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1.
NeuroQuantology ; 20(19):2964-2970, 2022.
Article in English | EMBASE | ID: covidwho-2206894

ABSTRACT

Aim-Covid 19 spike during Phase-II brought more organized multidisciplinary health care based on evidence. Chest physiotherapy, including proning, was recommended for desaturating patients in ICU. However, all patients did not tolerate changes in positions and proning. This study aimed at clinical profiling of patients as well as the development of a physiotherapy plan of care based on the needs of patients at different levels. Material and methods-Clinical profile of patients diagnosed with SARS-COV-2 during two months when there was peak in second wave were analysed. Patients' status and physiotherapy treatment mode and safety of positioning and physiotherapy was established. Results-There were 99 patients referred for physiotherapy from COVID ICU during the period of study. Patients had different co-morbidities and reasons for desaturation which cannot be concluded. However, a plan of physiotherapy care was developed in the study which is the first of its kind. Conclusion-The laid protocol of care based upon understanding the needs of these patients, logical classification as per their status, way to improve postural desaturation and prioritize the need of care in terms of bronchial hygiene, work of breathing, or improving compliance was a novel and helpful approach. Copyright © 2022, Anka Publishers. All rights reserved.

2.
Journal of Pharmaceutical Negative Results ; 13:6243-6251, 2022.
Article in English | EMBASE | ID: covidwho-2206805

ABSTRACT

Covid-19 pandemic has quickly spread over the world between 2019 and 2020, reaching Indonesia and Papua Province. Furthermore, public health services are affected by this pandemic. Therefore, this study differentiates between the infected, treated, recovering, and dying of Covid-19 patients in bad and good regencies in Papua Province. During the epidemic, a cross-sectional approach was employed to compare and contrast the health care services in bad and good regencies. This study's secondary and primary data were analyzed using a paired samples t-test. According to the results, the several factors that differentiate between bad and good regencies, include the confirmation of Covid-19, being treated, healed, died, the Covid-19 pandemic, integrated health service posts, community health service centers, hospital health services, and doctors/midwives practice. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

3.
Journal of Pharmaceutical Negative Results ; 13:3738-3740, 2022.
Article in English | EMBASE | ID: covidwho-2206772

ABSTRACT

Background: The novel coronavirus disease (COVID-19) has affected over 50 million people and has inflicted more than 1.2 million casualties ever since its inception in December 2019. Besides, multiple hematological and biochemical parameters have emerged as potential biomarkers to predict severe disease and mortality in COVID-19. One such biochemical biomarker is hypocalcemia. Hypocalcemia is associated with severe disease, organ failure, increased likelihood of hospitalization, admission to the intensive care unit, need for mechanical ventilation, and death from COVID-19. Hence, the present study was undertaken to compare the serum total calcium in patients infected with COVID-19 and a normal healthy population. Aim(s): To compare serum total calcium in patients infected with COVID-19 and normal healthy populations. Material(s) and Method(s): This is a case-control study with 50 COVID-19 patients and 50 normal healthy individuals as controls. Serum calcium was determined by Arsenazo III method using Vitros 5600 autoanalyser. Result(s): Chi-square analysis was done and the p-value between cases and control was < 0.05 which is significant. 20% of the COVID -19 patients had very severe hypocalcemia ranging between 4.5-6 mg/dl, 47% of the COVID-19 patients had moderate to severe hypocalcemia with values between 6.6-8.5 mg/dl, and 33% of the COVID -19 patients had normal calcium levels ranging from 8.6-10 mg/dl. Conclusion(s): Hypocalcemia is highly prevalent in COVID-19 patients implying that hypocalcemia is intrinsic to the disease. Prospective studies with a larger number of patients are required to prove this hypothesis and unravel the underlying pathophysiological mechanisms. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

