Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 2.075
Filter
Add filters

Year range
1.
Journal of Voice ; 2022.
Article in English | ScienceDirect | ID: covidwho-2165660

ABSTRACT

Summary Objectives/Hypothesis Behavioral cough suppression therapy (BCST) has demonstrated up to 88% effectiveness at treating refractory chronic cough (RCC). With onset of the COVID-19 pandemic, along with many other medical services, BCST shifted to telehealth delivery. Our group hypothesized that BCST delivered via telemedicine by a specialized Speech-Language Pathologist would be comparable to previously reported response to treatment for in-person settings. Study Design Retrospective review. Methods An Emory IRB approved, retrospective review of electronic medical records was completed for RCC patients who received BCST via telehealth from March 2020 through January 2022 at Emory Voice Center. Patients were included in the study if they had a diagnosis of RCC, were referred for BCST, were seen for at least one therapy session in the telehealth setting, and provided Cough Severity Index (CSI) data pre and post-treatment. Patients were excluded if they had incomplete datasets, a known pulmonary condition, structural laryngeal disorders, smoking history, dysphagia, and ACE-inhibitor use. Change in CSI score pre- and post-treatment was calculated to determine treatment effect. Paired-samples t-tests were conducted to compare pre-and post-treatment CSI score change. Results Fifty-one RCC patients were included in this study;88% were female with an average age of 60 years (SD = 12.68). Post-treatment CSI scores were significantly lower than pretreatment CSI scores (P < 0.0001). These findings are comparable to historical documented CSI change achieved with in-person BCST. Conclusions This study provides preliminary evidence of the efficacy of BCST via telehealth for treating RCC. The findings of this study support the continued flexibility in speech-language pathology service delivery to include in-person and telehealth platforms for RCC beyond the COVID-19 pandemic.

2.
Journal of Surgical Research ; 2022.
Article in English | ScienceDirect | ID: covidwho-2165638

ABSTRACT

Introduction The coronavirus disease-2019 (COVID-19) pandemic has substantially affected the delivery of healthcare globally. The purpose of this study was to evaluate the association of this era with the timeline of care in esophageal cancer patients. Methods We performed a retrospective chart-review of patients presenting to a single, high-volume, tertiary care center with the diagnosis of esophageal cancer. COVID-era was defined as 3/2020 – 12/2020 and compared with the year before (3/2019 – 12/2019). Results In total, 117 patients presented in the COVID-era versus 190 in pre-COVID. Stage 3+4 disease was found in 77.8% of the patients in the COVID-era compared to 68.9% in the pre-COVID era (p=0.34). Diagnoses through emergency-department admission were 35.5% in the COVID vs 26.7% in the pre-COVID group (p=0.15). In the COVID era it took a median of 78 days to visit primary care provider (versus 52 days, p=0.12 in pre-COVID), 45 days to endoscopy (versus 18 days, p=0.004) and 38 days to treatment initiation (versus 36 days, p=0.48). Thirty-five% of the patients underwent esophagectomy compared to 26% in the pre-COVID-era. Median days of intensive-care-unit (ICU) (2vs3, p=0.16) and hospital stay (14vs15, p=0.28) were similar in both groups as well as post-operative 30-day morbidities (63 vs 63%, p=0.48). 1-year follow-up showed 83.7% (95% CI: 73.8-90.1%) survival in the COVID-group compared to 76.4% (95% CI: 66.9-83.5%) in the pre-COVID-group (p=0.58). Only three patients had a positive COVID result. Conclusions Our institution treated fewer esophageal cancer patients during COVID-19 accompanied by a delay in endoscopic diagnosis. Post-operative outcomes and 1-year survival remained similar.

3.
Journal of Reproductive Immunology ; : 103798, 2023.
Article in English | ScienceDirect | ID: covidwho-2165634

ABSTRACT

Omicron exhibits reduced pathogenicity in general population than the previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. However, the severity of disease and pregnancy outcomes of Omicron infection among pregnant women have not yet been definitively established. Meanwhile, substantial proportions of this population have doubts about the necessity of vaccination given the reports of declining efficacy of coronavirus disease 2019 (COVID-19) vaccines. Herein, we comprehensively discuss the clinical outcomes of infected pregnant women during the Omicron period and summarize the available data on the safety and efficacy profile of COVID-19 vaccination. The results found that the incidence of moderate and severe disease, maternal mortality, pregnancy loss, preterm delivery, stillbirth, preeclampsia/eclampsia, and gestational hypertension during the Omicron period are similar to those during the Pre-Delta period. In view of the effects of mass vaccination and previous natural infection on disease severity, the virulence of Omicron in pregnant women may be comparable to or even higher than that of the Pre-Delta variant. Moreover, the currently approved COVID-19 vaccines are safe and effective for pregnant women. Particularly, those who received a second or third dose had significantly less severe disease with little progression to critical illness or death compared with those who were unvaccinated or received only one dose. Therefore, in the case of the rapid spread of Omicron, pregnant women should still strictly follow preventive measures to avoid infection and receive the COVID-19 vaccine in a timely manner.

