WHO's Community-Centered Epidemic and Pandemic Information Platform: Hive.

Each epidemic and pandemic is accompanied by an infodemic. The infodemic during the COVID-19 pandemic was unprecedented. Accessing accurate information was difficult and misinformation harmed the pandemic response, the health of individuals and trust in science, governments and societies. WHO is building a community-centered information platform, the Hive, to deliver on the vision of ensuring that all people everywhere have access to the right information, at the right time, in the right format in order to make decisions to protect their health and the health of others. The platform provides access to credible information, a safe space for knowledge-sharing, discussion, and collaborating with others, and a forum to crowdsource solutions to problems. The platform is equipped with many collaboration features, including instant chats, event management, and data analytics tools to generate insights. The Hive platform is an innovative minimum viable product (MVP) that seeks to leverage the complex information ecosystem and the invaluable role communities play to share and access trustworthy health information during epidemics and pandemics.

Wastewater monitoring can anchor global disease surveillance systems.

To inform the development of global wastewater monitoring systems, we surveyed programmes in 43 countries. Most programmes monitored predominantly urban populations. In high-income countries (HICs), composite sampling at centralised treatment plants was most common, whereas grab sampling from surface waters, open drains, and pit latrines was more typical in low-income and middle-income countries (LMICs). Almost all programmes analysed samples in-country, with an average processing time of 2·3 days in HICs and 4·5 days in LMICs. Whereas 59% of HICs regularly monitored wastewater for SARS-CoV-2 variants, only 13% of LMICs did so. Most programmes share their wastewater data internally, with partnering organisations, but not publicly. Our findings show the richness of the existing wastewater monitoring ecosystem. With additional leadership, funding, and implementation frameworks, thousands of individual wastewater initiatives can coalesce into an integrated, sustainable network for disease surveillance-one that minimises the risk of overlooking future global health threats.

COVID-19 Lockdown Pandemic Period Effects in Highly Impacted Aquatic Ecosystems.

Human activities severely affect aquatic ecosystems: the lockdown restrictions due to SARS-CoV-2 (COVID-19) have proved that reducing anthropogenic activities can positively influence the environment and mitigate atmospheric pollution. In addition, studies on aquatic ecosystems have highlighted the decrease in suspended matter and pollutant concentrations associated with reduced marine transport and industrial activities. We evaluated the effects of the reduction of anthropogenic activities in highly impacted water ecosystems. Three of the sampling sites were on the Tiber River's lower stretch close to the urban area of Rome (Italy), and the other two were transitional waters located in the southern Latium region coastal area. These sampling sites have been studied by our research group for at least 20 years. The present study involved analysis of chemical and physicochemical parameters, biological communities, and land use. Microbiological fecal indicators and Salmonella spp. were also analyzed. There were two sampling campaigns, the first one in May 2020 (ID II) at the end of lockdown measures, and the second one a year later, in June 2021 (ID III). The data were compared with our old data, collected from 2002 to 2015 (ID I), to evaluate the potential effects of the restrictive measures. Biotic communities were dominated by pollution-tolerant taxa, indicating eutrophication and organic pollution. Furthermore, the high concentrations of microbiological indicators was mainly due to sewage from the urban area. The results of the research indicated no significant changes from past years (ID I) to 2020 (ID II) and 2021 (ID III). In conclusion, the restrictions adopted in Italy during the pandemic period were not sufficient to mitigate the heavy pressure of urbanization and agriculture that have long affected the studied aquatic ecosystems. Environ Toxicol Chem 2023;42:966-977. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

Occurrence and risks of microplastics in the ecosystems of the Middle East and North Africa (MENA).

