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1.
Acta Neurobiologiae Experimentalis ; 81(4):386, 2021.
Article in English | ProQuest Central | ID: covidwho-1887893

ABSTRACT

COVID‑19 is an infection caused by the new coronavirus SARS‑CoV‑2. Headache is one of the most common neurological findings. In the treatment of various chronic headaches, the greater occipital nerve (GON) block is often used as a safe and effective method. The aim of our study was to investigate the effectiveness of the GON block in the treatment of headaches observed in COVID‑19 patients. Between March and May 2020, 27 patients (with laboratory‑confirmed 2019‑nCoV infection by next‑generation sequencing confirmation of real‑time PCR) that had moderate or severe headache associated with COVID‑19 and treated with a single session of GON block were retrospectively analyzed. The visual analogue scale (VAS) values and the number of analgesic usage of patients were recorded before and after the blockade on the 1st and 10th days. Fifteen (55.6%) patients included in the study were male and twelve (44.4%) were female. In terms of VAS values, the difference between pre‑treatment and post‑treatment values on the 1st and 10th days was found statistically significant. Likewise, the difference between analgesic use before and after the procedure was statistically significant. GON block appears to be an effective pain management method in COVID‑19 related headache, and it revealed promising reductions in pain scores and analgesic usage. As well as we know, this is the first study of "COVID‑19 associated headache treated with GON blockade". More long term and well‑designed prospective studies with more participants are needed to better define this headache and develop effective treatment strategies.

2.
Int Arch Occup Environ Health ; 2022 Jun 08.
Article in English | MEDLINE | ID: covidwho-1888864

ABSTRACT

OBJECTIVES: In March 2020, the COVID-19 pandemic necessitated a rapid public health response which included mandatory working from home (WFH) for many employees. This study aimed to identify different trajectories of multisite musculoskeletal pain (MSP) amongst employees WFH during the COVID-19 pandemic and examined the influence of work and non-work factors. METHODS: Data from 488 participants (113 males, 372 females and 3 other) involved in the Employees Working from Home (EWFH) study, collected in October 2020, April and November 2021 were analysed. Age was categorised as 18-35 years (n = 121), 36-55 years (n = 289) and 56 years and over (n = 78). Growth Mixture Modelling (GMM) was used to identify latent classes with different growth trajectories of MSP. Age, gender, working hours, domestic living arrangements, workstation comfort and location, and psychosocial working conditions were considered predictors of MSP. Multivariate multinomial logistic regression was used to identify work and non-work variables associated with group membership. RESULTS: Four trajectories of MSP emerged: high stable (36.5%), mid-decrease (29.7%), low stable (22.3%) and rapid increase (11.5%). Decreased workstation comfort (OR 1.98, CI 1.02, 3.85), quantitative demands (OR 1.68, CI 1.09, 2.58), and influence over work (OR 0.78, CI 0.54, 0.98) was associated with being in the high stable trajectory group compared to low stable. Workstation location (OR 3.86, CI 1.19, 12.52) and quantitative work demands (OR 1.44, CI 1.01, 2.47) was associated with the rapid increase group. CONCLUSIONS: Findings from this study offer insights into considerations for reducing MSP in employees WFH. Key considerations include the need for a dedicated workstation, attention to workstation comfort, quantitative work demands, and ensuring employees have influence over their work.

3.
Pan African Medical Journal ; 41, 2022.
Article in English | EMBASE | ID: covidwho-1887339

ABSTRACT

Acute acalculous cholecystitis is an acute inflammation of the gallbladder in the absence of stones, usually occurring in elderly and critically ill patients with underlying conditions. A 29-year-old man presented to the hospital complaining of abdominal pain in the right hypochondrium with permanent fever three days after Janssen COVID-19 vaccine inoculation. Abdominal ultrasound revealed a thickened gallbladder wall without evidence of gallstone consistent of an acute acalculous cholecystitis. Blood analyses revealed thrombocytopenia, eosinophilia and liver dysfunction. The Polymerase Chain Reaction (PCR) COVID-19 test was negative. As treatment, the patient benefited of pain management, antibiotic and fluid. In the evolution, there was a regression of clinical signs with persistence of liver dysfunction. The patient was discharged ten days after hospitalization. The Janssen COVID-19 vaccine is likely to induce acute acalculous cholecystitis as adverse event following vaccination.

