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1.
European Research Journal ; 8(6):755-761, 2022.
Article in English | EMBASE | ID: covidwho-2164410

ABSTRACT

Objectives: We aimed to reveal how four different areas that are important in the functioning of the urology clinic (outpatient clinic, inpatient clinic, operating room, and consultations) were affected during the COVID-19 pandemic. Method(s): Patients admitted to the surgical branches between March 11, 2018 and March 10, 2021 were retrospectively evaluated in terms of their demographic data. The data between these dates were analyzed by dividing the patients into three groups as Groups A, B, and C for the pandemic period, the year before the pandemic, and two years before the pandemic, respectively. Result(s): A total of 1,222,967 patients were included in the study. During the pandemic period, the number of urology outpatient clinic admissions decreased by more than half compared to the previous years (37,471, 93,582, and 89,031 for Groups A, B, and C, respectively). Admissions to the urology inpatient clinic decreased both numerically and proportionally when compared to the other surgical branches (1,301 [5.1%] for Group A, 3,884 [7.7%] for Group B, and 3,761 [7.7%] for Group C]). While the mortality rate did not change proportionally in the urology clinic in all groups (0.3%), it increased both numerically and proportionally in all surgical branches (339 [1.3%], 304 [0.6%], and 256 [0.5%]). Conclusion(s): Admissions to the urology clinic were determined to have decreased during the pandemic compared to the pre-pandemic period, especially due to restriction measures taken by countries and concerns about the unknowns of the disease. As a result of this decrease, the number of operations and the number of hospitalized patients were also reduced. Although the mortality rate was not affected in the short-term followup of patients, long-term outcomes remain uncertain. ©Copyright © 2022 by Prusa Medical Publishing.

2.
Journal of Cell Science ; 135(2) (no pagination), 2022.
Article in English | EMBASE | ID: covidwho-2162487
3.
Pulmonary Circulation. Conference: 6th International Leh Symposium. Leh India ; 12(3), 2022.
Article in English | EMBASE | ID: covidwho-2157901

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) has affected every demography disproportionately, including even the native highland populations. Hypobaric-hypoxic settings at high altitudeS (HAS, >=2500 m) present an extreme environment that impacts the survival of permanent residents, possibly including SARS-CoV-2. Conflicting hypotheses have been presented for coronavirus disease 2019 (COVID-19) incidence and fatality at HA. To evaluate protection or risk against COVID-19 incidence and fatality in humans under hypobaric-hypoxic environment of HA (>=2501 masl). Global COVID-19 data for March 2020-2021 obtained from official websites of the Indian Government, John Hopkins University, and Worldometer were clustered into six altitude categories. Clinical cofactors and comorbidities data were evaluated with COVID-19 incidence and fatality. Extensive comparisons and correlations using several statistical tools estimated the risk and protection. Of relevance, data analyses revealed four distinct responses, namely, partial risk, total risk, partial protection, and total protection from COVID-19 at HA, indicating a mixed baggage and complexity of the infection. Surprisingly, it included the countries within the same geographic region. Moreover, body mass index, hypertension, and diabetes correlated significantly with COVID-19 incidence and fatality rate (p <= 0.05). Varied patterns of protection and risk against COVID-19 incidence and fatality were observed among the HA populations. However, it is premature to generalize COVID-19 effects on any particular demography without further extensive studies.

4.
Journal of Mazandaran University of Medical Sciences ; 32(215):163-168, 2022.
Article in Persian | EMBASE | ID: covidwho-2156500

ABSTRACT

Background and purpose: Tocilizumab (TCZ), a monoclonal antibody against interleukin-6 (IL-6) receptor, is emerged as an alternative treatment for COVID-19 patients with a risk of cytokine storms. This study aimed at investigating the efficacy of TCZ in patients with COVID-19. Material(s) and Method(s): In a retrospective observational study, we examined the demographic and clinical characteristics of patients with COVID-19 and also the outcomes of TCZ therapy (Actemra and Temziva) in Qaemshahr Razi Hospital. Result(s): Out of 56 cases, 32 (57.1%) were women and the median age of the patients was 57.5 years. Among the patients, 19 (33.9%) were admitted to ICU where seven (12.7%) were intubated and eight (14.3%) patients deceased. Before TCZ therapy, mean oxygen saturation level was 90.1% which elevated to 93.8% after receiving TCZ (P=0.001). In this study, Temziva was associated with lower mortality rate compared with Actemra (P=0.004). Conclusion(s): TCZ therapy in patients with COVID-19 could improve oxygen saturation level and Temziva results in lower mortality rate. However, further studies with larger sample size are required to confirm these results. Copyright © 2022, Mazandaran University of Medical Sciences. All rights reserved.