The ubiquitous nature of microplastics (MPs) in nature and the risks they pose on the environment and human health have led to an increased research interest in the topic. Despite being an area of high plastic production and consumption, studies on MPs in the Middle East and North Africa (MENA) region have been limited. However, the region witnessed a research surge in 2021 attributed to the COVID-19 pandemic. In this review, a total of 97 studies were analyzed based on their environmental compartments (marine, freshwater, air, and terrestrial) and matrices (sediments, water columns, biota, soil, etc.). Then, the MP concentrations and polymer types were utilized to conduct a risk assessment to provide a critical analysis of the data. The highest MP concentrations recorded in the marine water column and sediments were in the Mediterranean Sea in Tunisia with 400 items/m3 and 7960 items/kg of sediments, respectively. The number of MPs in biota ranged between 0 and 7525 per individual across all the aquatic compartments. For the air compartment, a school classroom had 56,000 items/g of dust in Iran due to the confined space. Very high risks in the sediment samples (Eri > 1500) were recorded in the Caspian Sea and Arab/Persian Gulf due to their closed or semi-closed nature that promotes sedimentation. The risk factors obtained are sensitive to the reference concentration which calls for the development of more reliable risk assessment approaches. Finally, more studies are needed in understudied MENA environmental compartments such as groundwater, deserts, and estuaries.

Validation of the Attitude Scale on Prospective Teachers' Perceptions of the Consequences on Their Psychological State: Well-Being and Cognition.

The aim of this study was to analyse the validated psychometric characteristics of the "Scale of Attitudes towards New Post-Pandemic Scenarios" (SANPS) tool using a short version on Perceptions of Future Teachers towards the New Post-Pandemic Educational Scenarios; describe the attitudes of future teachers towards motivation, collaboration, and emerging active pedagogies; and determine the internal consistency and reliability of the tool. The design structure of the instrument consists of the following three latent factors, which were obtained through an exploratory factor analysis (EFA): empowerment/motivation, autonomy/situated learning and emerging digital pedagogies. The questionnaire was administered to a sample of 966 participants. In the confirmatory factor analysis (CFA), a previous hypothesis was established regarding the relationship of the factors and their number and nature, specifying the number of factors and the way in which the variables are related to each other. The 66.53% of total variance was explained. The reliability, calculated with Cronbach's alpha, reached a global value of over 0.90 (α = 0.94). This valid and reliable questionnaire, which incorporates a dimension that measures the transfer of learning in hybrid and multimodal models of digital ecosystems in Higher Education, can be applied in the evaluation of online education processes.

Decreased tourism during the COVID-19 pandemic positively affects reef fish in a high use marine protected area.

Humans alter ecosystems through both consumptive and non-consumptive effects. Consumptive effects occur through hunting, fishing and collecting, while non-consumptive effects occur due to the responses of wildlife to human presence. While marine conservation efforts have focused on reducing consumptive effects, managing human presence is also necessary to maintain and restore healthy ecosystems. Area closures and the tourism freeze related to the COVID-19 pandemic provided a unique natural experiment to measure the effects of decreased tourism on fish behavior in a high use no-take marine protected area (MPA) in Hawai`i. We found that when tourism shut down due to COVID restrictions in 2020, fish biomass increased and predatory species increased usage of shallow habitats, where tourists typically concentrate. When tourism resumed, fish biomass and habitat use returned to pre-pandemic levels. These displacement effects change fish community composition and biomass, which could affect key processes such as spawning, foraging and resting, and have knock-on effects that compromise ecosystem function and resilience. Managing non-consumptive uses, especially in heavily-visited MPAs, should be considered for sustainability of these ecosystems.

Regulatory, health technology assessment and company interactions: the current landscape and future ecosystem for drug development, review and reimbursement.

BACKGROUND: Multi-stakeholder interactions have evolved at product and policy levels. There is a need to assess the current and future landscape of interactions between companies, and regulatory and HTA agencies to address challenges and identify areas for improvement. OBJECTIVES: The aims of this study were to review the current interactions within and across regulatory and HTA agencies, and companies' experiences in engaging in these activities; to assess the added value of interactions as well as limitations; to explore the future ecosystem for stakeholder interactions. METHOD: Three separate questionnaires were developed for companies, regulators and HTA agencies, respectively, to assess their experiences and perceptions. The responses were analyzed using descriptive statistics and discussed at a multi-stakeholder workshop. Key outcomes from the surveys and workshop discussion were reported. RESULTS: All seven regulators and seven HTA agencies in the survey indicated that they had stakeholder interactions. More formal collaboration occurred with regulators compared with HTA agencies. All nine companies have taken early advice but indicated the need for future prioritization. Success indicators can be built at the product and therapy levels, with the added value of faster patient access. Four principles were proposed for the future ecosystem: separate remit and functions between regulators and HTA; align processes; converge evidence requirements where possible; increase transparency. CONCLUSIONS: This research brought together regulators, HTA agencies, companies to examine how they interact with one another. We propose measures of value and make recommendations on future evolution to enable better evidence generation and improve regulatory and HTA decision-making.

