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1.
Case Reports in Ophthalmology ; 13(1):297-304, 2022.
Article in English | ProQuest Central | ID: covidwho-1824363

ABSTRACT

The recent outbreak of the severe acute respiratory syndrome coronavirus-2 has been declared a worldwide pandemic by the WHO. Within various multi-organ involvements, several ocular manifestations have been described. We report the case of a patient diagnosed with COVID-19 who presented with a progressive increase of bilateral cotton wool spots over a 1-week period, despite quick and complete recovery of systemic signs of the disease and no ocular symptoms. We followed the evolution of such lesions over a 3-month period. Here, we underline the importance of retinal screening even if no ocular symptom is reported. Furthermore, we demonstrate the essential role of fundus examination as a reflection of systemic vascular changes.

2.
Case Reports in Oncology ; 15(1):442-446, 2022.
Article in English | ProQuest Central | ID: covidwho-1824208

ABSTRACT

Tumor lysis syndrome (TLS) is an oncologic emergency characterized by the destruction of tumor cells leading to an influx of large amounts of uric acid, potassium, and phosphorus into systemic circulation. It most often occurs after the initiation of cytotoxic therapy in high-grade lymphomas and leukemias;however, rarely it may occur spontaneously. The authors report a case of spontaneous tumor lysis causing electrolyte abnormalities and acute kidney injury in a patient with subsequently diagnosed large chronic lymphocytic leukemia tumor burden. Spontaneous TLS can be the first presentation of underlying malignancy;therefore, physicians should be aware of the associated findings.

3.
Case Reports in Neurology ; 14(1):25-30, 2022.
Article in English | ProQuest Central | ID: covidwho-1823985

ABSTRACT

Acute toxic leukoencephalopathy (ATL) and delayed post-hypoxic leukoencephalopathy (DPHL) are two possible adverse entities related to opioid intoxication (OI), each having a distinct clinical course. While ATL shows a monophasic course with gradual neurological deterioration, DPHL has a distinct biphasic course. We report a case of ATL along with a case of DPHL happening in young male patients with OI, including their clinical courses as well as imaging characteristics with comparable time intervals. Initially, both leukoencephalopathies typically show magnetic resonance imaging findings with confluent and symmetric white matter (WM) abnormalities in the periventricular regions on T2 and fluid-attenuated inversion recovery images along with restricted diffusion on diffusion-weighted imaging. The DPHL patient however also presented with WM cystic substance loss in the deterioration phase, several weeks after hospital admission, which was previously described in a case of DPHL. Interestingly, similar WM changes have recently been observed in virus-associated necrotizing disseminated acute leukoencephalopathy in patients with coronavirus disease 2019 which may suggest a common pathophysiological mechanism. Knowing the distinct imaging features of ATL and DPHL along with their typical clinical courses can provide a faster and more reliable differentiation between these two entities.

4.
Egyptian Journal of Hospital Medicine ; 87:1035-1038, 2022.
Article in English | Academic Search Complete | ID: covidwho-1823665

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) may benefit from a chest CT scan for diagnosis, identification of sequelae, and prognosis. Ground-glass opacities, vascular enlargement, bilateral abnormalities, lower lobe involvement, and posterior inclination have all been found on chest CT in more than 70% of RT-PCR test-proven COVID-19 cases. In more than one-third of patients who survived severe coronavirus illness 2019 pneumonia, a six-month follow-up CT revealed fibrotic-like alterations in the lung. COVID-19 survivors exhibited continued improvement on chest CT following a year of follow-up after discharge. Residual lesions, on the other hand, could be seen and linked with lung volume metrics. Early diagnosis of post-COVID-19 pulmonary fibrosis cases may allow for the prevention or at least modification of this disabling consequence. Objective: Highlight chest CT imaging for the symptomatic COVID-19 patient after three months and the radiologist should be aware of the pulmonary sequelae changes at imaging. Methods: These databases were searched for articles published in English in 3 databases (PubMed - Google scholarscience direct) and Boolean operators (AND, OR, NOT) had been used such as (Chest CT AND COVID-19 Patients OR CT chest findings) and in peer-reviewed articles between February 2020 and December 2021. Documents in a language apart from English have been excluded as sources for interpretation were not found. Papers apart from main scientific studies had been excluded: documents unavailable as total written text, conversation, conference papers, and dissertations. Conclusion: Chest CT imaging plays an important role in diagnosis and follow-up patients in COVID-19 disease. [ FROM AUTHOR] Copyright of Egyptian Journal of Hospital Medicine is the property of Egyptian Journal of Hospital Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