5.
Bulletin of Emergency and Trauma ; 10(4):172-180, 2022.
Article in English | EMBASE | ID: covidwho-2156116

ABSTRACT

Objective: To compare clinical and paraclinical similarities between trauma patients with positive RT-PCR tests (PCR+ve) and the RT-PCR negative ones (PCR-ve). Method(s): This a case-control study, where cases had a PCR+ve and controls had a negative result. Two groups were compared regarding (para) clinical values. Multivariable binary logistic regression analysis investigated the variables predicting COVID-19 and the mortality rate. Result(s): Both groups were similar regarding the clinical findings and comorbidities ( p>0.05). PCR+ve group had lower lymphocyte count (1.41 [1.45] vs. 1.66 [1.61], p=0.030), CPK level (411 [928.75] vs. 778 [1946.5]. p=0.006) and CRP level (17 [42.5] vs. 24 [50.75], p=0.004). However, none of these findings were significant in the multivariable analysis. Finally, PCR+ve group had increased odds of death (OR=2.88;95% CI=1.22-7.41). Conclusion(s): Unlike our primary hypothesis, the study failed to mark any significant (para) clinical features guiding us to detect COVID-19 earlier in trauma patients. Moreover, the PCR+ve group is at increased mortality risk. A larger, multicentric prospective study should be designed to address this issue. Copyright © 2022 Trauma Research Center, Shiraz University of Medical Sciences.

6.
European Psychiatry ; 65(Supplement 1):S522, 2022.
Article in English | EMBASE | ID: covidwho-2154056

ABSTRACT

Introduction: Covid19 has led in major changes in our lives, while fear was one of the major psychological symptoms that emerged in psychological first aid evaluations. Objective(s): The aim of the present study was to report the major factors creating anxiety and fear, affecting everyday life of people in Greece during the two years of the pandemic. Method(s): A sample of 1,158 Greeks (280 males [24.2%] participated voluntarily in the study through online platforms. The Fear factors was assessed through an open question which was then analyzed with SPSS 24. Result(s): According to the findings, the main source of anxiety and fear arises from the situation that prevails in other European countries with increasing death rates (20.9%) presented in television, followed by what is shown in the news and news programs on television (14, 8%), the fear that the individual may get sick, watching television and radio (9.7%), the experts announcements in public (7.8%), the announcement of new measures by the government and the Ministry of Health in media (6.1%), the existence of elderly parents in the family (4.6%) and social networks (3.8%), while 12.6% stated that they have no fear or anxiety. Gender differences were significant in most of the factors x2=51.167 p=.001. Conclusion(s): According to the findings the effect that media have in anxiety and fear creation (64.1%), a result that can be used in designing effective health measures that can help people deal with the psychological aftermath of the pandemic.

7.
The Lancet Infectious Diseases ; 22(12):1676, 2022.
Article in English | EMBASE | ID: covidwho-2150865
8.
Medical Journal of Malaysia ; 77(Supplement 4):47, 2022.
Article in English | EMBASE | ID: covidwho-2147813

ABSTRACT

Introduction: The COVID-19 pandemic has spread rapidly across the global resulting in recurrent waves worldwide. This study aims to describe the epidemiological characteristics of COVID-19 cases and mortality during each wave of COVID-19 in Malaysia from the beginning of the outbreak in 2020 to 2021. Material(s) and Method(s): Data was sourced from GitHub repository and the Ministry of Health (MOH), Malaysia official COVID-19 website. Data was aggregated by epidemiological weeks and analysed by years (2020 and 2021) and COVID-19 waves (first, second and third wave). Result(s) and Conclusion(s): A total of 2,761,472 cases and 31,514 deaths were reported from 2020 to 2021. The COVID-19 incidence and mortality rates were 40.6 and 0.46 per 1,000 populations respectively from 2020 to 2021. By wave, a total of 22(0.001%), 10,145 (0.4%) and 2,751,305 (99.6%) cases were reported during the first, second and third wave respectively while 131 (0.4%) and 31,383 (99.6%) deaths were reported during second and third wave. Higher cases and deaths was reported in the year 2021 and during the third wave. We concluded that, the third wave of COVID-19 was the most severe in terms of number of infected individuals and deaths, which is due to the longer outbreak duration larger magnitude and severity compared to the previous waves. Close monitoring and surveillance of the COVID-19 outbreak would preventing future resurgence of COVID-19 case which could potentially have more devastating effects.

