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1.
Heliyon ; : e12744, 2022.
Article in English | ScienceDirect | ID: covidwho-2165334

ABSTRACT

SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection and replication. If druggable, host factor dependencies may present an attractive strategy for anti-viral therapy. In this study, we performed genome wide CRISPR knockout screens in Vero E6 cells and four human cell lines including Calu-3, UM-UC-4, HEK-293 and HuH-7 to identify genetic regulators of SARS-CoV-2 infection. Our findings identified only ACE2, the cognate SARS-CoV-2 entry receptor, as a common host dependency factor across all cell lines, while other host genes identified were largely cell line specific, including known factors TMPRSS2 and CTSL. Several of the discovered host-dependency factors converged on pathways involved in cell signalling, immune-related pathways, and chromatin modification. Notably, the chromatin modifier gene KMT2C in Calu-3 cells had the strongest impact in preventing SARS-CoV-2 infection when perturbed.

2.
Abu Dhabi International Petroleum Exhibition and Conference 2022, ADIPEC 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2162747

ABSTRACT

Low oil prices, coupled with operational challenges in offshore environment due to COVID-19 restrictions, have driven oil and gas operators to implement low-cost technological solutions to optimize fields' production. For mature oil fields in offshore East Malaysia, sand production has become one of the onerous challenges that requires this approach. Sand production is known to adversely affect the well deliverability and it also contributes to safety concerns due to surface flowline leak and equipment failure. Hence, it is of upmost importance for operators to address the sand production downhole. To achieve this, through-tubing sand screens (TTSS) installation is opted due to its ease of installation and low-cost slickline operation. Although there have been many TTSS installations to date, there is still limited understanding of the factors that affect TTSS lifespan, and this has led to frequent TTSS changeout. Based on the operator's experience, TTSS lifespan can vary significantly across different wells ranging from just a few days to years of production. To improve the understanding of TTSS performance with the aim to increase TTSS longevity, a comprehensive study on potential contributing factors has been conducted by analyzing the past TTSS installations. Over the years, there were more than 75 TTSS installations performed in oil fields offshore East Malaysia. Lookback analysis was conducted to evaluate the effectiveness of TTSS as remedial downhole sand control and investigate the factors affecting TTSS performance such as TTSS type, well production rates, TTSS deployment method, installation depth relative to perforation interval and well interruption frequency. Several criteria identified as the key performance indicators have been investigated to evaluate the performance of each TTSS installation, including the well flowing parameters, production uptime and sand production trend. Thorough study across different TTSS installations has concluded that TTSS lifespan varies according to well properties and well operating parameters. This paper presents best practices and lessons learnt from past installations to predict and improve the mean time between failures (MTBF) for TTSS. Case studies for several wells have been scrutinized to highlight the learnings for further enhancement of TTSS lifespan. Additionally, recommendations for further research and development of erosion resistant TTSS technology are also discussed. Copyright © 2022, Society of Petroleum Engineers.

3.
5th International Conference on Information Science and Systems, ICISS 2022 ; : 43-48, 2022.
Article in English | Scopus | ID: covidwho-2162027

ABSTRACT

With the development of multimedia technology, people have fully enjoyed the pleasure of audio and video and start to pursue the immersion of multi-sensory interactive experience. Touching is the third interactive media after vision and hearing. We are eager to touch our loved ones remotely, not just through a cold screen to video them, especially during the COVID-19 epidemic. Operating the remote robot, We want to get tactile feedback without time delay as if we were there so as to complete the task better. We hope that the material of the scene can be felt and we can enjoy patting shoulders and clapping hands with each other. Therefore, it is necessary to build a new basic communication in the digital world, enabling low latency end-to-end transmission of tactile information and making our communication interaction warm and emotional. This paper presents an overview of the latest research progress of tactile communication from end-to-end. This paper briefly describes the tactile communication system, studies the current status of acquisition, display, compression and transmission of tactile data, analyzes application scenarios of tactile communication. Finally, the paper provides a conclusion and prospects the next research directions. It is hoped that this review can provide some insights into future research on tactile communication. © 2022 ACM.

