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Int J Mol Sci ; 24(3)2023 Feb 03.
Article in English | MEDLINE | ID: covidwho-2285508


Lichen planus is a chronic disease affecting the skin, appendages, and mucous membranes. A cutaneous lichen planus is a rare disease occurring in less than 1% of the general population, while oral illness is up to five times more prevalent; still, both forms equally impair the patient's quality of life. The etiology of lichen planus is not entirely understood. Yet, immune-mediated mechanisms have been recognized since environmental factors such as hepatitis virus infection, mechanical trauma, psychological stress, or microbiome changes can trigger the disease in genetically susceptible individuals. According to current understanding, lichen planus immunopathogenesis is caused by cell-mediated cytotoxicity, particularly cytotoxic T lymphocytes, whose activity is further influenced by Th1 and IL-23/Th-17 axis. However, other immunocytes and inflammatory pathways complement these mechanisms. This paper presents a comprehensive insight into the actual knowledge about lichen planus, with the causal genetic and environmental factors being discussed, the immunopathogenesis described, and the principal effectors of its inflammatory circuits identified.

Lichen Planus , Quality of Life , Humans , Skin
J Drugs Dermatol ; 21(5): 521-522, 2022 May 01.
Article in English | MEDLINE | ID: covidwho-1836609


With the onset of the SARS-CoV-2 pandemic, a number of nail unit changes have been associated with SARS-CoV-2 infection. We report a new unique nail finding within one month of infection and RT-PCR test positivity characterized by an abrupt proximal superficial nail plate change characteristic of shoreline nails. The possibility that this nail change may represent a Koebner phenomenon in patients prone to lichen planus is raised. J Drugs Dermatol. 2022;21(5):521-522. doi:10.36849/JDD.2105.

COVID-19 , Lichen Planus , Nail Diseases , COVID-19/diagnosis , Humans , Lichen Planus/diagnosis , Nail Diseases/diagnosis , Nails , SARS-CoV-2
Zh Nevrol Psikhiatr Im S S Korsakova ; 122(1): 122-125, 2022.
Article in Russian | MEDLINE | ID: covidwho-1689705


The authors present a clinical case of a female patient with depression who developed lichen planus during the COVID-19 pandemic and describe the anamnesis, skin and mental status of the patient. The phenomenon of amplified itching in the clinical picture in the post-covid period in the framework of depressive cataesthetic hyperesthesia is considered. A comprehensive psychosomatic assessment of the condition and the inclusion of approaches of psychocorrection in basic dermatotropic therapy contributed to the normalization of mood, rapid and complete reduction of itching, improvement of the skin status and patient's quality of life.

COVID-19 , Depression , Lichen Planus , COVID-19/epidemiology , COVID-19/psychology , Depression/epidemiology , Female , Humans , Lichen Planus/diagnosis , Lichen Planus/psychology , Pandemics , Quality of Life