4.
Cillóniz, Catia, Motos, Anna, Castañeda, Tatiana, Gabarrús, Albert, Barbé, Ferran, Torres, Antoni, Gumucio-Sanguino, Víctor D.; Mañez, Rafael, Solé-Violan, Jordi, de Castro, Felipe Rodríguez, Suarez-Sipmann, Fernando, García, Ruth Noemí Jorge, Aznar, María Mora, Torres, Mateu, Martinez, María, Alegre, Cynthia, Riera, Jordi, Contreras, Sofía, Pericas, Juan Manuel, Ferrer, Ricard, Riera, Jordi, Caballero, Jesús, Trujillano, Javier, Vallverdú, Montse, León, Miguel, Badía, Mariona, Balsera, Begoña, Servià, Lluís, Vilanova, Judit, Rodríguez, Silvia, Montserrat, Neus, Iglesias, Silvia, Prados, Javier, Carvalho, Sula, Miralbés, Mar, Monclou, Josman, Jiménez, Gabriel, Codina, Jordi, Val, Estela, Pagliarani, Pablo, Rubio, Jorge, Morales, Dulce, Pujol, Andrés, Furro, Àngels, García, Beatriz, Torres, Gerard, Vengoechea, Javier, Calvo, David de Gozalo, González, Jessica, Gomez, Silvia, Gómez, José M.; Franco, Nieves, Barberán, José, Albaiceta, Guillermo M.; Espina, Lorena Forcelledo, Prieto, Emilio García, Vicente, Paula Martín, del Busto Martínez, Cecilia, Vidal-Cortés, Pablo, Garmendia, José Luis García, Cabello, María Aguilar, Fernández, Carmen Eulalia Martínez, Carbonell, Nieves, Cortés, María Luisa Blasco, Lázaro, Ainhoa Serrano, Díaz, Mar Juan, Ortiz, Aaron Blandino, Menendez, Rosario, Valdivia, Luis Jorge, Boado, María Victoria, Chinesta, Susana Sancho, del Carmen de la Torre, Maria, Varela, Ignacio Martínez, Vieiro, María Teresa Bouza, Arijón, Inés Esmorís, Hermoso, David Campi, Salinas, Rafaela Nogueras, Monjo, Teresa Farre, Bou, Ramon Nogue, Naya, Gregorio Marco, Barberà, Carme, Coll, Núria Ramon, Catalán-González, Mercedes, Montejo-González, Juan Carlos, Sanchez-Giron, Gloria Renedo, Bustamante-Munguira, Juan, Bustamante-Munguira, Elena, Avila, Ramon Cicuendez, Herrera, Nuria Mamolar, Almansa, Raquel, Ortega, Alicia, Bermejo-Martin, Jesús, Sagredo, Víctor, Añon, Jose, Agrifoglio, Alexander, Cachafeiro, Lucia, Maseda, Emilio, Socias, Lorenzo, Novo, Mariana Andrea, Figueras, Albert, Janer, Maria Teresa, Soliva, Laura, Ocón, Marta, Clar, Luisa, Ayestarán, J. Ignacio, Peñasco, Yhivian, Fernández, Sandra Campos, Serra-Fortuny, Mireia, Forcadell-Ferreres, Eva, Salvador-Adell, Immaculada, Bofill, Neus, Adell-Serrano, Berta, Díaz, Josep Pedregosa, Casacuberta-Barberà, Núria, Urrelo-Cerrón, Luis, Piñol-Tena, Àngels, Roche-Campo, Ferran, de la Gándara, Amalia Martínez, Murúa, Pablo Ryan, Ruíz, Covadonga Rodríguez, García, Laura Carrión, Álvarez, Juan I. Lazo, Lorente, José Ángel, Loza-Vázquez, Ana, Guerrero, Desire Macias, Huerta, Arturo, Tognetti, Daniel, Redruello, Carlos García, Rodríguez, David Mosquera, Fernández, Eva María Menor, Adrio, Sabela Vara, Casal, Vanesa Gómez, Pensado, Marta Segura, Vilas, María Digna Rivas, Sagastume, Amaia García, de Pablo Sánchez, Raul, Laguna, David Pestaña, Bardi, Tommaso, Villar, Rosario Amaya, Gonzalez, Carmen Gómez, Castillo, Maria Luisa Gascón, Garnacho-Montero, José, Cantón-Bulnes, María Luisa, Marin-Corral, Judith, Pérez, Cristina Carbajales, Masclans, Joan Ramon, Degracia, Ana Salazar, Bigas, Judit, Muñoz-Bermúdez, Rosana, Vilà-Vilardel, Clara, Parrilla, Francisco, Dot, Irene, Zapatero, Ana, Díaz, Yolanda, Gracia, María Pilar, Pérez, Purificación, Castellví, Andrea, Climent, Cristina, Serra, Lidia, Barbena, Laura, Cano, Iosune, Ricart, Pilar, Herraiz, Alba, Marcos, Pilar, Rodríguez, Laura, Sariñena, Maria Teresa, Sánchez, Ana, Úbeda, Alejandro, Delgado, María Cruz Martin, Gallego, Elena, Jimenez, Juan Fernando Masa, Gomà, Gemma, Díaz, Emi, Ibarz, Mercedes, De Mendoza, Diego, Barbeta, Enric, Alcaraz-Serrano, Victoria, Badia, Joan Ramon, Castella, Manuel, Bueno, Leticia, Ceccato, Adrian, Palomeque, Andrea, Barat, Laia Fernandez, Cillóniz, Catia, Conde, Pamela, Fernández, Javier, Gabarrus, Albert, Kiarostami, Karsa, López-Gavín, Alexandre, Mantellini, Cecilia L.; Speziale, Carla, Vázquez, Nil, Yang, Hua, Yang, Minlan, Ferrando, Carlos, Castro, Pedro, Arrieta, Marta, Nicolas, Jose Maria, Andrea, Rut, Barroso, Marta, Pérez, Raquel, Álvarez, Sergio, Garcia-Gasulla, Dario, Tormos, Adrián, Lomas, Luis Tamayo, Aldecoa, Cesar, Herrán-Monge, Rubén, García, José Ángel Berezo, Giraudo, Pedro Enríquez, Fernández, Pablo Cardinal, López, Alberto Rubio, Pravia, Orville Báez, Messa, Juan López, Bastida, Leire Pérez, Ruiz, Antonjo Alvarez, Trenado, José, Pous, Anna Parera, Galbán, Cristóbal, Lago, Ana López, Paz, Eva Saborido, Segade, Patricia Barral, Mariño, Ana Balan, Mendez, Manuel Valledor, de Frutos, Raúl, Aguilera, Luciano, Pérez-García, Felipe, López-Ramos, Esther, Ruiz-García, Ángela Leonor, Beteré, Belén, Blancas, Rafael, Dólera, Cristina, Planelles, Gloria Perez, Peis, Enrique Marmol, Juan, Maria Dolores Martinez, Miralles, Miriam Ruiz, Rubio, Eva Perez, Martin-Montalvo, Maria Van der Hofstadt, Sánchez-Miralles, Ángel, Warrington, Tatiana Villada, Pozo-Laderas, Juan Carlos, Estrella, Angel, Cano, Sara Guadalupe Moreno, Gordo, Federico, Palacios, Basilisa Martinez, Nieto, Maite, Nieto, Maria Teresa, Ossa, Sergio, Ortega, Ana, Sanchez, Miguel, Santacoloma, Bitor.
Journal of Infection ; 2022.
Article in English | ScienceDirect | ID: covidwho-2165580
5.
IJID Regions ; 2022.
Article in English | ScienceDirect | ID: covidwho-2165407

