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This study aimed to investigate the most common Coronavirus pathogens in humans in the third millennium. In this study, all documents in English on pathogenic coronaviruses were examined from the beginning of 2002 to March 27, 2020. Articles were searched through reliable databases such as PubMed, Web of Science, Scopus, Google scholar, Science Direct, Cochrane library, and BioRxiv using the keywords "COVID-19", "Coronavirus 2019", "SARS-CoV," and" MERS-CoV." In addition, reliable health websites, such as WHO and the Centers for Disease Control and Prevention (CDC), were used to obtain new figures and information on these diseases. A total of 1563 articles and documents were extracted, and after reviewing the full texts of these articles, 100 papers and documents with necessary eligibility were finally selected in the present review study. The outbreak of pathogenic viruses, especially the latest one, i.e., COVID-19, as a severe threat can affect the entire global community, in particular medical staff who are at the forefront of fighting against the virus. It can generally be concluded that coronaviruses have high pathogenesis, with very rapid person-to-person transmission. Since human knowledge is not yet complete about the new type of this virus, i.e., COVID-19, there are no definitive treatments for the virus. Thus, the best and only way to prevent affection from this virus is currently fully implementing health protocols and preventing self-infection and the virus outbreak.
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Introduction: In patients presented with hypertensive crises, a fundoscopic assessment is necessary because once hypertensive retinopathy is discovered, a hypertensive emergency is diagnosed, and intravenous antihypertensive medication is recommended. However, direct ophthalmoscopy is relatively underutilized, especially under the social distance regulation, which may result in delayed diagnosis and treatment. The novel method, namely, smartphone-based fundoscopy offers longer working distance and shorter doctor-patient contact time, however, there is limited data regarding its feasibility and effectiveness. Objective: We aimed to gather scientific evidence on the smartphone-based fundoscopy in terms of its effectiveness, accessibility, and trainability in detecting hypertensive retinopathy among hypertensive crisis patients in emergency room settings. Methods: A literature search was conducted on PubMed, Google Scholar, and the Cochrane Library for papers published from January 2010 to November 2021. Keywords including hypertensive crisis, hypertensive retinopathy, target organ damage, fundoscopic optic examination, direct ophthalmoscope, fundus images, smartphone fundoscopy, digital fundus camera, and COVID-19 were used. Full papers published in English and s of non-English publications were all reviewed. Results: Eight studies out of 34 fulfilled our search criteria. Five observational studies confirmed the effectiveness of smartphone-based fundoscopy in obtaining fundus images adequate for interpretation compared with those from commercially available fundus cameras. Also, smartphone-based fundoscopy offers time-saving properties as it allows fundus examination to be effectively completed within 74 seconds compared to 130 seconds with a traditional direct ophthalmoscope. Two studies investigated the accessibility of smartphonebased fundoscopy and discovered that fundus images can be obtained by using 20 diopter condensing lenses with the video mode of the smartphone camera, which can be easily provided even at a primary level hospital due to their low cost. Another study reviewed the trainability of the smartphone-based fundoscopy in 137 undergraduate medical students which concluded that 75% of these students can identify the optic nerve within 20-25 minutes of face-to-face demonstration. Conclusion: With a greater diagnostic capability, accessibility, and trainability of smartphone-based fundoscopy makes it a potentially game-changing technique for detecting hypertensive retinopathy in hypertensive emergency patients, especially during the current COVID-19 pandemic, in which longer working distance and shorter doctor-patient contact time are both required.
