Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 235
Filter
1.
Journal of Pharmaceutical Negative Results ; 13:8176-8179, 2022.
Article in English | EMBASE | ID: covidwho-2206821

ABSTRACT

The Covid-19 pandemic affects maternal health both directly and indirectly, and direct and indirect effects are intertwined. To provide a comprehensive overview on this broad topic in a rapid format behooving an emergent pandemic we conducted a scoping review. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

2.
African Health Sciences ; 22(4):587-596, 2022.
Article in English | EMBASE | ID: covidwho-2202272

ABSTRACT

Background: COVID-19 is caused by a single-stranded novel coronavirus that severely affects the respiratory system. The first human COVID-19 was reported in Wuhan city, China, in December 2019. Closing the gap and enhancing knowledge of pregnant women on COVID-19 prevention methods is crucial. However, the studies conducted in Ethiopia were inconsistent and non-conclusive. So, this review aimed to estimate the pooled knowledge prevalence on prevention of COVID 19 and factors associated among pregnant women in Ethiopia. Method(s): The data were extracted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guide-lines. We accessed studies through electronic web-based search from PubMed, Cochrane Library, and Google Scholar. We did all statistical analyses using STATA version 14 software with a random-effects model. Result(s): Seven studies with 2,594 participants were included in this systematic review and the overall estimated status of assessment of knowledge towards prevention of COVID-19 among pregnant women in Ethiopia was 52.27% (31.60, 68.94). According to the region subgroup analysis, the highest ad the lowest estimated status of the knowledge is 85.34% in Jimma town and 19.01 in Metu town respectively in the Oromia region. Conclusion(s): This systemic review showed that only half of the pregnant women in Ethiopia had good knowledge about COVID-19, and urban residence was significantly associated with knowledge towards the prevention of COVID-19 among pregnant women in this review. So, the responsible body better strengthen their awareness creation among rural residents and old-age pregnant women. Copyright © 2022 Eniyew MA et al. Licensee African Health Sciences.

3.
BMJ open ; 12(12):e068575, 2022.
Article in English | EMBASE | ID: covidwho-2193804

ABSTRACT

OBJECTIVE: To identify independent risk factors for severe COVID-19 in pregnant women and to evaluate the impact of disease severity on preterm birth. DESIGN: A case-control study based on data from a nationwide questionnaire-based survey of maternity services in Japan. SETTING: A questionnaire was mailed to all 2135 delivery institutions in Japan between July and August 2021. A total of 1288 institutions responded (60% of all delivery institutions in Japan). 566 facilities reported having cared for pregnant women with COVID-19, and 722 facilities reported having had no such patients. PARTICIPANTS: One thousand and forty-three hospitalised and non-hospitalised pregnant women diagnosed with COVID-19 between July 2020 and 30 June 2021. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was progression to severe COVID-19. The secondary outcome was preterm birth due to COVID-19 infection. RESULT(S): 56 cases (5.4%) were severe, and 987 (94.6%) were non-severe. Multivariable logistic regression analysis showed that gestational age>=24 weeks (adjusted OR (aOR) 6.68, 95%CI 2.8 to 16.0) and maternal age>=32 years (aOR 2.40, 95%CI 1.3 to 4.3) were independently associated with severe cases. Using the Kaplan-Meier method, the probability of continued pregnancy at 14 days after diagnosis for severe cases was 0.57 between 24 and 31 weeks' gestation and 0.27 between 32 and 36 weeks' gestation. The probability for non-severe cases was 1.0 between 24 and 31 weeks' gestation and 0.8 between 32 and 36 weeks' gestation. Among the patients with COVID-19 in the preterm period, preterm birth due to infection was significantly more common in severe than non-severe cases (48% vs 6%, p< 0.0001). CONCLUSION(S): Severe COVID-19 in pregnant women was associated with gestational age>=24 weeks and maternal age>=32. The rate of preterm delivery due to the infection was significantly higher in severe COVID-19 cases. Copyright © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

