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1.
Front Cell Infect Microbiol ; 12: 726263, 2022.
Article in English | MEDLINE | ID: covidwho-2198679

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is resilient, highly pathogenic, and rapidly transmissible. COVID-19 patients have been reported to have underlying chronic liver abnormalities linked to hepatic dysfunction. Discussion: Viral RNAs are detectable in fecal samples by RT-PCR even after negative respiratory samples, which suggests that SARS-CoV-2 can affect the gastrointestinal tract and the liver. The case fatality rates are higher among the elderly and those with underlying comorbidities such as hypertension, diabetes, liver abnormality, and heart disease. There is insufficient research on signaling pathways. Identification of molecular mechanisms involved in SARS-CoV-2-induced damages to hepatocytes is challenging. Herein, we demonstrated the multifactorial effects of SARS-CoV-2 on liver injury such as psychological stress, immunopathogenesis, systemic inflammation, ischemia and hypoxia, drug toxicity, antibody-dependent enhancement (ADE) of infection, and several others which can significantly damage the liver. Conclusion: During the COVID-19 pandemic, it is necessary for clinicians across the globe to pay attention to SARS-CoV-2-mediated liver injury to manage the rising burden of hepatocellular carcinoma. To face the challenges during the resumption of clinical services for patients with pre-existing liver abnormalities and HCC, the impact of SARS-CoV-2 on hepatocytes should be investigated both in vitro and in vivo.


Subject(s)
COVID-19 , Carcinoma, Hepatocellular , Gastrointestinal Diseases , Liver Neoplasms , Aged , COVID-19/complications , Humans , Liver/pathology , Liver Neoplasms/pathology , Pandemics , SARS-CoV-2
2.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114993
3.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114965
4.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114955
5.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114953
6.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114873
7.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114830
8.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114812
9.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114770
10.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114761
11.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114755
12.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114714
13.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114701
14.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114661
15.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114632
16.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114521
17.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114494
18.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114443
19.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114420
20.
United European Gastroenterol J ; 10 Suppl 8: 1-1126, 2022 10.
Article in English | MEDLINE | ID: covidwho-2114412
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