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In recent years, new data have been obtained on the significant prevalence of vitamin D (VD) deficiency in the population, and knowledge about the role of vitamin D in the regulation of many physiological processes in the body, including the functioning of the immune system, has increased. The SARS-CoV-2 pandemic has further highlighted the issue of an adequate immune response in vitamin D deficiency. Objective of the review. To present and summarize the evidence on the role of VD in different parts of the immune response in COVID-19, to analyze available studies of the VD status effect on the course and outcome of COVID-19 in patients from different population groups. Material and methods. A search of domestic and foreign literature on the role of VD in the immune response in respiratory viral infections and SARS-CoV-2, as well as practical measures of VD-status correction in COVID-19, was performed. We used Scopus, Web of Science, PubMed, Google Scholar, eLibrary, and Cyberleninka databases. Results. Numerous clinical and observational studies have found an association between 25-hydroxyvitamin D levels, COVID-19 severity, and mortality. This association can be explained by the multifaceted role of vitamin D in the physiology of the human immune and endocrine systems. On the immunological side, the active form of VD promotes the secretion of antimicrobial peptides responsible for inhibiting viral replication and stimulates autophagy by increasing the level of Beclin1 protein and decreasing the level of mTOR protein regulating cellular homeostasis. It leads to the presentation of antigens followed by activation of the antiviral pathway of type I interferons. VD also stabilizes intercellular junctions, including those in the airway epithelium, reducing their permeability to pathogens, stimulates the activity of angiotensin-converting enzyme-2, whose receptors are a conduit for SARS-CoV-2 into cells, and several pathophysiological responses associated with the disease symptoms and acute lung injury. Adequate vitamin D status can provide significant benefits during the pandemic. Conclusion. To date, ideas about the role of vitamin D in regulating the immune response in respiratory infections have significantly expanded. However, its use in the complex preventive measures and adjuvant therapy of viral infections, including COVID-19, should be the subject of further scientific research.
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Objective: to carry out an updated bibliographic review focused on maternal and neonatal morbidity due to SARSCoV-2 infection with the purpose of evaluating the severity that could occur in these risk groups. Methodology: this study consisted of a systematic review between December 2019 and September 2020 using platforms such as: PubMed, Scopus, Digital Library of the Complutense University of Madrid, Google Scholar and Scielo. The data were tabulated according to the recommendations of the PRISMA guide. Result(s): Of 116 pregnant women with a positive diagnosis for COVID 19, 91.3% had a favorable evolution without requiring intensive care;8.62% presented severe pneumonia and mechanical respiratory assistance and none of them died. On the other hand, of 117 neonates, 93.2% had negative results for COVID-19 while 6.8% had positive results and there were three neonatal deaths not related to COVID-19. Conclusion(s): This indicates that SARS-CoV-2 does not generate greater susceptibility in obstetric patients or neonates and usually only manifests with mild to moderate symptoms. Copyright © 2022, Venezuelan Society of Pharmacology and Clinical and Therapeutic Pharmacology. All rights reserved.
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Context: Amelioration of olfactory and gustatory dysfunction (OGD) disorders has become a common requirement due to COVID-19. Although it's hardly exclusive to COVID-19, OGD's prevalence requires exploration of therapeutic and restorative modalities, on the broadest scale possible. No specific medication or treatment of any noteworthy efficacy exists for OGD. Objective(s): As Part 1 of a three-part article, a narrative review intended to examine the known causes of OGD, not restricted to COVID-19, and frame their relevance for development of new treatments or the repurposing of existing ones. Design(s): The researcher performed a narrative review by searching databases including PubMed, Sciencedirect, Google Scholar, Old Dominion University Libraries, and the websites of various medical journals. Searches included numerous combinations of keywords accompanied by the phrases, loss of sense of smell and taste, olfactory and gustatory dysfunction disorders, as well as the terms anosmia, parosmia, ageusia, and parageusia. Such keywords included viruses, bacteria, fungi, protozoa, parasites, infection, COVID-19, treatments, medications, steroids, supplements, nutrients, alternative medicine, acupuncture, olfactory training, clinical trials, cranial nerves, pathogenesis, pathophysiology, and etiology. Setting(s): The Liebell Clinic, Virginia Beach, VA, USA. Result(s): Scientific investigation into mechanisms and treatment of OGD appears to be historically limited and unremarkable. Medical literature spanning decades reports a bleak clinical outlook with an abundance of speculation and hypotheses. Limited evidence of effective or reliable treatment exists, especially for chronic cases. Conclusion(s): With a dismal lack of medical support for a suddenly prevalent, but hardly novel set of maladies of taste and smell perception;the imperative for multifaceted and broad investigations across all medical disciplines is without question. Global urgency for the development of any treatment capable of reducing or resolving OGD triggered by COVID-19 is unprecedented. Part 2 of the current author's three-part series will address the details of current and past treatment approaches and clinical trials.