4.
Geburtshilfe und Frauenheilkunde ; 82(12):1320-1321, 2022.
Article in German | EMBASE | ID: covidwho-2186335
5.
American Family Physician ; 106(3):1DUIMMY, 2022.
Article in English | EMBASE | ID: covidwho-2168015
6.
Z Gesundh Wiss ; : 1-12, 2022.
Article in English | Web of Science | ID: covidwho-2174452

ABSTRACT

AIM: This study aimed to assess COVID-19 (coronavirus disease 2019)-related attitude and risk perception among pregnant women attending antenatal care, and the associated factors, at public health facilities of the East Gojjam Zone, Ethiopia. SUBJECTS AND METHODS: A multi-center cross-sectional study was conducted, from December 1-30, 2020. A total of 847 pregnant women were included in the study using a simple random sampling technique. To collect the data, we used an interviewer-administered questionnaire. Bi-variable and multi-variable logistic regression analyses were used to identify factors associated with pregnancy-related anxiety. A p-value of < 0.05 with a 95% confidence level was used to declare statistical significance. RESULTS: The magnitude of COVID-19-related positive attitude and high-level risk perception among pregnant women was 51.12% and 37.2% respectively. Having adequate knowledge [AOR: 2.09, 95% CI = (1.49-2.95)], >/= 3 ANC visits [AOR: 1.43, 95% CI = 1.0-1.98], and a low level of risk perception [AOR: 6.27, 95% CI = (4.42-8.89)] were factors associated with a positive attitude of pregnant women with regard to the COVID-19 pandemic. Being urban residents [AOR: 2.24, 95% CI: 1.6-3.10], having wanted pregnancy [AOR: 3.35, 95% CI: 1.18-9.49], having a negative attitude [AOR: 6.21, 95% CI: 4.43-8.70], and a complicated pregnancy [AOR: 1.67, 95% CI: 1.02--2.75] were factors significantly associated with risk perception of pregnant women with regard to the COVID-19 pandemic. CONCLUSIONS: Despite its high fatality, COVID-19 pandemic-related attitude and risk perception among pregnant women were low. As a result, health caregivers and other concerned bodies should consider interventions to improve pregnant women's risk perception and attitude during antenatal care and through various community information platforms. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10389-022-01797-x.

7.
African Journal of Reproductive Health ; 26(10):44-54, 2022.
Article in English | Scopus | ID: covidwho-2164606

ABSTRACT

Antenatal care is vital in improving pregnancy outcomes. It is a vehicle for assisting in the reduction of maternal mortality. For this to be realized, there is a need for antenatal care that is effective, acceptable, and accessible to the users. However, South Africa is faced with challenges that impact the utilization of the service. A descriptive phenomenological design was used to explore the challenges of pregnant women attending antenatal care at selected facilities in Gauteng Province. Data were collected from 14 purposefully selected participants through in-depth individual telephonic interviews. Data analysis was guided by the Colaizzi steps. Credibility, dependability, confirmability, and transferability measures were applied to ensure trustworthiness. Ethical principles were adhered to throughout the study. Three themes emerged: resources and Covid-19-related challenges, overwhelming logistical processes, and suggested recommendations for ANC improvement. Management should provide sufficient resources and counselling services for staff and prioritize antenatal care services. (Afr J Reprod Health 2022;26[10]: 44-54). © 2022, Women's Health and Action Research Centre. All rights reserved.

