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1.
Aging Medicine and Healthcare ; 13(2):49-50, 2022.
Article in English | EMBASE | ID: covidwho-1957662
2.
Drugs of the Future ; 47(5):381-385, 2022.
Article in English | EMBASE | ID: covidwho-1957096

ABSTRACT

The 2022 American Society for Clinical Pharmacology and Therapeutics (ASCPT) Annual Meeting held virtually, with "Disruptive innovation" as the motto, offered attendees an outstanding scientific program focused on clinical pharmacology, translational medicine, drug discovery and drug development. It is the most important event for scientists involved in clinical pharmacology and translational medicine. The ASCPT conference offers scientists from different professional scopes and around the world the perfect opportunity to discuss emerging science. It focuses on improving the understanding and use of existing drug therapies and developing safer and more effective treatments for the future. Oral and poster presentations were available for participants during the running of the conference to accommodate the different time zones. Presentations covered the latest research with the option to ask questions after each presentation via a chat function. Discussion boards were available to provide networking opportunities for virtual attendees.

3.
Drugs of the Future ; 47(3):229-231, 2022.
Article in English | EMBASE | ID: covidwho-1957095

ABSTRACT

The 70th annual meeting of the American Society of Tropical Medicine and Hygiene was kicked off by Dr. Tedros Ghebreyesus, the Director-General of the World Health Organization (WHO). The virtual gathering format included plenary sessions, science and clinical sessions, E-poster sessions, and an exhibit hall featuring the latest products and services for tropical diseases and global health. This report provides highlights from the oral and poster sessions, focusing on developments in the treatment of tropical diseases.

4.
Heroin Addiction and Related Clinical Problems ; 24(3):41-45, 2022.
Article in English | EMBASE | ID: covidwho-1955735

ABSTRACT

The SARS-CoV-2 pandemic poses new challenges and requires new solutions for problems previously not faced by our generation. This particularly applies to the field of opioid dependence therapy due to the physical and psychological vulnerability of patients and the treatment model that often requires daily attendance. An overview is given of the responses of the physicians and the recommendations of medical societies in Germany during the year 2020 with a special focus on the lockdown periods and the challenges and guidelines for the patients, patient organizations and physicians, both outpatient and in prison. Reduced travel and empty inner cities led to reduced patient income combined with closed patient organizations during lockdown, leading to a temporary increase of patients in opioid dependence therapy. New hygiene procedures had to be implemented. A temporary change in the German Narcotics Prescription Ordinance, including longer periods for take-home prescriptions, allowed for ongoing supply with improved social distancing. Depot buprenorphine significantly reduces the risk of infection by avoiding the daily commute and presence at the practice with many other patients. This is even more favourable in prison settings by greatly reducing the movement of prisoners and diversion of drugs.

5.
Deutsches Arzteblatt International ; 119(17):A749, 2022.
Article in German | EMBASE | ID: covidwho-1955688
6.
Canadian Veterinary Journal ; 63(1):22, 2022.
Article in French | EMBASE | ID: covidwho-1935146
8.
Congenital Heart Disease ; 17(4):399-419, 2022.
Article in English | EMBASE | ID: covidwho-1939710