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Background: It is very important to monitor changes in substance use during the pandemic period, as individuals dealing with substance use may be at greater risk for COVID-19, and stress factors and changes resulting from the pandemic may cause alterations in substance use models. Method(s): In this review, the existing literature on how COVID-19 affected people's alcohol consumption, smoking, and vaping use in different societies was evaluated. Articles that are relevant to the subject were searched using PubMed, ScienceDirect and Google Scholar and reviewed. Result(s): It was observed that due to COVID-19, there may be no alterations in these substance use types or it may result in a decrease of consumption of substances or a quit attempt due to health concerns about COVID-19 or it may cause an increase in the alcohol, or cigarette consumption. Conclusion(s): With this review we hope to present detailed information on the impact of the pandemic on alcohol consumption, and cigarette or e-cigarette use from various studies conducted in different societies all around the world and highlight the importance and necessity of new studies on this subject. Copyright © 2023 Taylor & Francis Group, LLC.
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Cyberchondria is defined as excessive online health research followed by distress. Theoretical models of cyberchondria suggest that it can be influenced by both characteristics of the internet (content, information ranking, amount and quality of information) and individual vulnerability factors (general health anxiety or COVID-19 fear). In order to simultaneously explore the role of both factors, an innovative search engine software (Foogle) was developed and used in the present study that enables manipulation of the presented content and content ranking while also recording users' online behavior. A total of 36 participants with high and 28 participants with low COVID-19 fear searched for the long-term health effects of COVID-19 using Foogle. They were presented with search engine results that rank long-term health effects of COVID-19 from more to less severe or vice versa (randomized). Results revealed that participants who were presented with articles describing more to less severe long-term COVID-19 health effects accessed articles with a higher mean severity index. In general, participants spent more time on articles depicting more severe content. Participants with high COVID-19 fear felt more anxious post-search than those with low COVID-19 fear and expressed a greater wish to continue searching. © Creative Commons.
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The paper is devoted to the analysis of the spread of the COVID-19 pandemic in Ukraine based on finding the correlation between search terms in Google search engine and laboratory-confirmed cases. Statistics were obtained from open sources. The analysis was performed on matrices based on the Pearson correlation coefficient. To do this, we analyzed 25 typical search phrases, and after grouping them-7 remained. The data were reduced to the same discreteness. Correlation matrices were calculated for each wave of the pandemic and for altogether. As a result, the correlation between search phrases and laboratory-confirmed cases was observed only in the second and third waves of the pandemic. Moreover, in the first wave, the preconditions for its occurrence were found;in the second-Pearson's correlation coefficient was 0.74, and in the third wave, it decreased to 0.57. Other correlations that are specific to each pandemic wave are also analyzed. Additionally, it was proved that polynomials of the 6th degree most effectively restore lost data. © 2022 IEEE.
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BACKGROUND: Respiratory syncytial virus (RSV) is a major cause of respiratory infection in children. Despite usually following a consistent seasonal pattern, the 2020-2021 RSV season in many countries was delayed and changed in magnitude. OBJECTIVE: This study aimed to test if these changes can be attributed to nonpharmaceutical interventions (NPIs) instituted around the world to combat SARS-CoV-2. METHODS: We used the internet search volume for RSV, as obtained from Google Trends, as a proxy to investigate these abnormalities. RESULTS: Our analysis shows a breakdown of the usual correlation between peak latency and magnitude during the year of the pandemic. Analyzing latency and magnitude separately, we found that the changes therein are associated with implemented NPIs. Among several important interventions, NPIs affecting population mobility are shown to be particularly relevant to RSV incidence. CONCLUSIONS: The 2020-2021 RSV season served as a natural experiment to test NPIs that are likely to restrict RSV spread, and our findings can be used to guide health authorities to possible interventions.
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COVID-19 , Respiratory Syncytial Virus Infections , Respiratory Syncytial Virus, Human , Child , Humans , COVID-19/epidemiology , COVID-19/prevention & control , Pandemics/prevention & control , Seasons , Respiratory Syncytial Virus Infections/epidemiology , Respiratory Syncytial Virus Infections/prevention & control , Search Engine , SARS-CoV-2ABSTRACT
Background: The modern coronavirus infectious disease COVID-19 has been labeled internationally as a pandemic and is considered an emergency to the public health. Many studies were targeting university students as they play a great role after healthcare workers in relaying and spreading the awareness of COVID-19 and its preventive measures among colleagues, families, and friends. Therefore, it is of great importance to increase the knowledge and awareness about COVID-19. Objective(s): In this review article, we compare the most relevant studies that measure health awareness and attitude towards the COVID-19 pandemic. Method(s): The articles are obtained from electronic databases such as PubMed, Science Direct and Google Scholar that are published during 2020. Conclusion(s): Most studies showed high level of awareness among university students, and social media was found to be their main source of information. Among all the selected research papers, we found that the studies conducted in both the United Arab Emirates and Qassim Universities showed results that may be comparable to our topic. Copyright © 2023 Ubiquity Press. All rights reserved.