Impact of COVID-19 pandemic on cultural ecosystem services from urban green spaces: a case from English Bazar Urban Agglomeration, Eastern India.

Urban green space (UGS) provides multiple cultural ecosystem services (CES) and enhances people's physical and mental well-being. The importance of UGS was more critical during crisis periods such as the COVID-19 pandemic. Recently, UGS has been under severe threats due to rapid urban expansion and climate change. Particularly, the cities in developing countries have experienced a dramatic loss of green spaces due to land use and land cover (LULC) change. This study aims to assess the impact of the COVID-19 pandemic on CES perception obtained from two public UGS, i.e., Subhankar Sishu Uddyan (SSU) and Bandh Road (BR) in English Bazar Urban Agglomeration (EBUA), Eastern India. A survey was performed to assess the valuation of CES, CES obtained from UGS, and the use of CES difference during partial (unlock phases) and after lockdown periods. The non-parametric tests were carried out to understand the significant differences between CES and UGS perceived by the respondents. Explanatory factor analysis was also performed to find the association among CES for each UGS. The results reported substantial variations of UGS use during partial and after lockdown periods. During the after-lockdown period, the UGS mainly were used for social relations (51%), spending time with relatives and friends (25%), spending time with children (11%) in SSU and walking (25%), spending time with relatives and friends (21%), and physical activities (17%) in BR. During the partial lockdown period, a significant difference between SSU and BR was recorded from social relations and health value among all CES. After the full lockdown period, a significant difference was observed in recreation, social relations, health, and aesthetic value. The frequency and duration of UGS use during partial lockdown periods substantially increased. About 12% of the total visitor visited UGS daily after the lockdown, whereas it was 4% during the partial lockdown. The study's findings will assist urban planners and policymakers in understanding the need for UGS to promote the well-being of the citizens.

Collection of triatomines from sylvatic habitats by a Trypanosoma cruzi-infected scent detection dog in Texas, USA.

BACKGROUND: Triatomine insects, vectors of the etiologic agent of Chagas disease (Trypanosoma cruzi), are challenging to locate in sylvatic habitats. Collection techniques used in the United States often rely on methods to intercept seasonally dispersing adults or on community scientists' encounters. Neither method is suited for detecting nest habitats likely to harbor triatomines, which is important for vector surveillance and control. Furthermore, manual inspection of suspected harborages is difficult and unlikely to reveal novel locations and host associations. Similar to a team that used a trained dog to detect sylvatic triatomines in Paraguay, we worked with a trained scent detection dog to detect triatomines in sylvatic locations across Texas. PRINCIPLE METHODOLOGY/FINDINGS: Ziza, a 3-year-old German Shorthaired Pointer previously naturally infected with T. cruzi, was trained to detect triatomines. Over the course of 6 weeks in the fall of 2017, the dog and her handler searched at 17 sites across Texas. The dog detected 60 triatomines at 6 sites; an additional 50 triatomines were contemporaneously collected at 1 of these sites and 2 additional sites without the assistance of the dog. Approximately 0.98 triatomines per hour were found when only humans were conducting searches; when working with the dog, approximately 1.71 triatomines per hour were found. In total, 3 adults and 107 nymphs of four species (Triatoma gerstaeckeri, Triatoma protracta, Triatoma sanguisuga, and Triatoma indictiva) were collected. PCR testing of a subset revealed T. cruzi infection, including DTUs TcI and TcIV, in 27% of nymphs (n = 103) and 66% of adults (n = 3). Bloodmeal analysis of a subset of triatomines (n = 5) revealed feeding on Virginia opossum (Didelphis virginiana), Southern plains woodrat (Neotoma micropus), and eastern cottontail (Sylvilagus floridanus). CONCLUSION/SIGNIFICANCE: A trained scent detection dog enhanced triatomine detections in sylvatic habitats. This approach is effective at detecting nidicolous triatomines. Control of sylvatic sources of triatomines is challenging, but this new knowledge of specific sylvatic habitats and key hosts may reveal opportunities for novel vector control methods to block the transmission of T. cruzi to humans and domestic animals.