ABSTRACT

Background: Adult patients with congenital heart disease (ACHD) might be at high risk of Coronavirus disease-2019 (COVID-19). This study aimed to report on a one-year tertiary center experience regards COVID-19 infection in ACHD patients. Methods: This is a one-year (March-2020 to March-2021) tertiary-center retrospective study that enrolled all ACHD patients;COVID-19 positive patients’ medical records, and management were reported. Results: We recorded 542 patients, 205 (37.8%) COVID-19-positive, and 337 (62.2%) COVID-19-negative patients. Palliated single ventricle and Eisenmenger syndrome patients were more vulnerable to COVID-19 infection (P < 0.05*). Cardiovascular COVID-19 complications were arrhythmias in 47 (22.9%) patients, heart failure in 39 (19.0%) patients, cyanosis in 12 (5.9%) patients, stroke/TIA in 5 (2.4%) patients, hypertension and infective endo-carditis in 2 (1.0%) patients for each, pulmonary hypertension and pulmonary embolism in 1 (0.5%) patient for each. 11 (5.4%) patients were managed with home isolation, 147 (71.7%) patients required antibiotics, 32 (15.6%) patients required intensive care unit (ICU), 8 (3.9%) patients required inotropes, 7 (3.4%) patients required mechanical ventilation, and 2 (1.0%) patients required extracorporeal membrane oxygenation (ECMO). Thromboprophylaxis was given to all 46 (22.4%) hospitalized patients. American College of Cardiology/American Heart Association classification revealed that complex lesions, and FC-C/D categories were more likely to develop severe/critical symptoms, that required mechanical ventilation and ECMO (P < 0.05*). Mortality was reported in 3 (0.6%) patients with no difference between groups (P = 0.872). 193 (35.6%) patients were vaccinated. Conclusions: COVID-19 infection in ACHD patients require individualized risk stratification and management. Eisenmenger syndrome, single ventricle palliation, complex lesions, and FC-C/D patients were more vulnerable to severe/critical symptoms that required ICU admission, mechanical ventilation, and ECMO. The vaccine was mostly tolerable.

9.
Acta Informatica Medica ; 30(2-1):139-146, 2022.
Article in English | EMBASE | ID: covidwho-1928808
10.
American Journal of Respiratory and Critical Care Medicine ; 205(1), 2022.
Article in English | EMBASE | ID: covidwho-1927871

ABSTRACT

Rationale Per the CDC, Since the COVID-19 pandemic, at least 25,000 pregnant women have been hospitalized in the USA, with almost 4% requiring ICU admission. Care of the critically ill pregnant patient is distinct and complex due to changes in physiology, cardiovascular demands, and changes in immune system function. Though cardiac arrest in a pregnant patient is fortunately rare, a poor outcome can be devastating. Existing literature suggests that providers have knowledge deficits regarding recommended resuscitation practices of parturients (Cohen). Additionally, in simulated scenarios, teams exhibit significant deficiencies when scored on Advanced Cardiac Life Support (ACLS) metrics when responding to a simulated pregnant patient in cardiopulmonary arrest (Lipman). We developed a high fidelity simulation in accordance with the 2020 American Heart Association (AHA) ACLS guidelines, with the hope that deliberate practice would improve response to future resuscitation efforts (Panchal). Methods Between October and December 2021, we recruited eighty-six Internal Medicine residents at a large university hospital program to complete knowledge (multiple choice) and confidence (Likert scale) assessment before and after participation in a maternal arrest simulation. For the knowledge assessment component, we utilized questions relating to the resuscitation of a pregnant patient previously published in the anesthesia literature (Cohen). Questions were derived from high yield practices highlighted in the 2020 AHA guidelines for ACLS in the peripartum patient. Data were compared using a two-tailed t-test with unequal variance. Results Regarding clinical knowledge, participants showed significant improvement in correct patient positioning (+34.5%, P = 0.00), epinephrine dosing (+10.53%, P = 0.01), and timing of perimortem delivery (+22.5%, P = 0.00). Participants also had significantly improved confidence in approaching peripartum scenarios (+53%, P = 0.00) and general ACLS scenarios (+63%, P = 0.00). Conclusions Following participation in our simulation, residents demonstrated increased confidence and increased medical knowledge related to the resuscitation algorithm utilized when caring for pregnant patients. In the future, we plan to survey residents to determine if this knowledge and confidence persists or decays over time. (Table Presented).