4.
Journal of Clinical and Diagnostic Research ; 16(6):PR01-PR04, 2022.
Article in English | EMBASE | ID: covidwho-1887319

ABSTRACT

Jejunal diverticulosis is the herniation of mucosa through weakened wall of jejunum on the mesenteric border. Individuals are usually asymptomatic for most of their lives and are diagnosed incidentally by radiological investigations or during surgery. Increased number of hospital admissions and investigations done to better understand the phenomenon of Coronavirus Disease 2019 (COVID-19) had increased the rate of incidental diagnosis. Four patients admitted to the COVID-19 ward of the hospital were diagnosed with COVID-19. They were treated according to the protocol followed in the state, which included high dose of steroids. During the course of treatment, they experienced abdominal pain with distension and were diagnosed with Jejunal Diverticulitis with perforation. Exploratory laparotomy with jejunal resection and jejuno-jejunal anastomosis with feeding jejunostomy was performed and adequate postoperative care was provided. Two out of the four patients survived and were discharged after they achieved full recovery and became COVID-19 negative. The cause of perforation can be attributed to the high dose of steroids used during the treatment as steroids have been proved to cause spontaneous bowel perforations.

5.
Journal of Indian College of Cardiology ; 12(2):79-81, 2022.
Article in English | EMBASE | ID: covidwho-1887282

ABSTRACT

Long-Term sequelae following COVID-19 infection are not well established. Hence, COVID-19 sequelae are been studied extensively as cases are being followed up to reduce avoidable prolonged morbidity and mortality in the country. COVID-19 and currently available drugs for treatment are both reasons for a change in immune status of patients leading to reactivation or increase the chance of infection of common diseases like tuberculosis (TB), particularly in India. A case of post-COVID-19 disease (2 months back) presented with breathlessness and chest pain. On history, workup, and evaluation, the case was diagnosed with massive tubercular pericardial effusion suggesting reactivation of latent TB in a post-COVID-19 disease. Due to COVID-19 disease itself and possible immunomodulatory drugs used for treatment, reactivation of latent TB has to be considered in post-COIVD-19 disease with nonspecific presentation and unexplained prolonged clinical course of the disease. This case highlights the need of further follow-up of COVID-19 patients to understand the effects of disease on the immune system and the possibilities of opportunistic infections, especially after this second wave of COVID-19.

6.
Pediatrics International ; n/a(n/a):e15272, 2022.
Article in English | Wiley | ID: covidwho-1886707

ABSTRACT

Background In this study, we investigated how the incidence and course of acute appendicitis (AA) changed in children, during the pandemic. Methods Children diagnosed with AA during the one-year pandemic period after the first COVID-19 case in Turkey and the previous one year were included in the study. Children were divided into two groups: those hospitalised during the pandemic (group A) and hospitalized in the previous year of the pandemic (group B). Furthermore, we compared the findings obtained for COVID-19-positive and COVID-19-negative children in the whole study group and within group A. Results In our study, a significant difference was found between the two groups in terms of gender, the rate of vomiting and number of days of vomiting. Complicated AA findings were found more frequently from the results of patients in group B than in group A. In addition, the hospital stay was longer, and the mean number of days with fever, and mean body temperature were higher in COVID-19 positive patients in the whole study group and within group A. Conclusions Contrary to most studies in the literature, in our study patients were admitted to hospital later in the pre-pandemic period, and therefore the frequency of complicated AA might have been more common in these patients. In conclusion, the arrangements and warnings of health authorities during the pandemic, might have reduced the anxiety and the hesitancy of the families to go to the hospital and relatively the rate of complicated acute appendicitis.