8.
Journal of Pharmaceutical Negative Results ; 13:135-140, 2022.
Article in English | EMBASE | ID: covidwho-2156356

ABSTRACT

Background: The outbreak of the Covid-19 pandemic in Indonesia impacts women's reproductive health services, including pregnant women services that meet the standard, namely the administration of TT immunization. Officers at the Community Health Center (Puskesmas) are more focused on controlling the spread of COVID-19. The problem that arises due to pregnant women who are not administered Tetanus Toxoid during pregnancy is the occurrence of tetanus in the mother and baby. Objective(s): To determine the relationship between knowledge, attitudes, and support of MCH officers towards the administration of Tetanus Toxoid immunization during the COVID-19 pandemic at UPT PuskesmasPasundan, Garut Regency, for the period of June-July 2021. Method(s): Analytic observational with the cross-sectional approach. The study was conducted from June to July 2021. The population and research sample consisted of 50 people. A questionnaire was used as a research instrument.Analysis: Univariate to explain the research variables and bivariate analysis to explain the relationship between knowledge, attitudes of pregnant women, and the support of MCH officers in administering Tetanus Toxoid immunization during the covid-19 pandemic. Hypothesis testingused a statistical test, namely the Chi-Square test with SPSS 2013, and the significance level was 0.05. Result(s): Relationship between Knowledge and Administration of Tetanus Toxoid Immunization, p-value = 0.015 (p < 0.05). Relationship between Attitude and Administration of Tetanus Toxoid Immunization, p-value = 0.0001 (P <0.05). Relationship between support of MCH officers and Administration of Tetanus Toxoid immunization, p-value = 0.0001 (p < 0.05). Conclusion(s): There is a relationship between knowledge, attitudes, and support of MCH officerstowards the administration of Tetanus Toxoid immunization. It illustrates that the presence of COVID-19 slightly interferes with the administration of TT immunization to pregnant women.Suggestion: It is important to make various efforts and ways to increase the coverage of TT immunization for pregnant women during the covid-19 pandemic. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

9.
European Psychiatry ; 65(Supplement 1):S489, 2022.
Article in English | EMBASE | ID: covidwho-2153971

ABSTRACT

Introduction: Pregnancy and childcare are naturally stressful for women, often accompanied by the asthenic syndrome. In a pandemic situation, this type of stress may be potentiated by external conditions. Objective(s): The study aimed to investigate the life-state orientations and asthenia levels of pregnant women and young mothers in the context of a pandemic. We also analyzed the correlations between the life-state orientations and the different types of asthenias. Method(s): Data collection was carried out in June 2020 using a Google form that we developed. Pregnant women and young mothers with children under seven years of age participated in the study with 47 respondents. We used the Purpose-in-Life Test to investigate the meaningful orientations and the MFI-20 to determine the level of asthenia. Both questionnaires were adapted for use in Russia. Result(s): We found that the mean overall MFI-20 score (M = 58.0+/-5.9) exceeded the mean values in our sample, indicating the presence of the asthenic syndrome. Physical asthenia (M = 12.9+/-1.4) and decreased activity (M = 12.0+/-1.7) were the strongest, with the lowest score on the general asthenia scale (M = 10.6+/-1.8). Correlation analysis showed that all components of meaningful orientations had multiple positive correlations with different types of asthenias, and the overall asthenia score was 100 % related to life meaningfulness (p < 0.01). Conclusion(s): Pregnant women and young mothers are at risk for asthenia in the COVID-19 pandemic. This is obviously due to many responsibilities of mothers raising children.

10.
BMJ Innovations ; 8(4):247-254, 2022.
Article in English | EMBASE | ID: covidwho-2137664

ABSTRACT

Introduction The delay in seeking emergency obstetric care leads to significant maternal morbidity and mortality and can worsen during pandemics, especially in humanitarian conflict settings with low uptake of obstetric services. To mitigate the challenges related to the second delay caused by lack of transport in the COVID-19 pandemic, the organisation United Nations Population Fund implements a community-based referral project called Referral Hub in the Rohingya refugee population in Bangladesh. The objective of the paper is to describe the implementation process of the Referral hub and present clients' utilisation and perception of the service. Methods Findings from part of a larger mixed-method study, the analysis of the standard operating protocol of the intervention, secondary data of routine utilisation of the 12 referral hubs between January and August 2020, 21 key informant interviews and a community survey among 100 pregnant women are presented in this paper. Results The findings show an increasing trend in the referral hub utilisation and a strong recommendation of the service. Conclusion Due to a robust referral mechanism by collaborating with the community and engaging accessible and free of cost transport service, the intervention has high potential to improve access to facility care in low-resource and humanitarian contexts, especially during pandemics. Copyright ©

