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Clinics (Sao Paulo) ; 77: 100004, 2022.
Article in English | MEDLINE | ID: covidwho-1719496


This work aimed to better understand the impact of pandemics of respiratory viruses on children with hemoglobinopathies through a comprehensive review of the literature. MEDLINE, SCIELO, LILACS, and PUBMED were used as data sources to find articles without time period restrictions. Previous observations suggest that patients with hemoglobinopathies are a group especially susceptible to the complications of viral respiratory infections, with greater morbidity and mortality related to them. Within this context, this review found that, during the 2009 H1N1 pandemic, the risk of hospitalization in children and adults increased, especially in patients with a history of complications such as acute chest syndrome. In addition, the Coronavirus Disease 2019 (COVID-19) pandemic appears to have less repercussion among children with hemoglobinopathies compared to adults, similar to what is seen in the general population. In the H1N1 pandemic, patients with hemoglobinopathies behaved as a group more susceptible to complications, with increased morbidity and mortality. However, for COVID-19, the existing data to date on these patients do not show the same clinical impact. Thus, although these children deserve attention in case of infection due to their potential risks, they seem to have a favorable evolution.

COVID-19 , Hemoglobinopathies , Influenza A Virus, H1N1 Subtype , Adult , Child , Hemoglobinopathies/complications , Hemoglobinopathies/epidemiology , Humans , Pandemics , SARS-CoV-2
Am J Hematol ; 97(2): E75-E78, 2022 02 01.
Article in English | MEDLINE | ID: covidwho-1565162
Lancet Haematol ; 7(10): e756-e764, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-624236


The COVID-19 pandemic has major implications for blood transfusion. There are uncertain patterns of demand, and transfusion institutions need to plan for reductions in donations and loss of crucial staff because of sickness and public health restrictions. We systematically searched for relevant studies addressing the transfusion chain-from donor, through collection and processing, to patients-to provide a synthesis of the published literature and guidance during times of potential or actual shortage. A reduction in donor numbers has largely been matched by reductions in demand for transfusion. Contingency planning includes prioritisation policies for patients in the event of predicted shortage. A range of strategies maintain ongoing equitable access to blood for transfusion during the pandemic, in addition to providing new therapies such as convalescent plasma. Sharing experience and developing expert consensus on the basis of evolving publications will help transfusion services and hospitals in countries at different stages in the pandemic.

Betacoronavirus , Blood Banks/statistics & numerical data , Blood Donors/supply & distribution , Blood Transfusion , Coronavirus Infections , Pandemics , Pneumonia, Viral , Antibodies, Viral/therapeutic use , Blood Coagulation Disorders/etiology , Blood Coagulation Disorders/therapy , Blood Preservation , Blood Safety , Blood Transfusion/statistics & numerical data , COVID-19 , Coronavirus Infections/blood , Coronavirus Infections/complications , Coronavirus Infections/prevention & control , Coronavirus Infections/therapy , Donor Selection , Elective Surgical Procedures , Health Care Rationing , Health Policy , Health Services Needs and Demand , Hemoglobinopathies/complications , Hemoglobinopathies/therapy , Humans , Immunization, Passive , Pandemics/prevention & control , Pneumonia, Viral/blood , Pneumonia, Viral/complications , Pneumonia, Viral/prevention & control , Pneumonia, Viral/therapy , Randomized Controlled Trials as Topic , SARS-CoV-2