5.
Egyptian Journal of Hospital Medicine ; 87:1017-1023, 2022.
Article in English | Academic Search Complete | ID: covidwho-1823608

ABSTRACT

Background: The recent widespread of COVID-19 led to a marked increase in the number of CT chest examinations. This led to frequent encounters of associated incidental findings as thyroid nodules. Thyroid imaging reporting and data system (TI-RADS) using variable ultrasound feature-allowed systematic reproducible approach for diagnosis and management of thyroid nodules. Objective: This study aimed to detect the prevalence of incidental thyroid nodules in CT chest for COVID-19 cases as well as the percentage of malignant nodules among them and the concordance of TI-RADS classification with fineneedle aspiration cytology (FNAC) results. Patients and methods: This retrospective study included 895 patients with CT findings of COVID-19 pneumonia. 203 patients were excluded due to absent PCR confirmation of COVID-19, lack of ultrasound confirmation of thyroid nodules or lack of FNAC results, so our study included 692 patients with confirmed COVID-19 pneumonia. Results: A solitary thyroid nodule was discovered in 134 CT chest scans of 692 patients with confirmed COVID-19 pulmonary pneumonia, with a 19.4% incidence. These patients underwent ultrasound evaluation for the thyroid nodule. The nodules with TI-RADS 1-3 score were considered benign yet those with 4-5 score were classified as malignant. The results of the FNAC were compared to the thyroid TI-RADS classification, with nodules classified as Bethesda II-III being benign and those classified as Bethesda IV to VI being malignant. Conclusion: Incidental thyroid nodule discovered during CT chest examination is an important finding and should be investigated and categorized using the TI-RADS system as even though the incidence of malignancy is not high, early diagnosis of thyroid malignancy can have a huge effect on the patient outcome. [ FROM AUTHOR] Copyright of Egyptian Journal of Hospital Medicine is the property of Egyptian Journal of Hospital Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

6.
Akademik Acil Tip Olgu Sunumlari Dergisi ; 12(4):100-102, 2021.
Article in English | EMBASE | ID: covidwho-1822753

ABSTRACT

A 43-year-old male patient without any additional disease, surgery or anticoagulant use admitted to the emergency department. After evaluation with computed tomography (CT), pulmonary findings were consistent with COVID-19 pneumonia. The patient was hospitalized and enoxaparin sodium 60 mg / 0.6 ml (two subcutaneous injections per day) was initiated for prophylactic purpose. In the 16th day after admission, his hemoglobin level decreased to 7.4 g/dL. On CT scan, a right flank hematoma reaching approximately 10 cm in width, starting from the subcostal level and continuing to the inguinal canal level, was seen. Anticoagulant therapy was stopped. Erythrocyte suspension (ES), totally 10 units, were given to keep the hemoglobin level above 7 g/dL. On the 32th day after admission, the patient was discharged because his hemoglobin value, which was 10.2 g/dL at that point, had not decreased, his vital signs were stable, and his treatment for COVID-19 was completed.

7.
Akademik Acil Tip Olgu Sunumlari Dergisi ; 12(3):91-93, 2021.
Article in English | EMBASE | ID: covidwho-1822752

ABSTRACT

Introduction: Many studies have shown that coagulation disorders and increased risk of thrombosis may occur during coronavirus disease 2019 (COVID-19) infection. Although cardiac or pulmonary vascular pathologies has been detected in most cases, cerebral sinus thrombosis are rare. During COVID-19 infection patients rarely present with neurological symptoms. Case Report: A 19-year-old man was admitted to our emergency department with neurological symptoms. Cerebral venous sinus thrombosis (CVST) was detected in Brain Computerized Tomography and Magnetic Resonance Imaging examinations. Our patient was hospitalized in the neurology department of our hospital for medical treatment and was discharged after clinical recovery. Discussion: In this case report we wanted to draw attention to cerebral venous sinus thrombosis which is a rare but treatable complication of COVID-19 infection in a young patient. We examined our patient in the light of literature. Conclusion: Clinicians should keep in mind the diagnosis of CVST that may occur due to infection associated thrombosis in COVID-19 patients presenting with neurological symptoms and consider adding anticoagulants to the treatment if necessary.

