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1.
Ann Intern Med ; 174(2): 283, 2021 02.
Article in English | MEDLINE | ID: covidwho-1110701
2.
Arch. venez. farmacol. ter ; 39(6): 795-807, 2020. tab, graf
Article | LILACS (Americas) | ID: covidwho-1110615

ABSTRACT

La pandemia producida por el virus SARS-CoV-2 es el gran enigma que enfrenta la salud global debido a su rápida ex- pansión, ante este escenario, la fitoterapia ha demostrado desde tiempos inmemorables su importancia en el aporte de innovaciones terapéuticas. En este contexto, se efectuó una revisión de las referencias bibliográficas oficiales del país, cruzándolas con la base de datos Natural medicine del Insti- tuto Karolinska, obteniendo 25 plantas medicinales con efec- to antiviral e inmunomodulador. Luego se utilizó tres bases de datos: Scopus, Google académico y BVS-MTCI, los que me- diante un screening focalizado en ambos efectos para virus ARN, quedaron 79 artículos, correspondientes a 14 plantas medicinales; de ellas 7 presentaron efectos anti-coronavirus: Sambucus nigra, Chinaca purpurea, Astragalus membra- naceus, Glycyrrhiza glabra, Eucaliptus globulus, Aloe vera, y Camellia sinensis; estas tres últimas, además, poseen un potencial efecto contra SARS-CoV-2, por lo que se propone profundizar en el estudio terapéutico de las mismas.


The pandemic caused by the SARS-CoV-2 virus is the great- est issue facing global health due to its rapid expansion. Given this scenario, the phytotherapy has demonstrated its importance since time immemorial providing therapeutic in- novations. In this context, a review of the official bibliographic references of the country was carried out, crossing them with the Natural medicine database of the Karolinska Institute, ob- taining 25 medicinal plants with antiviral and immunomodu- latory effects. Then, three databases were used: Scopus, Google Scholar and BVS-MTCI, which through a focused screening in both effects for RNA viruses, it was left 79 ar- ticles, corresponding to 14 medicinal plants; of these plants, 7 presented anti-coronavirus effects: Sambucus nigra, Echi- nacea purpurea, Astragalus membranaceus, Glycyrrhiza gla- bra, Eucalyptus globulus, Aloe vera, and Camellia sinensis; the last three from these, in addition, have a potential effect against SARS-CoV-2, and for this reason, an in-depth study of their therapeutic properties is proposed.


Subject(s)
Humans , Antiviral Agents , Coronavirus Infections/epidemiology , Immunologic Factors , Plants, Medicinal , Phytotherapy
3.
Rev. ciênc. farm. básica apl ; 40: [3], 01/01/2019.
Article in English | LILACS (Americas) | ID: covidwho-1106950

ABSTRACT

The use of chloroquine and hydroxychloroquine as off-label treatments for covid-19 disease is a resort for critical care patients under enteral nutrition (EN). However, the use of solid pharmaceutical forms of these drugs through feeding tubes can pose a challenge to the health care team. Therefore, we performed a review of literature regarding administration of chloroquine and hydroxychloroquine through feeding tubes. For this end, a search was performed on PubMed and Lilacs database using key-words and free terms referring to drug administration via feeding tubes, and, specifically chloroquine and hydroxychloroquine. Also, a search on Micromedex® database and on the Handbook of Drug Administration via Enteral Feeding Tubes were performed. A total of 1.784 articles were retrieved. However, 4 articles fitted in the inclusion criteria. Two articles exploring the administration of chloroquine via feeding tubes on children with malaria found no difference on clinical results or tolerability when comparing it with oral or intramuscular administration. Other article showed full dispersion of hydroxychloroquine on water after crushing with mortar and pestle. A review found no information regarding the administration of hydroxychloroquine via postpyloric feeding tubes. No information was found on Micromedex® or the consulted Handbook; however, they pointed out the interaction between chloroquine and multivalent ions if coadministered.(AU)