4.
4th IEEE Eurasia Conference on Biomedical Engineering, Healthcare and Sustainability, ECBIOS 2022 ; : 241-244, 2022.
Article in English | Scopus | ID: covidwho-2161390

ABSTRACT

Because of the prevalence of COVID-19, medical capacity reduction, and inconvenience due to epidemic prevention policies, the development of telemedicine has been emphasized. An AI sensing device (i.e., Azure Kinect DK) with a mixed reality device (i.e., HoloLens 2) and window application are combined to design a system that completes the consultation process from a distance. This registering system uses an SQL server database, which reads the data of registered patients, selects the registration time and department on its own, and converts the data by PC/SC with an ISO7816 database. For the window application, the patient side screen and audio content for the window screen are captured through the lens and microphone array of Azure Kinect DK. HoloLens 2 is used as the main device on the doctor's side to design the window application for dictating case conversion and transmission, whereas the Unity engine is used to create mixed-reality scenes for viewing medical records and photos of patients. In the consultation part, doctor and patient devices use Dynamic 365 Assist to conduct video consultations via Microsoft Teams, transforming the traditional consultation form into a remote consultation service via the Internet. The consultation process records the consultation data by voice and then the prescription by Speech to Text and Azure cognitive voice service. It is expected to develop a hybrid-reality telemedicine system and combine metaverse-related technologies for more online interactive service functions. The future development goal is to integrate the virtual reality rehabilitation training system further to make the application of telemedicine more complete. © 2022 IEEE.

5.
24th ACM International Conference on Multimodal Interaction, ICMI 2022 ; : 591-596, 2022.
Article in English | Scopus | ID: covidwho-2153120

ABSTRACT

Gaze-based interaction has until now been almost an exclusive prerogative of the assistive field, as it is considered not sufficiently performing compared to traditional communication methods based on keyboards, pointing devices, and touch screens. However, situations such as the one we are experiencing now due to the COVID-19 pandemic highlight the importance of touchless communication, to minimize the spread of the disease. In this paper, as an example of the potential pervasive use of eye tracking technology in public contexts, we propose and study five interfaces for a gaze-controlled scale, to be used in supermarkets to weigh fruits and vegetables. Given the great heterogeneity of potential users, the interaction must be as simple and intuitive as possible and occur without the need for calibration. The experiments carried out confirm that this goal is achievable and show strengths and weaknesses of the five interfaces. © 2022 ACM.

6.
Int J Environ Res Public Health ; 19(21)2022 Nov 02.
Article in English | MEDLINE | ID: covidwho-2099505

ABSTRACT

Mandatory home isolation caused by COVID-19 in professional contexts led to a situation that required work activities to be converted into a remote modality. The literature on this topic is very recent, given the pandemic and the uncertainty of virtual and face-to-face work modalities. This study aimed to examine the effects of adults' prolonged exposure to screens on sleep quality, the type of devices used according to age and gender, periods of access to such devices and the impact on performance in the context of telework due to COVID-19. Specifically, the study analyzed the differences in the use of devices and in the time spent using them during and after teleworking between genders and age groups. A total of 127 Portuguese participants answered the Pittsburgh Sleep Quality Index and a questionnaire that we specifically developed to characterize teleworking habits. The results showed differences between men and women regarding the use of devices and its impact on sleep quality, as well as differences in terms of age. These results are discussed in terms of how the current work context may affect performance, sleep, gender differences and the adverse effects of exposure to screens during and after work hours.


Subject(s)
COVID-19 , Sleep Wake Disorders , Adult , Female , Humans , Male , Teleworking , COVID-19/epidemiology , Pandemics , Sleep , Sleep Wake Disorders/epidemiology
7.
2022 IEEE World Conference on Applied Intelligence and Computing, AIC 2022 ; : 326-331, 2022.
Article in English | Scopus | ID: covidwho-2051922

ABSTRACT

Medical images such as X-Ray images, Mammograms and Ultrasound images are very useful diagnostic techniques used for understanding the functions of different internal organs, bones, tissues, etc. Most of the times these medical images are degraded by some noises and different kinds of blur. Image blurring and degradation leads to loss of quality of images which in hand causes difficulty in proper diagnosis. This paper emphases on the efficacy of Wiener filter in image de blurring and denoising Chest X-Ray of Covid-19 patients, ultrasound images of fetal abdominal cyst, umbilical cord cyst and Common Carotid Artery, Mammogram of both pathological and non-pathological breasts. Performance of Wiener filter is analyzed using image restoration parameters like Structural Similarity (SSIM), Histogram, Peak Signal to Noise Ratio and Mean Square Error. © 2022 IEEE.

