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1.
Telehealth and Medicine Today ; 7(3), 2022.
Article in English | ProQuest Central | ID: covidwho-2026497

ABSTRACT

Remote patient monitoring (RPM) programs have been shown to effectively decrease rates of healthcare utilization among patients with chronic conditions. Immediately enrolling a patient and activating them in the RPM program either upon or soon after discharge is an important step in achieving these benefits. We tested interventions across three Plan-Do-Study-Act quality improvement cycles to understand the extent to which operational improvements would lead to timely activation. Each improvement cycle resulted in decreased time to activation, with the cumulative effect (as applied to patients on the COVID-19 RPM program) resulting in a reduction that was overall greater than the sum of the individual improvements. As additional healthcare systems develop and deploy RPM programs, the learnings from this project can help to provide insight into the operational and logistical challenges encountered in providing these services as well as potential interventions that can be used to achieve timely activation.

3.
Pharmaceutical Technology ; 45(11):34-40, 2021.
Article in English | EMBASE | ID: covidwho-1935337
4.
J Thorac Dis ; 14(6): 1794-1801, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1934830

ABSTRACT

Background: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory coronavirus-2 (SARS-CoV-2) has placed enormous diagnostic burden on hospitals and testing laboratories. It is thus critical for such facilities to optimize the diagnostic process to enable maximum testing on minimum resources. The current standard of diagnosis is the detection of the viral nucleic acid in clinical specimens. Methods: In order to optimize the laboratory's nucleic acid testing system for COVID-19, we performed a Discrete-Event-Simulation using the Arena Simulation Software to model the detection process based on the data obtained from the First Affiliated Hospital of Guangzhou Medical University (FAHGMU). The maximum of total time that specimens spent and the equipment consumption was compared under different scenarios in the model. Results: Seven scenarios were performed to simulate actual situation and improved situations. We analyzed conditions that adding a new nucleic acid extraction system (NAES), shifting a member from night duty to morning duty, using specimen tubes containing guanidine isothiocyanate (GITC), then tested the maximum testing capacity in the current number of technicians. In addition, the costs including personal protective equipment (PPE) and testing kits was calculated. Conclusions: A work schedule based on specimen-load improves efficiency without incurring additional costs, while using the specimen tubes containing GITC could reduce testing time by 30 min. In contrast, adding new NAESs or polymerase chain reaction (PCR) instruments has minimal impact on testing efficiency.

5.
2021 IEEE 13th International Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment, and Management, HNICEM 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1788676

ABSTRACT

The Philippines' Land Transportation Office (LTO) has the task of evaluating and processing citizen's applications for driver's license for professional and non-professional purposes. The office sees many customers each day and the need for an efficient waiting sitting was needed. Several process optimization and productivity improvements will be discussed in this research. Improvements along the lines of robotic process optimization, social media bots, existing efficient and effective processes, and the like, will be considered in developing suggestions for optimizing waiting line management in the LTO. In addition, existing congestion surveillance methods are explored to consider more solutions. The LTO currently implements a multi-channel, multi-phase line management system for all branches in the country. The research aims to evaluate its effectiveness in processing new driver's license applications in the National Capital Region within a set period of days. The system has proven inefficient based on recent data taken between 2019-2020 [1], even considering the decline in applications because of the COVID-19 pandemic. There is an expected spike in citizens applying for driver's licenses once the quarantine restrictions are lifted entirely, and an effective waiting line management system will be needed. A solution can be created by taking inspiration from efficient process systems from the United States and United Kingdom. © 2021 IEEE.

6.
2021 International Conference on Optoelectronic Materials and Devices, ICOMD 2021 ; 12164, 2022.
Article in English | Scopus | ID: covidwho-1735988

ABSTRACT

Isopropanol is an extremely widely used chemical product. With the outbreak of COVID-19 worldwide, the export demand of isopropanol keeps increasing, and the supply is in short supply. In order to meet the demand of isopropyl alcohol in the international market, the existing production process faces new challenges and needs to be improved and upgraded. In this design, Aspen Plus was used to simulate the existing hydrogenation process of acetone to isopropanol, and it was improved and optimized to establish an annual output of 5 kT isopropanol and a variety of by-products of different specifications. The process adopts double-effect distillation and heat pump distillation to reduce energy consumption, and a set of waste liquid recovery device is designed to effectively recover the by-products and achieve the purpose of improving economic benefits. Simulation results of Aspen Plus show that energy consumption, carbon emission, water consumption and solid waste utilization rate can be reduced by 36.73%, 40%, 45% and 80% respectively, meeting the requirements of “Made in China 2025”. © 2022 SPIE. All rights reserved.

