal. Positivity for rapid tests of the disease was considered as the outcome variable. Logistic regression analysis was applied to identify associations between variables. The incidence of COVID-19 was 46% (95% CI: 45.7-46.2). Being male, over 80 years old and waiting 22 days or more to perform the tests after the onset of symptoms increased the chances for a positive result. It can be concluded that there is a high incidence of COVID-19 in the state. Non-pharmacological measures and case tracking strategies are important alternatives to mitigate the pandemic.

17.
Saude e Pesquisa ; 14(2):247-259, 2021.
Article in Portuguese, English | CAB Abstracts | ID: covidwho-2056618

ABSTRACT

This study aimed to assess the quality of life (QOL) of dental students in the 2019 Coronavirus Disease pandemic (COVID-19). A cross-sectional study was carried out with undergraduate students in Dentistry from Higher Education Institutions (HEIs) in the state of Ceara, Brazil. Data collection took place in May 2020, online, using questionnaires with sociodemographic, course-related and behavioral variables, in addition to the World Health Organization Questionnaire for Quality of Life-bref (WHOQOL-bref). Multinomial logistic regression was performed. 864 students participated in this study. Variables such as higher income (p = 0.034), having religion (p = 0.010), having health insurance (p = 0.005), satisfaction with sleep quality (p < 0.001), absence of insomnia (p < 0.001) and practicing physical activity always (p < 0.001) were associated with greater satisfaction regarding QOL. The QoL of dental students was classified in the dissatisfaction category, being perhaps impacted by the pandemic of COVID-19. Variables that reflected a more economically favorable living condition were associated with satisfaction with the quality of life of this public in the COVID-19 pandemic.

18.
Chinese Journal of School Health ; 43(7):1061-1065, 2022.
Article in Chinese | GIM | ID: covidwho-2056575

ABSTRACT

Objective: To investigate mental health and its associated factors in college students during COVID-19 confinement in campus, and to provide a scientific basis for mental health education.

19.
Chinese Journal of School Health ; 43(7):1055-1060, 2022.
Article in Chinese | GIM | ID: covidwho-2056574

ABSTRACT

Objective: To explore the prevalence and related factors of depressive symptoms in Chinese college students before and after the COVID-19 epidemic and to provide a reference for mental health education and management.

20.
Chinese Veterinary Science / Zhongguo Shouyi Kexue ; 50(1):10-19, 2020.
Article in Chinese | CAB Abstracts | ID: covidwho-2056573

ABSTRACT

The aim of this study is to establish an indirect ELISA technique for detecting the SIgA antibody against porcine epidemic diarrhea virus (PEDV) to evaluate its mucosal immunity. Firstly, the S1D gene (534-789 aa) of PEDV was cloned into the pET-28a(+) vector, and induced in Escherichia coli BL21 (DE3) by IPTG, the product of which was in the form of inclusion bodies. According to Western-blot, the target protein S1D with antigenic activity was 32 ku in molecular weight and could be well detected. Then, the S1D protein was denatured by 8 mol/L urea, purified and gradient as the coating antigen to establish an indirect ELISA for detecting the PEDV specific SIgA antibody in nasal or oral mucus by optimizing conditions. And the optimal antigen coating concentration of ELISA was 2 micro g mL, the working concentrations of nasal mucus was 1:1 and the optimal blocking solution was 50 g/L skimmed milk, while the working concentrations and optimal blocking solution were 1:2 and 30 g/L BSA in oral mucus, the working concentrations of the enzyme-labeled antibody was 1:2 000 in nasal and oral mucus. Finally, 84 samples of oral and nasal mucus from immunized pigs were detected by S1D of ELISA, and the coincidence rate could reach 95.2% compared with purified PEDV of ELISA. In conclusion, the indirect ELISA established in this study provided a quick, simple, sensitive, and specific method to detect PEDV specific SigA for evaluating the level of PEDV mucosal immunity.

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