Boost the resilience of protected areas to shocks by reducing their dependency on tourism.

Ecotourism is widely considered a strong mechanism for the sustainable funding of protected areas (PAs). Implemented during the 1990s in Madagascar, nature-based tourism experienced positive growth over the last 30 years with increasing numbers of visits to the parks and reserves. Revenue earned from entrance fees to the network of PAs managed by Madagascar National Parks has never been sufficient to finance their management. Political crises and the COVID-19 pandemic in particular, have highlighted for park managers, the risk of relying on such earnings when they covered just 1% of the required funding in 2021. Alternative mechanisms of funding are analysed for all of Madagascar's PAs with a view to facilitating sustainable conservation of the localities and protection of the island's biodiversity.

Acknowledging geodiversity in safeguarding biodiversity and human health.

Our existence on Earth is founded on a vital nature, which supports human physical and mental health. However, nature is often depicted only through biodiversity, whereas geodiversity-the diversity of non-living nature-has so far been neglected. Geodiversity consists of assemblages, structures, and systems of geological, geomorphological, soil, and hydrological components that fundamentally underlie biodiversity. Biodiversity can support overall human health only with the foundation of geodiversity. Landscape characteristics, such as varying topography or bodies of water, promote aesthetic and sensory experiences and are also a product of geodiversity. In this Personal View, we introduce the concept of geodiversity as a driver for planetary health, describe its functions and services, and outline the intricate relationships between geodiversity, biodiversity, and human health. We also propose an agenda for acknowledging the importance of geodiversity in health-related research and decision making. Geodiversity is an emerging topic with untapped potential for ensuring ecosystem functionality and good living conditions for people in a time of changing environments.

Nutrition in City Ecosystems (NICE): Protocol of a multi-sectoral development project to improve food and nutrition security of secondary city populations in Bangladesh, Kenya and Rwanda.

Background: Secondary cities tend to be better linked with local food systems than primate cities, acting as important platforms to trade agricultural produce with rural surrounding. COVID-19, conflicts and climate change continue to expose inefficiencies in food systems and have further exacerbated malnutrition, calling for substantial food systems transformations. However, tackling current food systems' challenges requires new approaches to ensure food and nutrition security. Nutritious and agroecologically produced food offer the potential to transform food systems by improving diets and alleviating pressure on the environment, as well as by creating jobs and reducing poverty. This paper describes the design of a project by a Swiss public-private consortium to improve food and nutrition security and to reduce poverty in city ecosystems in six secondary cities in Bangladesh, Kenya and Rwanda through governance/policy and supply and demand side interventions. Methods: The Nutrition in City Ecosystems (NICE) project promotes well-balanced nutrition for city populations through interdisciplinary agricultural, food, and health sector collaborations along city-specific value chains. Adopting a transdiciplinary systems approach, the main interventions of NICE are (i) advocacy and policy dialogue, (ii) building of decentralized institutional capacity in multi-sectoral collaborations, (iii) support of data-driven planning, coordination and resource mobilization, (iv) anchoring of innovations and new approaches in city-level partnerships, (v) capacity building in the agricultural, retail, health and education sectors, as well as (vi) evidence generation from putting policies into practice at the local level. NICE is coordinated by in-country partners and local offices of the Swiss public-private consortium partners. Discussion: The NICE project seeks to contribute to urban food system resilience and enhanced sustainable nutrition for city populations by (A) strengthening urban governance structures involving key stakeholders including women and youth, (B) generating income for producers along the supply chain, (C) triggering change in producers' and consumers' behavior such that nutritious and agroecologically produced foods are both in demand as well as available and affordable in urban markets, and (D) allowing a scale up of successful approaches to other national and international cities and city networks.

A Decade of Scientific and Technological Innovation at Chinese Academy of Medical Sciences & Peking Union Medical College: Retrospect and Prospect.