ABSTRACT

Background : Before the COVID-19 pandemic, tuberculosis (TB) was the leading infectious cause of death globally. In low- and middle-income countries (LMIC) including Lesotho, treatment outcome is lower than the recommended rate and poor TB treatment outcomes remain a programmatic challenge. The aim of this study was to determine unfavourable treatment outcomes and associated risk factors among TB patients in Butha Buthe district. Methods : This was a retrospective record review of TB patients registered between January 2015 and December 2020. Data were collected from TB registers and patients' files and entered Microsoft excel 2012. Analysis was conducted using R and INLA statistical software. Descriptive statistics were presented as frequencies and percentages. The differences between groups were compared using Pearson's X2 test in bivariate analysis. Frailty cox proportional hazards model was used to determine the risk of unfavourable outcomes among the variables. Results : A total of 1792 TB patients were enrolled in the study with about 70% males (1,257). Majority (71.7%) of the patients were aged between 20 and 59 years with 48% of the patients being unemployed. Almost a quarter of the patients (23.1%) had unfavourable outcomes with death (342 patients) being the most common unfavourable outcome. Our study has shown that patients older than 59 years, and unemployment increased the risk of having unfavourable treatment outcomes. Death was the most common unfavourable outcome followed by lost-to-follow up. We also observed that the patients in the initiation phase of treatment died at a faster rate compared to those in the continuation phase (p=0.02). Conclusion : TB treatment programs should have efficient follow-up methods geared more towards elderly patients. Active case finding to identify population at risk should be part of a TB program which would improve early diagnosis and treatment initiation. Patients in the intensive phase of the treatment program should be monitored more closely to determine adverse drug effects and nutritional requirement to prevent death during this phase of treatment.

6.
International Journal of Infectious Diseases ; 2022.
Article in English | ScienceDirect | ID: covidwho-2165385

ABSTRACT

Objectives : Peru has had the highest death toll from the pandemic worldwide, but it is not clear what the effects of the different variants on these outcomes are. The study aimed to evaluate the risk of death, hospitalization and ICU admission of COVID-19 according to the SARS-CoV-2 variants detected in Peru from March 2020-February 2022. Methods : Retrospective study using open-access databases published by the Peruvian Ministry of Health. Databases of genomic sequencing, death, COVID-19 cases, hospitalization and ICU, and vaccination were used. Crude and adjusted Cox proportional hazards regressions with clustered variances were modeled to calculate the hazard ratio of outcomes by variant. Results : Lambda had the highest risk of death (HR 1.92, 95%CI 1.37-2.68), and Delta the lowest (HR 0.50, 95%CI 0.31 - 0.82). Mu had the highest risk of hospitalization (HR: 2.39, 95%CI 1.56-3.67), and Omicron the lowest (HR 0.45, 95%CI 0.23-0.90), and Gamma had the highest ICU admission rate (HR 1.95, 95%CI 1.40-2.71). Conclusion : SARS-CoV-2 variants showed distinctive risks of clinical outcomes, which could have implications for the management of infected persons during the pandemic.