8.
Akademik Acil Tip Olgu Sunumlari Dergisi ; 12(3):85-87, 2021.
Article in English | EMBASE | ID: covidwho-1822751

ABSTRACT

Introduction: Epistaxis and gingival bleeding are among the most common presentation to the emergency department for patients with thrombocytopenia. Here, we present a case who was admitted to the emergency department with thrombocytopenia and was diagnosed with metastatic cancer of unknown primary origin. Case Report: A 26-year-old male patient was admitted to the emergency department with gingival bleeding and epistaxis. The body temperature was 38.3 °C. Petechial rash, ecchymosis or organomegaly was not detected on physical examination. Laboratory results revealed thrombocytopenia as 31 × 103 (159-388 × 103/μL). Although hemoglobin and leukocyte counts were normal, no band or precursor cell was observed in the patient's peripheral blood smear. There was no history of weight loss, night sweats, arthritis, malar rash, photosensitivity, contact with ticks, animals, or a COVID-19 patient. Serological tests performed for infections such as HIV, EBV, HCV, Crimean-Congo hemorrhagic fever were negative. Bone marrow biopsy was performed due to the unexplained cytopenia, reported as "signet ring cell metastatic adenocarcinoma". Gastrointestinal system endoscopy was performed to detect primary cancer. A biopsy was taken from the antrum and corpus revealed gastritis. An FDG PET-CT was revealed heterogeneously pathologically increased FDG attitude in all axial and appendicular bones. Despite all the modalities of diagnosis, the origin was not found and the patient was transferred to the oncology department for treatment with a diagnosis of cancer of unknown origin with bone marrow infiltration. Conclusion: Bone marrow metastases should be kept in mind in patients presenting with thrombocytopenia.

9.
Journal of Advances in Medical and Biomedical Research ; 30(140):223-231, 2022.
Article in English | EMBASE | ID: covidwho-1822725

ABSTRACT

Background & Objective: Hospital readmissions are common and expensive. Identifying the patients who are at high risk of readmission can decrease readmission cases. Hence, in the present study, the clinical characteristics, biomarker results, and Computed Tomography (CT) criteria of all the readmitted patients were assessed. Materials & Methods: Data of 98 readmitted patients to the Baqiyatallah Hospital in Tehran were reviewed from December 22, 2019 through June 20, 2020. We classified the readmitted patients into three groups: patients (1) without COVID-19 symptoms, (2) with suspected COVID-19, and (3) with confirmed COVID-19 infection. Results: Our data revealed that the frequency of gender was significantly different between the groups (with higher frequency in men). The duration between the two admissions was significantly low in the confirmed COVID-19 group. Ischemic heart disease, hypertension, and diabetes mellitus were more common in confirmed COVID-19 group. High levels of CRP, and ESR were detected in the confirmed COVID-19 group. During the first admission, the WBC count was significantly lower in the confirmed COVID-19 group, the RBC count and hemoglobin level were significantly higher in both first and second admissions in the confirmed COVID-19 group. Most of the patients had bilateral lung lesions and ground glass opacities (GGO) in their CT Scans in the second admission. Conclusion: Our data suggested that the older men and ischemic heart disease, hypertension, and diabetes mellitus had a high risk of hospital readmission in COVID-19. The confirmed COVID-19 group showed a shorter time to be readmitted.

10.
Journal of Advances in Medical and Biomedical Research ; 30(140):215-222, 2022.
Article in English | EMBASE | ID: covidwho-1822724

ABSTRACT

Background & Objective: Measurement of inflammatory markers and lactate dehydrogenase (LDH) may contribute to the evaluation of lung involvement severity. This study aimed to evaluate relationship between severity of primary lung involvement with highest level of erythrocyte sedimentation rate (ESR) and LDH in patients with COVID-19. Materials & Methods: This descriptive-analytical study was conducted on 123 patients with COVID-19 in Shahid Sadoughi Hospital. Data including age, gender, ESR (mm/h), LDH (U/L), and high-resolution Computed Tomography scan (HRCT) findings and hospitalization ward were extracted from medical records. The regression model was used to determine the relation between HRCT findings with LDH and ESR. Results: Mean LDH, ESR, and HRCT findings were 508.41±224.65, 52.23±29.56, and 37.17± 22.18 respectively. A significant relation was seen between HRCT findings with highest level of LDH and ESR (P=0.001). A significant relation was observed between the highest levels of ESR and HRCT findings, regarding age, gender, and hospitalization wards (P<0.01). There was a significant relation between the highest level of LDH and HRCT findings regarding age group and hospitalization wards (P<0.01). Conclusion: A significant relation was seen between HRCT findings and highest levels of ESR and LDH in patients with COVID-19. Therefore, it seems that assessment of laboratory findings such as LDH and ESR can be helpful as cost-effective markers instead of chest CT scan for predicting the severity of lung injury when the CT scan report is controversial. The relation between HRCT findings with LDH and ESR were affected by age and hospitalization ward. However, more studies should be conducted in this regard.

