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Sensitive Detection of SARS-CoV-2-Specific Antibodies in Dried Blood Spot Samples.

Morley, Gabriella L; Taylor, Stephen; Jossi, Sian; Perez-Toledo, Marisol; Faustini, Sian E; Marcial-Juarez, Edith; Shields, Adrian M; Goodall, Margaret; Allen, Joel D; Watanabe, Yasunori; Newby, Maddy L; Crispin, Max; Drayson, Mark T; Cunningham, Adam F; Richter, Alex G; O'Shea, Matthew K.

Emerg Infect Dis ; 26(12): 2970-2973, 2020 12.

Article in English | MEDLINE | ID: covidwho-792953

ABSTRACT

Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.

Subject(s)

COVID-19/diagnosis , Dried Blood Spot Testing/methods , Antibodies, Viral/immunology , COVID-19 Serological Testing/methods , Case-Control Studies , Dried Blood Spot Testing/economics , Humans , Predictive Value of Tests , SARS-CoV-2/immunology , Spike Glycoprotein, Coronavirus/immunology , Spike Glycoprotein, Coronavirus/isolation & purification

ABSTRACT

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