4.
Journal of Pharmaceutical Negative Results ; 13:2780-2788, 2022.
Article in English | EMBASE | ID: covidwho-2206733

ABSTRACT

Background: Despite its widespread usage, invasive positive pressure ventilation (IPPV) has a dismal track record in COVID-19 patients with SARDS. Currently, there is a paucity of evidence supporting the usefulness of noninvasive positive pressure ventilation (NIPPV) in the treatment of severe ARDS, as well as a significant risk of aerosol formation in patients with COVID-19 infection. Objective(s): This study aims to assess the efficacy and safety of NIPPV administration to COVID-19 patients. Method(s): The trial included 130 participants with moderate tosevere ARDS based to the Berlin criteria (PaO2/FiO2 ratio of 200mmHg, GCS > 13, respiratory breathing index (RBI) of 105, and no systemic issues). They were treated with NIPPV with awake proaning up to 12 hours per day at a hospital in Muzaffarabad. The addition of a heat and moisture exchanger (HME) and viral/bacterial filters to the expiratory limb of the ventilator circuit represented a minor improvement. Result(s): In an average of six days, the PaO2/FiO2 ratio indicates that the severity of ARDS has improved from moderate/severe to mild in 64 percent of patients. 36 percent of individuals who had a defined airway experienced IPPV or failure of NIV. During the study period, 1 % the of healthcare workers (HCW) were infected with COVID19. The delivery of NIPPV was associated with claustrophobia, nasal crusting, aspiration, and barotrauma (0.7 percent). Conclusion(s): In selected patients, NIV with awake proaning up to 12 hours per day can be employed to give respiratory support without the need for IPPV, hence eliminating the need for IPPV in those patients. However, larger-scale investigations are required to validate our findings. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

5.
Journal of Advanced Research in Applied Sciences and Engineering Technology ; 29(1):198-206, 2022.
Article in English | Scopus | ID: covidwho-2206478

ABSTRACT

Since 2019, the Coronavirus infection has substantially impacted the worldwide ecosystem. This disease has apparently become airborne and has spread globally. Most daily activities have been curtailed to prevent the spread of the disease. Several measures have been devised by the World Health Organization to control the transmission of disease among humans. However, interior spaces are also crucial because individuals spend most of their time inside. To improve the interior living environment, it is necessary to develop a way to prevent the spread of airborne diseases. To obtain the desired level of efficiency and the requisite level of health for people to stay indoors, it is essential to install an efficient ventilation system. To avoid the transmission of airborne infections in confined areas, the purpose of this work is to examine the impact of the filtering mechanism in a controlled environment provided by Heating, Ventilation, and Air Conditioning (HVAC) systems. According to the study, ventilation, along with MERV13 or above recirculating filters, for instance, must be used (High-Efficiency Particulate Air) This criterion can be met with HEPA or a combination of outside air, filtration, and air-cleaning technology. To reduce the transmission of airborne diseases, the outcome of the study will result in a more effective installation of the mechanism of HVAC systems in interior environments. © 2022, Penerbit Akademia Baru. All rights reserved.

6.
Journal of Critical and Intensive Care ; 13(3):84-89, 2022.
Article in English | EMBASE | ID: covidwho-2206459

ABSTRACT

Aim: In the present study, our purpose was to evaluate the efficacy of the pulse-steroid treatment used in COVID-19 associated severe ARDS patients, and also to identify its effects on mortality in different doses. Study design: Retrospective Study Method: Patients with severe COVID-19 associated ARDS who had not previously received steroids, but were administered 1 g methylprednisolone (group 1) or 250 mg methylprednisolone (group 2) for 3 days, then 1 mg/kg/day during their hospitalization were retrospectively analyzed. The primary end-point was the discharge rate from the ICU or death. The secondary end-point was the 15th day survival rate. Result(s): A total of 48 patients with a mean age of 70.96+/-11.04 years were included. Twenty-six (54.2%) of them were male, 22 (45.8%) were female. Group 1 included 21 patients, group 2 included 27 patients. There was no difference in terms of demographic characteristics, comorbidities present, and medical findings between the groups on admission, except for the ferritin value which was lower in group 2 (p=0.027). There was no significant difference between groups groups in the 15-day mortality (p=0.134) and length of ICU stay (p=0.329). There was no difference between the groups in terms of discharge rates (p=0.55), need for mechanical ventilation (p=0.381), and complications (p=0.784). The odds ratio regarding the mortality of the patients in the 1 g pulse-steroid group was 3.17 times more likely than the 250 mg pulse-steroid group. Conclusion(s): Our results support that pulse-steroid therapy with 250 mg methylprednisolone may be more effective in patients admitted to intensive care units with ARDS due to COVID-19. Copyright © 2022 by Society of Turkish Intensivist.

