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1.
Odontoestomatol ; 24(39): 1-19, 2022.
Article in Spanish | WHO COVID, LILACS (Americas) | ID: covidwho-1863564

ABSTRACT

La enfermedad por coronavirus es una infección respiratoria causada por el virus SARS-CoV 2, el cual genera una cascada de eventos sistémicos, afectando diferentes órganos y tejidos. El entendimiento de la fisiopatología del COVID-19 es indispensable no solo al momento de brindar tratamiento a los pacientes, sino que también para comprender las causas de las complicaciones que presentan un número importante de pacientes recuperados. El objetivo de este trabajo es presentar una revisión actualizada de los efectos de la infección en diferentes órganos y sistemas principales que sea de utilidad como material de referencia para profesionales y estudiantes de la salud. Para ello se realizó una búsqueda bibliográfica en los portales PubMED, Scielo, Google Scholar, Cochrane y Springer Link, así como en las bases de repositorios científicos pre-publicación bioRxiv ("bioarchives") y medRxiv ("med-archives") y sobre un total de cerca de 200 mil artículos, se seleccionaron 100 artículos para esta revisión en base a su relevancia o sugerencias de parte de profesionales especializados.


Coronavirus disease is a respiratory infection caused by the SARS-CoV-2 virus, which causes a cascade of systemic events, affecting various organs and tissues. Understanding the pathophysiology of COVID-19 is essential to treat patients and understand the causes of the complications in a significant number of recovered patients. This article presents a review of the effects of infection on various organs and systems that will be useful as reference material for healthcare professionals and medical students. To this end, a literature search was conducted in PubMED, Scielo, Google Scholar, Cochrane, and Springer Link portals, as well as in the pre-publication scientific repositories bioRxiv ("bioarchives") and medRxiv ("med-archives") databases. From about 200,000 papers, 100 articles were selected for this review based on their relevance or suggestions from experts in the field.


A doença coronavírus é uma infecção respiratória causada pelo vírus SARS-CoV-2, que gera uma cascata de eventos sistêmicos, afetando diferentes órgãos e tecidos. Compreender a fisiopatologia da COVID-19 é essencial não apenas no tratamento de pacientes, mas também para compreender as causas das complicações que um número significativo de pacientes recuperados apresenta. O objetivo deste trabalho é apresentar uma revisão atualizada dos efeitos da infecção em diferentes órgãos e principais sistemas que seja útil como material de referência para profissionais de saúde e estudantes. Para isso, foi realizada uma pesquisa bibliográfica nos portais PubMED, Scielo, Google Scholar, Cochrane e Springer Link, bem como nos repositórios científicos de pré-publicação bioRxiv ("bioarquivos") e medRxiv ("arquivos med"). Num total de cerca de 200 mil artigos, 100 artigos foram selecionados para esta revisão por sua relevância ou sugestões de profissionais especializados.


Subject(s)
Humans , COVID-19/physiopathology , Pulmonary Alveoli/physiopathology , Cardiovascular Diseases/physiopathology , Central Nervous System Diseases/physiopathology , Digestive System Diseases/physiopathology , Endocrine System Diseases/physiopathology , SARS-CoV-2/metabolism , COVID-19/epidemiology , Mouth Diseases/physiopathology
2.
Postgrad Med ; 133(1): 20-27, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-759669

ABSTRACT

While COVID-19 has primarily been characterized by the respiratory impact of viral pneumonia, it affects every organ system and carries a high consequent risk of death in critically ill patients. Higher sequential organ failure assessment (SOFA) scores have been associated with increased mortality in patients critically ill patients with COVID-19. It is important that clinicians managing critically ill COVID-19 patients be aware of the multisystem impact of the disease so that care can be focused on the prevention of end-organ injuries to potentially improve clinical outcomes. We review the multisystem complications of COVID-19 and associated treatment strategies to improve the care of critically ill COVID-19 patients.


Subject(s)
COVID-19/physiopathology , COVID-19/mortality , Cardiovascular Diseases/physiopathology , Critical Illness , Cytokines/biosynthesis , Endocrine System Diseases/physiopathology , Gastrointestinal Diseases/physiopathology , Hematologic Diseases/physiopathology , Humans , Kidney Diseases/physiopathology , Musculoskeletal Diseases/physiopathology , Nervous System Diseases/physiopathology , Obesity/physiopathology , Organ Dysfunction Scores , Respiratory Tract Diseases/physiopathology , Risk Factors , SARS-CoV-2 , Skin Diseases/physiopathology , Systemic Inflammatory Response Syndrome/physiopathology
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