Subject(s)
Acute Kidney Injury , COVID-19 , Acute Kidney Injury/prevention & control , Angiotensin Receptor Antagonists/pharmacology , Angiotensin Receptor Antagonists/therapeutic use , Angiotensin-Converting Enzyme Inhibitors/pharmacology , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Antihypertensive Agents , Humans , Renin-Angiotensin SystemSubject(s)
Acute Kidney Injury , Coronavirus Infections , Darunavir , Drug Interactions , Hydroxychloroquine , Liver Transplantation/methods , Pandemics , Pneumonia, Viral , Prednisone , Ritonavir , Tacrolimus , Acute Kidney Injury/chemically induced , Acute Kidney Injury/diagnosis , Acute Kidney Injury/prevention & control , Adult , Antiviral Agents/administration & dosage , Antiviral Agents/adverse effects , Betacoronavirus/isolation & purification , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques/methods , Coronavirus Infections/diagnosis , Coronavirus Infections/drug therapy , Coronavirus Infections/physiopathology , Darunavir/administration & dosage , Darunavir/adverse effects , Drug Monitoring/methods , Humans , Hydroxychloroquine/administration & dosage , Hydroxychloroquine/adverse effects , Immunosuppressive Agents/administration & dosage , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/blood , Male , Pneumonia, Viral/diagnosis , Pneumonia, Viral/drug therapy , Pneumonia, Viral/physiopathology , Prednisone/administration & dosage , Prednisone/adverse effects , Risk Adjustment/methods , Ritonavir/administration & dosage , Ritonavir/adverse effects , SARS-CoV-2 , Tacrolimus/administration & dosage , Tacrolimus/adverse effects , Tacrolimus/blood , Transplant Recipients , Treatment OutcomeABSTRACT
Hemoperfusion (HP) was helpful to prevent the development and progression of acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), liver failure, and septic shock by removing cytokines and other inflammatory mediators and ultimately preventing progression toward multiple organ failure. A 54-year-old man diagnosed with COVID-19 was hospitalized in the intensive care unit. The patient's O2 saturation was 80% using an oxygen mask, which was gradually declining. After 4 sessions of HP/continuous renal replacement therapies (CRRT), O2 saturation reached to 95%, and the patient was transferred to the general ward. Performing HP/CRRT at the early stages of ARDS can obviate the need for intubating patients with COVID-19. Punctual and early use of HP and CRRT in the treatment of ARDS in patients with COVID-19 prevented the progression of ARDS and patient intubation, reduced respiratory distress and the patient's dependence on oxygen, prevented other complications such as AKI and septic shock in the patient, and reduced mortality and hospital length of stay.