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Diabetes Obes Metab ; 22(10): 1897-1906, 2020 10.
Article in English | MEDLINE | ID: covidwho-436533

ABSTRACT

AIM: To evaluate the association between different degrees of hyperglycaemia and the risk of all-cause mortality among hospitalized patients with COVID-19. MATERIALS AND METHODS: In a retrospective study conducted from 22 January to 17 March 2020, 453 patients were admitted to Union Hospital in Wuhan, China, with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection. Patients were classified into four categories: normal glucose, hyperglycaemia (fasting glucose 5.6-6.9 mmol/L and/or HbA1c 5.7%-6.4%), newly diagnosed diabetes (fasting glucose ≥7 mmol/L and/or HbA1c ≥6.5%) and known diabetes. The major outcomes included in-hospital mortality, intensive care unit (ICU) admission and invasive mechanical ventilation (IMV). RESULTS: Patients with newly diagnosed diabetes constituted the highest percentage to be admitted to the ICU (11.7%) and require IMV (11.7%), followed by patients with known diabetes (4.1%; 9.2%) and patients with hyperglycaemia (6.2%; 4.7%), compared with patients with normal glucose (1.5%; 2.3%), respectively. The multivariable-adjusted hazard ratios of mortality among COVID-19 patients with normal glucose, hyperglycaemia, newly diagnosed diabetes and known diabetes were 1.00, 3.29 (95% confidence interval [CI] 0.65-16.6), 9.42 (95% CI 2.18-40.7) and 4.63 (95% CI 1.02-21.0), respectively. CONCLUSION: We showed that COVID-19 patients with newly diagnosed diabetes had the highest risk of all-cause mortality compared with COVID-19 patients with known diabetes, hyperglycaemia and normal glucose. Patients with COVID-19 need to be kept under surveillance for blood glucose screening.


Subject(s)
Asymptomatic Diseases/mortality , COVID-19/mortality , COVID-19/therapy , Diabetes Mellitus/mortality , Diabetes Mellitus/therapy , Aged , Asymptomatic Diseases/therapy , Blood Glucose/physiology , COVID-19/complications , COVID-19/epidemiology , China/epidemiology , Diabetes Mellitus/diagnosis , Female , Hospital Mortality , Hospitalization/statistics & numerical data , Humans , Hyperglycemia/complications , Hyperglycemia/diagnosis , Hyperglycemia/mortality , Hyperglycemia/therapy , Intensive Care Units/statistics & numerical data , Male , Middle Aged , Pandemics , Retrospective Studies , Risk Factors , SARS-CoV-2/physiology
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