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1.
Gastroenterol Clin North Am ; 50(2): 383-402, 2021 06.
Article in English | MEDLINE | ID: covidwho-1201631

ABSTRACT

Nonhepatotropic viruses such as adenovirus, herpes simplex virus, flaviviruses, filoviruses, and human herpes virus, and bacteria such as Coxiella burnetii, can cause liver injury mimicking acute hepatitis. Most of these organisms cause a self-limited infection. However, in immunocompromised patients, they can cause severe hepatitis or in some cases fulminant hepatic failure requiring an urgent liver transplant. Hepatic dysfunction is also commonly seen in patients with severe acute respiratory syndrome coronavirus-2 infection. Patients with preexisting liver diseases are likely at risk for severe coronavirus disease 2019 (COVID-19) and may be associated with poor outcomes.


Subject(s)
Adenovirus Infections, Human/complications , COVID-19/complications , Hepatitis/diagnosis , Hepatitis/virology , Herpes Simplex/complications , Q Fever/complications , Alanine Transaminase/blood , Aspartate Aminotransferases/blood , Flavivirus Infections/complications , Hepatitis/pathology , Hepatitis/therapy , Humans , Liver/physiopathology , Liver Transplantation , SARS-CoV-2
2.
BMJ Case Rep ; 14(3)2021 Mar 10.
Article in English | MEDLINE | ID: covidwho-1133189

ABSTRACT

Neonatal herpes simplex virus (HSV) infection is rare, with an estimated incidence of 3.58 per 100 000 live births in the UK and should be suspected in any newborn with fever and bacterial culture-negative sepsis. We describe a case of a previously well full-term male neonate who presented with persistent fever and elevated ferritin level that was carried out during the era of the COVID-19 pandemic as part of SARS-CoV-2 panel investigations. Despite the initial negative HSV serology, HSV-1 PCR from a scalp lesion returned positive. He made a full recovery after acyclovir therapy. This case highlights the importance of maintaining a high clinical index of suspicion of HSV infection in any febrile neonate even with absence of maternal history and negative serology, particularly if associated with hyperferritinaemia. We also address the challenge of interpreting inflammatory biomarkers' results for SARS-CoV-2 infection in neonates.


Subject(s)
COVID-19/epidemiology , Ferritins/blood , Fever/etiology , Herpes Simplex/diagnosis , Pregnancy Complications, Infectious/diagnosis , Acyclovir/therapeutic use , Antiviral Agents/therapeutic use , Female , Herpes Simplex/complications , Herpes Simplex/drug therapy , Herpesvirus 1, Human/isolation & purification , Humans , Infant, Newborn , Male , Pandemics , Polymerase Chain Reaction , Pregnancy , Pregnancy Complications, Infectious/drug therapy , SARS-CoV-2 , Treatment Outcome
5.
Eur Rev Med Pharmacol Sci ; 24(17): 9151-9153, 2020 09.
Article in English | MEDLINE | ID: covidwho-790175

ABSTRACT

OBJECTIVE: The present case report aims to make a discussion concerning oral manifestations in a patient with a confirmed diagnosis of COVID-19. Female patient, 20 years old, nursing technician, showed severe sore throat and headache without presence of fever. She tested positive for COVID-19 RT-PCR test in 2 episodes. She also showed lesions in the median lower lip semimucosa and severe pruritus, with a clinical course of 14 days, in which we performed a clinical diagnosis of herpes simplex infection. We need to be precise in terms of clinical appearance and possible relation with the disease, as the clinicians have access to the patients.


Subject(s)
Coronavirus Infections/diagnosis , Herpes Simplex/diagnosis , Pneumonia, Viral/diagnosis , Betacoronavirus/genetics , Betacoronavirus/isolation & purification , COVID-19 , Coronavirus Infections/complications , Coronavirus Infections/virology , Female , Herpes Simplex/complications , Humans , Mouth Mucosa/pathology , Pandemics , Pneumonia, Viral/complications , Pneumonia, Viral/virology , Pruritus/complications , Pruritus/pathology , RNA, Viral/metabolism , SARS-CoV-2 , Young Adult
6.
Andrologia ; 52(9): e13791, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-712969

ABSTRACT

Male infertility is linked to some viral infections including human papillomavirus (HPV), herpes simplex viruses (HSV) and human immunodeficiency viruses (HIVs). Almost nothing is known about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) effect on fertility. The possible risk factors of coronavirus disease 2019 (COVID-19) infection on fertility comes from the abundance of angiotensin-Converting Enzyme-2 (ACE2), receptor entry of the virus, on testes, a reduction in important sex hormone ratios and COVID-19-associated fever. Recent studies have shown a gender difference for COVID-19 rates and comorbidity. In this review, we will discuss the potential effect of COVID-19 on male fertility and talk about what needs to be done by the scientific community to tackle our limited understanding of the disease. On the other side, we will focus on what is known so far about the risk of COVID-19 on pregnancy, neonatal health and the vertical transfer of the virus between mothers and their neonates. Finally, because reproduction is a human right and infertility is considered a health disease, we will discuss how assisted reproductive clinics can cope with the pandemic and what guidelines they should follow to minimise the risk of viral transmission.


Subject(s)
Coronavirus Infections/complications , Infectious Disease Transmission, Vertical , Infertility, Male/virology , Pneumonia, Viral/complications , Pregnancy Complications, Infectious/virology , Reproductive Health , Angiotensin-Converting Enzyme 2 , Betacoronavirus/isolation & purification , Betacoronavirus/metabolism , Betacoronavirus/pathogenicity , COVID-19 , Coronavirus Infections/epidemiology , Coronavirus Infections/transmission , Coronavirus Infections/virology , Female , HIV Infections/complications , HIV Infections/transmission , HIV Infections/virology , Herpes Simplex/complications , Herpes Simplex/transmission , Herpes Simplex/virology , Humans , Infertility, Male/pathology , Male , Pandemics , Papillomavirus Infections/complications , Papillomavirus Infections/transmission , Papillomavirus Infections/virology , Peptidyl-Dipeptidase A/metabolism , Pneumonia, Viral/epidemiology , Pneumonia, Viral/transmission , Pneumonia, Viral/virology , Pregnancy , Risk Factors , SARS-CoV-2 , Spike Glycoprotein, Coronavirus/metabolism , Testis/metabolism , Testis/pathology
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