Subject(s)
Humans , Chloroquine/administration & dosage , Enteral Nutrition/instrumentation , Coronavirus , Hydroxychloroquine/administration & dosage , Coronavirus Infections/therapy
4.
Rev. ciênc. farm. básica apl ; 40: [3], 01/01/2019.
Article in English | LILACS (Americas) | ID: covidwho-1106949

ABSTRACT

The use of chloroquine and hydroxychloroquine as off-label treatments for covid-19 disease is a resort for critical care patients under enteral nutrition (EN). However, the use of solid pharmaceutical forms of these drugs through feeding tubes can pose a challenge to the health care team. Therefore, we performed a review of literature regarding administration of chloroquine and hydroxychloroquine through feeding tubes. For this end, a search was performed on PubMed and Lilacs database using key-words and free terms referring to drug administration via feeding tubes, and, specifically chloroquine and hydroxychloroquine. Also, a search on Micromedex® database and on the Handbook of Drug Administration via Enteral Feeding Tubes were performed. A total of 1.784 articles were retrieved. However, 4 articles fitted in the inclusion criteria. Two articles exploring the administration of chloroquine via feeding tubes on children with malaria found no difference on clinical results or tolerability when comparing it with oral or intramuscular administration. Other article showed full dispersion of hydroxychloroquine on water after crushing with mortar and pestle. A review found no information regarding the administration of hydroxychloroquine via postpyloric feeding tubes. No information was found on Micromedex® or the consulted Handbook; however, they pointed out the interaction between chloroquine and multivalent ions if coadministered.(AU)


Subject(s)
Humans , Chloroquine/administration & dosage , Enteral Nutrition/instrumentation , Coronavirus , Hydroxychloroquine/administration & dosage , Coronavirus Infections/therapy
6.
Rev. Nutr. (Online) ; 33: e200212, 2020. tab, graf
Article in English | LILACS (Americas) | ID: covidwho-1105905

ABSTRACT

ABSTRACT Objective The objective of this work was to review papers that deal with nutritional therapy of inpatients with Covid-19 from the beginning of the pandemic. The survey covered the period until the month of September 2020. Methods This is a review of the indexed literature (Scopus, Pubmed and Lilacs), including area consensus. Results The review showed that the initial recommendations were based on generic assumptions and, as specific knowledge was being produced, the recommendations became more targeted. Conclusion In the health crisis generated by Covid-19, in the context of uncertainties related to nutritional care procedures, knowledge and action strategies were generated, coordinated by researchers and health professionals.


RESUMO Objetivo O objetivo deste trabalho foi revisar as publicações que trataram da terapia nutricional do paciente hospitalizado com Covid-19 desde o início da pandemia até o mês de setembro de 2020. Métodos Trata-se de uma revisão dos trabalhos indexados nas bases de dados Scopus, Pubmed e Lilacs, incluindo consensos da área. Resultados A revisão mostrou que as recomendações iniciais pautaram-se em pressupostos genéricos e, conforme o conhecimento específico foi sendo produzido, as recomendações passaram a ser mais direcionadas. Conclusão Na crise sanitária gerada pela Covid-19, no contexto de incertezas relacionadas aos procedimentos de atenção nutricional, foram gerados conhecimentos e estratégias de ação, coordenados por pesquisadores e profissionais de saúde.


Subject(s)
Nutritional Status , Coronavirus Infections/diet therapy , Nutrition Therapy
7.
Rev. Nutr. (Online) ; 33: e200171, 2020.
Article in English | LILACS (Americas) | ID: covidwho-1105900

ABSTRACT

ABSTRACT In Brazil, indigenous peoples present a complex reality characterized by a marked social vulnerability that is manifested in health and nutritional indicators. In this scenario, poor sanitary conditions prevail, with a high burden of chronic noncommunicable diseases; infectious/parasitic diseases; and nutritional disorders, including malnutrition and anemia. This situation is reflected in numerous aspects of food insecurity, placing this population in a position of particular vulnerability to the coronavirus disease 2019 pandemic and its effects. The objective of our study was to present a set of preliminary reflections on food insecurity and indigenous protagonism in times of Covid-19. The pandemic has deepened the inequalities that affect the indigenous peoples, with a direct impact on food security conditions. Amid the effects of the pandemic, indigenous protagonism has played a fundamental role in guaranteeing these peoples' rights and access to food, denouncing the absent and slow official responses as acts of institutional violence, which will have serious and lasting effects on the lives of indigenous peoples.