8.
3rd International Conference on Intelligent Engineering and Management, ICIEM 2022 ; : 75-80, 2022.
Article in English | Scopus | ID: covidwho-2018842

ABSTRACT

A chatbot is a software that produces a computer model of conversation through auditory or textual method between the user and the computer. Such bots use AI and NLP to understand user's questions and automate responses to them, simulating human conversation. In this modern technology almost, every person utilize smartphones in their day to day lives. Simply because, it has made life of a person simple by the touch of the screen, from extracting information from the internet, to provide personal assistance to entertainment everything happens just by the click of a button. Today Chatbots are used in various domains like education, customer service, medical, website help etc for seeking information, FAQ answering and guidance. Due to the advancements in AI and techniques used in data mining, healthcare chatbots are often used for medical screening. The aim of this paper is to do detailed study of various research papers related to chatbots and analyze the different tools, algorithms, software and platforms that are utilized. © 2022 IEEE.

9.
Geoscientific Instrumentation, Methods and Data Systems ; 11(2):263-277, 2022.
Article in English | ProQuest Central | ID: covidwho-1988295

ABSTRACT

Climate science depends upon accurate measurements of air temperature and humidity, the majority of which are still derived from sensors exposed within passively ventilated louvred Stevenson-type thermometer screens. It is well-documented that, under certain circumstances, air temperatures measured within such screens can differ significantly from “true” air temperatures measured by other methods, such as aspirated sensors. Passively ventilated screens depend upon wind motion to provide ventilation within the screen and thus airflow over the sensors contained therein. Consequently, instances of anomalous temperatures occur most often during light winds when airflow through the screen is weakest, particularly when in combination with strong or low-angle incident solar radiation. Adequate ventilation is essential for reliable and consistent measurements of both air temperature and humidity, yet very few systematic comparisons to quantify relationships between external wind speed and airflow within a thermometer screen have been made. This paper addresses that gap by summarizing the results of a 3-month field experiment in which airflow within a UK-standard Stevenson screen was measured using a sensitive sonic anemometer and comparisons made with simultaneous wind speed and direction records from the same site. The mean in-screen ventilation rate was found to be 0.2 m s-1 (median 0.18 m s-1), well below the 1 m s-1 minimum assumed in meteorological and design standard references, and only about 7 % of the scalar mean wind speed at 10 m. The implications of low in-screen ventilation on the uncertainty of air temperature and humidity measurements from Stevenson-type thermometer screens are discussed, particularly those due to the differing response times of dry- and wet-bulb temperature sensors and ambiguity in the value of the psychrometric coefficient.

10.
South African Journal of Industrial Engineering ; 33(2):62-77, 2022.
Article in English | Scopus | ID: covidwho-1975301

ABSTRACT

The intensive and repetitive use of touch-screens may pose significant problems, such as ergonomic pain or musculoskeletal disorders. This research aims to study the effect of using mobile touch-screen devices on the human musculoskeletal system during the COVID-19 pandemic lockdown and to develop a model for classifying the effects of musculoskeletal stress (pain and discomfort) on the performance of educational activities. The Cornell musculoskeletal discomfort questionnaire was given to 544 participants (71% males and 29% females). An Association Rule Mining approach was applied to illustrate the correlation, and multiple machine-learning models – used to predict the impact of pain and discomfort on different body regions – were applied to determine risk levels that might interfere with the ability to perform daily activities. Most musculoskeletal disorders were reported in the neck region and lower back (64.33% and 55.33% respectively), followed by upper back (44.30%) and the right shoulder (38%). Analysis of association rules showed high positive correlation between the lower back and the neck (support = 43%, confidence = 77%). Additionally, it was found that the radial basis function network has the highest accuracy in prediction (84%). The results of the radial basis function model showed that interference in educational activities can be predicted by using pain indicators in body parts resulting from touch-screen device usage. © 2022, South African Institute of Industrial Engineering. All rights reserved.