7.
European Review of Applied Psychology ; : 100867, 2022.
Article in English | ScienceDirect | ID: covidwho-2165285

ABSTRACT

Background: As we live in the era of technology, it is clear that employees' technical skills and savviness are important to their work performance. With the COVID-19 pandemic, these qualities have become a "necessity‿ for many employees as they have switched to remote working. Less attention, however, has been given to empirical evidence regarding how employees' technological competencies influence their work outcomes during a forced shift to remote work. Integrating the theories of Job Demands-Resources and Conservation of Resources, this study sought to provide evidence regarding the joint effect of job/personal resources and technological competency on levels of employees' remote work engagement and performance. Method: A total of 131 teachers working in Turkey completed an online survey during the initial months of the COVID-19 pandemic. SPSS Process Macro (Model 7) was used for hypotheses testing. Results: We found partial support for the proposed moderated mediation model. Specifically, psychological resilience (as a personal resource) increased the level of work performance through work engagement and this relationship was stronger among employees with high levels of technological competency. However, the results did not provide support for the hypothesized interaction effect of workplace support (as a job resource) and technological competency on work performance through work engagement. Conclusion: This research advances the theoretical and empirical understanding of the role of technological competency in the motivational process of the Job Demands-Resources model. Our findings suggest that providing training activities aimed at promoting employee learning in the domain of online work tools can accelerate the effect of personal resources on work outcomes, especially during enforced remote working, as in the case of COVID-19. Résume Contexte: Comme nous vivons dans l'ère de la technologie, il est clair que les compétences techniques et le savoir-faire des employés, sont important pour leur rendement au travail. Avec la pandémie de COVID-19, ces qualités sont devenues une "nécessité‿ pour de nombreux employés qui sont passés au télétravail. Cependant, moins d'attention a été accordée aux preuves empiriques concernant la façon dont les compétences technologiques des employés influencent leurs résultats au travail pendant l'adaptation forcé au télétravail. En intégrant la théorie d'exigence ressources de l'épuisement professionnel et conservation des ressources, cette étude a cherché à fournir des preuves concernant l'effet conjoint du travail/ressources personnel et des compétences technologiques sur les niveaux d'engagement et rendement des employés au télétravail. Méthode: Un totale de 131 professeurs travaillant en Turquie ont répondu à un sondage en ligne pendant les premiers mois de la pandémie de COVID-19. Pour tester les hypothèses, le SPSS Process Macro (Model 7) a était utilisé. Résultats: Nous avons trouvé un soutien partiel pour le model de médiation modérée propose. Plus précisément, la résilience psychologique (en tant que ressource personnelle) a augmenté le niveau de rendement au travail grâce à l'engagement au travail, et cette relation était plus forte chez les employés ayant des niveaux élevés de compétence technologique. Cependant, les résultats n'ont pas démontré l'hypothèse de l'effet d'interaction du soutient en milieu de travail (en tant que ressource professionnelle) et des compétences technologiques sur le rendement au travail par le biais de l'engagement au travail. Conclusion: Cette recherche fait progresser la compréhension théorique et empirique du rôle de la compétence technologique dans le processus du modèle d'exigences-ressources de l'épuisement professionnel. Nos résultats suggèrent qu'offrir des activités de formations visant à promouvoir l'apprentissage des employés dans le domaine des outils de travail en ligne peut accélérer l'effets des ressources personnelles sur les résultats au travail, pa ticulièrement pour le télétravail forcé, comme ce fut le cas durant la pandémie de COVID-19.

8.
Best Practice & Research Clinical Anaesthesiology ; 2022.
Article in English | ScienceDirect | ID: covidwho-2165117

ABSTRACT

During the spring of 2020, as COVID-19 infections rapidly spread across the globe, all sectors of healthcare, everywhere, would change in ways that were unimaginable. Early on, the ambulatory surgery space, being no exception, would suffer deep and impactful reductions in patient volume and revenue. Though actual care stoppages were short lived, decreased ambulatory surgical patient volumes continued for a myriad of reasons, though in some cases, Ambulatory Surgery Centers (ASCs) provided surgical care in limited numbers to patients who were "offloaded” from inpatient lists. Released March 24, 2020, herein, we address key perioperative issues as they relate to COVID-19 and ambulatory surgery including the many complexities and challenges of a new and rapidly changing virus, the impact of viral infection and vaccine development on perioperative outcomes, key ambulatory surgical approaches to COVID-19 related patient and staff safety, and lastly, managing issues related to both supply chain (PPE and other necessary equipment) and facility staffing.

