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1.
Pan Afr Med J ; 39: 283, 2021.
Article in French | MEDLINE | ID: covidwho-1472501

ABSTRACT

Self-denial and sense of duty are fundamental ethical principles in health care. Since the outbreak of health crisis, healthcare workers have been the first bulwark against the spread of coronavirus, and therefore, the occupational category at higher risk of contamination. In this regard, in a statement dated 23 March 2020, the World Health Organization published a guidance regarding the management of the disease caused by Covid-19 in health workers, but also in workers employed in all sectors exposed to the risk of contamination. In Morocco, the Ministry of Health published on April 6, on its official website, a condolence message to the families of the first two doctors died following contraction of coronavirus, while specifying that coronavirus infection was not due to the exercise of their professional functions. The Minister of Labor and Professional Integration recently appointed an internal committee to undertake a reflection on this issue. At present, given Morocco's law, what are the chances to categorize coronavirus as an occupational disease?


Subject(s)
COVID-19/prevention & control , Health Personnel/psychology , Occupational Diseases/prevention & control , Occupational Exposure/prevention & control , Occupational Health , Pandemics/prevention & control , COVID-19/epidemiology , Disease Outbreaks , Humans , Morocco/epidemiology , Personal Protective Equipment , SARS-CoV-2
2.
JMIR Public Health Surveill ; 7(9): e31930, 2021 09 17.
Article in English | MEDLINE | ID: covidwho-1417047

ABSTRACT

This report aimed to provide an overview of the epidemiological situation of COVID-19 in Morocco and to review the actions carried out as part of the national response to this pandemic. The methodology adopted was based on literature review, interviews with officials and actors in the field, and remote discussion workshops with a multidisciplinary and multisectoral working group. Morocco took advantage of the capacities already strengthened within the framework of the application of the provisions of the International Health Regulations (IHR) of 2005. A SWOT analysis made it possible to note that an unprecedented political commitment enabled all the necessary means to face the pandemic and carry out all the response activities, including a campaign of relentless communication. Nevertheless, and despite the efforts made, the shortage of human resources, especially those qualified in intensive care and resuscitation, has been the main drawback to be addressed. The main lesson learned is a need to further strengthen national capacities to prepare for and respond to possible public health emergencies and to embark on a process overhaul of the health system, including research into innovative tools to ensure the continuity of the various disease prevention and control activities. In addition, response to a health crisis is not only the responsibility of the health sector but also intersectoral collaboration is needed to guarantee an optimal coordinated fight. Community-oriented approaches in public health have to be strengthened through more participation and involvement of nongovernmental organizations (NGOs) and civil society in operational and strategic planning.


Subject(s)
COVID-19/prevention & control , Public Health/methods , COVID-19/epidemiology , COVID-19 Testing/methods , COVID-19 Testing/standards , Humans , Morocco/epidemiology , Public Health/statistics & numerical data , Quarantine/psychology , Quarantine/standards , Workforce/standards
3.
Future Oncol ; 17(35): 4871-4882, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1394695

ABSTRACT

Objective: Our study goal was to evaluate the behavioral response and practices of cancer patients to the coronavirus disease 2019 (COVID-19) pandemic in the Middle East and north Africa. Methods: A cross-sectional study was conducted using a validated anonymous 45-question survey administered via SurveyMonkey® to cancer patients in 13 centers in Algeria, Egypt, Jordan, Kuwait, Morocco and Saudi Arabia. Results: During the study period (from 21 April to 30 May 2020), 3642 patients participated in the study. The majority of patients (84.81%) were worried about contracting the infection. The reported strict adherence to precautions included avoiding the following actions: hand-shaking (77.40%), hugging and kissing (82.89%), social gathering (90.09%), meeting friends (84.68%) and visiting markets (75.65%). In a multivariate analysis, patients with poor precautionary practices were about twice as likely to cancel their medical appointment or a treatment session. Conclusion: Improving cancer patients' knowledge of and adherence to precautionary measures is needed not just to reduce the risk of acquiring infection but also to minimize the interruption of their medical care.