11.
IEEE Robotics and Automation Letters ; : 1-8, 2022.
Article in English | Scopus | ID: covidwho-1961414

ABSTRACT

We design a central controller system (CCS) and a tele-controlled system (TCS) with an aim of developing the integrated tele-monitoring/operation system that can enable the medical staff to tele-monitor the state of therapeutic devices utilized in the isolation intensive care unit (ICU) and to tele-operate its user interfaces. To achieve this aim, we survey the medical staff for medical requirements first and define the design guideline for tele-monitoring/operation functionality and field applicability. In designing the CCS, we focus on realizing the device having intuitive and user-friendly interfaces so that the medical staff can use the device conveniently without pre-training. Further, we attempt to implement the TCS capable of manipulating various types of user interfaces of the therapeutic device (e.g., touch screen, buttons, and knobs) without failure. As two core components of the TCS, the precision XY-positioner having a maximum positioning error of about 0.695 mm and the end-effector having three-degrees-of-freedom motion (i.e., pressing, gripping, and rotating) are applied to the system. In the experiment conducted for assessing functionality, it is investigated that the time taken to complete the tele-operation after logging into the CCS is less than 1 minute. Furthermore, the result of field demonstration for focus group shows that the proposed system could be applied practically to the medical fields when the functional reliability is improved. IEEE

12.
8th International Conference on Movement and Computing, MOCO 2022 ; Par F180475, 2022.
Article in English | Scopus | ID: covidwho-1950316

ABSTRACT

Skin Hunger is a web-based interactive system for telematic installation and performance that plays on the zoom-style video-chat that has become ubiquitous during the COVID-19 pandemic. Participants in the telematic installation can reach across the webcam screens to virtually 'touch' one another. By touching or moving together, participants create virtual organisms and sounds that emerge and evolve from participant relation and interaction, making the intangible connection tangible and giving it life. Skin Hunger explores a new way of enabling embodied joint music making and movement over a distance. © 2022 ACM.

13.
REVISTA BRASILEIRA DE EDUCACAO DO CAMPO-BRAZILIAN JOURNAL OF RURAL EDUCATION ; 7, 2022.
Article in Spanish | Web of Science | ID: covidwho-1939529

ABSTRACT

The COVID-19 pandemic has forced the virtualization of the activities that people carried out in person to comply with the mandatory social isolation provisions and prevent infection rates from increasing. Therefore, it was necessary for them to be connected for many hours to digital devices such as computers, laptops, tablets and cell phones, mainly, which could have caused computer vision syndrome, a condition that impacts the normal development of academic activities, labor, social, etc. In this sense, we consider that although during the pandemic it could have been evidenced more frequently, it would have a prevalence that would continue to be significant in the current post-pandemic context.

14.
2022 International Conference on Innovations in Science, Engineering and Technology, ICISET 2022 ; : 362-366, 2022.
Article in English | Scopus | ID: covidwho-1901440

ABSTRACT

According to ways-to-die website, over 150,000 people die every day. And the most common cause of death, i.e., about 20% of all deaths, is heart diseases. So, the most crucial contribution from our side to lower this percentage can be to monitor the cardiac values as much as possible. There are conventional methods to measure patients' health and condition, but they are laborious;have possibilities of errors;and nocturnal monitoring has as well been very difficult. Moreover, since 2019, COVID19 has caused more than five million deaths all around the world, as stated by WHO. And it made the physical presence of doctors and caretakers almost impossible. So, we have designed an up-to-date IoT-based project that continuously monitors the patient's body temperature, heart-rate and oxygen saturation level;keep the data readings in display before the patient and in the screen of the doctor's mobile;and it also provides a non-touching handsanitizing system. The proposed design integrates NodeMCU, DS18B20 Temperature sensor, Max30100 Pulse-oximeter, and other required materials in a small box. The readings are as accurate as the conventional medical equipments while it just takes less than a minute of time to perform the whole procedure. The developed project has outperformed the conventional method by providing a safer, less complex, cost effective and faster service. © 2022 IEEE.