Focusing on the reform initiatives of Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC) in medical scientific and technological innovation from perspectives of deepening the reform and optimizing the ecosystem of science and technology innovation, this article summarizes the highlights of CAMS & PUMC's efforts in safeguarding people's health and promoting the Healthy China 2030 strategy through scientific and technological innovation in the fields including basic research, disease prevention and treatment, and medical technology in the past ten years. These achievements embody the endeavors and responsibility of CAMS & PUMC in realizing self-reliance and self-improvement of Chinese medical science and technology and highlight its contributions to the development of medical science and technology of China.

European fluxes of medical gadolinium to the ocean: A model based on healthcare databases.

Marine ecosystems are exposed to a multitude of stresses, including emerging metals as Rare Earth Elements. The management of these emerging contaminants represents a significant environmental issue. For the past three decades, the increasing medical use of gadolinium-based contrast agents (GBCAs) has contributed to their widespread dispersion in hydrosystems, raising concerns for ocean conservation. In order to control GBCA contamination pathways, a better understanding of the cycle of these elements is needed, based on the reliable characterization of fluxes from watersheds. Our study proposes an unprecedented annual flux model for anthropogenic gadolinium (Gdanth) based on GBCA consumption, demographics and medical uses. This model enabled the mapping of Gdanth fluxes for 48 European countries. The results show that 43 % of Gdanth is exported to the Atlantic Ocean, 24 % to the Black Sea, 23 % to the Mediterranean Sea and 9 % to the Baltic Sea. Together, Germany, France and Italy contribute 40 % of Europe's annual flux. Our study was therefore able to identify the current and future major contributors to Gdanth flux in Europe and identify abrupt changes related to the COVID-19 pandemic.

Using the International Pandemic Instrument to Revitalize the Innovation Ecosystem for Antimicrobial R&D.

The inclusion of antimicrobial resistance (AMR) and increased research and development (R&D) capabilities in the most recent outline of the World Health Organization's (WHO's) international pandemic instrument signals an opportunity to reshape pharmaceutical R&D system in favour of antimicrobial product development. This article explains why the current innovation ecosystem has disadvantaged the creation of antimicrobial products for human use. It also highlights how the COVID-19 pandemic experience can inform and stimulate international cooperation to implement innovative R&D incentives to bring new, life-saving antimicrobial products to the market.

Could the lake ecosystems influence the pathogenicity of the SARS-COV-2 in the air?

During the first 200 days of the Covid-19 pandemic in Poland, lower morbidity and mortality due to SARS-COV-2 infection were recorded in three regions covered by many small and large lakes (West Pomerania 5.8 deaths/100 000 population, Warmian and Masurian 7.6 deaths/100 000 population, Lubusz 7.3 deaths /100 000 population, compared to Poland average of 16.0 deaths/100 000 population). Moreover, in Mecklenburg (Germany), bordering West Pomerania, only 23 deaths (1.4 deaths/100 000 population) were reported during the same period (Germany 10 649 deaths, 12.6 deaths/100 000 population). This unexpected and intriguing observation would not have been noticed if SARS-CoV-2 vaccinations were available at that time. The hypothesis presented here assumes the biosynthesis of biologically active substances by phytoplankton, zooplankton or fungi and transfer of these lectin-like substances to the atmosphere, where they could cause agglutination and/or inactivation of pathogens through supramolecular interactions with viral oligosaccharides. According to the presented reasoning, the low mortality rate due to SARS-CoV-2 infection in Southeast Asian countries (Vietnam, Bangladesh, Thailand) could be explained by the influence of monsoons and flooded rice fields on microbiological processes in the environment. Considering the universality of the hypothesis, it is important whether the pathogenic nano- or micro particles are decorated by oligosaccharides (as in case of the African swine fever virus, ASFV). On the other hand, the interaction of influenza hemagglutinins with sialic acid derivatives biosynthesized in the environment during the warm season may be linked to seasonal fluctuations in the number of infections. The presented hypothesis may be an incentive to study unknown active substances in the environment by interdisciplinary teams of chemists, physicians, biologists, and climatologists.

The Importance of Fostering and Funding Scientific Research, and its Relevance to Environmental Toxicology and Chemistry.