RESUMO No Brasil, os povos indígenas apresentam uma realidade complexa e caracterizada por uma acentuada vulnerabilidade social, manifesta em indicadores de saúde e de nutrição. Neste cenário prevalecem condições sanitárias precárias, com elevada carga de doenças crônicas não transmissíveis, doenças infecto-parasitárias e agravos nutricionais diversos, incluindo desnutrição e anemia. Esse quadro se reflete em inúmeras faces da insegurança alimentar, situando-os em uma posição particularmente vulnerável à pandemia e seus efeitos. O objetivo deste trabalho é apresentar um conjunto de reflexões, em caráter preliminar, sobre a insegurança alimentar e o protagonismo indígena em tempos de Covid-19. A pandemia vem aprofundando as iniquidades que os atingem, com impactos diretos nas condições de segurança alimentar. O protagonismo indígena tem tido um papel fundamental na garantia de seus direitos e acesso à alimentação, denunciando a ausência e a lentidão das respostas oficiais como ações de violência institucional, que terão graves e duradouros efeitos nas trajetórias destes povos.


Subject(s)
Humans , Coronavirus Infections/ethnology , Food and Nutrition Security , Indigenous Peoples , Social Organization
9.
Bratisl Lek Listy ; 122(3): 206-211, 2021.
Article in English | MEDLINE | ID: covidwho-1097343

ABSTRACT

INTRODUCTION: Coronavirus disease 2019 (COVID-19) has become a serious public health problem for    183 out of 197 countries in the world. Understanding the routes and pathogenesis of the coronavirus is important and it is considered that the studies on host cell receptor Angiotensin Converting Enzyme 2 (ACE2) may be valuable for the treatment and prevention of the disease. AIM: To evaluate the possibility of inhibition of SARS-CoV-2 at throat. METHODS: A comprehensive literature search was conducted. CONCLUSION: In view of the fact that the mouth and nose have higher number of ACE2 expressed cells, they serve as a gateway for the virus to enter. Thus, blocking the gate could be a good choice to reduce or even prevent the transmission. Small interfering RNAs (siRNAs) are double-stranded RNA molecules and could be designed easily and directed against many strains of a virus. Due to their features, siRNAs can provide a potential strategy to interfere with the replication of viral diseases. We think that since oral and nasal epithelial cells are relatively easily accessible it may allow to develop siRNA molecules to inhibit SARS-CoV-2 already at the entry where it continues to replicate for a period (Fig. 1, Ref. 50).


Subject(s)
Coronavirus Infections , Humans , Peptidyl-Dipeptidase A/genetics , Pharynx
12.
Nat Commun ; 12(1): 780, 2021 02 16.
Article in English | MEDLINE | ID: covidwho-1087442

ABSTRACT

Novel pathogenic coronaviruses - such as SARS-CoV and probably SARS-CoV-2 - arise by homologous recombination between co-infecting viruses in a single cell. Identifying possible sources of novel coronaviruses therefore requires identifying hosts of multiple coronaviruses; however, most coronavirus-host interactions remain unknown. Here, by deploying a meta-ensemble of similarity learners from three complementary perspectives (viral, mammalian and network), we predict which mammals are hosts of multiple coronaviruses. We predict that there are 11.5-fold more coronavirus-host associations, over 30-fold more potential SARS-CoV-2 recombination hosts, and over 40-fold more host species with four or more different subgenera of coronaviruses than have been observed to date at >0.5 mean probability cut-off (2.4-, 4.25- and 9-fold, respectively, at >0.9821). Our results demonstrate the large underappreciation of the potential scale of novel coronavirus generation in wild and domesticated animals. We identify high-risk species for coronavirus surveillance.