9.
Journal of the American Society of Nephrology ; 33:71, 2022.
Article in English | EMBASE | ID: covidwho-2125312

ABSTRACT

Background: There is a scarcity of information on the incidence and outcomes of acute kidney injury in COVID-19 patients in India. Therefore, we analysed the correlation of AKI risk factors and compared the outcomes of the first and second COVID-19 waves in a tertiary care centre. Method(s): *Single centre retrospective analysis *Patients who tested positive for COVID-19 between July 2020 and May 2021, with serum creatinine levels measured on admission (n= 1260). *AKI was defined according to the KDIGO clinical practice guidelines. *Multivariate binomial logistic regression yielded odds ratios for risk variables of AKI. *Age-adjusted odds ratios(OR) were used to compare COVID-19 outcomes between the first and second waves. Result(s): Baseline characteristics: *Median Age= 56 (IQR 47-66) *Population with diabetes-55.2% *Population with hypertension-42.11% All AKI (n=86) *Stage 1 (n=57) *Stage 2 (n=20) *Stage 3 (n=9) Risk factors for AKI: *Diabetes OR 1.9 (1.2 - 3.1) *Hypertension OR 3.2 (2.0 - 5.2) *C-reactive protein >= 10 mg/dl, OR 3.6 (1.6 - 8.0). *D-dimer >= 250 pg/ml, OR 4.2 (2.5 - 6.8). *Need for ventilation OR 3.06 (1.8 - 4.9) Comparison of COVID -19 outcomes: Compared to the first wave, the second wave cohort had lower risk for: *Acute kidney injury (adj OR: 0.4;CI: 0.2-0.7) *Mortality (adj OR: 0.2;CI: 0.09-0.7) *Invasive mechanical ventilation (adj OR: 0.2;CI: 0.06 - 0.8) *Length of ICU stay > 5days (adj OR: 0.4;CI: 0.2 - 0.7) Conclusion(s): In our retrospective study, AKI prevalence was 6.8%, and the mortality rate of 2.9%. Our analysis shows that the second wave of COVID -19 exhibits improved clinical outcomes compared to the first wave. (Table Presented).

10.
Journal of the American Society of Nephrology ; 33:321, 2022.
Article in English | EMBASE | ID: covidwho-2125303

ABSTRACT

Background: The global Covid-19 pandemic is a particular risk for dialysis patients, the Covid-associated mortality of dialysis patients is known to be higher than that of the general population. From the DaVita network, we present the course of SARSCoV-2 infections from 65 German centers with around 3,300 active dialysis patients and approximately 1,500 employees. Method(s): To reduce the risk of infection, a triage system was introduced, regulating how dialysis patients are treated in the centers. The triage is based on items like clinical symptoms, swab results and contact with confirmed positive individuals and determines further dialysis in isolation. Point-of-care antigen tests were introduced early and routinely used as a screening measure for both dialysis patients and medical staff. Further to general hygiene measures, a traffic light system was implemented depending on the local incidence rate. This provided for further measures such as a ban on visits, cohort isolation, area care and isolated trips to dialysis. The local vaccination status was also recorded in this system. Result(s): In general, the course of incidences among patients reflects that of the general population. We recorded the peak incidence of SARS-CoV-2 at the end of 2021. The cumulative total number of patients who tested positive is currently 1545 cases, which corresponds to a rate of around 48% of patients (officially 30.4% in Germany as of April 2022. With regard to the infection rate per center, there are marked differences within the network, ranging from 1% to 65%. The mortality rate from SARS-CoV-2 among dialysis patients who tested positive was 10.2% as of April 2022 (158/1545;currently around 0.5% across Germany). Since 2021, a significantly reduced Covid-associated mortality rate was noticed decreasing continuously from around 23% in August 2021 to 1.5% in April 2022. The infection rate of the staff was around 37.1% (587/1583) in the network. The rate of dialysis patients with at least three vaccinations is currently at 84.9%. Conclusion(s): In summary, the measures taken were able to effectively control for the occurrence of infection within the network. The higher incidence rate of Covid infections amongst patients may be due to more frequent routine testing than in the general population. The markedly decreasing Covid-associated mortality is possibly due to vaccinations and the milder omicron variant.