7.
Indian Journal of Public Health Research and Development ; 14(1):290-293, 2023.
Article in English | EMBASE | ID: covidwho-2206452

ABSTRACT

Background: In patients with comorbid illnesses, COVID 19 disease is a severe acute respiratory syndrome that is linked to a variety of opportunistic bacterial and fungal infections. Finding the cause of fungal infections among post-covid patients in tertiary care hospitals is the aim of the study. Objective(s): To study the etiology of post-covid fungal infections among various age groups Methods: Out of 578 samples (pus/tissue/biopsy) collected from patients attending Koti ENT hospital with complaints of pain in eye, cheek swelling, headache. All samples were subjected to direct KOH mount and inoculated on SDA, incubated for 1 week at 25degreeC. Result(s): Out of 578 samples 214 are KOH positive and 291 are culture positive with fungi isolated - Mucor species, Aspergillus species and Candida species. Conclusion(s): As post covid fungal infections are rapidly progressive and devascularised disease, timely diagnosis helps in effective management and treatment of patients. Copyright © 2023, Institute of Medico-legal Publication. All rights reserved.

8.
Marine Intellectual Technologies ; - (4):33-39, 2022.
Article in Russian | Web of Science | ID: covidwho-2206377

ABSTRACT

The air environment is favorable for the reproduction of microorganisms and viruses. The problem has become particularly urgent in connection with the Cov19 coronavirus pandemic, which undoubtedly affected the operation of all types of fleet. The need for a concealed installation of an air disinfection device is due to safety requirements during the operation of the vessel. The recirculators currently in use are not elements of shipboard ventilation systems. The article proposes the modernization of this system using an integrated air disinfection unit. A schematic diagram of such an installation is proposed. An experimental stand has been developed to determine the effectiveness of air disinfection by studying microbial contamination. The planning and processing of the experiment results were carried out using a software product. A mathematical model has been developed for the operation of the supply air disinfection unit in the ship's ventilation system, which provides the necessary efficiency with minimal energy and heat costs for air treatment.

9.
Anesteziologie a Intenzivni Medicina ; 32(1):9-13, 2021.
Article in Czech | EMBASE | ID: covidwho-2206300

ABSTRACT

Acute hypoxemic respiratory failure (which occures also with severe course of COVID-19) requires oxygen therapy. The in vasiveness and intensity of chosen therapy corresponds with patient's condition and technical means available. If a large number of patients with hypoxic failure suddenly occur, the available equipment and/or human capacity to provide effective oxygen therapy may be greatly strained. The goal of our experiment was to test functionality of a simple device equipped with a Venturi nozzle Corovalve which we designed and printed on a 3D printer. We incorporated the nozzle into a system assembled from parts commonly available in the Czech Republic. We put this device through a static test and a dynamic test performed on ourselves and measured its basic parameters. In our experiment during spontaneous ventilation the device was able to generate positive mean airway pressure. At higher flow rates, the system was able to maintain a slightly positive pressure even during the inspiration, so we can talk about a system that allows, under certain circumstances, spontaneous ventilation at continuous positive airway pressure. The most effective from setting tested was oxygen input of 15 L/min combined with PEEP valve set to 10-15 cm H 2 O. Mean airway pressure ranged at 9-12 cm H 2 O and oxygen concentration in the inspiration mixture was 40-42%. We therefore conclude that our nozzle Corovalve printed on a 3D printer can be used in a simple device allowing positive pressure oxygen application during spontaneous ventilation EPAP/CPAP. It is economical and easy to provide method and therefore of a rather interesting potential. With a sufficient number of 3D printed nozzles it could be deployed quickly and on a mass scale. Copyright © 2021, Czech Medical Association J.E. Purkyne. All rights reserved.