7.
Gastrointestinal Endoscopy ; 95(6):AB189, 2022.
Article in English | EMBASE | ID: covidwho-1885785

ABSTRACT

DDW 2022 Author Disclosures: Dennis Jensen: NO financial relationship with a commercial interest ;Rome Jutabha: NO financial relationship with a commercial interest ;Gareth Dulai: NO financial relationship with a commercial interest ;Noam Jacob: NO financial relationship with a commercial interest ;Jeffrey Gornbein: NO financial relationship with a commercial interest Background and Aims: The best strategy to prevent DPPIUH is controversial. Some colonoscopists recommend hemoclip closure of PPIU’s but this has mixed success rates in different RCT’s and is reported not to be cost effective. In addition to known risks, arterial blood flow detected in PPIU’s is an important predictor of DPPIUH. Our AIMS are to report study methods and interim results of a RCT of blood flow monitoring to prevent DPPIUH. Methods: This is an ongoing blinded RCT at several major Los Angeles Medical Centers by experienced colonoscopists. Outpatients having colonoscopies are screened and consented for enrollment. Sessile and multilobulated polyps are removed by EMR techniques. Thermal coagulation is used for polypectomies in this study. Randomized patients are stratified by whether they take chronic anti-platelet or anti-thrombotic drugs and have PPIU’s of 10-40 mm;or those without bleed drugs and have PPIU’s between 15-40 mm. By opening a sealed envelope after polypectomies, randomization is to either standard management (e.g. following ASGE guidelines of bleed drugs) or DEP interrogation of the PPIU and guided treatment of the artery with hemoclips or multipolar probe coagulation in the PPIU until blood flow is eradicated. Patients and their care givers were blinded to treatments allocated during colonoscopy. Prospective follow-up is by a research coordinator contacting each patient at 7, 14, and 30 days to record whether any complications (e.g. pain, vomiting, or bleeding);or rectal bleeding and its severity (e.g. # and days of bloody BM’s);whether they sought ER, clinic, or telemedicine care for bleeding;or were hospitalized. Major DPPIUH was diagnosed in patients with hospitalization for severe bleeding and/or for 3 or more days of ongoing severe rectal bleeding but refusal of hospitalization because of high rates of COVID here. Demographic, laboratory, colonoscopic, and pathology results are recorded on standard forms along with 30-day outcomes. Patients are assigned a code, data are entered onto HIPAA compliant computer files by a data manager and managed with SAS. With half the projected sample size randomized and followed up (e.g. 133 of 268 total), this is a planned interim analysis of the primary outcome - rates of DPPIUH by treatment. Severe adverse events (SAE’s) were also reviewed. Results: For 133 high risk patients randomized to date, 67 are in the standard group and 66 in the DEP group. The groups were well matched in risk factors – see Table 1. Overall, the Doppler group had lower rates of delayed PPIU bleeding – both major and total- see Table 2. There were no SAE’s. Conclusions: The major DPPIUH rate was higher with standard treatment than DEP treatment (7.46 % vs. 0 %), as was the rate of Total DPPIUH (10.45 % vs. 1.52%). Based upon these promising results, this RCT will continue. [Formula presented] [Formula presented]

8.
Clinica Chimica Acta ; 530:S72, 2022.
Article in English | EMBASE | ID: covidwho-1885648

ABSTRACT

Background-aim: Tumor markers (TM) in body fluids have been studied for years and several authors have proposed different cut-off. An apparently more accurate strategy is the one proposed by Molina et al. considering that the ratio TM in fluid with regard to TM in serum >1.2 indicates local production in the pleura, however if the ratio is <1.2 the presence of TM in the fluid would be explained by serum extravasation. Despite enough evidence to manage this biomarkers in body fluids, the practice is not widely extended in the clinical setting yet. Methods: AFP, CA19.9, CA15.3, CEA, CA125, PSA and SCC were analyzed in Alinity i platform (Abbott diagnostics) HCG and NSE was performed in Cobas e411 (Roche diagnostics). Results: Here we describe the case of a 69-year-old patient attending the Emergency Room due to pain in both hemythoraxes. Also remarkable was a wasting syndrome (5 kg weight loss in the past month). In Emergency blood analysis: VSG 50, PT 75%, DD 765 ng/mL, ferritin 368 ng/mL and LDH 385 U/L were outsdanding. Thorax radiology showed a pleural effusion. The patient was diagnosed with COVID19 bronchitis.TC scan evidenced pleural solid metastasis, multiple bone lesions and hepatic M1. Serum TM: AFP, CA19.9, PSA, NSE, SCC and HCG were normal. CA125 2992,60 U/mL (<35), CA15.3 614,70 U/mL (<32), CEA 400.82 ng/mL (<5). Pleural fluid TM: CEA 284.32 ng/mL;CA15.3 2210.3 U/mL. TM ratio: CA15.3: 3.6 (>1.2) this result indicates local synthesis of CA15.3, therefore pleural metastasis;CEA: 0.7 (<1.2) indicates that the CEA found un the fluid was extravasated from serum. Pathological examination was only positive for CK7 and mixt CK. All other markers were negative. It was concluded to be an undifferentiated carcinoma, cytologically reminding of an adenocarcinoma. Due to TTF1 and napsine negativity lung neoplasm could not be discarded.The patient was diagnosed with undifferentiated lung cancer stage IV. Conclusions: This a good example of different molecular patterns reflecting tumor heterogeneity evidenced by protein expression by each lesion: Pleural metastases expressed high amounts of CA15.3, however not CEA. Hepatic metastases and probably main tumor in the lung expressed CEA and CA15.3. It is arguable whether CA15.3 was expressed at lower quantities from the main tumor or the dilution of the protein in the bloodstream results in lower concentrations in relation to the ones found in the pleura.