Lay abstract COVID-19 poses a higher risk for patients with cancer than other patients; therefore, it is prudent that they adhere to precautionary measures to protect themselves from the infection. We conducted a study to evaluate the behaviors and practices of these patients in response to the COVID-19 pandemic in the Middle, East and North Africa. We developed a survey of 45 questions that was distributed in 13 centers in Algeria, Egypt, Jordan, Kuwait, Morocco and Saudi Arabia between 21 April and 30 May 2020. About 85% of the 3642 patients who participated in the study were worried about contracting the infection. A substantial percentage of them (10­30%) were not adhering to various precautions and social distancing rules. On the other hand, 16% of them canceled medical appointments and 12% canceled treatment sessions. Our study showed the need for better adherence of patients with cancer to the infection precautions and most importantly, the need to have a better compliance with their treatment plans, such as keeping their scheduled appointments, to avoid harms from treatment delays.


Subject(s)
Anxiety/epidemiology , COVID-19/epidemiology , Neoplasms/epidemiology , Pandemics , Adolescent , Adult , Aged , Aged, 80 and over , Anxiety/complications , Anxiety/psychology , Anxiety/virology , COVID-19/complications , COVID-19/psychology , COVID-19/virology , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Morocco/epidemiology , Neoplasms/complications , Neoplasms/psychology , Neoplasms/virology , SARS-CoV-2/pathogenicity , Saudi Arabia/epidemiology , Surveys and Questionnaires , Young Adult
4.
Virus Genes ; 56(6): 767-771, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-1384547

ABSTRACT

In the present work, two complete genome sequences of SARS-CoV-2 were obtained from nasal swab samples of Tunisian SARS-CoV-2 PCR-positive patients using nanopore sequencing. The virus genomes of two of the patients examined, a Tunisian soldier returning from a mission in Morocco and a member of another Tunisian family, showed significant differences in analyses of the total genome and single nucleotide polymorphisms (SNPs). Phylogenetic relationships with known SARS-CoV-2 genomes in the African region, some European and Middle Eastern countries and initial epidemiological conclusions indicate that the introduction of SARS-CoV-2 into Tunisia from two independent sources was travel-related.


Subject(s)
COVID-19/epidemiology , Genome, Viral , Pandemics , Phylogeny , SARS-CoV-2/genetics , Adult , Asymptomatic Diseases , COVID-19/diagnosis , COVID-19/transmission , COVID-19/virology , Europe/epidemiology , Female , Hospitals, Military , Humans , Male , Middle Aged , Military Personnel , Morocco/epidemiology , Pedigree , RNA, Viral/genetics , SARS-CoV-2/classification , SARS-CoV-2/isolation & purification , Travel-Related Illness , Tunisia/epidemiology , Viral Load , Whole Genome Sequencing
6.
Int J Environ Res Public Health ; 18(11)2021 05 27.
Article in English | MEDLINE | ID: covidwho-1256501

ABSTRACT

To assess whether knowledge, attitude, and perceptions of the COVID-19 pandemic predicted changes in behaviors among the general Moroccan population, a cross-sectional online survey was conducted between 30 March and 20 April involving a total of 14,157 participants. The statistical analysis of the data included univariate and multivariate logistic regression analysis. Our results suggest that less than ten days after the Moroccan government announced "Health state of Emergency" response to the COVID-19 outbreak, public knowledge, attitude and responses to the pandemic were relatively high. More than half the respondents (63.2%) reported that they complied with more than five of nine recommended safety measures, including avoiding going out (93.2%), and frequent handwashing with soap and water (78.2%). Factors associated with an increased likelihood to adopt safety measures included perceptions that COVID-19 was a human health risk, the pandemic will continue for a long time, availability of clear information, and a lack of medicine. The largest predictor of safety behavior change was age; participants older than 55 were more likely to adopt recommended safety behaviors. Although knowledge and perception among the general public was reasonable, more encouragement from government via health education programs is needed to maintain appropriate behaviors.