9.
The American Journal of Cardiology ; 190:54-60, 2023.
Article in English | ScienceDirect | ID: covidwho-2165045

ABSTRACT

COVID-19 with myocardial injury, defined as troponin elevation, is associated with worse outcomes. The temporal changes in outcomes during various phases of the pandemic remain unclear. We evaluated outcomes during the Omicron phase compared with previous phases of the pandemic. We analyzed patients who were COVID-19-positive with evidence of myocardial injury who presented to the MedStar Health system (11 hospitals in Washington, District of Columbia, and Maryland) during phase 1 of the pandemic (March to June 2020), phase 2 (October 2020 to January 2021), and phase 3 (Omicron;December 2021 to March 2022), comparing their characteristics and outcomes. The primary end point was in-hospital mortality. The cohort included 2,079 patients admitted who were COVID-19 positive and for whom troponin was elevated (phase 1: n = 150, phase 2: n = 854, phase 3: n = 1,075). Baseline characteristics were similar overall. Inflammatory markers were significantly elevated in phase 1 compared with phases 2 and 3. The use of remdesivir and dexamethasone was highest in phase 2. In phase 3, 52.6% of patients were fully vaccinated. In-hospital mortality, though high, was lower in phase 3 than in phases 1 and 2 (59.3% vs 28.1% vs 23.3%;p <0.001). Patients who were vaccinated showed more favorable in-hospital outcomes than did those who were unvaccinated (18.3% vs 24.2%, p = 0.042). In conclusion, patients with COVID-19 with elevated troponin during phase 3 tended to have improved outcomes when compared with patients in earlier waves of the pandemic. This improvement could be attributed to the implementation of the COVID-19 vaccines, advances in COVID-19 treatment options, provider experience, and less virulent variants.

10.
J Vasc Interv Radiol ; 2022 Oct 17.
Article in English | MEDLINE | ID: covidwho-2150232

ABSTRACT

PURPOSE: To assess the mortality, readmission rates and practice variation of percutaneous cholecystostomy (PC) in patients with acute calculous cholecystitis within the UK MATERIALS AND METHODS: A total of 1186 consecutive patients [636 (53.6%) males, median age (range) 75 (24-102) years] who underwent PC for acute calculous cholecystitis between 1st January 2019 and 31st December 2020 were included retrospectively from 36 UK hospitals. Volume-outcome analysis was undertaken. Exclusion criteria were diagnostic aspirations, absence of acute calculous cholecystitis or age <16. The UK COVID-19 lockdown was declared on the 26/3/20 which served to distinguish groups. RESULTS: Most patients (66.3%) had PC as definitive treatment whereas 31.3% had PC as a bridge to surgery. The overall 30-day readmission rate was 42.2% (500/1186) and 30-day mortality 9.1% (108/1186). Centres performing <30 PC per year had higher 90-day mortality compared to centres performing >60 (19.3% vs 11.0%, p = 0.006) A greater proportion of patients presented with complicated acute calculous cholecystitis during the COVID-19 pandemic compared with pre-COVID-19 (49.9% vs. 40.9%, p=0.007) resulting in more PCs (61.3 per month vs. 37.9 per month, p<0.001). More PCs were performed in tertiary hospital (9 vs. 3 per 100 beds, p<0.001) with a greater proportion as a bridge to surgery (50.5% vs. 22.8%, p<0.001) compared with district general hospitals. Cholangiograms via PC drain were performed in 538/1039 (51.7%) patients prior to removal. CONCLUSION: The practice of PC is highly variable throughout the UK. Readmission rates are high and there is significant correlation between mortality and PC case volume.

11.
Immun Inflamm Dis ; 10(11): e722, 2022 11.
Article in English | MEDLINE | ID: covidwho-2148332

ABSTRACT

BACKGROUND: The recent outbreak of Human Monkeypox (MPXV) in nonendemic regions of the world is of great concern. OBJECTIVE: We aimed to systematically analyze the current epidemiology, clinical presentation, and outcomes of the Monkeypox virus. METHOD: Systematic literature was conducted in PubMed, Embase, Google Scholar, and Scopus using predefined MESH terms by using "AND" and "OR." The following search terms were used: Monkeypox [MeSH] OR "Monkeypox virus" [MeSH] OR "POX" OR "Monkeypox" AND "Outbreak" AND "Outcomes" from December 2019 till 14th June 2022 without restrictions of language. RESULTS: A total of 1074 (99.90%) patients tested positive for Monkeypox virus through RT-PCR while 1 (0.09) patient was suspected. There was a gender difference with male predominance (54.23% vs. 45.48%) compared with female patients. Mean age (±SD) of patients was 20.66 ± 16.45 years. The major symptoms were rash (100%), fever (96%), and other important symptoms were upper respiratory symptoms (97%), headache (95%), vomiting (95%), oral ulcers (96%), conjunctivitis (96%) and lymphadenopathy (85%). The average mean duration of treatment was 5 days, while the mean hospitalization duration was 13.3 ± 6.37 days. The outcome of 20 patients was available, 19 of 20 patients recovered fully from monkeypox, however, 1 patient was not able to survive resulting in death. CONCLUSION: The recent monkeypox virus outbreak has shown that the virus could transmit in ways that were not previously expected. Further research is needed to understand the possible outcomes and association with humans and their different organ systems.