9.
Pediatric Blood and Cancer ; 69(SUPPL 2):S139, 2022.
Article in English | EMBASE | ID: covidwho-1885445

ABSTRACT

Background: Inferior Vena Cava (IVC) abnormalities are a risk factor for the development of lower extremity deep vein thrombosis (DVT). Abnormalities can be congenital or acquired and include IVC atresia, a rare and lesser known problem for adolescents. Adolescents with IVC atresia are at high risk for DVT's that are often refractory to standard anticoagulation methods, including thrombolysis. Objectives: The purpose of this report is to highlight a young patient with extensive lower extremity DVT in the setting of underlying IVC atresia and describe the complex care required. The patient is a 16-year-old with a history of venous insufficiency who presented with low back pain and lower extremity swelling. Thrombotic risk factors included factor V Leiden heterozygosity, oral contraceptive use, and recent COVID-19 vaccination. An MRI completed by the orthopedist for back pain was concerning for abnormal signal in the IVC as well as an IVC aneurysm. A contrast enhanced CT was obtained and demonstrated atresia of the suprarenal IVC, subacute thrombosis of the infrarenal IVC along with an IVC aneurysm, and subacute thrombosis of the bilateral iliac veins. Design/Method: A retrospective chart review of the patient's initial presentation, imaging, and treatments was conducted along with a review of the literature involving similar cases. Results: Initial treatment was intravenous heparin and t-PA mediated thrombolysis. After overnight thrombolysis, venography revealed significant clot lysis;thus, she was transitioned to subcutaneous enoxaparin and discharged home with therapeutic anti-Xa levels. Follow up imaging 3 days later revealed recurrent thrombosis of the deep veins in both lower extremities. She was readmitted, placed on intravenous heparin, and received catheter directed t-PA thrombolysis. Clot burden was so extensive it was further reduced using Angio jet thrombectomy and balloon angioplasty. Because the recurrent clots were attributed to lack of outflow from the underlying IVC atresia, interventional radiology completed endovascular reconstruction of the IVC. She then transitioned from intravenous heparin to therapeutic enoxaparin, clopidogrel, and aspirin. At three month follow up, imaging was negative for clot and her vasculature was widely patent. Conclusion: Pediatric patients with bilateral lower extremity DVTs are uncommon and underlying IVC abnormalities should be considered in the evaluation. Optimal treatment strategies are evolving and include aggressive anticoagulation and endovascular reconstruction.

10.
Retos-Nuevas Tendencias En Educacion Fisica Deporte Y Recreacion ; - (45):1019-1030, 2022.
Article in Spanish | Web of Science | ID: covidwho-1885127

ABSTRACT

Objective: To verify the association between the levels of physical activity, sedentary lifestyle and the presence of back pain in nutrition and dietetics students from a private university. Methods: Analytical cross-sectional study, the population were students of nutrition and dietetics. Adults with at least one semester of studies were included. Back pain was evaluated using the Nordic standardized Kourinka questionnaire, physical activity and sedentary behavior using the International Physical Activity Questionnaire short version. Controlling for sex, age, cycle, hours spent studying, practicing physical activity and qualified athlete status. The instruments were applied using virtual format. Results: 108 participants of both sexes were analyzed. The students carry out an average of 4.6 hours of study per day outside the virtual classes received, 74.1% were physically active and 74% sit for more than eight hours a day. 65.7% refer to having suffered from back pain and the associated factors are the hours of study per day (RPa = 1,088), the average sitting hours per day (RPa = 1,047), as well as accumulating more than 8 hours sitting a day has an RPa = 1,372 compared to that they accumulate less than eight hours sitting daily. Conclusions: sedentary behavior and especially the hours of study outside the class carried out by nutrition and dietetic students are directly related to back pain, thus greater sedentary behavior increases the probability of suffering from back pain.