10.
Revista Mexicana de Anestesiologia ; 46(1):61-66, 2023.
Article in Spanish | EMBASE | ID: covidwho-2206226

ABSTRACT

The severe form of SARS-CoV-2 pneumonia (COVID-19) occurs in most cases with acute respiratory distress syndrome (ARDS), requiring the use of sedation during mechanical ventilation, with propofol being the most widely used for its pharmacokinetics and pharmacodynamics. Propofol is a widely used anesthetic in intensive care units (ICU). Its use can cause an infrequent but extremely serious adverse effect, known as propofol infusion syndrome (PRIS), which is closely associated with the speed of infusion coupled with risk factors specific to the patient, the clinical features of PRIS are hemodynamic instability, lactic acidosis and with progression to multi-organ dysfunction. We present a case of SIP in a patient with acute respiratory distress syndrome (ARDS) secondary to SARS-CoV-2 who develops this complication associated with sedation, discusses clinical pathophysiology and considerations that should be taken into account when using it in continuous infusion. Copyright © 2023, Colegio Mexicano de Anestesiologia A.C.. All rights reserved.

11.
Environmental Research and Technology ; 5(2):172-180, 2022.
Article in English | Scopus | ID: covidwho-2206222

ABSTRACT

Houses are the places where people spend most of their time. That is why indoor air quality at home is essential for public health. Sufficient ventilation is the factor to avoid accumulation of pollutants in indoor air, which include microorganisms, such as SARS-CoV-2. Therefore, adequate ventilation is needed to provide good indoor air quality for human health and reduce infection risk at home. There are no reports of residential ventilation rates in Turkey. In this study, CO2 concentrations were measured in two residences in Izmir, Turkey. Three experiments were conducted to determine background concentrations and the rate of natural ventilation with infiltration and opening windows. Results show that air exchange provided by infiltration is low for both case rooms, while adequate ventilation could be achieved with natural ventilation under the studied conditions. Infiltration provided air exchange and ventilation rates of 0.18 h-1 and 5.9 m3/h for Case 1 and 0.29 h-1 and 8.23 m3/h for Case 2, respectively. Air exchange and ventilation rates were increased to 2.36 h-1 and 76.9 m3/h for Case 1 and 1.2 h-1 and 34 m3/h for Case 2, respectively, by opening the windows. Although ventilation can be provided by opening the windows, the other factors that determine its rate, e.g., meteorological variables, cannot be controlled by the occupants. Consequently, people cannot ensure the good indoor air quality in bedrooms and sufficient reduction in transmission of pathogenic microorganisms;therefore, risk of spreading diseases such as COVID-19 at home. © 2022 by the Author(s).

12.
Turk Geriatri Dergisi ; 25(4):622-631, 2022.
Article in English | EMBASE | ID: covidwho-2205769

ABSTRACT

Introduction: We aimed to compare the COVID-19 outcomes in unvaccinated and CoronaVac vaccinated older adults. Material(s) and Method(s): In this single-center study, patients aged >=65 years who were hospitalized for COVID-19 were retrospectively analyzed in two groups: unvaccinated and vaccinated. Result(s): A total of 742 patients were included. The mean age was 76.6+/-7.6 years. Of these, 46.1% (n=342) were male, 76.0% (n=564) were vaccinated. Among patients who were transferred to the intensive care unit (n=217), 206 (27.8%) received invasive mechanical ventilation support and 194 (26.1%) were died. In the multivariate analysis, advanced age (OR=1.03, 95%CI=1.01-1.06, p<0.01) and a high Charlson Comorbidity Index (OR=1.24, 95%CI=1.12-1.38, p<0.01) were predictors of mortality, while being vaccinated (OR=0.75, 95%CI=0.62-0.91, p<0.01) was associated with survival. Vaccination reduced the need for intensive care by 26.5% and mortality by 24.9 %. When the vaccinated group was evaluated, high Charlson Comorbidity Index (OR=1.428, 95%CI=1.14-1.64, p<0.01) was an independent predictor for mortality. However, booster vaccination in the last 130 days was the only protective factor that reduced mortality (p=0.04, 95%CI=0.43-0.99, OR=0.66) in multivariate analysis. Booster dose vaccination in the last 130 days reduced mortality by 33.8%. Conclusion(s): CoronaVac vaccination improved survival in hospitalized older adult patients (>=65 years old) with COVID-19. However, delaying the booster dose for more than 130 days were significantly associated with decreased survival. Therefore, older adults who completed their primary vaccination series with CoronaVac should not delay their booster dose to reduce the risk of death. Copyright © 2022, Geriatrics Society. All rights reserved.