Subject(s)
COVID-19 , Pandemics , Cross-Sectional Studies , Disease Outbreaks , Health Knowledge, Attitudes, Practice , Humans , Morocco/epidemiology , Perception , SARS-CoV-2 , Surveys and Questionnaires
7.
BMC Psychiatry ; 21(1): 264, 2021 05 22.
Article in English | MEDLINE | ID: covidwho-1238712

ABSTRACT

BACKGROUND: The Coronavirus Disease 2019 (COVID-19) pandemic has triggered fear and distress among the public, thus potentiating the incidence rate of anxiety and depression. This study aims to investigate the psychological effect of quarantine on persons living in Morocco when the first COVID-19 cases were identified. The associations between anxiety, depression symptoms, and their predictors (sociodemographics, fatigue, and religious coping) were examined. METHODS: A web-based cross-sectional survey, with a total of 1435 participants (≥18 years) recruited anonymously, was conducted during the COVID-19 pandemic (from 3 to 30 April 2020). A structured questionnaire was used to assess psychosocial factors, COVID-19 epidemic-related factors, and religious coping. Religious coping, fatigue, and depression, and anxiety were measured by Brief Religious Coping Scale (Brief RCOPE), Chalder Fatigue Scale (CFS), and Hospital Anxiety and Depression Scale (HADS), respectively. A generalized linear model (logistic regression) was used to determine the predictive factors of depression and anxiety. RESULTS: The prevalence of anxiety and depression was 43.0% (n = 621) and 53.0% (n = 766), respectively. Both were associated with female gender, household income decline, tracking COVID-19 news, and fear to contract COVID-19 (aOR = 1.36 to 2.85). Additionally, 32.0% (n = 453) and 26.0% (n = 372) reported severe physical fatigue, and mental fatigue, respectively. Both latter factors were significantly and positively associated with depression as well as with anxiety. Depressive and anxious patients used more negative religious coping, while positive religious coping was slightly associated with depression. CONCLUSION: In this online survey of the general population in Morocco, anxiety and depressive symptoms are prevalent during the COVID-19 pandemic. Pandemic and psychosocial factors, such as female gender, income decline, infection fears, massive COVID-19 news exposure, negative religious coping, and fatigue were associated with increased risk of depression and anxiety symptoms. Psychosocial and financial support should be provided to the quarantined population.


Subject(s)
COVID-19 , Pandemics , Adaptation, Psychological , Anxiety/epidemiology , Cross-Sectional Studies , Depression/epidemiology , Female , Humans , Internet , Morocco/epidemiology , SARS-CoV-2 , Stress, Psychological
8.
Rev Epidemiol Sante Publique ; 69(3): 116-126, 2021 Jun.
Article in French | MEDLINE | ID: covidwho-1221021

ABSTRACT

OBJECTIVE: To objectively assess the quality of "crisis communication" media, during the COVID-19 pandemic, in the three Greater Maghreb countries (Tunisia, Algeria, Morocco). METHODS: A compliance audit for press releases and epidemiological bulletins was analyzed against a quality benchmark, which had been specifically designed by the authors. This framework, made up of five dimensions and 50 items, graded (0/1), was applied by two researchers in preventive medicine. Multiplying the scores by a coefficient of two resulted in a partial score of 20 points for each dimension and a total score of 100 points for the checklist taken as a whole. The quality of the communication media was considered to be good when exceeding the thresholds of 15/20 for the different dimensions and 75/100 for the entire grid. RESULTS: A total of 141 information media were included in this audit (Tunisia: 60; Algeria: 60; Morocco: 21). The overall median quality score for these media was only 56/100 (IIQ: [46-58]), without major variability between countries. The most appreciated dimension was "maintaining the confidence of the population", with an overall median score of 14/20 (12/20 for epidemiological bulletins and 16/20 for press releases). The most poorly rated dimension was "strengthening community participation", with a median score of only 4/20 (6/20 for epidemiological bulletins and 4/20 for press releases). CONCLUSION: The quality of the Maghreb crisis communication media during COVID-19 was insufficient in most of its dimensions and items, particularly from a psychosocial standpoint. Reinforcement of the capacities of communication officers to develop information material and supports during health crises is indispensable and should be considered as an urgent matter.


Subject(s)
COVID-19/epidemiology , Communications Media/standards , Algeria/epidemiology , Humans , Morocco/epidemiology , Tunisia/epidemiology
9.
Int J Environ Res Public Health ; 18(8)2021 04 20.
Article in English | MEDLINE | ID: covidwho-1194660