7.
Nanomaterials (Basel) ; 11(12)2021 Nov 23.
Article in English | MEDLINE | ID: covidwho-1598768

ABSTRACT

An automatic lab-scaled spray-coating machine was used to deposit Ag nanoparticles (AgNPs) on textile to create antibacterial fabric. The spray process was monitored for the dual purpose of (1) optimizing the process by maximizing silver deposition and minimizing fluid waste, thereby reducing suspension consumption and (2) assessing AgNPs release. Monitoring measurements were carried out at two locations: inside and outside the spray chamber (far field). We calculated the deposition efficiency (E), finding it to be enhanced by increasing the spray pressure from 1 to 1.5 bar, but to be lowered when the number of operating sprays was increased, demonstrating the multiple spray system to be less efficient than a single spray. Far-field AgNPs emission showed a particle concentration increase of less than 10% as compared to the background level. This finding suggests that under our experimental conditions, our spray-coating process is not a critical source of worker exposure.

8.
J Med Internet Res ; 23(6): e27348, 2021 06 07.
Article in English | MEDLINE | ID: covidwho-1259301

ABSTRACT

BACKGROUND: Overcoming the COVID-19 crisis requires new ideas and strategies for online communication of personal medical information and patient empowerment. Rapid testing of a large number of subjects is essential for monitoring and delaying the spread of SARS-CoV-2 in order to mitigate the pandemic's consequences. People who do not know that they are infected may not stay in quarantine and, thus, risk infecting others. Unfortunately, the massive number of COVID-19 tests performed is challenging for both laboratories and the units that conduct throat swabs and communicate the results. OBJECTIVE: The goal of this study was to reduce the communication burden for health care professionals. We developed a secure and easy-to-use tracking system to report COVID-19 test results online that is simple to understand for the tested subjects as soon as these results become available. Instead of personal calls, the system updates the status and the results of the tests automatically. This aims to reduce the delay when informing testees about their results and, consequently, to slow down the virus spread. METHODS: The application in this study draws on an existing tracking tool. With this open-source and browser-based online tracking system, we aim to minimize the time required to inform the tested person and the testing units (eg, hospitals or the public health care system). The system can be integrated into the clinical workflow with very modest effort and avoids excessive load to telephone hotlines. RESULTS: The test statuses and results are published on a secured webpage, enabling regular status checks by patients; status checks are performed without the use of smartphones, which has some importance, as smartphone usage diminishes with age. Stress tests and statistics show the performance of our software. CTest is currently running at two university hospitals in Germany-University Hospital Ulm and University Hospital Tübingen-with thousands of tests being performed each week. Results show a mean number of 10 (SD 2.8) views per testee. CONCLUSIONS: CTest runs independently of existing infrastructures, aims at straightforward integration, and aims for the safe transmission of information. The system is easy to use for testees. QR (Quick Response) code links allow for quick access to the test results. The mean number of views per entry indicates a reduced amount of time for both health care professionals and testees. The system is quite generic and can be extended and adapted to other communication tasks.


Subject(s)
COVID-19/diagnosis , COVID-19/psychology , Communication , Medical Informatics/organization & administration , Medical Informatics/standards , Pandemics , Patient Participation , SARS-CoV-2/isolation & purification , COVID-19/epidemiology , COVID-19/virology , Germany , Humans , Time Factors
9.
Appl Microbiol Biotechnol ; 105(4): 1421-1434, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1052958

ABSTRACT

Similar to the recent COVID-19 pandemic, influenza A virus poses a constant threat to the global community. For the treatment of flu disease, both antivirals and vaccines are available with vaccines the most effective and safest approach. In order to overcome limitations in egg-based vaccine manufacturing, cell culture-based processes have been established. While this production method avoids egg-associated risks in face of pandemics, process intensification using animal suspension cells in high cell density perfusion cultures should allow to further increase manufacturing capacities worldwide. In this work, we demonstrate the development of a perfusion process using Madin-Darby canine kidney (MDCK) suspension cells for influenza A (H1N1) virus production from scale-down shake flask cultivations to laboratory scale stirred tank bioreactors. Shake flask cultivations using semi-perfusion mode enabled high-yield virus harvests (4.25 log10(HAU/100 µL)) from MDCK cells grown up to 41 × 106 cells/mL. Scale-up to bioreactors with an alternating tangential flow (ATF) perfusion system required optimization of pH control and implementation of a temperature shift during the infection phase. Use of a capacitance probe for on-line perfusion control allowed to minimize medium consumption. This contributed to a better process control and a more economical performance while maintaining a maximum virus titer of 4.37 log10(HAU/100 µL) and an infectious virus titer of 1.83 × 1010 virions/mL. Overall, this study clearly demonstrates recent advances in cell culture-based perfusion processes for next-generation high-yield influenza vaccine manufacturing for pandemic preparedness. KEY POINTS: • First MDCK suspension cell-based perfusion process for IAV produciton was established. • "Cell density effect" was overcome and process was intensified by reduction of medium use and automated process control. • The process achieved cell density over 40 × 106 cells/mL and virus yield over 4.37 log10(HAU/100 µL).


Subject(s)
Influenza A Virus, H1N1 Subtype/physiology , Virus Cultivation/methods , Virus Replication/physiology , Animals , Bioreactors , Dogs , Madin Darby Canine Kidney Cells
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