13.
Turk Geriatri Dergisi ; 25(4):529-541, 2022.
Article in English | EMBASE | ID: covidwho-2205765

ABSTRACT

Introduction: Advanced age is an important prognostic indicator for the mortality of coronavirus disease 2019, especially in patients over 65. Patients with chronic underlying conditions such as hypertension showed the worst outcomes. This study aimed to identify predictors of mortality in elderly hypertensive patients hospitalized in intensive care units. Material(s) and Method(s): Demographic, clinical, treatment, and laboratory data were extracted from electronic medical records and compared between survivors and non-survivors. Univariate and multivariate logistic regression methods were used to explore the indicators of in-hospital mortality. Result(s): One hundred and ninety-eight patients with a median age of 75 years (65-94 years) were included in this study, of whom 95 were discharged from the intensive care units, and 103 died. Shortness of breath [hazard ratio (HR): 1.65, 95% confidence interval (CI): 1.04-2.61, p: 0.034], C-reactive protein (CRP)/albumin ratio (>51.32) (HR: 1.83, 95% CI: 1.12-2.97, p: 0.015), serum creatinine (>1.62 mg/dl) (HR: 2.04, 95% CI: 1.13-3.33, p: 0.001), aspartate transaminase (>34 u/l) (HR: 1.99, 95% CI: 1.28-3.09, p: 0.002), D-dimer (>781 ng/ml) (HR: 1.59, 95% CI: 1.04-2.43, p: 0.031), leukocyte (>12,000' 103/microl) (HR: 1.68, 95% CI: 1.09-2.59, p: 0.018) and lymphocyte count, (<=660' 103/microl) (HR: 1.76, 95% CI: 1.17-2.63, p: 0.006) were independent predictors for mortality in elderly hypertensive patients. Conclusion(s): Using these predictors with cut-off values can identify patients at risk of death and needing aggressive intervention earlier in the disease course. Copyright © 2022, Geriatrics Society. All rights reserved.

14.
Gaceta Medica de Mexico ; 158(6):425-431, 2022.
Article in Spanish | EMBASE | ID: covidwho-2205315

ABSTRACT

Introduction: SARS-CoV-2 infection has in, most cases, a mild course, although acute respiratory distress syndrome is associated with higher mortality. Objective(s): To determine overall mortality in hospitalized or intensive care unit (ICU)-admitted COVID-19 patients. Method(s): Inferential analysis from a database of the General Directorate of Epidemiology of Mexico. SARS-CoV-2-positive patients, hospitalized within the January 2020-December 2021 period, were included. General characteristics were described and a binary regression model was created to determine associations with mortality. Result(s): 116,446 patients who required hospital admission were identified. Overall mortality was 44%;in-hospital mortality, 33%;and ICU mortality, 33%. Mortality of patients with mechanical ventilation and hospital admission was 87%, and with ICU admission, 75%. In the public sector, hospital admissions at the Mexican Institute of Social Security and the Ministry of Health predominated, with OR = 2.24 (p = 0.004) and OR = 2.55 (p = 0.001), respectively, for mortality. Conclusion(s): Mortality was higher in the public sector, and this could be due to the overcrowding of services, which determined a scarcity of resources. Copyright © 2022, Academia Nacional de Medicina. All rights reserved.

15.
Minerva Respiratory Medicine ; 61(4):204-211, 2022.
Article in English | EMBASE | ID: covidwho-2205203

ABSTRACT

The number of COVID-19 cases only seem to be soaring. As clinicians are making more progress in understanding this new disease, new complications associated with the disease are catching attention. We present five cases of spontaneous pneumothorax in patients with COVID-19. These cases reveal that a pneumothorax can develop at any phase of the disease, and in patients without any contributing history and/or association with mechanical ventilation due to COVID-19. One plausible explanation is bulla formation resulting to pneumothorax. Clinicians treating COVID-19 must be aware of this complication, which could emerge at any stage of the disease, and misinterpreting this dyspnea as progression of ARDS, could prove fatal to the patient. Copyright © 2021 EDIZIONI MINERVA MEDICA.