11.
Int J Environ Res Public Health ; 19(12)2022 Jun 10.
Article in English | MEDLINE | ID: covidwho-1887199

ABSTRACT

The pandemic of the 21st century had a significant influence on the lives of the world population in a negative way. This situation determined a change of lifestyle; it caused the necessity of social isolation for a great number of people. In fact, people tended to avoid crowded environments, social events, to reduce medical checks and sports activities, favoring sedentary life because of fear of the virus. This social attitude brought a high level of stress that worsened many health conditions. This study has the aim of evaluating the possible influence of the pandemic on temporomandibular joint (TMJ) disorders, obstructive sleep apnea syndrome (OSAS) and body mass index (BMI). An anonymized survey, available in two languages (Italian and English), was given to 208 patients from different private dental practices. In this questionnaire, the patients shared experiences about their life during the pandemic. The article highlighted that during this health emergency, there was an increase in body weight in the considered sample. This brought a worsening of OSAS in 65% of patients with a previous diagnosis. Eventually, an increase in TMJ disorders and orofacial pain was reported.


Subject(s)
COVID-19 , Sleep Apnea, Obstructive , Temporomandibular Joint Disorders , Body Mass Index , COVID-19/epidemiology , Humans , Pandemics , SARS-CoV-2 , Sleep Apnea, Obstructive/diagnosis , Sleep Apnea, Obstructive/epidemiology , Temporomandibular Joint Disorders/epidemiology
12.
Can J Pain ; 6(1): 33-44, 2022.
Article in English | MEDLINE | ID: covidwho-1886360

ABSTRACT

Background: With hundreds of pain management apps on the Canadian marketplace, it can be challenging for patients and clinicians to select effective and evidence-based mobile health (mHealth) apps that address pain from a biopsychosocial perspective. Aims: The aim of this study is to identify pain management apps within the Canadian app marketplaces to aid clinicians in recommending apps. Methods: The iOS and Android marketplaces were systematically searched to identify pain management apps that included at least one core component of cognitive behavioral therapy (CBT) or mindfulness- and acceptance-based therapies. Selected apps were assessed using a researcher developed psychological components checklist, and the Mobile App Rating Scale (MARS). These two measures provided a robust assessment of the apps' technical abilities and psychological principles being implemented. Results: Five hundred eight pain management apps were identified, yet only 12 included a psychological component and were available for evaluation. On average, apps contained 8.10 out of 18 psychological components (SD = 2.77) with a MARS quality rating of 4.02 out of 5 (SD = 0.32). The most common psychological components were grounded in CBT, including psychoeducation, sleep hygiene, behavioral activation, coping skills training, and social support. Among the least commonly included components were goal setting, values, and culture/diversity. Two-thirds of the apps involved health care practitioners in their development, but independent scientific review of apps was scarce. Conclusion: The highest scoring apps (Curable, Pathways, Vivify) are highlighted for health care practitioners who may wish to recommend mHealth technologies to their patients for pain management. Future directions for research and app development are discussed.


Contexte: Le fait qu'il existe des centaines d'applications de prise en charge de la douleur sur le marché canadien peut faire en sorte qu'il soit difficile pour les patients et les cliniciens de choisir une application de santé mobile (mHealth) efficace et fondée sur des données probantes, qui aborde la douleur d'un point de vue biopsychosocial.But: Le but de cette étude est de répertorier les applications de prise en charge de la douleur disponibles sur les marchés des applications canadiens afin d'aider les cliniciens à en recommander certaines.Méthodes: Les marchés iOS et Android ont été systématiquement consultés pour répertorier les applications de prise en charge de la douleur qui comprennent au moins une composante de base de la thérapie cognitivo-comportementale (TCC) ou des thérapies fondées sur la pleine conscience et l'acceptation. Les applications sélectionnées ont été évaluées à l'aide d'une liste de vérification des composantes psychologiques élaborée par un chercheur et le Mobile App Rating Scale (MARS). Ces deux mesures ont fourni une évaluation robuste des capacités techniques et des principes psychologiques mis en œuvre.Résultats: Cinq cent huit applications de prise en charge de la douleur ont été répertoriées, mais seulement 12 d'entre elles comprenaient une composante psychologique et étaient disponibles pour l'évaluation. En moyenne, les applications contenaient 8,10 des 18 composantes psychologiques (ÉT = 2,77) et obtenaient un score de qualité MARS de 4,02 sur 5 (ÉT = 0,32. Les composantes psychologiques les plus courantes étaient ancrées dans la TCC, y compris la psychoéducation, l'hygiéne du sommeil, l'activation comportementale, la formation aux compétences d'adaptation et le soutien social. Les composantes les moins souvent incluses étaient l'établissement d'objectifs, les valeurs et la culture/diversité. Deux-tiers des applications avaient impliqué des praticiens de la santé dans leur développement, mais peu d'entre elles avaient été soumises à un examen scientifique indépendant.Conclusion: Les applications ayant obtenu les scores les plus élevés (Curable, Pathways, Vivify) sont mises en évidence à l'intention des praticiens des soins de santé qui peuvent souhaiter recommander des technologies de santé mobile à leurs patients pour la prise en charge de la douleur. Les orientations futures pour la recherche et le développement d'applications sont abordées.