15.
International Journal of Automation Technology ; 16(3):286-295, 2022.
Article in English | Scopus | ID: covidwho-1879729

ABSTRACT

Manufacturing functions are often performed by groups of engineers who cooperate and gather at work sites. However, since the beginning of the COVID-19 pandemic, the movement and activities of groups of people have been restricted, especially in indoor spaces. This reduction in travel by engineers also implies a reduction in associated costs. Telepresence technology, which is studied in the field of virtual re-ality, can be used as a way to reduce travel. Telep-resence allows users to engage with a site from a remote location as if they were present. Thus, engineers would be able to participate in a working group with-out the necessity of physically traveling to the site to cooperate with local manufacturing people. A variety of telepresence systems have been proposed;however, relatively few methods have been widely implemented compared with video chat applications that have re-cently become an established infrastructure in many companies. This is most likely because most proposed systems use robots, head-mounted displays, or dedi-cated multi-functional applications that require engineers to learn how to use them. One way to use a video chat application to understand a remote space is to have a remote participant move a camera used in a video chat application. In contrast, many VR social networking services use a viewing method with which users can change their viewing direction on the computer screen. In this study, we demonstrate that a system that allows users to rotate their viewing perspec-tive on a laptop computer screen can provide an easier understanding of a virtual space than a system that re-quires a remote person to move a webcam. Based on these results, we propose a system that allows users to view a remote location on a laptop computer screen via a video chat application and an off-the-shelf spherical camera, and evaluate its usefulness. © Fuji Technology Press Ltd.

16.
J Sleep Res ; 2022 Jun 07.
Article in English | MEDLINE | ID: covidwho-1879082

ABSTRACT

The COVID-19 pandemic had a major impact on people of all ages. Adolescents' exposure to online learning is linked to excessive screen time on digital devices, which leads to poor sleep quality. This study aimed to investigate the association between screen time on different electronic devices and sleep quality among adolescents in the United Arab Emirates. This study was based on a self-reported questionnaire, which was administered online to school-aged adolescents (aged 12-19 years). The multicomponent questionnaire collected information on sociodemographic characteristics, sleep quality using the Pittsburgh Sleep Quality Index (PSQI), and screen time (minutes) on TV, TV-connected devices, laptops, smartphones, and tablets on weekdays, weeknight, and weekends using the Screen Time Questionnaire (STQ). Univariate and multivariate analyses were used to identify factors correlated with poor sleep quality. A total of 1720 adolescents were recruited from private and public schools (mean age 14.6 ± 1.97 years). The mean PSQI score was 8.09 ± 3.37, and 74.3% of participants reported poor sleep (cutoff score >5). Mean scores were highest for the sleep latency (1.85 ± 0.97) and sleep disturbance (1.56 ± 0.62) domains. The highest STQ score was observed for smartphones, with a median screen time of 420 min on weekdays and 300 min on weekends. Screen time related to smartphones on weekends (p = 0.003) and increased screen time in bed (p < 0.001) were significantly associated with poor sleep. Our results confirmed the correlation between sleep and screen time in adolescents. The results may inform educational polices that target screen time and sleep among adolescents during and after the COVID-19 pandemic.

17.
2022 CHI Conference on Human Factors in Computing Systems, CHI 2022 ; 2022.
Article in English | Scopus | ID: covidwho-1874711

ABSTRACT

The COVID-19 pandemic created unprecedented questions for touch-based public displays regarding hygiene, risks, and general awareness. We study how people perceive and consider hygiene on shared touchscreens, and how touchscreens could be improved through hygiene-related functions. First, we report the results from an online survey (n = 286). Second, we present a hygiene concept for touchscreens that visualizes prior touches and provides information about the cleaning of the display and number of prior users. Third, we report the feedback for our hygiene concept from 77 participants. We find that there is demand for improved awareness of public displays' hygiene status, especially among those with stronger concerns about COVID-19. A particularly desired detail is when the display has been cleaned. For visualizing prior touches, fingerprints worked best. We present further considerations for designing for hygiene on public displays. © 2022 ACM.