16.
Annals of Palliative Medicine ; 11(12):3794-3803, 2022.
Article in English | Scopus | ID: covidwho-2204827

ABSTRACT

Background: Acute respiratory distress syndrome (ARDS) is a very common disease in the intensive care unit (ICU), with rapid progression and high mortality. Infections caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can easily progress to ARDS in severely ill patients. Early and rapid diagnosis as well as screening for ARDS during treatment is very important. Owing to the particularity of patients with coronavirus disease 2019 (COVID-19), computed tomography (CT) examination is not always possible, and chest radiographs have a low sensitivity and specificity for the diagnosis of lung diseases. Therefore, bedside lung ultrasound (LUS) can be used as a new tool for the diagnosis of ARDS in patients with COVID-19. In the non-gravity-dependent pulmonary field, there are bilateral non-uniform B lines. In the dorsal pulmonary field, the B lines are denser and even appears as "white lung”. Areas of consolidation are usually found in the dorsal pulmonary field, especially at the basilar part, with static or dynamic air bronchogram sign. In the fused B-line area, the "lung slip” usually decreases or disappears. The pleural line is irregular, thickened, and rough, with multiple small consolidations. The pulmonary ultrasound findings of primary and secondary ARDS were similar. Case Description: In the abovementioned context, we share our experience with the treatment of one critical COVID-19 case and review the literature. An 81-year-old male patient with ARDS which is caused by COVID-19. The implementation of prone ventilation was guided by LUS, and we found that the pulmonary edema in the gravity-dependent area did improve over time. After 9 h of prone ventilation, the consolidation of the posterior area began to open. LUS shows the change from fragment sign to B line. After 16 h, the B-line was educed, indicating that pulmonary edema was improving. The oxygenation could be improved. Pulmonary ultrasound makes the monitoring of prone ventilation visualized. As the same time, the patient was accepted high-flow nasal oxygen, mechanical ventilation and treated with oseltamivir, lopinavir/ ritonavir, abidol and cefoperazone-sulbactam. Conclusions: LUS-guided treatment was the key factor in the successful treatment of this case. © Annals of Palliative Medicine. All rights reserved.

17.
Tem Journal-Technology Education Management Informatics ; 11(4):1563-1568, 2022.
Article in English | Web of Science | ID: covidwho-2204564

ABSTRACT

People spend much of their lives indoors, so air quality is particularly important to their health, ability to work, and well-being. The COVID-19 pandemic has heightened people's awareness of the importance of maintaining high indoor air quality. Such an emergency has underscored the need for adequate heating, ventilation and air conditioning systems that can provide a good indoor air quality, especially ventilation systems as important players in preventing and reducing the risk of airborne infections. In this paper, we review natural and mechanical ventilation and their roles in dealing with coronavirus, focusing on key factors for healthy indoor air. Two pillars are critical for ventilation: increased air exchange rate and air filtration in ventilation systems.

