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1.
Pract Neurol ; 21(6): 466-467, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1526526
3.
Adv Biol Regul ; 77: 100745, 2020 08.
Article in English | MEDLINE | ID: covidwho-741319

ABSTRACT

Coronavirus disease 2019 caused by SARS-CoV-2 originated from China and spread across every corner of the world. The scientific interest on COVID-19 increased after WHO declared it a pandemic in the early February of 2020. In fact, this pandemic has had a worldwide impact on economy, health, and lifestyle like no other in the last 100 years. SARS-CoV-2 belongs to Coronaviridae family and causes the deadliest clinical manifestations when compared to other viruses in the family. COVID-19 is an emerging zoonotic disease that has resulted in over 383,000 deaths around the world. Scientists are scrambling for ideas to develop treatment and prevention strategies to thwart the disease condition. In this review, we have attempted to summarize the latest information on the virus, disease, prevention, and treatment strategies. The future looks promising.


Subject(s)
Betacoronavirus/pathogenicity , COVID-19/epidemiology , Communicable Disease Control/organization & administration , Coronavirus Infections/epidemiology , Pandemics , Pneumonia, Viral/epidemiology , Antiviral Agents/therapeutic use , Ataxia/diagnosis , Ataxia/physiopathology , Ataxia/virology , COVID-19/prevention & control , COVID-19/therapy , COVID-19/transmission , Communicable Disease Control/methods , Coronavirus Infections/prevention & control , Coronavirus Infections/therapy , Coronavirus Infections/transmission , Humans , Hydroxychloroquine/therapeutic use , Nausea/diagnosis , Nausea/physiopathology , Nausea/virology , Pandemics/prevention & control , Personal Protective Equipment/supply & distribution , Physical Distancing , Pneumonia, Viral/prevention & control , Pneumonia, Viral/therapy , Pneumonia, Viral/transmission , Quarantine/methods , Quarantine/organization & administration , Risk Factors , SARS-CoV-2 , Severity of Illness Index , Vomiting/diagnosis , Vomiting/physiopathology , Vomiting/virology
5.
J Med Virol ; 92(7): 699-702, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-96729

ABSTRACT

Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS-CoV-2.


Subject(s)
Ageusia/diagnosis , Ataxia/diagnosis , Betacoronavirus/pathogenicity , Coronavirus Infections/diagnosis , Olfaction Disorders/diagnosis , Pneumonia, Viral/diagnosis , Seizures/diagnosis , Aged , Ageusia/complications , Ageusia/physiopathology , Ageusia/virology , Ataxia/complications , Ataxia/physiopathology , Ataxia/virology , Betacoronavirus/genetics , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques/methods , Coronavirus Infections/complications , Coronavirus Infections/physiopathology , Coronavirus Infections/virology , Endothelial Cells/pathology , Endothelial Cells/virology , Fatal Outcome , Frontal Lobe/blood supply , Frontal Lobe/pathology , Frontal Lobe/virology , Hospitalization , Humans , Lung/blood supply , Lung/pathology , Lung/virology , Male , Neurons/pathology , Neurons/virology , Olfaction Disorders/complications , Olfaction Disorders/physiopathology , Olfaction Disorders/virology , Pandemics , Pneumonia, Viral/complications , Pneumonia, Viral/physiopathology , Pneumonia, Viral/virology , RNA, Viral/genetics , Reverse Transcriptase Polymerase Chain Reaction , SARS-CoV-2 , Seizures/complications , Seizures/physiopathology , Seizures/virology
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