11.
Journal of Experimental and Clinical Medicine (Turkey) ; 39(4):1038-1042, 2022.
Article in English | EMBASE | ID: covidwho-2146837

ABSTRACT

Coronavirus disease-19 (COVID-19) is a novel emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2). In this study, we aimed to examine the relationship between demographic indicators and mortality rates in Covid-19 disease in different Covid-19 waves in Iran. In this retrospective cross-sectional study, the study population consisted of 9874 patients of Covid-19 admitted to Hazrat Rasoul Akram Hospital of Tehran, from the beginning of the disease to the end of the fifth wave. Demographic variables such as age and sex as well as clinical variables such as hospitalization date and mortality rate were collected and evaluated. The analysis was performed using SPSS software version 26. The mean age of 9874 participants was 58.9 +/- 17.0 years. In this study 5510 (55.8%) of patients were male. 1762 (17.8%) patients died. The fifth wave had the highest number of patients (31.1%) and the trend in the number of patients was increasing from wave second to fifth. However, the percentage of death was lower in waves fourth (14.5%) and fifth (15.3%). The mean age of deceased patients was significantly greater than alive patients (69.25 +/- 14.60 vs. 56.76 +/- 16.75, P=0.0001). The frequency of male deaths was significantly higher than female deaths (P=0.0001). The results of the present study indicate that the frequency of mortality in recent waves, despite a significant increase in hospitalization, has been decreased. It can also be said that mortality increases with age as well as male gender, and males are more prone to death due to covid-19 disease with age. Copyright © 2022 Ondokuz Mayis Universitesi. All rights reserved.

12.
Journal of Pharmaceutical Negative Results ; 13(3):659-661, 2022.
Article in English | EMBASE | ID: covidwho-2146653

ABSTRACT

The problem of coronavirus infection is sweeping the world at lightning speed in 2020. It is because the pandemic has spread across the globe. There is not a single corner of the globe that the virus has not reached. High contagiousness and, consequently, high morbidity and mortality initially affected the world and the entire medical community. Doctors did not know how to treat or what to do. A period of panic started in the public health service of almost all countries. Kazakhstan is no exception. The sad statistics are as follows: as of 31.01.2021, 103 million 213 thousand 392 people were infected. 2,231,154 people died. The mortality rate was 2.16%. We offer to your attention a clinical case of an elderly patient with a confirmed diagnosis of Covid-19 against a background of multimorbid somatic pathology. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

13.
Extreme Medicine ; - (2):67-72, 2022.
Article in English | Scopus | ID: covidwho-2146632

ABSTRACT

COVID-19 pandemic announced by World Health Organization in March 2020 raised concern on potential demographic losses. This retrospective study was aimed to analyze the pandemic-related changes in the demographic status of the Ozyorsk urban district located close to the nuclear industry facility — the “Mayak” Production Association. Population changes in the Ozyorsk urban district over the last decade were analyzed based on the open-access demographic data. The impact of the COVID-19 pandemic on the demographic status of the Ozyorsk urban district was assessed using the crude overall mortality rates. Comparison of the overall mortality rates has been performed between 2020 and each previous year to assess the deviation of mortality from the forecasted value. The overall mortality rate in 2020 has been found increased significantly by 19%. Excess mortality attributed to the impact of the pandemic was 13.4%. The expected absolute number of excess deaths from COVID-19 being the main cause of death was 60 (4.2%). The COVID-19 pandemic had a significant negative impact on the demographic status of the Ozyorsk urban district;however, the role of COVID-19-associated deaths in overall mortality was not predominant. © 2022 Federal Medical Biological Agency Publishing Group. All Rights Reserved.

14.
Journal of Research in Pharmacy ; 26(6):1513-1526, 2022.
Article in English | EMBASE | ID: covidwho-2146291

ABSTRACT

Due to the high mortality rate and rapid spread in the early phase of the COVID-19 pandemic, the healthcare system used various treatment options. The pathology associated with COVID-19 includes inflammatory responses which ultimately lead to multi-system organ failure or "cytokines storm". Treating COVID-19 at the initial stage of pandemic has become a challenge as there are no medications that have yet been approved by the FDA or other regulatory agencies. There are many medications have been used by the practitioners to combat the severity of the inflammatory responses. This article summarized the repurposed medications that have received attention during the COVID-19 pandemic and provided an outline of the therapeutic agents, which are under clinical trial that may be helpful to treat COVID-19. This article also emphasizes on pharmacist roles and responsibilities during disasters and pandemics and discussed various vaccines undergoing clinical trials currently. Copyright © 2022 Marmara University Press.