11.
New Armenian Medical Journal ; 16(2):25-32, 2022.
Article in English | EMBASE | ID: covidwho-2067787

ABSTRACT

Objectives: to assess the effect-related inflammatory and coagulation biomarkers in pregnancy and their connection with the coronavirus disease of 2019 (COVID-19). Method(s): A prospective case-control study was carried out among normal third-trimester pregnant women admitted to the labor room of Dr. Soetomo General Academic Hospital between January until June 2021. Two classified groups of patients were established in accordance with the result of the RT-PCR test. Demographic, clinical and laboratory results data of the two groups were collected and compared. Result(s): Platelet-to-lymphocyte ratio (PLR) was shown to be the only significant biomarkers found in the expectant with COVID-19, which was 35.8% higher compared to the ones free of COVID-19 [212.25 (157.57-269.37) vs 156.29 (128.55-195.3), p=0.048]. Logistic regression analysis of PLR between groups showed that the level of PLR was an independent factor in pregnant women with COVID-19 (OR 4.483, 95%CI 1.262-15.926). The ROC analysis showed that the PLR cut-off among the expectant was 171.335, with both sensitivity and specificity were 66.7% (p=0.021). The result shows no significant differences in leukocyte count, absolute neutrophils - lymphocyte count and percentage, neutrophil-to-lymphocyte ratio (NLR) and D-Dimer level between pregnant women infected with COVID-19 and free of the virus (p>0.05). Conclusion(s): Intriguingly, physiological adaptation during the course of the third trimester of pregnancy found no difference in most inflammation and coagulation markers, both in the condition of infected COVID-19 or not. The evidence from this single-centre study supports the viewpoint that elevated PLR was associated with independent biomarkers and thereby might be helpful to detect expectant with COVID-19. Copyright © 2022, Yerevan State Medical University. All rights reserved.

12.
Italian Journal of Gynaecology and Obstetrics ; 34(3):235-242, 2022.
Article in English | EMBASE | ID: covidwho-2067680

ABSTRACT

Objective. The lockdown due to COVID-19 has been associated with a reduction of physical activity and a change in eating behaviors, with consequent weight gain, in general and specific populations. The objective of this study was to assess whether women whose pregnancies encompassed the lockdown due to COVID-19 in 2020 had an excess gestational weight gain as compared with those who were pregnant in the same periods of previous years. Materials and Methods. This was a retrospective cohort study based on anony-mous data from the Birth Attendance Certificate (CedAP) information flow which is mandatorily collected in all Italian Regions. In the Autonomous Province of Trento, North-Eastern Italy, more information than those required as a minimum data set are collected, including maternal weight at the first gestational obstetric visit, initial body mass index (BMI), and maternal weight at delivery. We calculat-ed mean gestational weight gain for women whose pregnancy encompassed the 2-month lockdown in 2020 and for those who were pregnant in corresponding periods of the years 2016-2019. Linear and logistic regression models were built to assess the association between lockdown and weight gain or excess weight gain, respectively, adjusting for the potential confounding effect of gestational month at the beginning of lockdown or corresponding period and pre-pregnancy body mass index. Results. In 2020, mean gestational weight gain was not significantly different from the previous years, nor was the likelihood of gaining excess weight. Conclusions. Unlike other populations that increased weight during the COVID-19 lockdown, the Italian population of pregnant women described in this study has a gestational weight gain comparable with that of the previous years. Public health and environmental interventions, as well as dedicated programs taking care of women from conception to post-partum may have a role in the health of future mothers and should be promoted.