11.
Horizonte Medico ; 22(1), 2022.
Article in Spanish | EMBASE | ID: covidwho-1822693

ABSTRACT

This is the case of a 49-year-old male with spontaneous pneumomediastinum due to Macklin effect, who presented comorbidities and was diagnosed with COVID-19. The patient was placed on life support but showed an unfavorable progression with hemodynamic instability, which led to obstructive shock caused by pneumomediastinum. Despite being an unusual clinical entity, it is important to know its approach, diagnosis and management in the intensive care units.

12.
ACG Case Reports Journal ; 9(3), 2022.
Article in English | EMBASE | ID: covidwho-1822626

ABSTRACT

Liver injury is a common manifestation of coronavirus disease 2019 (COVID-19), with most injuries manifesting as transient mild hepatocellular injury. Cholestatic injury occurs less commonly and is typically mild. Severe cholestatic injury is rare, with only 4 cases reported in the literature. We present a 70-year-old woman with no known liver disease who presented with severe COVID-19 and developed severe cholestatic hepatitis. A liver biopsy was performed demonstrating bile duct injury, uncommonly reported in patients with COVID-19. This complication needs greater awareness because it has been known to cause progressive liver disease requiring transplantation.

13.
Journal of Radiology Case Reports ; 2022(2):12-20, 2022.
Article in English | EMBASE | ID: covidwho-1822480

ABSTRACT

IgG4-related disease is an autoimmune condition that results in inflammation and fibrosis throughout multiple organ systems. This disease is rare;however, it can mimic many more prevalent conditions clinically and thus should be included in their differential diagnoses. Although autoimmune pancreatitis is the most common abdominal manifestation, the disease can afflict the hepatobiliary, vascular and renal systems as well. We present a case of a 78-year-old male with symptoms of chronic fatigue and weight loss. Imaging was performed with the expectation of revealing a malignancy, although the features of IgG4-related disease involving multiple organs were detected instead. Serology confirmed the diagnosis. It is imperative to diagnose IgG4-related disease early as it has a different treatment and favorable prognosis compared to many malignancies.

14.
Infection and Drug Resistance ; 15:1995-2013, 2022.
Article in English | EMBASE | ID: covidwho-1822314

ABSTRACT

Background & Aims: Coronavirus disease 2019 (COVID-19) is a global health problem, presenting with symptoms ranging from mild nonspecific symptoms to serious pneumonia. Early screening techniques are essential in the diagnosis and assessment of disease progression. This consensus was designed to clarify the role of lung ultrasonography versus other imaging modalities in the COVID-19 pandemic. Methods: A multidisciplinary team consisting of experts from different specialties (ie, pulmonary diseases, infectious diseases, intensive care unit and emergency medicine, radiology, and public health) who deal with patients with COVID-19 from different geographical areas was classified into task groups to review the literatures from different databases and generate 10 statements. The final consensus statements were based on expert physically panelists’ discussion held in Cairo July 2021 followed by electric voting for each statement. Results: The statements were electronically voted to be either “agree,” “not agree,” or “neutral.” For a statement to be accepted to the consensus, it should have 80% agreement. Conclusion: Lung ultrasonography is a rapid and useful tool, which can be performed at bedside and overcomes computed tomography limitations, for screening and monitoring patients with COVID-19 with an accepted accuracy rate.

