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Genet Resour Crop Evol ; 68(6): 2235-2263, 2021.
Article in English | MEDLINE | ID: covidwho-2323346


A wide array of medicinal plants in India, primarily used by locals for health care, have found wide acceptance and adoption globally (either directly or processed) due to distinct advantages of good results, low or no side-effects and ease of access to general public. Indigenous and traditional systems of medicine in practice since historical times have shown potential (direct or indirect as immune-boosters) against many dreaded ailments including the recent global pandemic of COVID-19. With prediction of sixth mass extinction, there is worldwide concern as majority of these plants, collected from natural stands, are also facing threat of extinction. Since 1990s concerted efforts have been directed towards assessment of threat status, the basic requirement for prioritizing conservation activity to various species of plants and animals. In literature there is staggered information regarding list of threatened plants, including medicinal plants of India, compiled at either state level or national or international level. Analysis of these publications led to collation of a consolidated list of 84 species and the same is presented here. A brief account of conservation efforts in India at national level and supportive policy framework is also included. This compilation is aimed to serve as a comprehensive reference especially for beginners, researchers, conservationists, foresters, pharmaceutical professionals as well as policy makers.

Journal of Agriculture and Food Research ; : 100632, 2023.
Article in English | ScienceDirect | ID: covidwho-2321347


Worldwide, Severe acute respiratory syndrome Coronavirus (SARS-CoV-2) pandemic crisis, causing many morbidities, mortality, and devastating impact on economies, so the current outbreak of the CoV-2 is a major concern for global health. The infection spread quickly and caused chaos in many countries around the world. The slow discovery of CoV-2 and the limited treatment options are among the main challenges. Therefore, the development of a drug that is safe and effective against CoV-2 is urgently needed. The present overview briefly summarizes CoV-2 drug targets ex: RNA-dependent RNA polymerase (RdRp), papain-like protease (PLpro), 3-chymotrypsin-like protease (3CLpro), transmembrane serine protease enzymes (TMPRSS2), angiotensin-converting enzyme 2 (ACE2), structural protein (N, S, E, and M), and virulence factors (NSP1, ORF7a, and NSP3c) for which drug design perspective can be considered. In addition, summarize all anti-COVID-19 medicinal plants and phytocompounds and their mechanisms of action to be used as a guide for further studies.

Journal of the Chilean Chemical Society ; 67(3):5656-5661, 2022.
Article in English | CAB Abstracts | ID: covidwho-2326837


The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, in December 2019 and quickly spread across the worldwide. It becomes a global pandemic and risk to the healthcare system of almost every nation around the world. In this study thirty natural compounds of 19 Indian herbal plants were used to analyze their binding with eight proteins associated with COVID -19. Based on the molecular docking as well as ADMET analysis, isovitexin, glycyrrhizin, sitosterol, and piperine were identified as potential herbal medicine candidates. On comparing the binding affinity with Ivermectin, we have found that the inhibition potentials of the Trigonella foenum-graecum (fenugreek), Glycyrrhiza glabra (licorice), Tinospora cordifolia (giloy) and Piper nigrum (black pepper) are very promising with no side-effects.

Biuletyn Wydzialu Farmaceutycznego Warszawskiego Uniwersytetu Medycznego ; 21(2):1-21, 2023.
Article in English | Web of Science | ID: covidwho-2324993


The treatment of microbial infections has proven challenging for humans in recent years. Synthetic medications, such as antimicrobial agents, are used for treating these infections. Antimicrobials derived from natural sources have gained popularity as an alternative to manufactured medications due to their lack of adverse effects. Plants, which play a significant role in this setting, have historically served as a reliable natural defence against several pathogens. In this study, studies on plants used against viral diseases are mentioned. Studies on viruses that cause disease have been compiled in the literature. According to the findings, it has been reported in the literature that many different plant species are effective against herpes simplex virus (HSV-1, HSV-2), human immunodeficiency virus (HIV), influenza virus (A, B) and parainfluenza, Poliovirus, Astrovirus, Parvovirus, Sindbis virus (SINV), Feline calicivirus (FCV), Rhinovirus, Echovirus, Rotavirus, Bovine alphaherpesvirus 1 (BoHV-1), Reovirus, Vaccinia virus (VACV), Cardiovirus A (Encephalomyocarditis virus;EMCV), Coxsackie virus, Semliki forest, Measles virus, Newcastle disease virus (NDV), Coronavirus, Adenovirus (ADV-3, ADV-5, ADV-8, ADV-11), Canine distemper virus (CDV), Lumpy skin disease virus (LSDV), Hepatitis A, B, C virus and Enterovirus. To combat viruses, plants can be considered a potentially invaluable natural resource.

Journal of the Cameroon Academy of Sciences ; 18(Suppl):548-557, 2022.
Article in English | CAB Abstracts | ID: covidwho-2320950
Journal of Hydrology and Hydromechanics ; 71(2):156-168, 2023.
Article in English | ProQuest Central | ID: covidwho-2320327
African Journal of Pharmacy and Pharmacology ; 17(1):1-9, 2023.
Article in English | CAB Abstracts | ID: covidwho-2319486
Journal of Mycology and Plant Pathology ; 51(4):338-346, 2021.
Article in English | CAB Abstracts | ID: covidwho-2317579
The Thai Journal of Pharmaceutical Sciences ; 46(3):300-306, 2022.
Article in English | CAB Abstracts | ID: covidwho-2315819
Avicenna Journal of Phytomedicine ; 13(3):231-239, 2023.
Article in English | CAB Abstracts | ID: covidwho-2314201
Revista Del Cuerpo Medico Del Hospital Nacional Almanzor Aguinaga Asenjo ; 15(4), 2022.
Article in English | Web of Science | ID: covidwho-2310412