15.
International Journal of Stroke ; 17(3 Supplement):110, 2022.
Article in English | EMBASE | ID: covidwho-2139003

ABSTRACT

Background and Aims: To study the epidemiology and features of the course of stroke in Uzbekistan according to the register for three years, followed by improvement of the system of prevention of patient care. Method(s): The stroke registry method is the best method not only for detecting new and recurrent cases of stroke among permanent residents of a certain region, but also for determining the main epidemiological indicators such as morbidity, mortality, which makes it possible for health authorities to take into account when planning a health care network. Result(s): The stroke registry was conducted throughout the Republic from January 1, 2019 to December 31, 2021.In the first year of the study 63000 cases In the second and third 45479 and 59280 of stroke were registered respectively.The average annual incidence of stroke per 1000 population in 2019 was 1.88, and in 2020 and 2021 this figure was 1.34 and 1.65, respectively. Moreover, the incidence rate tended to decrease from 1.88 to 1.34 per 1000 population in 2019-2020.It should be emphasized that the average annual incidence of stroke in 2020 did not decrease due to a decrease in true incidence rates, but due to the emerging Covid-19 pandemic, in which a large number of patients who had stroke, fearing to contract a viral infection, received treatment at home, without official registration Conclusion(s): When studying the mortality rates from stroke in the Republic for the study period, it was found that the average annual mortality per 1000 population was 0.37, 0.36 and 0.34 in 2019, 2020 and 2021, respectively.

16.
Multiple Sclerosis Journal ; 28(3 Supplement):637, 2022.
Article in English | EMBASE | ID: covidwho-2138846

ABSTRACT

Introduction: Understanding how immunomodulatory therapies influence COVID-19 outcomes in people living with multiple sclerosis (PlwMS) is vital to patients and physicians alike. Aims and Objective: Evaluate COVID-19 outcomes in PlwMS receiving either fingolimod or siponimod. Method(s): The Novartis clinical trial (CT) and safety databases were reviewed to identify confirmed (CT: confirmed if patient is SARS COV-2 positive;post-marketing [PM]: considered as reported) or suspected cases of COVID-19 in PlwMS receiving either fingolimod or siponimod (CT cut-off: fingolimod 04-Aug- 2021, siponimod 29-Oct-2021;PM cut-off: fingolimod 28-Feb- 2022, siponimod 25-Mar-2022). Result(s): For fingolimod, there were 1054 cases comprising of 45 suspected (PM=45) and 1009 confirmed cases (CT=9;PM=1,000) of COVID-19 (mean age in years: 17 [CT], 43 [PM];female: 71% [715/1009;CT=4, PM=711];male: 25% [254/1009;CT=5, PM=249] and not reported: 4% [40/1009;PM=40]). Of these, 35% (358/1009;CT=8, PM=349) were from Europe, 30% (305/1009;PM=305) from the US and 34% (347/1009;CT=1, PM=346) from the rest of the world (ROW). Hospitalisation was required for 13% of patients (130/1009;PM=130);1% (13/1009;PM=13) had a fatal outcome;and 43% (437/1009;CT=9, PM=428) recovered or were recovering at the most recent follow-up. For siponimod there were 321 cases comprising of 6 suspected (CT=1;PM=5) and 315 confirmed cases (CT=53;PM=262) of COVID-19 (mean age in years: 49 [CT], 53 [PM];female: 68% [214/315;CT=34, PM=180];male: 28% [88/315;CT=19, PM=69] and not reported: 4% [13/315;PM=13]). Of these, 53% (168/315;CT=6, PM=162) were from the US;30% (96/315;CT=46, PM=50) from Europe;and 16% (51/315;CT=1, PM=50) from the ROW. Hospitalisation was required for 19% of patients (60/315;CT=15, PM=45);2% (7/315;CT=3, PM=4) had a fatal outcome;and where information was provided 42% (131/315 CT=50, PM=81) recovered or were recovering at the most recent follow-up. Conclusion(s): Available data indicates that most COVID-19 cases among PlwMS treated with fingolimod or siponimod were nonserious. Among PlwMS exposed to disease-modifying therapies (DMTs), the reported hospitalisation and mortality rates are 12.8%-21.5% and 1.62%-3.5%, respectively (Reder et al 2021;Sormani et al 2022). Thus, hospitalisation and fatality rates with siponimod and fingolimod in these series of Novartis reported cases were similar to those observed in PlwMS on other DMTs.

