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J Drugs Dermatol ; 21(5): 521-522, 2022 May 01.
Article in English | MEDLINE | ID: covidwho-1836609


With the onset of the SARS-CoV-2 pandemic, a number of nail unit changes have been associated with SARS-CoV-2 infection. We report a new unique nail finding within one month of infection and RT-PCR test positivity characterized by an abrupt proximal superficial nail plate change characteristic of shoreline nails. The possibility that this nail change may represent a Koebner phenomenon in patients prone to lichen planus is raised. J Drugs Dermatol. 2022;21(5):521-522. doi:10.36849/JDD.2105.

COVID-19 , Lichen Planus , Nail Diseases , COVID-19/diagnosis , Humans , Lichen Planus/diagnosis , Nail Diseases/diagnosis , Nails , SARS-CoV-2
Zh Nevrol Psikhiatr Im S S Korsakova ; 122(1): 122-125, 2022.
Article in Russian | MEDLINE | ID: covidwho-1689705


The authors present a clinical case of a female patient with depression who developed lichen planus during the COVID-19 pandemic and describe the anamnesis, skin and mental status of the patient. The phenomenon of amplified itching in the clinical picture in the post-covid period in the framework of depressive cataesthetic hyperesthesia is considered. A comprehensive psychosomatic assessment of the condition and the inclusion of approaches of psychocorrection in basic dermatotropic therapy contributed to the normalization of mood, rapid and complete reduction of itching, improvement of the skin status and patient's quality of life.

COVID-19 , Depression , Lichen Planus , COVID-19/epidemiology , COVID-19/psychology , Depression/epidemiology , Female , Humans , Lichen Planus/diagnosis , Lichen Planus/psychology , Pandemics , Quality of Life
Dermatol Ther ; 35(3): e15283, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1583585


We report two cases of lichen planus following COVID-19 vaccination in two middle-aged women, where the first patient presented with lichenplanopilaris (LPP) relapse and development of lichen planus 14 days after the second dose of AstraZeneca vaccine, and the other patient who had a previous scattered lesion of LP which extended and increased in severity after the first and second dose of Sinopharm. The suggested cause could be due to immune dysregulation and up regulation of T cell lymphocytes which was triggered after COVID-19 vaccination. What supports our hypothesis that LP had occurred due to COVID-19 vaccination, is that one of the patients responded successfully to Metronidazole. This means that the infection process after vaccination could be the cause in aggravating LP. To add, one of the suggested mechanisms for the appearance of LP or reactivation of a dormant LPP can be cytotoxic CD8 T-lymphocytes which increase the secretion of IFN-γ and IL-5 cytokines and may also result in basal keratinocytes' apoptosis leading to cutaneous manifestations. This was supported by the efficacy of Tofacitinib that was used in the other patient who presented with reactivation of LPP in addition to LP. Tofacitinib decrease the number of T cell infiltration and adjust IFN expression.

COVID-19 , Lichen Planus , COVID-19/prevention & control , COVID-19 Vaccines/adverse effects , Female , Humans , Lichen Planus/diagnosis , Lichen Planus/drug therapy , Lichen Planus/etiology , Middle Aged , SARS-CoV-2 , Vaccination