Subject(s)
Coronavirus/physiology , Host-Pathogen Interactions , Mammals/virology , Animals , Coronavirus Infections/virology , Humans , Models, Biological , Phylogeny , Recombination, Genetic/genetics , Reproducibility of Results
13.
Cyberpsychol Behav Soc Netw ; 24(2): 79-85, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1083628

ABSTRACT

The persistence of the coronavirus-caused respiratory disease (COVID-19) and the related restrictions to mobility and social interactions are forcing a significant portion of students and workers to reorganize their daily activities to accommodate the needs of distance learning and agile work (smart working). What is the impact of these changes on the bosses/teachers' and workers/students' experience? This article uses recent neuroscience research findings to explore how distance learning and smart working impact the following three pillars that reflect the organization of our brain and are at the core of school and office experiences: (a) the learning/work happens in a dedicated physical place; (b) the learning/work is carried out under the supervision of a boss/professor; and (c) the learning/work is distributed between team members/classmates. For each pillar, we discuss its link with the specific cognitive processes involved and the impact that technology has on their functioning. In particular, the use of videoconferencing affects the functioning of Global Positioning System neurons (neurons that code our navigation behavior), mirror neurons, self-attention networks, spindle cells, and interbrain neural oscillations. These effects have a significant impact on many identity and cognitive processes, including social and professional identity, leadership, intuition, mentoring, and creativity. In conclusion, just moving typical office and learning processes inside a videoconferencing platform, as happened in many contexts during the COVID-19 pandemic, can in the long term erode corporate cultures and school communities. In this view, an effective use of technology requires us to reimagine how work and teaching are done virtually, in creative and bold new ways.


Subject(s)
Education, Distance , Interpersonal Relations , Neural Pathways , Spatial Behavior , Attention , Coronavirus Infections , Humans , Learning , Memory, Episodic , Mirror Neurons , Neurons , Pandemics , Spatial Navigation , Students , Videoconferencing
14.
Ann Intern Med ; 174(2): 286-287, 2021 02.
Article in English | MEDLINE | ID: covidwho-1083219
15.
Ann Intern Med ; 174(2): 284, 2021 02.
Article in English | MEDLINE | ID: covidwho-1081919
16.
Ann Intern Med ; 174(2): 285-286, 2021 02.
Article in English | MEDLINE | ID: covidwho-1081462
17.
Ann Intern Med ; 174(2): 284-285, 2021 02.
Article in English | MEDLINE | ID: covidwho-1081122
18.
Ann Intern Med ; 174(2): 283-284, 2021 02.
Article in English | MEDLINE | ID: covidwho-1080986
19.
Ann Intern Med ; 174(2): 286, 2021 02.
Article in English | MEDLINE | ID: covidwho-1080401
20.
Wiad Lek ; 73(12 cz 1): 2672-2676, 2020.
Article in English | MEDLINE | ID: covidwho-1080000

ABSTRACT

OBJECTIVE: The aim: To investigate the causes of the negative impact of diabetes mellitus co-morbidity on the onset and development of COVID-19 in diabetic patients. PATIENTS AND METHODS: Materials and methods: Electronic databases of MEDLINE and Google Scholar were searched using keyword searches. CONCLUSION: Conclusions: 1. Diabetes mellitus is not a verdict. Diabetic patients can have COVID-19 with the same frequency as other people. And diabetes mellitus co-morbidity does not increase the probability of development COVID-19. 2. Previous diabetes can contribute the complications of COVID-19, patient's severe condition and can increase the mortality. 3. The reasons for the negative results of COVID 19 treatment in patients with diabetes may be: features of autonomic innervation in patients with diabetes, impaired function of pancreatic islet cells due to the influence of SARS-CoV-2, use of some cardiac drugs, expression of inflammatory factors due to infection.


Subject(s)
Coronavirus Infections , Diabetes Mellitus , /drug therapy , Humans
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