13.
World Journal of Clinical Cases ; 10(15):5042-5050, 2022.
Article in English | EMBASE | ID: covidwho-1884759

ABSTRACT

BACKGROUND Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by systemic inflammatory response syndrome and vasculopathy. SARS-CoV-2 associated mortality ranges from 2% to 6%. Liver dysfunction was observed in 14%-53% of COVID-19 cases, especially in moderate severe cases. However, no cases of spontaneous hepatic rupture in pregnant women with SARS-CoV-2 have been reported. CASE SUMMARY A 32-year-old pregnant patient (gestational age: 32 wk + 4 d) without any remarkable medical history or long-term medication presented with epigastralgia. Infectious, non-infectious, and pregnancy-related hepatopathies were excluded. Sudden onset of right subcostal pain with D-dimer and liver enzyme elevation was followed by shock with thrombocytopenia. While performing an emergency cesarean section, hemoperitoneum was observed, and the patient delivered a stillbirth. A 6-cm liver rupture at the edges of segments V and VI had occurred, which was sutured and drained. SARS-CoV-2 positivity on reverse transcriptionpolymerase chain reaction was confirmed. Further revisions for intrahepatic hematoma with hemorrhagic shock and abdominal compartment syndrome were performed. Subsequently, the patient developed hemoptysis, which was treated using bronchoscopic therapy and non-invasive ventilation. Liver tissue biopsy revealed hemorrhagic foci and necrosis with an irregular centrilobular distribution. Antiphospholipid syndrome and autoimmune hepatitis were also ruled out. Fetal death was caused by acute intrauterine asphyxia.

14.
Indian Journal of Pharmaceutical Education and Research ; 56(2):S356-S364, 2022.
Article in English | EMBASE | ID: covidwho-1884618

ABSTRACT

Introduction: The meteoric spread of COVID-19 had facilitated the researchers to develop vaccines. One among the most recommended, Covishield requires further investigations for lighting up the society towards the immunization program. The study has determined the severity and frequency of adverse event following immunization concerning the first and booster dose of the Covishield vaccine. Also, we investigated the relationship between the participant’s demographic characteristics with the adverse events encountered due to the two doses. Materials and Methods: An observational cross-sectional study was conducted over 6 months among the individuals who were administered with Covishield vaccine registered via Indian government website, COWIN. Results: The study constituted of 2470 participants among them the frequency of females who received the vaccine (55.18%;62.36%) was more significant than the males, so as the adverse events (Female, first dose: 51.41%, Second dose: 64.92%). We observed participants with chronic diseases (39,5%) and had long term medications (15.57%). Those with age greater than 45 years (61.15%) were discerned by the unfavorable episodes of the vaccine compared to the youngsters. First dose predominantly spawn pain at the injection site (40.15%) whereas, fever (34.72%) was the major concern in the second. The causality assessment scale put forward by World Health Organization stated all the reported adverse events following immunization in the first (62.90%) and the second dose (30.28%) was allied to the same category, consistent causal association to immunization. Conclusion: The safety surveillance study helped in the investigation wherein the adverse event profile of Covishield vaccine was causal or coincidental. We intend the generated data would reduce the fear and augment the acceptance rate of COVID-19 vaccine among the mass population.