15.
Egyptian Journal of Radiology and Nuclear Medicine ; 53(1), 2022.
Article in English | EMBASE | ID: covidwho-1822229

ABSTRACT

Background: The recent pandemic of COVID‐19 has thrown the world into chaos due to its high rate of transmissions. This study aimed to highlight the encountered CT findings in 910 patients with COVID-19 pneumonia in Egypt including the mean severity score and also correlation between the initial CT finding and the short-term prognosis in 320 patients. Results: All patients had confirmed COVID-19 infection. Non-contrast CT chest was performed for all cases;in addition, the correlation between each CT finding and disease severity or the short-term prognosis was reported. The mean age was higher for patients with unfavorable prognosis (P < 0.01). The patchy pattern was the most common, found in 532/910 patients (58.4%), the nodular pattern was the least common 123/910 (13.5%). The diffuse pattern was reported in 124 (13.6%). The ground glass density was the most common reported density in the study 512/910 (56.2%). The crazy pavement sign was reported more frequently in patients required hospitalization or ICU and was reported in 53 (56.9%) of patients required hospitalization and in 29 (40.2%) patients needed ICU, and it was reported in 11 (39.2%) deceased patients. Air bronchogram was reported more frequently in patients with poor prognosis than patients with good prognosis (16/100;26% Vs 12/220;5.4%). The mean CT severity score for patients with poor prognosis was 15.2. The mean CT severity score for patients with good prognosis 8.7., with statistically significant difference (P = 0.001). Conclusion: Our results confirm the important role of the initial CT findings in the prediction of clinical outcome and short-term prognosis. Some signs like subpleural lines, halo sign, reversed halo sign and nodular shape of the lesions predict mild disease and favorable prognosis. The crazy paving sign, dense vessel sign, consolidation, diffuse shape and high severity score predict more severe disease and probably warrant early hospitalization. The high severity score is most important in prediction of unfavorable prognosis. The nodular shape of the lesions is the most important predictor of good prognosis.

16.
Therapeutic Advances in Respiratory Disease ; 16, 2022.
Article in English | EMBASE | ID: covidwho-1822140

ABSTRACT

Purpose: We aimed to better understand the pathophysiology of SARS-CoV-2 pneumonia in non-critically ill hospitalized patients secondarily presenting with clinical deterioration and increase in oxygen requirement without any identified worsening factors. Methods: We consecutively enrolled patients without clinical or biological evidence for superinfection, without left ventricular dysfunction and for whom a pulmonary embolism was discarded by computed tomography (CT) pulmonary angiography. We investigated lung ventilation and perfusion (LVP) by LVP scintigraphy, and, 24 h later, left and right ventricular function by Tc-99m-labeled albumin-gated blood-pool scintigraphy with late (60 mn) tomographic albumin images on the lungs to evaluate lung albumin retention that could indicate microvascular injuries with secondary edema. Results: We included 20 patients with confirmed SARS-CoV-2 pneumonia. All had CT evidence of organizing pneumonia and normal left ventricular ejection fraction. No patient demonstrated preserved ventilation with perfusion defect (mismatch), which may discard a distal lung thrombosis. Patterns of ventilation and perfusion were heterogeneous in seven patients (35%) with healthy lung segments presenting a relative paradoxical hypoperfusion and hypoventilation compared with segments with organizing pneumonia presenting a relative enhancement in perfusion and preserved ventilation. Lung albumin retention in area of organizing pneumonia was observed in 12 patients (60%), indicating microvascular injuries, increase in vessel permeability, and secondary edema. Conclusion: In hospitalized non-critically ill patients without evidence of superinfection, pulmonary embolism, or cardiac dysfunction, various types of damage may contribute to clinical deterioration including microvascular injuries and secondary edema, inconsistencies in lung segments vascularization suggesting a dysregulation of the balance in perfusion between segments affected by COVID-19 and others. Summary Statement: Microvascular injuries and dysregulation of the balance in perfusion between segments affected by COVID-19 and others are present in non-critically ill patients without other known aggravating factors. Key Results: In non-critically ill patients without evidence of superinfection, pulmonary embolism, macroscopic distal thrombosis or cardiac dysfunction, various types of damage may contribute to clinical deterioration including 1/ microvascular injuries and secondary edema, 2/ inconsistencies in lung segments vascularization with hypervascularization of consolidated segments contrasting with hypoperfusion of not affected segments, suggesting a dysregulation of the balance in perfusion between segments affected by COVID-19 and others.

