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Cell Transplant ; 30: 9636897211053872, 2021.
Article in English | MEDLINE | ID: covidwho-1477154


The 28th American Society for Neural Therapy and Repair (ASNTR) returned to the Sheraton Sand Key in Clearwater Beach, Florida after an 18 month hiatus. Like nearly all conferences during the pandemic, the ASNTR conference was held in person while offering a virtual option to the event. These formats are advantageous for those under travel restrictions or personal constraints, but they lack the spontaneity of in-person connections. Highlights from the meeting included the return of the Bernard Sanberg Memorial Award and the Roy Bakay Memorial lecture. The presidential lecture was given by Gabriel de Erausquin, who discussed the possibility of long-term CNS effects resulting from SARS-CoV2 infection. With both virtual and in-person events, including oral and poster presentations, the ASNTR managed to maintain the unique essence of this small important meeting.

COVID-19/diagnosis , COVID-19/therapy , Congresses as Topic , Cell Transplantation , Florida , Humans , Hydrogels , Magnetic Resonance Imaging , Neurodegenerative Diseases/therapy , Neurons/pathology , Neurons/physiology , Neuropathology/methods , RNA, Viral , SARS-CoV-2 , Societies, Medical , Telecommunications , United States
Arch Pathol Lab Med ; 144(11): 1311-1320, 2020 11 01.
Article in English | MEDLINE | ID: covidwho-608258


CONTEXT.­: The coronavirus disease 19 (COVID-19) pandemic is placing unparalleled burdens on regional and institutional resources in medical facilities across the globe. This disruption is causing unprecedented downstream effects to traditionally established channels of patient care delivery, including those of essential anatomic pathology services. With Washington state being the initial North American COVID-19 epicenter, the University of Washington in Seattle has been at the forefront of conceptualizing and implementing innovative solutions in order to provide uninterrupted quality patient care amidst this growing crisis. OBJECTIVE.­: To conduct a rapid validation study assessing our ability to reliably provide diagnostic neuropathology services via a whole slide imaging (WSI) platform as part of our departmental COVID-19 planning response. DESIGN.­: This retrospective study assessed diagnostic concordance of neuropathologic diagnoses rendered via WSI as compared to those originally established via traditional histopathology in a cohort of 30 cases encompassing a broad range of neurosurgical and neuromuscular entities. This study included the digitalization of 93 slide preparations, which were independently examined by groups of board-certified neuropathologists and neuropathology fellows. RESULTS.­: There were no major or minor diagnostic discrepancies identified in either the attending neuropathologist or neuropathology trainee groups for either the neurosurgical or neuromuscular case cohorts. CONCLUSIONS.­: Our study demonstrates that accuracy of neuropathologic diagnoses and interpretation of ancillary preparations via WSI are not inferior to those generated via traditional microscopy. This study provides a framework for rapid subspecialty validation and deployment of WSI for diagnostic purposes during a pandemic event.

Academic Medical Centers , Betacoronavirus/isolation & purification , Coronavirus Infections/diagnosis , Neuropathology/methods , Pathology, Clinical/methods , Pneumonia, Viral/diagnosis , Telepathology/methods , Betacoronavirus/physiology , COVID-19 , Coronavirus Infections/prevention & control , Coronavirus Infections/virology , Global Health , Humans , Image Interpretation, Computer-Assisted/methods , Microscopy/methods , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Pneumonia, Viral/virology , Reproducibility of Results , Retrospective Studies , SARS-CoV-2 , Sensitivity and Specificity , Universities , Washington
Acta Neuropathol ; 140(1): 1-6, 2020 07.
Article in English | MEDLINE | ID: covidwho-342904


We report the neuropathological findings of a patient who died from complications of COVID-19. The decedent was initially hospitalized for surgical management of underlying coronary artery disease. He developed post-operative complications and was evaluated with chest imaging studies. The chest computed tomography (CT) imaging results were indicative of COVID-19 and he was subsequently tested for SARS-CoV-2, which was positive. His condition worsened and he died after more than 2 weeks of hospitalization and aggressive treatment. The autopsy revealed a range of neuropathological lesions, with features resembling both vascular and demyelinating etiologies. Hemorrhagic white matter lesions were present throughout the cerebral hemispheres with surrounding axonal injury and macrophages. The subcortical white matter had scattered clusters of macrophages, a range of associated axonal injury, and a perivascular acute disseminated encephalomyelitis (ADEM)-like appearance. Additional white matter lesions included focal microscopic areas of necrosis with central loss of white matter and marked axonal injury. Rare neocortical organizing microscopic infarcts were also identified. Imaging and clinical reports have demonstrated central nervous system complications in patients' with COVID-19, but there is a gap in our understanding of the neuropathology. The lesions described in this case provide insight into the potential parainfectious processes affecting COVID-19 patients, which may direct clinical management and ongoing research into the disease. The clinical course of the patient also illustrates that during prolonged hospitalizations neurological complications of COVID may develop, which are particularly difficult to evaluate and appreciate in the critically ill.

Betacoronavirus/pathogenicity , Brain/pathology , Coronavirus Infections/pathology , Nervous System Diseases/pathology , Pneumonia, Viral/pathology , Aged , Autopsy , COVID-19 , Coronavirus Infections/diagnosis , Coronavirus Infections/virology , Humans , Magnetic Resonance Imaging/methods , Male , Neuropathology/methods , Pandemics , Pneumonia, Viral/diagnosis , Pneumonia, Viral/virology , SARS-CoV-2 , Tomography, X-Ray Computed/methods