13.
Italian Journal of Gynaecology and Obstetrics ; 34(3):172-179, 2022.
Article in English | EMBASE | ID: covidwho-2067679

ABSTRACT

Radiologic imaging in the evaluation of pregnant patients has significantly grown with the outbreak of the severe acute respiratory syndrome related to SARS-CoV-2 pandemic. Lung ultrasound is an emerging non-invasive bedside technique used to diag-nose interstitial lung syndrome through evaluation and quantitation of the number of B-lines, pleural irregularities and nodules or consolidations. In pregnant COVID-19 patients, lung ultrasound should be considered on ac-count of its various strengths, such as its being easily carried out bedside by trained sonographers for the monitoring of lung involvement in follow-ups, and its repeatability and affordability. However, pregnant patients could need chest radiography or computed tomo-graphic (CT) examinations for the diagnosis of pneumonia. Concerns and mis-conceptions about potential radiation-related risks for the embryo or fetus are still widespread among clinicians and can lead to excessive anxiety among pa-tients. Several well-recognized guidance documents were published in the last years as to the safety of a single-phase CT or an X-ray chest and related carcino-genic and teratogenic risk. This paper summarizes the safety of radiological examination for pneumonia in pregnant women affected by COVID 19, based on the estimated embryo-fetal radiation absorption per procedure (mGy).

14.
Turkiye Klinikleri Journal of Medical Sciences ; 42(3):204-212, 2022.
Article in English | EMBASE | ID: covidwho-2067037

ABSTRACT

Objective: To investigate the attitudes of health care professionals involved within the coronavirus disease-2019 (COVID-19) pandemic process towards the COVID-19 vaccine in line with their demographic characteristics. Material(s) and Method(s): A questionnaire consisting of 16 questions was conducted to 510 healthcare professionals working in Inegol State Hospital between December 2021-January 2022 and who agreed to participate in the study, to determine their approach to the COVID-19 vaccine. The data were collected with Student's t-test and Mann-Whitney U Test. Chi-square test was used in comparison of categorical variables. Result(s): While 54.3% of the respondents said that they don't want to have the COVID-19 vaccine, 69% answered that "Since there is not any adequate research on the vaccine, the vaccine is not reliable". Were observed that vaccine rejection was most common in the 20-29 age group (72.7%) and pregnant women (100%). In addition, as the education level increased, the number of people considering vaccination increased. The desire to be vaccinated was seen more in married, and it was noted that non-smokers had more COVID-19 (80.3%). Conclusion(s): Healthcare professionals who participated in study were found to have a negative attitude towards COVID-19 vaccine. Although healthcare professionals have hesitations about vaccine, in fact, noteworthy that they're afraid of the disease (43.8%). Despite of the pandemic, more than half (54.3%) of healthcare professionals working in Inegol State Hospital stated that they didn't think about getting a COVID-19 vaccine. Providing hospital staff with more education about the safety, efficacy, and value of currently available COVID-19 vaccines is critical to vaccine acceptance in this population. Copyright © 2022 by Turkiye Klinikleri.

15.
Journal of Acute Disease ; 11(4):120-126, 2022.
Article in English | EMBASE | ID: covidwho-2066823

ABSTRACT

Unbalanced magnesium levels in the body, like other minerals, are a factor that is important in the severity and mortality of COVID-19. This study was designed to investigate the relationship between serum magnesium levels and clinical outcomes in COVID-19 patients. In this systematic review, a comprehensive search was performed in PubMed, Scopus, and Web of Science databases until September 2021 by using the keywords COVID-19, severe acute respiratory syndrome coronavirus 2, coronavirus disease, SARS- COV-infection 2, SARS-COV-2, COVID 19, and magnesium. End-Note X7 software was used to manage the studies. Articles that evaluated effect of magnesium on COVID-19 were included in the analysis. After reviewing several articles,12 studies were finally included in the ultimate analysis. The studies show that hypomagnesemia and hypermagnesemia are both factors that increase mortality in patients with COVID-19, even in one study, hypomagnesemia is the cause of doubling thedeaths in COVID-19 patients. Some studies have also found a negative correlation between magnesium deficiency and infectionseverity, while some others have reported no correlation between magnesium level and disease severity. According to the important role of magnesium in the body and its involvement in many physiological reactions, as well as differences in physical and physiological conditions of COVID-19 patients, in addition to the need for studies with larger sample sizes, monitoring and maintaining normal serum magnesium levels during the disease seems necessary as a therapeutic target, especially in patients admitted to the intensive care unit.