11.
Global Advances in Health and Medicine ; 11:121, 2022.
Article in English | EMBASE | ID: covidwho-1916567

ABSTRACT

Methods: A cross-sectional study was conducted by sending a survey developed using SurveyMonkey. Local IRB approved the study. Responding to the survey was implied as providing consent. The survey was sent to all ayurveda professionals practicing in the United States. The list of professionals were obtained from the National Ayurveda Medical Association and through personal contacts of the principal investigator. The survey was open for 45 days and reminders were sent twice to the potential participants. Results: Eighty eight ayurvedic professionals completed the survey. Majority were females from California and belonged to Ayurveda Practitioner category and practiced mostly parttime. Ayurveda counselors and Ayurveda doctors (India based education) were the other categories of professionals, who also responded to the survey. The respondents reported that they adopted telehealth to continue their practice during the closures, but still majority reported that there was an economic impact of COVID-19 on their practices. Health promotion was the predominant type of service provided by these professionals. The methods included diet and lifestyle advices that incorporated dosha based diet and yoga and meditation practices. Additionally, they also provided some classical ayurveda formulas and simple herbal teas such as coriander tea and hot water to prevent easy susceptibility to viral infections. An important advice included a specific dosha based individual daily routine to improve general and mental health. Background: To understand the ayurveda practice patterns in the United States during COVID-19 Conclusion: Ayurveda, the oldest Indian System of Medicine may be a useful natural health care systemthat can be used for health promotion during a pandemic. The self-care practices do provide patient empowerment.

12.
Drugs of the Future ; 46(11):921-927, 2021.
Article in English | EMBASE | ID: covidwho-1896426

ABSTRACT

Atlanta, Georgia, was the grand setting of the Fall 2021 American Chemical Society (ACS) National Meeting & Exposition, subheaded ‘Resilience of Chemistry.’ The meeting was both an in-person and virtual meeting at Georgia World Congress Center, and consisted of poster presentations, oral sessions, symposia, press releases and media briefings from s chosen from thousands of scientific presentations on topics that include food and nutrition, medicine, health, energy, the environment, medicinal chemistry, biological chemistry, and other fields where chemistry plays a central role. Presentations were either in person or virtual, or both, allowing for an almost return to normal meeting attendance since the start of the COVID-19 pandemic, with live interaction possible in a room or online.

13.
Canadian Veterinary Journal ; 62(7):687-688, 2021.
Article in English | EMBASE | ID: covidwho-1865966
14.
Canadian Veterinary Journal ; 62(7):702, 2021.
Article in English | EMBASE | ID: covidwho-1865803
15.
Canadian Veterinary Journal ; 62(7):697, 2021.
Article in English | EMBASE | ID: covidwho-1865802
16.
Hematology, Transfusion and Cell Therapy ; 43:S477, 2021.
Article in Portuguese | EMBASE | ID: covidwho-1859688