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Objective: COVID-19 vaccine-induced myocarditis is becoming an important topic. As the internet is the leading source of information, it is crucial to evaluate the quality and readability of health information available to the general public as it has an impact on increasing awareness and encourage vaccinations. Method(s): The top 30 websites of 2 different search engines (Google, Bing) were collected using the term "Covid vaccine induced myocarditis" on a newly installed Mozilla Firefox browser. Physicianoriented websites, non-relevant content (not connected to the search keyword), and duplicates were all excluded. The quality of the websites were evaluated using the DISCERN tool by two physician reviewers who are knowledgeable and were blinded to each other's findings. After that, the data was evaluated to come up with an aggregated score for each website. Readability was assessed using the Flesch-Kincaid Readability Ease (FKRE) and the Flesch-Kincaid Grade Level (FKGL) tool. Result(s): A total of 19 websites were assessed after exclusion criteria. The average overall quality for DISCERN was 3.4 out of 5 with a median of 3.46 while the average total DISCERN score was 48.2 out of 80: the highest total quality among them being 63 out of 80. The average FKRE was 48.5 out of 100, while the average FKGL was 8.7 out of 18 with the lowest grade being 6.2. Conclusion(s): Overall, the quality of the information was rated as moderate or "fair" with an average of 3.4 out of 5. Most of the websites were accurate in the information provided. However, those websites that were high quality did require a higher level of education to be able to comprehend. The average reading grade level was 8.7 grade, which is higher than the average American reads (8th grade). The highest quality website based on DISCERN was Health U.S news. All websites encouraged vaccinations and explained the rarity of getting myocarditis from COVID 19 vaccine.
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Introduction: Google Trends is an online metadata platform that measures the relative search volume of every topic in online search engines. In medical settings, this behavior has been associated with active changes in people's perceptions and search for healthcare. This study aimed to evaluate the online search patterns of Portuguese extra-program and risk-based vaccination. Method(s): Analysis of the relative search volume was performed for extra-program and risk-based vaccines, in every Portuguese district between 2006 and 2021. Relative search volume was represented between 0 and 100 (highest interest in the query). Result(s): Rotavirus vaccine was consistently the most searched, followed by BCG and flu, the last of which, with abnormal peaks of search in November 2009 and October 2020. We registered a significant increase in the search for every vaccine in the last 5 years (p < 0.01). Particularly, during the COVID-19 pandemic, a more abrupt increase was registered for the flu vaccine, but most importantly for BCG (3,0[69,9] vs. 9,0[528,0]). Lisboa and Porto are the only Portuguese districts where percentual research is spread across all types of vaccines. On the other hand, in Portalegre, 84% of total searches correspond to BCG. Discussion and Conclusion(s): The recent increase in the interest in vaccination may translate into the investment of health professionals in primary prevention measures. However, the mediatic impact of pandemics is not neglectable. Health professionals must fight misinformation as it may have happened with the increasing interest in BCG, probably due to the protective association proposed with the infection by SARS-CoV-2. Copyright © 2022 The Author(s). Published by S. Karger AG, Basel.
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Background: With more than 244 million cases worldwide, the SARS-CoV-2 pandemic has affected almost every country on the planet. Its impact on the health, economy, education and scientific systems, among others, has been significant. The search for therapeutic tools for the treatment and control of this new disease, COVID-19, has been intense, but it has not yet been possible to select a specific and effective drug for its treatment. Methodology: the objective of this work is to summarize the existing information, related to some of the most common drugs used in therapy against COVID-19, to achieve this a search methodology was used in scientific and general databases (Pubmed, Google Scholar) using keywords related to the topic of interest. The results show that the most common drugs used in the treatment of this disease have mostly been evaluated in clinical trials. Conclusion(s): despite almost two years passed since the first case of COVID-19, effective and specific drugs have not been developed or reassigned for the treatment of the disease and some of of the already evaluated have shown controversial results. Copyright © 2021, Revista Salus. All rights reserved.