Subject(s)
COVID-19 , Monkeypox , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Male , Young Adult , Disease Outbreaks , Monkeypox/diagnosis , Monkeypox/epidemiology , Monkeypox virus/genetics , Prognosis
12.
Clin Kidney J ; 14(6): 1570-1578, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-2160997

ABSTRACT

BACKGROUND: Real-world data for patients with chronic kidney disease (CKD), specifically pertaining to clinical management, metabolic control, treatment patterns, quality of life (QoL) and dietary patterns, are limited. Understanding these gaps using real-world, routine care data will improve our understanding of the challenges and consequences faced by patients with CKD, and will facilitate the long-term goal of improving their management and prognosis. METHODS: DISCOVER CKD follows an enriched hybrid study design, with both retrospective and prospective patient cohorts, integrating primary and secondary data from patients with CKD from China, Italy, Japan, Sweden, the UK and the USA. Data will be prospectively captured over a 3-year period from >1000 patients with CKD who will be followed up for at least 1 year via electronic case report form entry during routine clinical visits and also via a mobile/tablet-based application, enabling the capture of patient-reported outcomes (PROs). In-depth interviews will be conducted in a subset of ∼100 patients. Separately, secondary data will be retrospectively captured from >2 000 000 patients with CKD, extracted from existing datasets and registries. RESULTS: The DISCOVER CKD program captures and will report on patient demographics, biomarker and laboratory measurements, medical histories, clinical outcomes, healthcare resource utilization, medications, dietary patterns, physical activity and PROs (including QoL and qualitative interviews). CONCLUSIONS: The DISCOVER CKD program will provide contemporary real-world insight to inform clinical practice and improve our understanding of the epidemiology and clinical and economic burden of CKD, as well as determinants of clinical outcomes and PROs from a range of geographical regions in a real-world CKD setting.

13.
Journal of the Pakistan Medical Association ; 72(12):2503-2508, 2022.
Article in English | EMBASE | ID: covidwho-2164792

ABSTRACT

Maternal and foetal care has become an important concern in the wake of enormous global spread of coronavirus disease-2019 (COVID-19), but there is scarcity of information about maternal and perinatal outcomes. The current review was conducted from March to July 2020. Appropriate and related databases were searched electronically by using terms, like "COVID-19 and pregnancy", "pregnancy outcomes of COVID-19". Pooled analysis of the reviewed studies showed that of the 164 newborns, vertical transmission was noted in 7(2.95%). The most common element 140(84.98%) was caesarean section deliveries. COVID-19 pneumonia developed in almost 54(30.90%) of 175 women. The most common symptom of COVID-19 among women was fever 88(50.77%). Adverse maternal and foetal outcomes were found to be associated with COVID-19 in the form of severe illness, increased rates of caesarean section deliveries and worse birth outcomes. Yet, vertical transmission of COVID-19 infection remains debatable. Copyright © 2022 Pakistan Medical Association. All rights reserved.

14.
International Journal of Academic Medicine and Pharmacy ; 4(4):364-369, 2022.
Article in English | EMBASE | ID: covidwho-2164776

ABSTRACT

Background: Jalgaon district was one of worst hit hotspot in Covid- 19 outbreak in 2021. Pediatric patients were also affected and some of them were even hospitalized for the same. The present retrospective study was undertaken in pursuit of throwing light on clinical characteristics, laboratory findings and clinical outcomes in pediatric patients diagnosed with Covid- 19 infection. Material(s) and Method(s): All children up to 12 years of age admitted to this tertiary care hospital (DCH) between period of March 19, 2021 and August 7, 2021 enrolled for the study. Their medical records were reviewed retrospectively. SARS-CoV-2 positive children were confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) or rapid antigen test. Result(s): Of the 56 patients who were diagnosed as Covid 19 positive, 32 (57%) patients were males. On age analysis, majority of the patients belonged to the age group 1 month to 5 years are 30 (54%). Amongst clinical features, fever was most commonly encountered symptom. Twenty-one (37%) patients in the present study were classified as category D of disease severity. Abnormal chest X-ray was found in 41 (73%) patients. Twenty-four (43%) patients had oxygen saturation (SpO2) < 94% at room temperature, out of which 6 (25%) of the patients required only oxygen, 14 (58%) of the patients required non-invasive ventilation in the form of continuous positive airway pressure (CPAP) with oxygen and 4 (17%) patients required invasive ventilation. Abnormal high resolution computed tomography (HRCT) chest was found only in 1 patient. Total leucocyte count was elevated in 13 (23%) patients. C-reactive protein, serum ferritin, lactate dehydrogenase (LDH), D-dimer was abnormally elevated in 14 (32%) patients, 16 (38%) out of 42 tested and serum blood urea nitrogen (BUN)/ creatinine ratio was elevated in 14 (36%), 38 (97%) and 26 (60%) patients, respectively. Forty-eight (86%) patients had recovered from the disease and discharged, and 4 (7%) patients succumbed to the disease. Conclusion(s): The Covid- 19 epidemic has wreaked havoc on the world's health. The severity of sickness in babies and children with Covid- 19 was significantly less than that reported in adults. Copyright © 2022 International Journal of Academic Medicine and Pharmacy. All rights reserved.