ABSTRACT

Objetivos: Revisão sistemática da literatura sobre os possíveis eventos tromboembólicos após a administração da vacina ChAdOx1 nCov-19/AZD1222 (Astrazeneca®). Materiais e métodos: A questão foi estruturada pelo sistema PICO, acrômio de Paciente/Problema (P), Intervenção (I), Comparação (C) e Resultado/Outcome (O). Estabelecemos que o P seria população vacinada, I seria vacina Astrazeneca, C seria nenhuma intervenção e O como efeitos tromboembólicos. Dessa forma, evidências foram pesquisadas nas principais bases científicas (MEDLINE/PubMed), utilizando os seguintes termos: ChAdOx1 nCov-19 AND thromboembolism. Foram incluídos estudos na língua inglesa sem limite no período consultado. Inicialmente, os estudos foram selecionados pelo título, sequencialmente pelo resumo, e por fim, pelo texto completo, o qual foi submetido a avaliação crítica. Recuperou-se 19 trabalhos, sendo acessados 4 textos completos que se relacionaram aos componentes PICO. Os principais motivos de exclusão foram os não relacionados aos componentes PICO. Resultados: Dados pela European Medical Association identificaram em 5,5 milhões de vacinados a ocorrência de 202 casos graves de eventos tromboembólicos. Destes, 122 em mulheres, observando os primeiros episódios alguns dias após a vacinação, que duraram de 2 a 3 dias, com agravamento do 6°ao 12°dia. Em outro estudo no Reino Unido, 3 pacientes (2 mulheres e 1 homem) após o 10°e 16°dia da 1°dose da vacina ChAdOx1 nCov-19 apresentaram reações tromboembólicas graves, como trombose extensa, aumento de dímero D e fibrinogênio limítrofe baixo. Dois desses pacientes foram diagnosticados com trombose do seio venoso cerebral (CVST), fatal em ambos os casos, enquanto o 3°paciente apresentou embolia pulmonar. GREINACH, A. et al avaliando 11 pacientes, sendo 9 do sexo feminino, descreveram presença de trombocitopenias e trombose venosa cerebral e esplênica após a vacinação com ChAdOx1 nCov-19. Ademais, pesquisas na Alemanha notaram o desenvolvimento de CVST em 3 mulheres vacinadas com a Astrazeneca®, em média de 15 dias entre a vacinação e os eventos. Discussão: As vacinas contra a COVID-19 tornaram-se ferramentas fundamentais para o controle da pandemia, todavia eventos trombolíticos foram identificados após a vacinação com a vacina Astrazeneca®, levantando preocupações. A Trombocitopenia trombótica induzida por vacina (VITT) é uma síndrome relatada entre 5 e 28 dias após a vacinação. Seus eventos tromboembólicos ocorrem devido às interações eletrostáticas entre o PF4 e a superfície do adenovírus, que, consequentemente, quando polarizados, ligam-se por meio do receptor FC às plaquetas, ativando os trombócitos e levando à VITT. O SARS-CoV-2 é um vírus de RNA de fita simples que apresenta proteínas spike (S) na superfície viral. A sua ligação com a enzima conversora de angiotensina 2 configura a entrada viral. A vacina ChAdOx1 é do tipo vetor viral não replicante, adenovírus, que codifica a proteína S com um peptídeo sinal do ativador do plasminogênio tecidual, podendo desencadear VITT. Todavia, embora seja raro ocorrer eventos trombolíticos na população vacinada, foram analisados casos de VITT após a 1°dose da vacina Astrazeneca®. Conclusão: Diante do exposto, conclui-se que os eventos tromboembólicos são raros, porém quando encontrados, foi observado que são mais frequentes na população vacinada com a Astrazeneca®, sendo a sua maioria mulheres. Contudo, constatou-se que os benefícios da vacina superam seus riscos.

17.
Archives of Psychiatry and Psychotherapy ; 24(1):5-6, 2022.
Article in English | EMBASE | ID: covidwho-1856341
18.
Psychiatry and Clinical Psychopharmacology ; 31(1):98-109, 2021.
Article in English | EMBASE | ID: covidwho-1856073

ABSTRACT

Objective: A better understanding of public attitudes towards vaccination and recognition of associated factors with vaccine hesitancy or refusal is important regarding the control of the pandemic. Our aim was to analyze the public’s attitudes toward COVID-19 vaccines and to identify factors affecting them. Materials and Methods: Data were drawn from the Turkish COVID-19 Snapshot Monitoring, between July-December 2020, a serial online cross-sectional survey. The sample comprised 3888 adult respondents. Attitudes to vaccines and trust were investigated in 3 periods corresponding to the timeline of pandemic-related events in Turkey. Results: In the third period of our study, in parallel with the increase in the spread of COVID-19, vaccine hesitancy/refusal increased significantly from 43.9% to 58.9% (P <.001). The significant predictors of vaccine refusal were female gender, being elder, and conspiracy thinking. Having a chronic illness, worrying more about loved ones and the health system being overloaded were significant predictors of vaccine willingness. Less compliance with preventive measures, less knowledge of prevention, reduced risk perception, and higher perception of media hype were COVID-19 variables that correlated with vaccine refusal. Trust in the Ministry of Health and medical professional organizations (e.g., Turkish Medical Association) was the lowest in the third period and vaccine refusal was significantly related to the decreased trust (P <.001, P =.002). Conclusion: Most respondents (approximately 60%) refused or hesitated to get a COVID-19 vaccine, though acceptability should be monitored when a vaccine becomes available. Health authorities should consider public trust, risk perception, and behavioral factors to improve COVID-19 vaccine acceptability.

19.
Trends in Anaesthesia and Critical Care ; 43:46-47, 2022.
Article in English | EMBASE | ID: covidwho-1852114
20.
Drug. Develop. Deliv. ; 21:61-63, 2021.
Article in English | EMBASE | ID: covidwho-1848761
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