18.
Russian Journal of Cardiology ; 27(11):40-48, 2022.
Article in Russian | EMBASE | ID: covidwho-2204231

ABSTRACT

Aim. To analyze the results of thrombectomy in lower-extremity ischemia in patients with coronavirus disease 2019 (COVID-19) and respiratory failure of different severity. Material and methods. This retrospective, cohort, comparative study for the period from May 1, 2020 to March 1, 2022 included 305 patients with acute lower-extremity ischemia and COVID-19. Depending on the type of oxygen support, three groups of patients were formed: group 1 (n=168) - nasal oxygen insufflation;group 2 (n=92) - non-invasive ventilation (NIV);group 3 (n=45) - artificial ventilation (AV). Thrombectomy was carried out according to the standard technique using Fogarty catheters (3F-6F - depending on the vessel size). After the diagnosis was established before and after the start of surgical treatment, all patients received the following therapy: Unfractionated IV heparin infusion at an initial rate of 1000 U/r, adjusted to maintain the activated partial thromboplastin time at 2-3 times the normal value;2. Oral acetylsalicylic acid 125 mg;3. Analgesics. Results. Myocardial infarction and ischemic stroke were not detected in the total sample. The highest number of deaths (group 1: 5,3%, n=9;group 2: 72,8%, n=67;group 3: 100%, n=45;p<0,0001), retrombosis (group 1: 18,4%, n=31;group 2: 69,5%, n=64;group 3: 91,1%, n=41;p<0,0001) and limb amputations (group 1: 9,5%, n=16;group 2: 56,5%, n=52;group 3: 91,1%, n=41;p<0,0001) was recorded in group 3 patients. Conclusion. In patients receiving mechanical ventilation, COVID-19 have more aggressive course, which is expressed in an increase in laboratory para-meters (C-reactive protein, ferritin, interleukin-6, D-dimer), the severity of pneumonia and location of thrombosis in the tibial arteries. Among patients with COVID-19 receiving mechanical ventilation, the greatest number of re-thromboses (91,1%), limb amputations (91,1%), and deaths (100%) are noted, which suggests the expediency of abandoning open thrombectomy in favor of anticoagulant/antiplatelet therapy in this cohort of patients. The development of arterial thrombosis in patients with COVID-19 receiving mechanical ventilation is an indicator of a high risk of death. Open thrombectomy in combination with anticoagulant/antiplatelet therapy is most effective in patients on nasal oxygen insufflation or NIV. Copyright © 2022, Silicea-Poligraf. All rights reserved.

19.
International Journal of Public Health Science ; 12(1):181-186, 2023.
Article in English | Scopus | ID: covidwho-2203632

ABSTRACT

Since the beginning of 2020, people all around the world have been struggling with the impacts of the COVID-19 pandemic. Concurrently, major flooding and a pandemic have struck numerous regions of the world. As a result, relief centres for flood victims have been established in the affected regions. There is a risk of COVID-19 infection spreading among flood victims and workers at flood relief centres due to the enormous number of flood victims. This study focused on the Johor, Malaysia flood catastrophe. From the 1st to the 16th of January 2022, a cross-sectional study was conducted in johor flood relief centres using secondary data from E notification and COVID-19-line listing. 1,531 flood victims were examined for COVID-19 and Rapid antigen testing was performed. 711 victims were asymptomatic, whereas 820 victims were symptomatic. Six patients were identified as positive. During audits of multiple evacuation centres, few concerns were found. There was no sufficient ventilation, there was no distribution of face masks to victims, and there were no daily health checks. COVID-19 preventive measures in all evacuation centres need to be practiced and given attention by all occupants and agencies. © 2023, Intelektual Pustaka Media Utama. All rights reserved.

20.
Journal of Clinical and Diagnostic Research ; 17(1):OE01-OE05, 2023.
Article in English | EMBASE | ID: covidwho-2203494

ABSTRACT

During the second wave of the viral pandemic, hospitals were overcrowded by the escalation of Coronavirus Disease-2019 (COVID-19) cases. To effectively address the drastic escalation of the COVID-19 pandemic, innovative solutions are warranted. The rising demand for critical-care services burdens hospitals;hence, to alleviate the burden on the healthcare system, asymptomatic patients or those with mild symptoms can be treated at home through continuous monitoring and care. Affected patients are at risk of hypoxia, which urgently requires oxygen therapy. Depending on the extent of oxygen demand, patients can boost their oxygen levels by making use of a nasal cannula, face mask, oxygen cylinder, and/or oxygen concentrator. Several risk factors are associated with the augmented probability of COVID-19 progression to severe status due to increased oxygen requirement, and they include advanced age, obesity, glucose intolerance, hypertension, and cardiovascular disease. A close monitoring of oxygen saturation (SpO2) along with other clinical investigations like complete and differential blood counts, serum electrolytes, random blood sugar, liver function tests, coagulation profile (Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT) and International Normalized Ratio (INR)), renal function test, C-reactive protein (CRP), D-dimer and ferritin level are mandatory for patients receiving home-based oxygen therapy. An awareness of safety considerations such as perfectly fitting, proper sized mask, availability of ventilation, knowledge of caregiver about danger signs and good functioning of fire alarm system at home are of prime importance before setting up oxygenation devices at home, and this further mandates a comprehensive evaluation of home-based management and treatment of mildly symptomatic patients with COVID-19. Copyright © 2023 Journal of Clinical and Diagnostic Research. All rights reserved.

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