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PLoS Negl Trop Dis ; 15(11): e0009842, 2021 11.
Article in English | MEDLINE | ID: covidwho-1523403


Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and are transmitted to humans through aerosolized viral particles generated by the excretions of infected individuals. Since the first description of HPS in Argentina, new hantaviruses have been reported throughout the country, most of which are pathogenic to humans. We present here the first HPS case infected with Alto Paraguay virus reported in Argentina. Until now, Alto Paraguay virus was considered a non-pathogenic orthohantavirus since it was identified in a rodent, Holochilus chacarius. In addition to this, with the goal of identifying potential hantavirus host species in the province of Santa Fe, we finally describe a novel orthohantavirus found in the native rodent Scapteromys aquaticus, which differed from other hantaviruses described in the country so far. Our findings implicate an epidemiological warning regarding these new orthohantaviruses circulating in Central Argentina as well as new rodent species that must be considered as hosts from now on.

Disease Reservoirs/virology , Hantavirus Pulmonary Syndrome/virology , Hantavirus/isolation & purification , Sigmodontinae/virology , Adolescent , Animals , Antibodies, Viral/blood , Argentina , Female , Hantavirus/classification , Hantavirus/genetics , Humans , Male , Phylogeny , Sigmodontinae/blood
PLoS Negl Trop Dis ; 15(8): e0009592, 2021 08.
Article in English | MEDLINE | ID: covidwho-1350166


BACKGROUND: Syrian hamsters infected with Andes virus (ANDV) develop a disease that recapitulates many of the salient features of human hantavirus pulmonary syndrome (HPS), including lethality. Infection of hamsters with Hantaan virus (HTNV) results in an asymptomatic, disseminated infection. In order to explore this dichotomy, we examined the transcriptome of ANDV- and HTNV-infected hamsters. RESULTS: Using NanoString technology, we examined kinetic transcriptional responses in whole blood collected from ANDV- and HTNV-infected hamsters. Of the 770 genes analyzed, key differences were noted in the kinetics of type I interferon sensing and signaling responses, complement activation, and apoptosis pathways between ANDV- and HTNV-infected hamsters. CONCLUSIONS: Delayed activation of type I interferon responses in ANDV-infected hamsters represents a potential mechanism that ANDV uses to subvert host immune responses and enhance disease. This is the first genome-wide analysis of hantavirus-infected hamsters and provides insight into potential avenues for therapeutics to hantavirus disease.

Hantavirus Infections/pathology , Hantavirus Pulmonary Syndrome/pathology , Hantavirus/genetics , Hantavirus/pathogenicity , High-Throughput Nucleotide Sequencing/methods , Animals , Chlorocebus aethiops , Cricetinae , Female , Hantavirus/isolation & purification , Mesocricetus , Vero Cells
Int J Environ Health Res ; 32(8): 1815-1826, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1196926


At the end of 2019 and 2020s, a wave of coronavirus disease 19 (COVID-19) epidemics worldwide has catalyzed a new era of 'communicable infectious diseases'. However, the world is not currently prepared to deal with the growing burden of COVID-19, with the unexpected arrival of Hantavirus infection heading to the next several healthcare emergencies in public. Hantavirus is a significant class of zoonotic pathogens of negative-sense single-stranded ribonucleic acid (RNA). Hemorrhagic renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) are the two major clinical manifestations. Till date, there is no effective treatments or vaccines available, public awareness and precautionary measures can help to reduce the spread of hantavirus disease. In this study, we outline the epidemiology, virology, clinical aspects, and existing HFRS and HCPS management approaches. This review will give an understanding of virus-host interactions and will help for the early preparation and effective handling of further outbreaks in an ever-changing environment.

COVID-19 , Hantavirus Infections , Hantavirus , Hemorrhagic Fever with Renal Syndrome , COVID-19/epidemiology , Disease Outbreaks , Hantavirus/genetics , Hantavirus Infections/epidemiology , Hemorrhagic Fever with Renal Syndrome/epidemiology , Humans