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1.
Hist Philos Life Sci ; 43(4): 116, 2021 Nov 11.
Article in English | MEDLINE | ID: covidwho-1527535

ABSTRACT

It has been claimed that the global pandemic is a 'great equaliser' that creates a sense of cohesion, however, this is problematic since COVID-19 has revealed the stark divisions in our societies. For instance, in the UK COVID-19 has hit northern cities particularly hard. Therefore, by focusing on the north of England, and Bradford especially, this paper offers suggestions which may help us see clearly through COVID-19, creating a future that is more equitable.


Subject(s)
COVID-19 , Humans , Pandemics , SARS-CoV-2 , Socioeconomic Factors , United Kingdom
2.
Curr Pain Headache Rep ; 25(11): 73, 2021 Nov 11.
Article in English | MEDLINE | ID: covidwho-1527506

ABSTRACT

PURPOSE OF REVIEW: Headache is a common symptom of COVID-19 with emerging literature being published on the subject. Although it may seem unspecific, scientific evidence has allowed a better definition of this headache type, revealing relevant associations with other COVID-19 symptoms and prognoses. We therefore sought to highlight the most remarkable findings concerning headache secondary to COVID-19, specifically focusing on epidemiology, characteristics, pathophysiology, and treatments. RECENT FINDINGS: The real prevalence of headache as a symptom of COVID-19 is still unclear ranging from 10 to 70%. Headache mainly has a tension-type-like phenotype, although 25% of individuals present with migraine-like features that also occur in patients without personal migraine history. This finding suggests that a likely pathophysiological mechanism is the activation of the trigeminovascular system. SARS-CoV-2 neurotropism can occur by trans-synaptic invasion through the olfactory route from the nasal cavity, leading to anosmia which has been associated with headache. SARS-CoV-2 protein has been found not only in olfactory mucosa and bulbs but also in trigeminal branches and the trigeminal ganglion, supporting this hypothesis. However, other mechanisms such as brain vessels inflammation due to SARS-CoV-2 damage to the endothelium or systemic inflammation in the context of cytokine storm cannot be ruled out. Interestingly, headache has been associated with lower COVID-19 mortality. No specific treatment for COVID-19 headache is available at present. Studies show that investigating COVID-19 headache represents an opportunity not only to better understand COVID-19 in general but also to advance in the knowledge of both secondary and primary headaches. Future research is therefore warranted.


Subject(s)
COVID-19/epidemiology , Headache/epidemiology , Anosmia/physiopathology , COVID-19/complications , COVID-19/mortality , COVID-19/physiopathology , Endothelium, Vascular , Headache/etiology , Headache/physiopathology , Headache/therapy , Humans , Inflammation , Migraine Disorders/physiopathology , SARS-CoV-2 , Tension-Type Headache/physiopathology , Trigeminal Ganglion/physiopathology , Trigeminal Ganglion/virology , Trigeminal Nerve/physiopathology , Trigeminal Nerve/virology , Viral Tropism
5.
Ann Intern Med ; 174(9): 1325-1326, 2021 09.
Article in English | MEDLINE | ID: covidwho-1526997
6.
Ann Intern Med ; 174(9): 1344-1345, 2021 09.
Article in English | MEDLINE | ID: covidwho-1526993

Subject(s)
COVID-19 , SARS-CoV-2 , Humans
7.
Ann Intern Med ; 174(7): 1037, 2021 07.
Article in English | MEDLINE | ID: covidwho-1526991

Subject(s)
COVID-19 , SARS-CoV-2 , Humans
8.
Ann Intern Med ; 174(4): 579-580, 2021 04.
Article in English | MEDLINE | ID: covidwho-1526990

Subject(s)
COVID-19 , Masks , Humans , SARS-CoV-2 , Textiles
9.
Ann Intern Med ; 174(4): 579, 2021 04.
Article in English | MEDLINE | ID: covidwho-1526989

Subject(s)
COVID-19 , Masks , Humans , SARS-CoV-2 , Textiles
10.
Ann Intern Med ; 174(6): 887-888, 2021 06.
Article in English | MEDLINE | ID: covidwho-1526988
12.
Ann Intern Med ; 174(5): 734-735, 2021 05.
Article in English | MEDLINE | ID: covidwho-1526986
13.
Ann Intern Med ; 174(5): 734, 2021 05.
Article in English | MEDLINE | ID: covidwho-1526985
17.
Ann Intern Med ; 174(2): 287-288, 2021 02.
Article in English | MEDLINE | ID: covidwho-1526981
19.
Ann Intern Med ; 174(1): JC2, 2021 01.
Article in English | MEDLINE | ID: covidwho-1526979

ABSTRACT

SOURCE CITATION: Lamontagne F, Agoritsas T, Macdonald H, et al. A living WHO guideline on drugs for covid-19. BMJ. 2020;370:m3379. 32887691.


Subject(s)
Adrenal Cortex Hormones/therapeutic use , COVID-19/drug therapy , Coronavirus Infections/drug therapy , Pneumonia, Viral/drug therapy , Practice Guidelines as Topic , Betacoronavirus , Critical Illness , Humans , Pandemics , SARS-CoV-2 , World Health Organization
20.
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