15.
Revista Medica de Chile ; 149(6):836-845, 2021.
Article in Spanish | EMBASE | ID: covidwho-1884523

ABSTRACT

Background: Upper limb (UL) function is compromised in university students due to prolonged academic activities and excessive use of electronic devices. However, it is unknown whether this relationship was affected by the COVID-19 pandemic situation. Aim: To determine the risk factors associated with reduced UL functionality in university students in a pandemic situation due to COVID-19. Material and Methods: Cross-sectional study that included 621 university students from the northern, central and southern areas of Chile. Physical variables, musculoskeletal, anthropometric and sociodemographic history were evaluated through self-reported questionnaires. Results: The factors with the higher association with a lower UL functionality were pain (Odds ratio (OR) = 17.6;95% confidence intervals (CI) = 5.2-60;p < 0.01) and injury (OR = 10.4;95% CI = 3.9-28.3;p < .001). Also, a low weight (OR = 10.5;95% CI = 2.2-49.6;p < 0.01) and a quarantine lasting for five or more weeks (OR = 9.1;95% CI = 1,1-77.2;p = 0.043) were considered risk factors. The lower probability was observed in male participants (OR = 0.2;95% CI = 0.1-0.51;p < 0.01) and in those with a moderate/high muscular condition (OR = 0.3;95% CI = 0.1-0.9;p = 0.031. Conclusions: The identification of these modifiable risk factors can help to implement preventive or rehabilitative actions at home or universities.

16.
Revista Medica de Chile ; 149(5):796-802, 2021.
Article in Spanish | EMBASE | ID: covidwho-1884521

ABSTRACT

COVID-19 infection causes a systemic inflammatory response, which mainly presents as a febrile syndrome with respiratory involvement. We report a 37-year-old male who consulted for myalgia, nausea and epigastric pain lasting three days. On admission, he had crepitations at the lung bases. The initial laboratory showed a creatine kinase of 62,768 U/L, a LDH of 1,110 IU/L, a creatinine a 2.1 mg/dL, an aspartate aminotransferase of 1,347 IU/L, a D-dimer of 1,140 ng/mL, a ferritin of 1,201 ng/mL and a lymphocyte count of 810 cells/mm3. The chest CT scan was compatible with multifocal pneumonia, suggesting a COVID-19 infection. COVID-19 PCR was positive. The patient was managed with hydration, sodium bicarbonate, ceftriaxone, and azithromycin, with a good clinical response.

17.
Bangladesh Medical Research Council Bulletin ; 47(1):3-8, 2021.
Article in English | EMBASE | ID: covidwho-1883887

ABSTRACT

Background: Severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) is shaking the world heavily. SARS-COV-2 (COVID-19) infection has a wide variety of presentations as it affects almost every system of body. Gastrointestinal and hepatobiliary symptoms are frequently overlooked especially in children. Objectives: The purpose of this review was to discuss the gastrointestinal and hepatobiliary presentations of COVID-19 in children and compare with non-gastrointestinal presentations. Methods: This study was a narrative review. Recent available literature was searched by keywords. The most recent information from relevant articles were collected and reviewed. This write up was compiled after the review of articles from the last one and half year. Results: About 50.0% symptomatic children with COVID-19 had gastrointestinal manifestations. COVID-19 with gastrointestinal symptoms had delayed diagnosis, delayed hospitalization and worse outcome in compare with Covid-19 with non-gastrointestinal symptoms. Conclusion: Vomiting, diarrhoea, abdominal pain, anorexia, nausea are common gastrointestinal manifestations in children with COVID-19. Elevated transaminasemia is not uncommon.