What do environmental contaminants and climate change have in common with the virus SARS-CoV-2 and the disease COVID-19? We argue that one common element is the wealth of basic and applied scientific research that provides the knowledge and tools essential in developing effective programs for addressing threats to humans and social-ecological systems. Research on various chemicals, including dichlorodiphenyltrichloroethane and per- and polyfluoroalkyl substances, resulted in regulatory action to protect environmental and human health. Moreover, decades of research on coronaviruses, mRNA, and recently SARS-CoV-2 enabled the rapid development of vaccines to fight the COVID-19 pandemic. In the present study, we explore the common elements of basic and applied scientific research breakthroughs that link chemicals, climate change, and SARS-CoV-2/COVID-19 and describe how scientific information was applied for protecting human health and, more broadly, socio-ecological systems. We also offer a cautionary note on the misuse and mistrust of science that is not new in human history, but unfortunately is surging in modern times. Our goal was to illustrate the critical role of scientific research to society, and we argue that research must be intentionally fostered, better funded, and applied appropriately. To that end, we offer evidence that supports the importance of investing in scientific research and, where needed, ways to counter the spread of misinformation and disinformation that undermines legitimate discourse. Environ Toxicol Chem 2023;42:581-593. © 2022 SETAC.

Enabling Value Co-Creation in Healthcare through Blockchain Technology.

The COVID-19 pandemic highlighted the need to manage complex relations within the healthcare ecosystem. The role of new technologies in achieving this goal is a topic of current interest. Among them, blockchain technology is experiencing widespread application in the healthcare context. The present work investigates how this technology fosters value co-creation paths in the new digital healthcare ecosystems. To this end, a multiple case study has been conducted examining the development and application of blockchain by 32 healthcare tech companies. The results show blockchain technology adoption's current and potential impacts on value co-creation regarding data and resource sharing, patient participation, and collaboration between professionals. Three main areas of activity emerge from the case studies where blockchain implementation brings significant benefits for value co-creation: improving service interaction, impacting actors' engagement, and fostering ecosystem transparency.

Impact of the COVID-19 pandemic on levels of deep-ocean acoustic noise.

The extraordinary circumstances of the COVID-19 pandemic led to measures to mitigate the spread of the disease, with lockdowns and mobility restrictions at national and international levels. These measures led to sudden and sometimes dramatic reductions in human activity, including significant reductions in ship traffic in the maritime sector. We report on a reduction of deep-ocean acoustic noise in three ocean basins in 2020, based on data acquired by hydroacoustic stations in the International Monitoring System of the Comprehensive Nuclear-Test-Ban Treaty. The noise levels measured in 2020 are compared with predicted levels obtained from modelling data from previous years using Gaussian Process regression. Comparison of the predictions with measured data for 2020 shows reductions of between 1 and 3 dB in the frequency range from 10 to 100 Hz for all but one of the stations.

Fe-Fe Double-Atom Catalysts for Murine Coronavirus Disinfection: Nonradical Activation of Peroxides and Mechanisms of Virus Inactivation.

Peroxides find broad applications for disinfecting environmental pathogens particularly in the COVID-19 pandemic; however, the extensive use of chemical disinfectants can threaten human health and ecosystems. To achieve robust and sustainable disinfection with minimal adverse impacts, we developed Fe single-atom and Fe-Fe double-atom catalysts for activating peroxymonosulfate (PMS). The Fe-Fe double-atom catalyst supported on sulfur-doped graphitic carbon nitride outperformed other catalysts for oxidation, and it activated PMS likely through a nonradical route of catalyst-mediated electron transfer. This Fe-Fe double-atom catalyst enhanced PMS disinfection kinetics for inactivating murine coronaviruses (i.e., murine hepatitis virus strain A59 (MHV-A59)) by 2.17-4.60 times when compared to PMS treatment alone in diverse environmental media including simulated saliva and freshwater. The molecular-level mechanism of MHV-A59 inactivation was also elucidated. Fe-Fe double-atom catalysis promoted the damage of not only viral proteins and genomes but also internalization, a key step of virus lifecycle in host cells, for enhancing the potency of PMS disinfection. For the first time, our study advances double-atom catalysis for environmental pathogen control and provides fundamental insights of murine coronavirus disinfection. Our work paves a new avenue of leveraging advanced materials for improving disinfection, sanitation, and hygiene practices and protecting public health.