16.
Open Access Macedonian Journal of Medical Sciences ; 10:1946-1949, 2022.
Article in English | EMBASE | ID: covidwho-2066707

ABSTRACT

Physiological changes during pregnancy and COVID-19 may affect one another. This report presents a 37-year-old female G4P10021 with gestational age 37+2 weeks infected with COVID-19 in Dr. Moewardi Hospital Surakarta, Central Java, Indonesia. The patient was diagnosed with antepartum hemorrhage due to total placenta previa with low-risk Morbidly Adherent Placenta score, a history of cesarean section, and ovarian cyst. The patient underwent conversion from spinal anesthesia to general anesthesia. Within 40 min after spinal anesthesia, the patient complained shortness of breath, which then worsened into decreased consciousness and inadequate spontaneous breathing. This may be complicated by the COVID-19 infection which has several effects on pregnancy.

17.
Open Access Macedonian Journal of Medical Sciences ; 10:644-648, 2022.
Article in English | EMBASE | ID: covidwho-2066695

ABSTRACT

BACKGROUND: In the COVID-19 pandemic situation, there are almost all routine services including maternal and newborn health services. For example, pregnant women are reluctant to go to the community health center or other facilities for fear of being infected and services delay pregnancy checks and classes for pregnant women. This causes maternal and newborn health services to be one of the services affected, both in terms of access and quality. Therefore, in improving maternal health, literacy about COVID-19 and Antenatal Care (ANC) services are needed during the adaptation period of the COVID-19 period. The general purpose of the study was to determine the effectiveness of providing literacy about COVID-19 on the compliance of pregnant women in conducting ANC in Pematangsiantar City. AIM: The specific objectives of the study were to determine the level of health literacy about COVID-19 in pregnant women, to know the coverage of ANC during the COVID-19 pandemic, and to analyze the effectiveness of providing literacy about COVID-19 on the compliance of pregnant women with ANC in Pematangsiantar City. METHODS: This research used a quasi-experimental design by providing literacy about COVID-19 and ANC to pregnant women. Literacy ability was assessed using a 16-item S-HLS-EU-Q questionnaire with a Likert scale. The number of samples in this study was 33 for the intervention group and 33 for the control group. Consecutive sampling and data analysis using the Chi-square test using the Statistical Package and Service Solutions version 25.0 application. RESULTS: The results of the study were 33 respondents in the intervention group, all of whom had high literacy about the health-care domain. While in the control group, only 75.8% had high literacy. The results of Fisher’s test showed p = 0.005. In the intervention group, 97% of the disease prevention domain had high literacy, and in the control group, there were 84.8% who had high literacy. The results of Fisher’s test showed p = 0.197. In the intervention group, the domain of health promotion overall had high literacy, and in the control group, there were 84.8% who had high literacy. Fisher’s test results show p = 0.053. CONCLUSION: The results, based on research, need to be made efforts to overcome the compliance of pregnant women in implementing an ANC.

18.
Open Access Macedonian Journal of Medical Sciences ; 10:1914-1921, 2022.
Article in English | EMBASE | ID: covidwho-2066688

ABSTRACT

BACKGROUND: The fluctuating COVID-19 cases among the pregnant women’s population encountered increased of cases and maternal mortality. AIM: This research aimed to describe the case of maternal deaths caused by COVID-19. CASE REPORT: We present nine serial cases of maternal death caused by COVID-19 who were admitted to Dr. Soetomo General Academic Hospital for 14 days in June. We found 32 positive COVID-19 obstetric cases and reported nine maternal deaths with a fatality rate of up to 28%. Seven of nine patients had reverse transcription-polymerase chain reaction–confirmed SARS-CoV-2 infection, while two had a positive antigen swab. Half of the patients ≥35 years old, and five of nine patients had Class I obesity as preexisting comorbidity. This study reported the death of pregnant woman at their 2nd trimester and 3rd trimester presenting infected by severe COVID-19. The usual symptoms are dyspnea, cough, fever, and decreased consciousness. The result of chest X-ray examination among eight patients showed bilateral pneumonia. Most of cases were referrals from a secondary hospital due to overload hospital capacity. Three patients were directly transferred to the tertiary hospital without receiving initial treatment. Eight of 9 patients (88.9%) were transferred to intensive care unit and intubated due to low oxygen saturation. CONCLUSION: In conclusion, the limited hospital facility and lack of intensive care capacity for obstetric cases during the second wave of the COVID-19 pandemic may enhance the probability of mortality and morbidity in pregnant women infected by COVID-19.

