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Nat Prod Res ; 36(4): 994-998, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-894501

ABSTRACT

COVID 19; an infectious disease; firstly identified in December 2019 in Wuhan, China and has since spread globally, resulting in an ongoing pandemic. Searching for protease inhibitors is a challenging task in controlling COVID 19. Genus Ficus is known to be a rich source of phenolic compounds. Metabolic profiling of leaves methanolic extract of Ficus microcarpa (Moraceae) revealed nine compounds (1-9) mainly phenolics. Docking studies concerning these compounds against SARS-CoV-2 main protease showed that quercetin 3,7-O-α-L-dirhamnoside (1) and rutin (3) possessed significant binding stability at the N3 binding site in different activity degrees, which is comparable with COVID-19 main protease inhibitor, darunavir. Our study suggests that compounds quercetin 3,7-O-α-L-dirhamnoside and rutin might be potential candidates for the development of therapies against SARS-CoV-2.


Subject(s)
Antiviral Agents , COVID-19 , Coronavirus 3C Proteases/antagonists & inhibitors , Ficus , Plant Extracts , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , COVID-19/drug therapy , Ficus/chemistry , Humans , Molecular Docking Simulation , Molecular Dynamics Simulation , Plant Extracts/chemistry , Plant Extracts/pharmacology , SARS-CoV-2/drug effects
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