ABSTRACT

The spread of coronavirus disease-2019 (COVID-19) levied on the Moroccan authorities to increase their mask production capacity, which reached up to 12 million facemask units produced per day. This increase in personal protective equipment (PPE) production and consumption is an efficient tool to address the spread of COVID-19. However, this results in more plastic and microplastic debris being added into the land and marine environments, which will harm the ecosystem, wildlife, and public health. Such a situation needs deep individual behavior observation and tracking, as well as an assessment of the potential environmental impact of this new type of waste. For this reason, we assessed the Moroccan population's behavior regarding the use and disposal of facemasks and gloves. An exploratory survey was prepared and shared via social media and email with the population of Rabat-Salé-Kénitra and Casablanca-Settat regions. Additionally, we calculated the estimated number and weight of daily and weekly PPE used and generated by the studied regions. The survey showed that 70% of the respondents threw their discarded masks and gloves in house trash or trash bins after their first use, whereas nearly 30% of respondents admitted that they did not wear masks because they did not leave their homes during the lockdown, while from the 70% of facemask users, more than five million (equivalent to 40,000 kg) of facemasks would be generated and disposed of daily by the community of these regions, which presents 35% of the total engendered facemask waste in Morocco. Accordingly, the environment impact of facemasks showed that the greenhouse gas footprint is about 640 kT CO2 eq./year for the whole of Morocco, while the energy footprint is around 60,000 GWh/year. Furthermore, an urgent multidisciplinary environmental assessment of the potential impact of PPE must be conducted among the 12 Moroccan regions. This study demonstrated the real impact of the COVID-19 PPE on human behavior and the environment and suggests a need for providing new didactic management of facemasks and gloves.


Subject(s)
COVID-19 , Pandemics , Communicable Disease Control , Ecosystem , Humans , Masks , Morocco/epidemiology , Personal Protective Equipment , Plastics , SARS-CoV-2
10.
Int J Clin Pract ; 75(6): e14127, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1105281

ABSTRACT

INTRODUCTION: The aim of this study was to assess the impact of the COVID-19 pandemic on the activity of private medical practices in Morocco. METHODS: An online survey was carried out in June 2020. The study population consisted of physicians (General practitioners and specialists) who run private practices in different regions of Morocco. The questionnaire comprised three sections: demographic and professional data, the impact noticed by the physicians and the strategies they adopted to tackle this impact. RESULTS: We analysed 225 responses. Specialists represented 71.6% of the respondents. The majority (94.2%) of the private practices were located in urban areas. Almost all respondents have noticed a change in the demand for medical services, mainly a decrease (96.4%). There was an increase in urgent consultations (30.7%) and consultations for acute motives (39.1%). Respondents also reported less (69.3%) or no (23.1%) regular follow-up visits for patients with chronic diseases. Decreased incomes concerned 97.3% of the practices. Practitioners reacted by working less hours (87.6%), delaying some procedures (78.2%) and applying recommended safety measures (100%). Telemedicine was used in an informal way to facilitate the communication with patients. DISCUSSION AND CONCLUSION: During this pandemic, private practices were challenged to contribute to the continuity of healthcare services while ensuring the safety of the staff and the patients. Several strategies were adopted to cope with the new situation and to survive its many challenges.


Subject(s)
COVID-19 , Pandemics , Humans , Morocco/epidemiology , Pandemics/prevention & control , Private Practice , SARS-CoV-2
12.
Rev Neurol (Paris) ; 177(3): 272-274, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-1078106

ABSTRACT

BACKGROUND: Governments around the world have imposed varied containment measures to curb the spread of the COVID-19 infection. The psychological impact could be highly negative in patients with neurologic condition like Parkinson's Disease (PD). METHODS: We prospectively evaluated symptoms of depression and anxiety in 50 (26 females; mean age at 60.4) non demented Moroccan PD patients, using Hospital Anxiety and Depression Scale (HADS), at the beginning and after 6 weeks of a full confinement. RESULTS: At the first evaluation, 28% of patients had depression while 32% had anxiety. After 6 weeks of confinement, some patients got worse and others got better scores but no significant statistical difference for both troubles was seen. CONCLUSION: Our results show that there is no significant impact of 6 weeks of confinement on overall anxiety and depression scores. However, confinement could have an unexpected positive psychological impact on a significant number of PD patients.