17.
British Journal of Haematology ; 197(2):171-187, 2022.
Article in English | EMBASE | ID: covidwho-1822046

ABSTRACT

Scope: The objective of this guideline is to provide healthcare professionals with clear guidance on the management of patients with Waldenström macroglobulinaemia. In individual patients, circumstances may dictate an alternative approach. Methodology: This guideline was compiled according to the British Society for Haematology (BSH) process at http://www.b-s-h.org.uk/guidelines/proposing-and-writing-a-new-bsh-guideline/. Recommendations are based on a review of the literature using Medline, Pubmed, Embase, Central, Web of Science searches from beginning of 2013 (since the publication of the previous guidelines) up to November 2021. The following search terms were used: Waldenström(’s) macroglobulin(a)emia OR lymphoplasmacytic lymphoma, IgM(-related) neuropathy OR cold h(a)emagglutinin disease OR cold agglutinin disease OR cryoglobulin(a)emia AND (for group a only) cytogenetic OR molecular OR mutation OR MYD88 OR CXCR4, management OR treatment OR transfusion OR supportive care OR plasma exchange OR plasmapheresis OR chemotherapy OR bendamustine OR bortezomib OR ibrutinib OR fludarabine OR dexamethasone OR cyclophosphamide OR rituximab OR everolimus, bone marrow transplantation OR stem cell transplantation. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) nomenclature was used to evaluate levels of evidence and to assess the strength of recommendations. The GRADE criteria can be found at http://www.gradeworkinggroup.org. Review of the manuscript was performed by the British Society for Haematology (BSH) Guidelines Committee Haemato-Oncology Task Force, the BSH Guidelines Committee and the Haemato-Oncology sounding board of BSH. It was also on the members section of the BSH website for comment. It has also been reviewed by UK Charity WMUK;these organisations do not necessarily approve or endorse the contents.

18.
18th IEEE International Symposium on Biomedical Imaging (ISBI) ; : 1665-1668, 2021.
Article in English | Web of Science | ID: covidwho-1822036

ABSTRACT

This work introduces a 3D deep learning methodology to stratify patients according to the severity of lung infection caused by COVID-19 disease on computerized tomography images (CT). A set of volumetric attention maps were also obtained to explain the results and support the diagnostic tasks. The validation of the approach was carried out on a dataset composed of 350 patients, diagnosed by the RT-PCR assay either as negative (control - 175) or positive (COVID-19 - 175). Additionally, the patients were graded (0-25) by two expert radiologists according to the extent of lobar involvement. These gradings were used to define 5 COVID-19 severity categories. The model yields an average 60% accuracy for the multi-severity classification task. Additionally, a set of Mann Whitney U significance tests were conducted to compare the severity groups. Results show that patients in different severity groups have significantly different severity scores (p < 0.01) for all the compared severity groups.

19.
18th IEEE International Symposium on Biomedical Imaging (ISBI) ; : 635-639, 2021.
Article in English | Web of Science | ID: covidwho-1822035

ABSTRACT

The current coronavirus pandemic (COVID-19) became a world-wide threat, infecting more than 42 million people since its outbreak in early 2020. Recent studies show that analyzing chest CT scans plays an essential role in assessing disease progression and facilitates early diagnosis. Automatic lesion segmentation constitutes a useful tool to complement more traditional healthcare system strategies to address the COVID-19 crisis. We introduce MASC-Net, a novel deep neural network that automatically detects COVID-19 related infected lung regions from chest CT scans. The proposed architecture consists of a multi-input encoder-decoder that aggregates high-level features extracted with variable-size receptive fields.

20.
Computer Journal ; : 10, 2022.
Article in English | Web of Science | ID: covidwho-1821728

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic has been a globally dangerous crisis that causes an increasingly high death rate. Applying machine learning to the computed-tomography (CT)-based COVID-19 diagnosis is essential and attracts the attention of the research community. This paper introduces an approach for simultaneously identifying COVID-19 disease and segmenting its manifestations on lung images. The proposed method is an asymmetric U-Net-like model improved with skip connections. The experiment was conducted on a light-weighted feature extractor called CRNet with a feature enhancement technique called atrous spatial pyramid pooling. Classifying between COVID-19 and non-COVID-19 cases recorded the highest mean scores of 97.1, 94.4, and 97.0% for accuracy, dice similarity coefficient (DSC) and F1 score, respectively. Alternatively, the respective highest mean scores of the classification between COVID-19 and community-acquired pneumonia were 99.89, 99.79, and 99.97%. The lesion segmentation performance was with the highest mean of 99.6 and 84.7% for, respectively, accuracy and DSC.

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