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Eur J Phys Rehabil Med ; 56(6): 853-857, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-1049277


BACKGROUND: According to literature, after COVID-19, patients may require rehabilitation care because of different degrees of physical impairments. Neurologic disorders are often described but no specific data about postacute cranial nerves involvement and possible correlation with dysphagia development are yet available. CASE REPORT: The patient is a 69-year-old man who presented acquired weakness and dysphagia with clinical cranial nerves impairment of lingual, IX, X and XII after SARS-CoV-2 infection, without electrophysiological alterations. He underwent rehabilitation program for two months, with slow recovery. However, at discharge residual hypoglossal nerve deficit sign was present. CLINICAL REHABILITATION IMPACT: This single case expands knowledge about clinical picture after SARS-CoV-2 disease. Is important to notice that cranial, particularly bulbar nerves could be involved as late complications. Thus, we discuss about risk factors, the nature of the damage and the impact in dysphagia pathophysiology and recovery. If supported by further studies, this case may help to understand dysphagia features in these patients.

COVID-19/complications , Cranial Nerve Diseases/complications , Cranial Nerves/physiopathology , Deglutition Disorders/etiology , Acute Disease , Aged , COVID-19/epidemiology , Cranial Nerve Diseases/physiopathology , Deglutition Disorders/physiopathology , Humans , Male , SARS-CoV-2
ACS Chem Neurosci ; 11(13): 1865-1867, 2020 07 01.
Article in English | MEDLINE | ID: covidwho-595686


Many COVID-19 patients are presenting with atypical clinical features. Happy hypoxemia with almost normal breathing, anosmia in the absence of rhinitis or nasal obstruction, and ageusia are some of the reported atypical clinical findings. Based on the clinical manifestations of the disease, we are proposing a new hypothesis that SARS-CoV-2 mediated inflammation of the nucleus tractus solitarius may be the reason for happy hypoxemia in COVID-19 patients.

Betacoronavirus , Coronavirus Infections/physiopathology , Hypoxia/physiopathology , Pneumonia, Viral/physiopathology , Solitary Nucleus/physiopathology , Solitary Nucleus/virology , COVID-19 , Coronavirus Infections/complications , Cranial Nerves/physiopathology , Cranial Nerves/virology , Humans , Hypoxia/etiology , Inflammation/etiology , Inflammation/physiopathology , Inflammation/virology , Pandemics , Pneumonia, Viral/complications , SARS-CoV-2