Subject(s)
Anxiety/epidemiology , COVID-19/epidemiology , Depression/epidemiology , Pandemics , Parkinson Disease/epidemiology , Quarantine/psychology , Aged , COVID-19/psychology , Female , Humans , Male , Middle Aged , Morocco/epidemiology , Parkinson Disease/complications , Parkinson Disease/psychology , SARS-CoV-2/physiology , Stress, Psychological/epidemiology , Stress, Psychological/psychology , Surveys and Questionnaires
14.
PLoS One ; 16(2): e0246295, 2021.
Article in English | MEDLINE | ID: covidwho-1063220

ABSTRACT

Since December 2019, the coronavirus disease (COVID-19) pandemic has catapulted the world into a marked health crisis, with over 29 million cases and >930,000 deaths. To better detect affected individuals at an early stage and stop disease progression to an advanced stage, several studies have been conducted to identify the clinical, biological, and radiological characteristics of COVID-19. This study aimed to enrich the literature by critically analyzing the clinical and biological characteristics of 134 patients from the North African Mediterranean region, including numerous genetic, epigenetic, and environmental factors that may influence disease evolution. This single-center retrospective study included all patients older than 18 years confirmed to have COVID-19 and hospitalized at the Cheikh Khalifa University Hospital affiliated with Mohammed VI University of Health Sciences, Casablanca, Morocco. Clinical, demographic, and biological data were analyzed in a cohort of severe and non-severe patients. Univariate analysis was performed to identify factors predictive of severity. There were 134 patients: the median age was 53 years, and 54.5% were male. Of these, 89 had mild to moderate disease; 45 had severe to critical disease, of which 14 died and 31 survived. Advanced age, presence of comorbidities, male sex, and infection in ethnic or family groups were risk factors for progression to severe disease. The presence of abnormalities in the following parameters were strongly associated with progression to severe disease: white blood cells (WBC), neutrophils, lymphocytes, C-reactive protein (CRP), procalcitonin, D-dimers, lactate dehydrogenase (LDH), ferritin, creatinine, aspartate aminotransferase (ASAT), and alanine aminotransferase (ALAT) during both admission and hospitalization. Based on these results and an extensive literature review, we recommend that clinicians closely monitor the biological parameters identified herein and perform immunological and genetic studies.


Subject(s)
COVID-19/blood , SARS-CoV-2/isolation & purification , Adult , Aged , COVID-19/diagnosis , COVID-19/epidemiology , Female , Humans , Male , Middle Aged , Morocco/epidemiology , Retrospective Studies , Severity of Illness Index
15.
Ann Glob Health ; 87(1): 7, 2021 01 06.
Article in English | MEDLINE | ID: covidwho-1052532

ABSTRACT

Background: Pandemic confinement of COVID-19 may influence dietary behaviors and physical activity, and increases the risk of stress, especially among adolescents. This increases the subsequent risk of degenerative diseases such as obesity, diabetes, cardiovascular disease, etc., which can lead to a higher risk of death. This study aims to evaluate the effect of confinement on the weight load, physical activity and dietary behavior of higher education students during the period of confinement. Methods: Data was collected by an anonymous online questionnaire with 406 students. Physical activity was evaluated with the International Physical Activity Questionnaire. A reference score of the National Nutrition and Health Program (PNNS-GS) was used to determine the dietary habits. Stress appreciation was assessed by using a psychological instrument known as the "Perceived Stress Scale" provided by Mind Garden. Results: More than a quarter of the students were overweight or obese. During the confinement of COVID-19, most of the students suffered from nutritional disorders, only one-third were moderately physically active, and the majority of students were at risk of stress. Multivariate analysis showed that the concept of threat of Stress increases the risk of weight gain at a risk level of 2.4 [95% CI 1.09-5.43], low physical activity increases the risk level to 1.9 [95% CI 1.18-3.04]. However, a balanced diet is protective against the occurrence of weight gain (ORa = 0.30, [95% CI 0.15-0.61]). Conclusion: The study showed that confinement appeared to contribute to weight gain and those students were more sedentary than active with unhealthy eating behaviors. Understanding these behaviors during COVID-19 confinement will help public health authorities implement future policies on recommendations when new pandemics arrive and confinement policies are implemented.