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Background: Lassa fever is an acute viral haemorrhagic disease caused by the Lassa virus (LASV). It is endemic in West Africa and infects about 300,000 people each year, leading to approximately 5000 deaths annually. The development of the LASV vaccine has been listed as a priority by the World Health Organization since 2018. Considering the accelerated development and availability of vaccines against COVID-19, we set out to assess the prospects of LASV vaccines and the progress made so far. Material(s) and Method(s): We reviewed the progress made on twenty-six vaccine candidates listed by Salami et al. (2019) and searched for new vaccine candidates through Google Scholar, PubMed, and DOAJ from June to July 2021. We searched the articles published in English using keywords that included "vaccine" AND "Lassa fever" OR "Lassa virus" in the title/. Result(s): Thirty-four candidate vaccines were identified - 26 already listed in the review by Salami et al. and an additional 8, which were developed over the last seven years. 30 vaccines are still in the pre-clinical stage while 4 of them are currently undergoing clinical trials. The most promising candidates in 2019 were vesicular stomatitis virus-vectored vaccine and live-attenuated MV/LASV vaccine;both had progressed to clinical trials. Conclusion(s): Despite the focus on COVID-19 vaccines since 2020, LASV vaccine is under development and continues to make impressive progress, hence more emphasis should be put into exploring further clinical studies related to the most promising types of vaccines identified. Copyright © 2022, African Traditional, Herbal Medicine Supporters Initiative. All rights reserved.
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Objective: The COVID-19 pandemic significantly disrupted access to primary care in Australia. This could have negatively impacted reproductive health services rates such as intrauterine device insertion rates, and interest in seeking information about intrauterine devices by searching on Google. We aimed to assess the trends of, and the association between, the actual Medicare service utilization rates for intrauterine device insertion and searching about intrauterine devices on Google, before and during the COVID-19 pandemic. Methods: We conducted systematic analyses of secondary data from June 2017 to May 2022, using Medicare and Google Trends data sources. We visualized the rates of intrauterine device insertion, plus Google's search volumes about 'Intrauterine device' and 'Progestin IUDs' as topics. Then, we assessed the correlation between intrauterine device insertion rates and Google search, using Spearman correlation. Results: The average yearly rates of intrauterine device insertion increased noticeably from 25.1-26.3 in 2018-2019 to 29.3-31.2 per 100,000 population in 2020-2021 (12-18% increase). The highest monthly intrauterine device insertion rate nationally (37 per 100,000 population) was seen in March 2021. By June 2020, search term use for the two intrauterine device-related topics returned to much higher levels (50% increase for 'Progestin IUDs', and 54% for 'Intrauterine device', respectively). A moderately strong correlation was seen between actual intrauterine device insertion rates and search on Google about intrauterine devices (Spearman rho = 0.61, p < 0.000). Conclusion: We demonstrated a moderately strong correlation between trends of intrauterine device insertion rates and search on Google about intrauterine devices, before and during the COVID-19 pandemic in Australia. Googling about intrauterine devices could, therefore, be a useful indicator to gauge future interest in actual intrauterine device insertion for months thereafter.
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Background and Aim: Although breastfeeding is highly important and has numerous health benefits, COVID-19 makes it difficult for mothers with suspected or confirmed COVID-19 to breastfeed their neonates. Various breastfeeding guidelines can confuse mothers and harm both mothers and their neonates. This study aims to evaluate the SARS-CoV-2 transmission from mothers to neonates and to encourage mothers with suspected or confirmed COVID-19 to breastfeed. Material(s) and Method(s): We searched PubMed and Google Scholar for literature on guidelines on COVID-19 and breastfeeding. We included English, free, and full-text articles. Result(s): SARS-CoV-2 is rarely transmitted via breast milk. The recommended strategy for breastfeeding is for parents and the health care team to make a joint decision. Mothers can breastfeed safely with strict infection prevention protocols. Breastfeeding mothers are advised to take the COVID-19 vaccination. It benefits both the mother and the neonate. Conclusion(s): The knowledge on COVID-19 and breastfeeding is continuously evolving. Our suggestions may serve as brief and flexible recommendations that can be customized based on local requirements. Copyright © 2022, Himalaya Wellness Company. All rights reserved.