15.
Neonatology ; 10(2):7-13, 2022.
Article in Russian | Scopus | ID: covidwho-2164677

ABSTRACT

The COVID-19 pandemic has led to significant changes in the provision of medical care, clinical management of pregnant women and newborns. Starting from the first, general "temporary” methodological recommendations, followed by specialized ones for pregnant women and newborns and children older than a month, interpreted the clinic, diagnostics, tactics due to the knowledge that was at the moment, but the availability of medical resources changed, new scientific data appeared and approaches to understanding the problem continued to develop. Objective – to evaluate maternal, perinatal and neonatal outcomes in the incidence of COVID-19 in the Khabarovsk Territory in the period from 2020 to 2021 [before the mass spread of Omicron strain SARS-CoV-2 (SARS-CoV-2 Omicron)]. Material and methods. A retrospective analysis of operational information for the entire period of COVID-19 morbidity in the Khabarovsk territory from March 11, 2020 to December 25, 2021 was carried out according to established reporting forms, including demographic indicators of the region and statistical data on COVID-19 for pregnant women, women in labor, women in labor, and children. Results. For today, the most prominent negative outcomes of COVID 19 during pregnancy and puerperal period are premature birth and stillbirth. Medical premature termination of pregnancy is usually indicated in severely affected hypoxic mothers. Unfavorable neonatal outcomes from infected mothers are mainly caused by complications of prematurity and concomitant diseases. Taking into account the hypoxic and infectious origin of placental pathology, detected in placentas of COVID-19 – infected mothers, a possibility of long-term complications should be considered. Conclusion. The perinatal period in COVID-19 is the period with the most unfavorable pregnancy outcomes for a mother-fetus couple, while newborns and young children are not at high risk of developing a severe course of COVID-19 infection. © 2022 by the Author(s).

16.
LUMAT ; 10(1):294-318, 2022.
Article in English | Scopus | ID: covidwho-2164633

ABSTRACT

Due to the onset of the COVID-19 pandemic, the education sector responded quickly to change the mode of delivering instructions to students in hybrid learning. Since in-school learning is no longer feasible, schools are devising teaching-learning pedagogies that are practical to achieving positive students' learning and quality instruction. This study aims to find out the impact of science investigatory projects, capstone projects, and robotics (SIPCaR) to students' engagement, and research and development (R&D) skills, and learning outcomes. Using purposive sampling and mixed-method research design, results revealed that students were very engaged, their R&D skills and learning outcomes proficiency are highly evident. Students were very cognitively engaged, behaviorally engaged, socially engaged, and moderately emotionally engaged, with means 4.27, 4.16, 4.41, and 3.44, respectively. Their R&D skills consist of analytical skills, information seeking skills, problem-solving skills, communication skills, and methodology skills are proficient with means 4.10, 4.06, 3.80, 4.30, and 3.78, sequentially. The findings of the study prove that, if appropriately implemented, SIPCaR projects open countless opportunities for students to achieve high-level learning outcomes, collaborate and innovate modern technologies that could potentially help emerging societal problems. Despite the challenges posed by the health crisis, STEM educators may formulate activities that result in students' holistic development in a remote classroom setting. © 2022 University of Helsinki. All rights reserved.

17.
Clinical and Experimental Obstetrics and Gynecology ; 49(11) (no pagination), 2022.
Article in English | EMBASE | ID: covidwho-2164628

ABSTRACT

Background: Undiagnosed ectopic pregnancies are among the main gynecological emergencies, and hemorrhage from an ectopic pregnancy is still the leading cause of maternal mortality in the first trimester. During the first lockdown period in Italy (March-April 2020) and in March 2021 restrictive measures were issued by the Italian government, but their impact on the incidence of ruptured tubal pregnancies remains unknown. Method(s): The purpose of this study was to evaluate the impact of restrictive measures for the COVID-19 outbreak on the incidence of ruptured tubal pregnancies at our referral center for endoscopic gynecologic surgery. In particular, the primary outcome was the comparison of the incidence of ruptured tubal pregnancies between the lockdown phases and the other months of the pandemic. For this retrospective cohort study we considered all women examined for tubal ectopic pregnancy at our emergency unit from 1 January 2019 to 30 April 2021. We divided patients into three groups according to the period they were referred to our center: 10 March 2019-10 March 2020 (Pre-Covid period);11 March-4 May 2020 and 6 March-30 April 2021 (Lockdown periods);5 May 2020-5 March 2021 (COVID-19 pandemic period without restrictive policies). We compared data acquired during the lockdown phases with data collected both before the COVID-19 pandemic and during the restriction-free COVID-19 period. Result(s): 31 of 85 women were diagnosed with a ruptured tubal pregnancy. The proportion of ruptured ectopic pregnancies was higher during the lockdown period than the other two periods combined (62.5% vs 30.4%, p = 0.016). Mean gestational age and beta-HCG levels showed the same tendency (7.31 +/- 1.25 weeks vs 5.99 +/- 1.28 weeks, p < 0.0001;7392.56 +/- 4337.50 mUI/mL vs 4188.36 +/- 3235.95 mUI/mL, p = 0.001). There were no differences between the proportion of ruptured pregnancies during the whole COVID-19 pandemic and the months preceding it (45.7% vs 25.6%, p = 0.07). Conclusion(s): Our study demonstrated that restrictive lockdown policies for the containment of the COVID-19 outbreak are associated with an increased rate of ruptured extrauterine tubal pregnancies. Copyright: © 2022 The Author(s).