17.
Journal of Feline Medicine and Surgery ; 24:E441, 2022.
Article in English | EMBASE | ID: covidwho-2138409

ABSTRACT

On 11 March 2020, the World Health Organization declared the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak to be a global pandemic. Restrictions were imposed to mitigate the transmission of the virus, and people's daily routines were interrupted. This exposed both cat caregivers and, potentially, their cats to additional stress factors, such as psychosocial stress. Lower urinary tract signs (LUTS) are common in domestic cats and can include some or different combinations of the following clinical signs: dysuria, haematuria, periuria, pollakiuria, stranguria and obstruction. Environmental and management factors, such as indoor environments and an increase in stressors, have been identified as predisposing factors to LUTS. This retrospective study attempted to assess the effects of the pandemic and cat caregiver's confinement at home, which may be considered a stressor, thus triggering more cases of LUTS in cats. The study included 298 cats that were presented to the Veterinary Hospital of Associaicao Zoofila Portuguesa, Lisbon, between 2019 and 2021. A group from the pre-pandemic period (PPP;control group) contained 142 cats and a group from the period during the pandemic (PDP;study group) contained 156 cats. In the PDP group there were decreases in LUTS relapses and subsequent obstructions (P <0.01) and mortality rate (P <0.05) compared with the PPP group. A statistically significant difference was also observed in terms of the number of episodes of LUTS, with the PPP group associated with two episodes and the PDP group more frequently seen with only one episode (P <0.01). The results appear to demonstrate a positive effect of the SARS-COV-2 pandemic on LUTS. This is perhaps owing to the increased wellbeing of the cats due to the increased amount of time caregivers spent with their cats. This might mean they were better able to observe and meet their cats' needs, thus reducing the cats' stress during the period of the pandemic-related restrictions.

18.
12th Annual IEEE Global Humanitarian Technology Conference, GHTC 2022 ; : 333-340, 2022.
Article in English | Scopus | ID: covidwho-2136177

ABSTRACT

Sierra Leone has one of the highest maternal mortality rates in the world. In 2010, a new initiative was implemented to provide free healthcare to pregnant women, breastfeeding mothers, and children under the age of five. While this well-intentioned initiative strengthened maternal health in some respects, it added additional dynamics to the complex patient-provider relationships at various levels of the referral-based public health infrastructure. The genesis of these observations and the subsequent research into the complexities of these relationships can be traced to the authors' work over the past five years in championing the integration of a low-cost diagnostic device for pregnant women across 56 rural health clinics. Based on a comprehensive review of the literature, this article describes the complexities of the various types of patient-provider relationships and the role that technology innovations might play in strengthening them. There is a specific emphasis on the impact of the Ebola epidemic in 2014-2016 and the COVID-19 pandemic on patient-provider relationships. This article is of particular interest to technology innovators seeking to integrate novel diagnostic and therapeutic interventions in rural settings in low-resource countries such as Sierra Leone. © 2022 IEEE.

19.
Pneumologie ; 76(10):661, 2022.
Article in German | EMBASE | ID: covidwho-2133750
20.
Balneo and Prm Research Journal ; 13(3), 2022.
Article in English | Web of Science | ID: covidwho-2124095

ABSTRACT

The iron deficient anaemia is a common medical condition in patients with heart failure receiving antithrombotic therapy. Especially during the COVID19 pandemic period the rate of bleeding complications associated with the antithrombotic therapy tend to be higher, as the patient's referral to medical services is lower and the interaction doctor-patient is limited. In our retrospective observational study we included 300 consecutive patients with decompensated heat failure associating iron deficient anaemia. For defining the medical conditions we used the ESC guidelines terminology and diagnostic criteria. We assessed the association between the iron deficient anaemia and different antithrombotic therapies, recommended in concordance to ESC Guidelines. We found that aspirin 75mg/day was statistical significant associated with iron deficient anaemia (p 0.012) and anaemia severity (p 0.002), this association being assessed by Chi square and Pearson tests. Also, neither clopidogrel, ticagrelor, VKA or non-VKA were associated to the presence of anaemia. By assessing the mortality rate associated to anaemia severity, the severe anaemia was associated to higher mortality rate, meanwhile no antithrombotic therapy was associated with higher readmission or mortality rate (p<0.001). In conclusion, aspirin was the only antithrombotic therapy associated with the presence of anaemia and anaemia severity, while only severe anaemia was associated with statistic significant increase of patient's mortality, with nonstatistical result regarding the readmission rate. This finding is concordant to the necessity of a permanent evaluation of the antithrombotic therapy in heart failure patients.

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