Subject(s)
COVID-19/prevention & control , Exercise , Feeding Behavior , Students/statistics & numerical data , Weight Gain , Adolescent , Body Mass Index , COVID-19/psychology , Cross-Sectional Studies , Diet , Female , Humans , Male , Morocco/epidemiology , Obesity/epidemiology , Protective Factors , SARS-CoV-2 , Sedentary Behavior , Stress, Psychological/epidemiology , Stress, Psychological/psychology , Students/psychology , Surveys and Questionnaires , Young Adult
16.
Rev Recent Clin Trials ; 16(3): 294-302, 2021.
Article in English | MEDLINE | ID: covidwho-1034907

ABSTRACT

BACKGROUND: At the time of writing this paper, no data was available for the clinical and epidemiological characteristics of African patients with COVID-19. Herein, we profiled retrospectively the epidemiological characteristics (clinical, laboratory, radiological, treatment, and clinical outcomes) of 64 confirmed cases of COVID-19 in the Regional Hospital Center (RHC) of Errachidia in Morocco. The aim of this study was to analyze the epidemiological characteristics and laboratory Findings of Covid-19 patients in Errachidia Province, Morocco. METHODS: This is a retrospective single-center study that included all COVID-19 confirmed patients (died or discharged) hospitalized in the Regional Center of Errachidia, Morocco, between March 20, 2020 and May 23, 2020. Patients were confirmed by real-time RT-PCR and epidemiological, demographic, clinical, laboratory, treatment, and outcomes of patients were extracted manually from patient's medical records. RESULTS: In a total of 64 patients with COVID-19, 60.9% of patients were men, with a mean age of 41.5 years (SD 18.62). At the admission, 38 patients were asymptomatic (59.4%), and 58 (90.6%) were clinically classified as being in a benign state. Chronic illnesses were the most comorbidities observed, including diabetes with 8 cases (12.5%), hypertension 3 cases (4.7%), and hyperlipidemia 1 patient (1.6%). The main symptoms were cough 15 (23.4%), fever 10 (15.6), diarrhea 8 (12.5%), headache 5 (7.8%), and sore throat 5 (7.8%). Only 7 patients (10.9%) had lung lesions, and lymphopenia was present in only 7 patients (11.1%). The median duration of viral shedding was 14.5 days (9-22). Concerning deceased cases, they were elderly subjects aged 69.75 years, and they have presented dyspnea, breathing problems, and respiratory distress as specific symptoms. In addition, an increase of the medians of serum AST, CRP, and glucose levels was noticed in this group. During hospitalization, they presented acute respiratory distress syndrome (ARDS), and they were transferred to intensive care before they died. CONCLUSION: This study revealed that covid-19 infection often appeared in a benign form in the studied population (90.6% in this study). This finding may incriminate the implication of some protective parameters such as genetic, nutritional or other factors in the Moroccan population.


Subject(s)
COVID-19/epidemiology , Adult , Aged , Asymptomatic Diseases/epidemiology , Comorbidity , Cough/epidemiology , Cough/virology , Diarrhea/epidemiology , Diarrhea/virology , Female , Fever/epidemiology , Fever/virology , Headache/epidemiology , Headache/virology , Humans , Male , Middle Aged , Morocco/epidemiology , Pandemics , Pharyngitis/epidemiology , Pharyngitis/virology , Retrospective Studies , Virus Shedding
17.
Pan Afr Med J ; 35(Suppl 2): 127, 2020.
Article in English | MEDLINE | ID: covidwho-962492

ABSTRACT

The potential threat of COVID-19 pandemic on the continuity of care for cancer patients is thought to be significant. Oncologists are weighing up the balance of risks and benefits carefully when planning daily cancer care and making treatment decisions in the face of rapid change during this public health crisis. This report describes management strategies and care models that have been adopted by a single Medical Oncology department in a North Africa, Morocco.


Subject(s)
COVID-19/epidemiology , Medical Oncology/organization & administration , Neoplasms/therapy , SARS-CoV-2 , COVID-19/prevention & control , Humans , Morocco/epidemiology , Pandemics
19.
Pan Afr Med J ; 37: 32, 2020.
Article in English | MEDLINE | ID: covidwho-934642