18.
Bulletin of Russian State Medical University ; 5:40-46, 2022.
Article in English | EMBASE | ID: covidwho-2164554

ABSTRACT

Investigation of the effect COVID-19 mediated with autoantibodies has on reproductive outcomes is important. This study aimed to evaluate the profile of antiphospholipid antibodies (aPL) and their association with the outcomes of assisted reproductive technology (ART) programs in patients with a history of COVID-19. The study included 240 patients: 105 of them did not have a history of COVID-19 (group 1) and 135 of them had a history of COVID-19 (group 2) with a mild course (subgroup 2a, n = 85) or moderate course (subgroup 2b, n = 50). With the help of ELISA, serum antibodies (M, G) to cardiolipin, beta2-glycoprotein-I, annexin V (AnV), phosphatidylethanolamine (PE), phosphatidylserine, and phosphatidylserine/prothrombin complex were determined. The evaluated parameters were the indices of oogenesis, embryogenesis, ART intervention outcomes. In group 2, growing levels of anti-AnV and anti-PE IgG were observed more often (in 28 (20.7%) and 8 (5.9%) patients) than in group 1 (in 10 (9.5%) and 1 (0.95%);p = 0.02 and p = 0.045, respectively). In subgroup 2b we registered a higher level of anti-PE IgG and a higher incidence of early miscarriages (in 6 (12%) patients) than in group 1 (in 3 (2.9%)) (p = 0.024). Weak inverse correlations were found between the level of anti-PE IgG and the number of oocytes and zygotes. The results of this study suggest a negative impact of aPL-mediated COVID-19 on the outcomes of ART programs and the course of early pregnancy. Copyright © 2022 Pirogov Russian National Research Medical University. All rights reserved.

19.
Frontiers in Public Health ; 10, 2022.
Article in English | Web of Science | ID: covidwho-2163193

ABSTRACT

IntroductionAcute kidney injury (AKI) is a prevalent complication of coronavirus disease 2019 (COVID-19) and is closely linked with a poorer prognosis. The aim of this study was to develop and validate an easy-to-use and accurate early prediction model for AKI in hospitalized COVID-19 patients. MethodsData from 480 COVID-19-positive patients (336 in the training set and 144 in the validation set) were obtained from the public database of the Cancer Imaging Archive (TCIA). The least absolute shrinkage and selection operator (LASSO) regression method and multivariate logistic regression were used to screen potential predictive factors to construct the prediction nomogram. Receiver operating curves (ROC), calibration curves, as well as decision curve analysis (DCA) were adopted to assess the effectiveness of the nomogram. The prognostic value of the nomogram was also examined. ResultsA predictive nomogram for AKI was developed based on arterial oxygen saturation, procalcitonin, C-reactive protein, glomerular filtration rate, and the history of coronary artery disease. In the training set, the nomogram produced an AUC of 0.831 (95% confidence interval [CI]: 0.774-0.889) with a sensitivity of 85.2% and a specificity of 69.9%. In the validation set, the nomogram produced an AUC of 0.810 (95% CI: 0.737-0.871) with a sensitivity of 77.4% and a specificity of 78.8%. The calibration curve shows that the nomogram exhibited excellent calibration and fit in both the training and validation sets. DCA suggested that the nomogram has promising clinical effectiveness. In addition, the median length of stay (m-LS) for patients in the high-risk group for AKI (risk score >= 0.122) was 14.0 days (95% CI: 11.3-16.7 days), which was significantly longer than 8.0 days (95% CI: 7.1-8.9 days) for patients in the low-risk group (risk score <0.122) (hazard ratio (HR): 1.98, 95% CI: 1.55-2.53, p < 0.001). Moreover, the mortality rate was also significantly higher in the high-risk group than that in the low-risk group (20.6 vs. 2.9%, odd ratio (OR):8.61, 95%CI: 3.45-21.52). ConclusionsThe newly constructed nomogram model could accurately identify potential COVID-19 patients who may experience AKI during hospitalization at the very beginning of their admission and may be useful for informing clinical prognosis.

20.
Frontiers in Psychology ; 13, 2022.
Article in English | Web of Science | ID: covidwho-2163108

ABSTRACT

BackgroundAccumulating evidence highlights the importance of pre- and post- migration stressors on refugees' mental health and integration. In addition to migration-associated stressors, experiences earlier in life such as physical abuse in childhood as well as current life stress as produced by the COVID-19-pandemic may impair mental health and successful integration - yet evidence on these further risks is still limited. The present study explicitly focused on the impact of severe physical abuse in childhood during the COVID-19 pandemic and evaluated the impact of these additional stressors on emotional distress and integration of refugees in Germany. MethodsThe sample included 80 refugees, 88.8% male, mean age 19.7 years. In a semi-structured interview, trained psychologists screened for emotional distress, using the Refugee Health Screener, and integration status, using the Integration Index. The experience of severe physical abuse in childhood was quantified as a yes/no response to the question: "Have you been hit so badly before the age of 15 that you had to go to hospital or needed medical attention?" Multiple hierarchical regression analyses further included gender, age, residence status, months since the start of the COVID-19 pandemic and length of stay in Germany to predict emotional distress and integration. ResultsTwo regression analyses determined significant predictors of (1) emotional distress (adjusted R-2 = 0.23): duration of being in the pandemic (ss = 0.38, p < 0.001) and severe physical abuse in childhood (ss = 0.31, p = 0.005), and significant predictors of (2) integration (adjusted R-2 = 0.53): length of stay in Germany (ss = 0.62, p < 0.001), severe physical abuse in childhood (ss = 0.21, p = 0.019) and emotional distress (ss = -0.28, p = 0.002). ConclusionIn addition to migration-associated stressors, severe physical abuse in childhood constitutes a pre-migration risk, which crucially affects the well-being, emotional distress and integration of refugees in Germany.

SELECTION OF CITATIONS
SEARCH DETAIL