18.
Current Respiratory Medicine Reviews ; 18(1):65-71, 2022.
Article in English | EMBASE | ID: covidwho-1883805

ABSTRACT

Background: COVID-19 is an infectious disease caused by SARS-CoV-2 and can lead to acute respiratory distress. Objective: We aimed to investigate the association between COVID-19 severity and serum apelin17 and inflammatory mediator levels. Methods: This cross-sectional study was conducted on patients with COVID-19. COVID-19 infection was confirmed by the RT-PCR test. The patients' data were extracted from their records. Venous blood samples were obtained from the patients to investigate the serum levels of apelin-17 and inflammatory mediators. Results: Eighty-six COVID-19 patients were studied. The mean age of the participants was 55.56±14.88, and 43 (50 %) were male. Clinical symptoms were dyspnea 77.6 %, fever 52.3 %, cough 48.8 %, gastrointestinal symptoms 15.1 %, and chest pain 7 %. The overall mortality rate was 7 %. No significant relationship was found between serum apelin-17 levels and COVID-19 severity (P= 0.48). However, there was a significant and direct relationship between COVID-19 severity and serum levels of CRP (P= 0.038) and D-dimer (P= 0.029). Conclusion: Serum apelin-17 levels were higher in recovered patients than those who died (4.90 vs. 3.19). Moreover, serum apelin-17 levels were higher in the patients admitted to the general ward than those admitted to the ICU (5.15 vs. 3.98). The difference was not statistically significant. However, there was a significant and direct relationship between serum apelin-17 levels and lymphocyte count (P= 0.022). Moreover, there was a significant and inverse relationship between lymphocyte count and COVID-19 severity (P= 0.004). Therefore, it can be interpreted that COVID-19 severity may decrease with an increase in serum apelin-17 levels. Therefore, to prove this hypothesis, a study with larger sample size is recommended.

19.
Int J Environ Res Public Health ; 19(11)2022 05 31.
Article in English | MEDLINE | ID: covidwho-1884115

ABSTRACT

There is mounting evidence to suggest that individuals with chronic pain adjusted poorly to and were impacted negatively by social distancing measures during the lockdown. However, there is limited data on the factors that might protect against the negative effects associated with social distancing measures, as most research has been conducted in the general population and in the initial stages of the lockdown. The aim of this study was to improve the understanding of the role that resilience, happiness, and social support, all factors that are thought to have a protective role, played in the psychological function (measured as anxiety, depression, and stress) to the social distancing measures during the late stages of the lockdown in a sample of adults with and without chronic pain living in Spain. A group of 434 adults responded to an online survey and provided information on sociodemographic issues, which included measures of pain, perceived health and quality of life, depression, anxiety, stress, resilience, happiness, and social support. The data showed that individuals with chronic pain (N = 200; 46%) reported statistically significant worst psychological function, that is to say, they reported higher levels of anxiety, depression, and stress (all ps < 0.001). Resilience, social support, and happiness proved to be significant predictors of anxiety, depression, and stress, after controlling for the effects of age, gender, and chronic pain. Although the effect sizes were small to medium, they are consistent with the findings of other studies. The findings from this study provide important additional new information regarding the associations between resilience, happiness, and social support and the adjustment to the social distancing measures during the late stages of the lockdown. These findings can be used to develop programs to improve adjustment to and coping with the demands of social distancing measures.


Subject(s)
Chronic Pain , Resilience, Psychological , Adult , Anxiety/epidemiology , Anxiety/psychology , Chronic Pain/epidemiology , Chronic Pain/psychology , Happiness , Humans , Pandemics , Physical Distancing , Quality of Life , Social Support
20.
Journal of Industrial Integration and Management-Innovation and Entrepreneurship ; 07(02):183-202, 2022.
Article in English | English Web of Science | ID: covidwho-1883313

ABSTRACT

Virtual reality (VR) has applications in cardiology to create enhancement, thereby improving the quality of associated planning, treatment and surgery. The need is to study different applications of this technology in the field of cardiology. We have studied research papers on VR and its applications in cardiology through a detailed bibliometric analysis. The study identified five significant steps for proper implementation of this technology in cardiology. Some challenges are to be undertaken by using this technology, and they can provide some benefits;thus, authors contemplate extensive research and development. This study also identifies 10 major VR technology applications in cardiology and provided a brief description. This innovative technology helps a heart surgeon to perform complex heart surgery effectively. Thus, VR applications have the potential for improving decision-making, which helps save human life. VR plays a significant role in the development of a surgical procedure. This technology undertakes 3D heart model information in full colour, which helps to analyze the overall heart vane, blockage and blood flow. With the help of this digital technology, a surgeon can improve the accuracy of heart surgery, and he can simulate the surgery. A surgeon can undertake surgery in a virtual environment on a virtual patient. The unique purpose of this technology is to practice pre-operatively on the specific circumstance. A cardiologist can also check the proper status of inner and outer heart wall layer. Thus, by using this 3D information, the surgeon can now interact with heart data/information without any physical touch. This technology opens a new opportunity to improve the heart surgery and development in cardiovascular treatment to improve patient outcome.

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