ABSTRACT

Diabetes is considered a risk factor for complications due to COVID-19. In order to clarify this association, we are exploring the characteristics, the clinical signs, the outcomes and death in diabetic patients with COVID-19. In this retrospective observational study we are evaluating the demographic characteristics, the comorbidities of the patients, the clinical signs of the infection, the signs of clinical severity, the biological assessment at admission, the treatment, the outcomes and the deaths of 133 patients with COVID-19, of which 25 (19,4%) had diabetes. In the compared COVID-19 patients, with and without diabetes, the patients with diabetes were older, had higher blood pressure and more cardio-vascular diseases. Severe forms were more present in diabetic patients (56% versus 27.1%). Weight loss was higher in diabetic patients (6kg versus 3kg). Biologically, diabetic patients had higher levels of C-reactive protein (28 versus 5.8mg/l), procalcitonin (0.28 versus 0,13ng/l), ferritin (501 versus 140ng/ml), lactic dehydrogenase (268 versus 226IU/l) and of D. dimer (665 versus 444µg/l). Diabetic patients required more oxygen therapy (60% versus 26.9%), more mechanical ventilation (20% versus 8.3%) and more frequent admission to the intensive care unit (60% versus 27.8%). They presented more thromboembolic complications (12% versus 9%) but there were not significant differences in the other outcomes and in death rates. The excess of morbidity and mortality due to diabetes was still not fully clarified; the role of demographic factors, the interaction of mediations with ACE-2 receptors and the role of co-morbidities will all need to be studied in order to identify the patient at risk profile, i.e. who can develop severe forms of the diseases and more outcomes. The early identification of a possible hyper inflammation could be very valuable. More attention should be paid to patients with COVID-19 with diabetes because they are at a high risk of complications.


Subject(s)
Betacoronavirus , Coronavirus Infections/epidemiology , Diabetes Mellitus/epidemiology , Pneumonia, Viral/epidemiology , Age Factors , C-Reactive Protein/analysis , COVID-19 , Cardiovascular Diseases/epidemiology , Coronavirus Infections/blood , Coronavirus Infections/complications , Coronavirus Infections/mortality , Critical Care/statistics & numerical data , Diabetes Complications/blood , Diabetes Complications/epidemiology , Diabetes Complications/mortality , Diabetes Mellitus/blood , Diabetes Mellitus/mortality , Ferritins/blood , Fibrin Fibrinogen Degradation Products/analysis , Humans , Hypertension/epidemiology , L-Lactate Dehydrogenase/blood , Middle Aged , Morocco/epidemiology , Oxygen/therapeutic use , Pandemics , Pneumonia, Viral/blood , Pneumonia, Viral/complications , Pneumonia, Viral/mortality , Procalcitonin/blood , Respiration, Artificial/statistics & numerical data , Retrospective Studies , SARS-CoV-2 , Thromboembolism/epidemiology
20.
Pan Afr Med J ; 36: 269, 2020.
Article in English | MEDLINE | ID: covidwho-827295

ABSTRACT

Introduction: coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 was first reported in Wuhan, China. Clinical spectrum of this disease has nonspecific symptoms shared by many other frequent infectious diseases of the respiratory tract and other respiratory tract diseases. This study explains the importance of differential diagnosis between COVID-19 and other lung diseases. Methods: we analyzed in this study, the demographic features, clinical presentations, laboratory data and radiologic findings of the COVID-19 patients in comparison to those with other respiratory infections or diseases. Results: the mean age of all patients was 38.04 years; 35 patients were later confirmed to be positive for SARS-CoV-2 infection. The most common symptoms reported by both groups included nonproductive cough and myalgia. Two of the non-COVID-19 patients were having below 92% oxygen saturation and low systolic blood pressure. The patients shared relatively similar laboratory findings except 3% of the non-COVID-19 patients who had lympho-neutropenia and 22.6% had high levels of C-reactive protein. Pulmonary tuberculosis and autoimmune disease respiratory disorder were suspected in 2 of the non-COVID-19 patients respectively. Conclusion: we emphasize the importance of good screening protocols, rapid detection of SARS-CoV-2 and other most common respiratory pathogens, which may help for a better control of COVID-19 spread and avoid delayed care of other lung diseases.


Subject(s)
Betacoronavirus , Clinical Laboratory Techniques , Coronavirus Infections/diagnosis , Pneumonia, Viral/diagnosis , Symptom Assessment/methods , Adolescent , Adult , Aged , Aged, 80 and over , Betacoronavirus/isolation & purification , COVID-19 , COVID-19 Testing , Coronavirus Infections/epidemiology , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Morocco/epidemiology , Oxygen/blood , Pandemics , Pneumonia, Viral/epidemiology , Respiratory Tract Diseases/diagnosis , SARS-CoV-2 , Young Adult
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