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Cyberchondria is defined as excessive online health research followed by distress. Theoretical models of cyberchondria suggest that it can be influenced by both characteristics of the internet (content, information ranking, amount and quality of information) and individual vulnerability factors (general health anxiety or COVID-19 fear). In order to simultaneously explore the role of both factors, an innovative search engine software (Foogle) was developed and used in the present study that enables manipulation of the presented content and content ranking while also recording users’ online behavior. A total of 36 participants with high and 28 participants with low COVID-19 fear searched for the long-term health effects of COVID-19 using Foogle. They were presented with search engine results that rank long-term health effects of COVID19 from more to less severe or vice versa (randomized). Results revealed that participants who were presented with articles describing more to less severe long-term COVID-19 health effects accessed articles with a higher mean severity index. In general, participants spent more time on articles depicting more severe content. Participants with high COVID-19 fear felt more anxious post-search than those with low COVID-19 fear and expressed a greater wish to continue searching. [ FROM AUTHOR]
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Introduction: A frequently discussed topic today, stigma and/or discrimination are social phenomena that, in the broader context of medical discourse and especially in the current epidemiological situation, Covid-19 pandemic, appear and need a detailed examination Objectives: This study aims are to examine the literature and to present the aforementioned phenomena, comparing them with the Link & Phelan stigma model and offering pros and cons for their congruence with the model. Method(s): Literature analysis with searching words: stigma, discrimination, Covid-19, medical and especially psychiatric pathology, in Pubmed and Google scholar engine. Result(s): The studied 32 articles provided 4 stigmatized subgroups in the social context of the pandemic: that of patients and medical staff, that of comorbidities sufferers, that of stigmatized ethnic groups, and that of stigmatized races. These groups, stigmatized directly or by overlapping with the actual group, were studied in the most relevant PubMed articles, and evidence for the congruence of their stigma with the model was presented in this review. Conclusion(s): This work could also serve as a starting point for further study on combating stigma, improving the lives of our patients, colleagues affected by occupational exposure, and, finally, society at large.
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Introduction: Prior to the COVID-19 pandemic, healthcare authorities and experts believed that the modern-time healthcare system was ready to face a global health crisis, but with over 5 hundred million cases, and 6 million deaths, the pandemic is still going on. This study aims to identify and classify factors into broad categories that had recurrent mentions as the reason for the prolonging pandemic. Material(s) and Method(s): A systematic review of 168 studies published between January and June 2022 available in PubMed, Scopus, Google Scholar database is being conducted. The search terms were 'COVID', 'issues', 'challenges', 'impact', and 'response'. Factors identified as homogenous were grouped together. Result(s) and Conclusion(s): The preliminary results showed that the factors for the continued pandemic can be classified into three broad categories: the characteristics of the virus, the adequate response of health authorities, and population attitude. All three identified categories had time-related variability throughout the pandemic. The success in controlling the pandemic relies on the harmony of the identified categories. The characteristics of the virus include virulence, pathogenicity, transmissibility, and variants of mutations. The second category concerns how international and local health authorities reacted to the early COVID infection by devising strategies to prevent the spread of the disease, cure the infected, and protect the population from the virus. Currently, global vaccination coverage is considered as one of the important factors in the end of the pandemic. Perhaps the most important factor is the attitude of the population. This includes compliance with local mandates and following appropriate hygiene practices. The pandemic is projected to transition into an endemic in the next few months where COVID-19 becomes less of an issue. The success of transition into an endemic lies in addressing the deficiencies of the identified categories.
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Context: An outbreak of the new coronavirus disease 2019 (COVID-19) was reported in Wuhan, China, in December 2019, subse-quently affecting countries worldwide and causing a pandemic. Although several vaccines, such as mRNA vaccines, inactivated vaccines, and adenovirus vaccines, have been licensed in several countries, the danger of severe acute respiratory syndrome coron-avirus 2 (SARS-CoV-2) variants persists. To date, Alpha (B.1.1.7), Beta (B.1.351, B.1.351.2, B.1.351.3), Delta (B.1.617.2, AY.1, AY.2, AY. 3), Gamma (P.1, P.1.1, P.1.2), and Iota (B.1 .526) circulating in the United States, Kappa (B.1.617.1) in India, Lambda (C.37) in Peru and Mu (B.1.621) in Colombia are considered the variants of concern and interest. Evidence Acquisition: Data were collected through the end of August 2021 by searching PubMed, Scopus, and Google Scholar databases. There were findings from in silico, in vitro cell-based, and non-cell-based investigations. Result(s): The potential and safety profile of herbal medicines need clarification to scientifically support future recommendations regarding the benefits and risks of their use. Conclusion(s): Current research results on natural products against SARS-CoV-2 and variants are discussed, and their specific molecular targets and possible mechanisms of action are summarized. Copyright © 2022, Brieflands All rights reserved.