19.
Open Access Macedonian Journal of Medical Sciences ; 10:217-221, 2022.
Article in English | EMBASE | ID: covidwho-2066680

ABSTRACT

INTRODUCTION: The first data for COVID-19 in pregnancy showed mild-to-moderate forms of the disease while the current data speak of severe forms in these subjects. Here, we present a case of a severe form of COVID-19 in a gemelar pregnant woman complicated with pneumomediastinum and pneumothorax, during her hospital stay, in a late stage of disease. CASE PRESENTATION: A 38-year-old multiparous woman was referred to university hospital at 25 weeks of gemelar pregnancy. On admission, the patient presented with signs of moderate respiratory insufficiency, which after 12 h progressed further to severe ARDS. She tested positive for SARS-CoV-2 on quantitative real-time polymerase chain reaction. Under these conditions, it was decided that the patient undergoes a cesarean section for termination of pregnancy. Remdesivir 200 mg/day and tocilizumab 8 mg/kg were administered, based on national guidelines. The patient’s fever subsided, but her SpO2 remained at 94%, even with a 15 L/min oxygen mask. After 12 days, the patient complains of a severe back pain and her respiratory condition rapidly worsened and reduced saturations up to 80% being under O2 therapy with facial mask with 15 l/min. Chest CT findings confirmed pneumomediastinum and pneumothorax, which deteriorated the patient’s status. Thereafter, tube thoracostomy was performed. There was a clinical and ABG analysis parameter’s improvement. The patient was discharged 34 days after cesarean delivery with a proper general health. CONCLUSION: Our case highlights even more convincingly the fact that, in pregnancy, can be severe to life-threating forms of COVID-19. Pneumothorax and pneumomediastinum are complications that can be encountered even in the late stages of severe forms cases with COVID-19 in pregnancy. Early diagnosis of these complications is essential in adequate management and treatment to avoid fatal outcome.

20.
Open Access Macedonian Journal of Medical Sciences ; 10(C):246-251, 2022.
Article in English | EMBASE | ID: covidwho-2066676

ABSTRACT

BACKGROUND: Pregnancy state affects the immune regulation including physical barrier, innate, and adaptive immunity-related to susceptibility of infections and increasing risk for severe to critical case of COVID-19. Further, high risk of thrombosis becomes a challenge in the management of COVID19 in pregnancy due to the strong association with worse outcome. CASE REPORT: Here, we present three cases of pregnant women infected with COVID-19 pneumonia with different outcomes in maternal and fetal condition related to high-risk thrombosis. Serial inflammatory markers were needed to the early detect the disease progressivity in pregnant women with COVID-19. Further, complete assessment of fetus including reverse transcriptase-polymerase chain reaction and chest X-ray must be performed to the early diagnosis of COVID-19 in neonatal whose mother was infected by SARS-CoV-2. CONCLUSION: Pregnancy state affects the immune regulation including physical barrier, innate, and adaptive immunity-related to susceptibility of infections and increasing risk for severe to critical case of COVID-19. Further, high risk of thrombosis becomes a challenge in the management of COVID19 in pregnancy due to the strong association with worse outcome. Although fetal transmission of COVID-19 to fetus remains unclear, complete assessment of fetus including RT-PCR, and chest X-ray must be performed to the early diagnosis of COVID-19 in neonatal whose mother was infected by SARS-CoV-2.

SELECTION OF CITATIONS
SEARCH DETAIL