18.
Ital J Pediatr ; 48(1): 74, 2022 May 14.
Article in English | MEDLINE | ID: covidwho-1846855

ABSTRACT

BACKGROUND: The SARS-CoV-2 outbreak pushed the Italian government to start a strict lockdown, replacing school attendance with long-distance learning. This caused reduced exposure to sunlight but increased exposure to screens. Vernal keratoconjunctivitis (VKC) is a chronic inflammatory ocular condition in which exposure to light plays a cardinal role. We conducted an online survey to evaluate the impact of screen exposure on children with VKC during the COVID-19 lockdown. METHODS: We performed a survey-based observational study, asking patients followed at the Allergology clinics of Meyer Children's University Hospital in Florence and of Policlinico Umberto I in Rome to provide grading on 6 subjective ocular clinical manifestations presented during the lockdown and to give an estimate of their hours/day of screen exposure. RESULTS: Mean scores of signs and symptoms increased homogeneously when studying patients exposed to longer screen time. When comparing scores collected in 2019 to those in 2020, there was not a significant reduction in clinical manifestations, although the situation differed between the two centers due to geographical differences in sunlight exposure. CONCLUSION: During the lockdown, there was a reduction in sunlight exposure but conversely an increase in the time spent in front of screens that correlated with the worsening of VKC signs and symptoms in direct proportion to the hours/day of screen exposure. Our results also showed a statistically significant difference in the relative impact of long-distance learning on VKC clinical manifestations in the different Italian regions.


Subject(s)
Conjunctivitis, Allergic , Screen Time , COVID-19/epidemiology , COVID-19/prevention & control , Child , Communicable Disease Control , Conjunctivitis, Allergic/epidemiology , Humans , Italy/epidemiology , Pandemics , Surveys and Questionnaires
19.
Revista Portuguesa De Investigacao Comportamental E Social ; 8(1):13, 2022.
Article in Portuguese | Web of Science | ID: covidwho-1744387

ABSTRACT

Background and Aim: Nomophobia (no mobile phone) is defined as a digital era phobia characterized by an excessive fear of not being able to use the cell phone. In the COVID-19 pandemic context, there was an intensification of information and communication technology. The current study aimed to explore differences in nomophobia levels during the COVID-19 pandemic and those evidenced before the pandemic situation. Additionally, we sought to analyze the relationship between nomophobia and variables such as the frequency of use of screens for professional purposes, the use of cell phone management, and to what extent the pandemic made screen use a recurrent practice. We hypothesize that the fact that most of the daily activities took place at home (e.g., teleworking, online classes), there is a global decrease of nomophobia levels. Methods: Cross-sectional study. The sample comprised 288 participants from the general population in a pandemic situation and 500 participants who took part in a survey conducted before the pandemic. All participants completed online the European Portuguese version of the Nomophobia Questionnaire. Results: The nomophobia levels observed during the pandemic situation were lower compared to the pre-pandemic period. There were no statistically significant differences in nomophobia levels by sex, marital status, or recurrent use of the screen. Nomophobia was not associated with age, use of screens for professional purposes, or mobile phone management. Conclusions: Given that most activities occurred at home (e.g., teleworking, online classes), the nomophobia levels during the Covid-19 pandemic were lower. This seems to be related to the global decrease of the fear of not being able to communicate through the smartphone, losing connectivity, not being able to access information and the fear of not having a Wi-Fi signal or running out of battery.

20.
Viruses ; 14(3)2022 03 15.
Article in English | MEDLINE | ID: covidwho-1742733

ABSTRACT

Viral replication and transmissibility are the principal causes of endemic and pandemic disease threats. There remains a need for broad-spectrum antiviral agents. The most common respiratory viruses are endemic agents such as coronaviruses, respiratory syncytial viruses, and influenza viruses. Although vaccines are available for SARS-CoV-2 and some influenza viruses, there is a paucity of effective antiviral drugs, while for RSV there is no vaccine available, and therapeutic treatments are very limited. We have previously shown that probenecid is safe and effective in limiting influenza A virus replication and SARS-CoV-2 replication, along with strong evidence showing inhibition of RSV replication in vitro and in vivo. This review article will describe the antiviral activity profile of probenecid against these three viruses.


Subject(s)
COVID-19 , Orthomyxoviridae , Respiratory Syncytial Virus, Human , COVID-19/drug therapy , Drug Repositioning , Humans , Probenecid/pharmacology , SARS-CoV-2
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