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1.
ACS Appl Mater Interfaces ; 14(7): 8718-8727, 2022 Feb 23.
Article in English | MEDLINE | ID: covidwho-1683917

ABSTRACT

Transparent antimicrobial coatings can maintain the aesthetic appeal of surfaces and the functionality of a touch-screen while adding the benefit of reducing disease transmission. We fabricated an antimicrobial coating of silver oxide particles in a silicate matrix on glass. The matrix was grown by a modified Stöber sol-gel process with vapor-phase water and ammonia. A coating on glass with 2.4 mg of Ag2O per mm2 caused a reduction of 99.3% of SARS-CoV-2 and >99.5% of Pseudomonas aeruginosa, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus compared to the uncoated glass after 1 h. We envisage that screen protectors with transparent antimicrobial coatings will find particular application to communal touch-screens, such as in supermarkets and other check-out or check-in facilities where a number of individuals utilize the same touch-screen in a short interval.


Subject(s)
Anti-Infective Agents/chemistry , Bacterial Infections/prevention & control , COVID-19/prevention & control , Oxides/chemistry , Silver Compounds/chemistry , Ammonia/chemistry , Anti-Infective Agents/pharmacology , Bacterial Infections/microbiology , COVID-19/virology , Glass/chemistry , Humans , Methicillin-Resistant Staphylococcus aureus/drug effects , Methicillin-Resistant Staphylococcus aureus/pathogenicity , Oxides/pharmacology , Pseudomonas aeruginosa/drug effects , Pseudomonas aeruginosa/pathogenicity , SARS-CoV-2/drug effects , SARS-CoV-2/pathogenicity , Silicates/chemistry , Silver Compounds/pharmacology , Water/chemistry
2.
ACS Appl Mater Interfaces ; 14(3): 4456-4468, 2022 Jan 26.
Article in English | MEDLINE | ID: covidwho-1619771

ABSTRACT

Coronavirus represents an inspiring model for designing drug delivery systems due to its unique infection machinery mechanism. Herein, we have developed a biomimetic viruslike nanocomplex, termed SDN, for improving cancer theranostics. SDN has a unique core-shell structure consisting of photosensitizer chlorin e6 (Ce6)-loaded nanostructured lipid carrier (CeNLC) (virus core)@poly(allylamine hydrochloride)-functionalized MnO2 nanoparticles (virus spike), generating a virus-mimicking nanocomplex. SDN not only prompted cellular uptake through rough-surface-mediated endocytosis but also achieved mitochondrial accumulation by the interaction of cationic spikes and the anionic mitochondrial surface, leading to mitochondria-specific photodynamic therapy. Meanwhile, SDN could even mediate oxygen generation to relieve tumor hypoxia and, consequently, improve macrophage-associated anticancer immune response. Importantly, SDN served as a robust magnetic resonance imaging (MRI) contrast agent due to the fast release of Mn2+ in the presence of intracellular redox components. We identified that SDN selectively accumulated in tumors and released Mn2+ to generate a 5.71-fold higher T1-MRI signal, allowing for effectively detecting suspected tumors. Particularly, SDN induced synergistic immunophotodynamic effects to eliminate malignant tumors with minimal adverse effects. Therefore, we present a novel biomimetic strategy for improving targeted theranostics, which has a wide range of potential biomedical applications.


Subject(s)
Drug Delivery Systems , Nanoparticles/chemistry , Neoplasms/therapy , SARS-CoV-2/chemistry , Bionics/methods , Cell Line, Tumor , Chlorophyllides/chemistry , Chlorophyllides/pharmacology , Contrast Media/chemistry , Contrast Media/pharmacology , Humans , Immunotherapy/methods , Manganese Compounds/chemistry , Manganese Compounds/pharmacology , Neoplasms/immunology , Oxides/chemistry , Oxides/pharmacology , Photochemotherapy/methods , Photosensitizing Agents/chemistry , Photosensitizing Agents/pharmacology , Polyamines/chemistry , Polyamines/pharmacology
3.
Biocontrol Sci ; 26(3): 129-135, 2021.
Article in English | MEDLINE | ID: covidwho-1438813

ABSTRACT

The current pandemic of novel coronavirus disease (COVID-19) has highlighted the importance of disinfectants. As a raw material for next-generation disinfectants, scallop shell-derived calcium oxide (CaO) has been revealed to exhibit significant virucidal and microbicidal activities and is compatible with living tissues and the environment. This minireview summarizes recent progress in the development of disinfectants from scallop shell-CaO, focusing especially on studies of clinical and daily use applications. We describe the preparation, basic characteristics, and virucidal and microbicidal activities of scallop shell-CaO disinfectants. Furthermore, their applications in the disinfection of contaminated masks and the treatment of infected wounds are briefly introduced.


Subject(s)
Animal Shells/chemistry , Calcium Compounds/pharmacology , Disinfectants/pharmacology , Disinfection/methods , Oxides/pharmacology , Pectinidae/chemistry , Animals , Disinfection/instrumentation , Disinfection/trends , Humans
4.
J Hosp Infect ; 118: 20-26, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1428164

ABSTRACT

BACKGROUND: A new coronavirus (SARS-CoV-2) abruptly emerged in Wuhan, China, in 2019 and rapidly spread globally to cause the COVID-19 pandemic. AIM: To examine the anti-SARS-CoV-2 activity of the potent disinfectant Cleverin, the major disinfecting component of which is chlorine dioxide (ClO2); and to compare the results with that of sodium hypochlorite in the presence or absence of 0.5% or 1.0% foetal bovine serum (FBS). METHODS: Concentrated SARS-CoV-2 viruses were treated with various concentrations of ClO2 and sodium hypochlorite and 50% tissue culture infective dose was calcurated to evaluate the antiviral activity of each chemical. FINDINGS: When SARS-CoV-2 viruses were treated with 0.8 ppm ClO2 or sodium hypochlorite, viral titre was decreased only by 1 log10 TCID50/mL in 3 min. However, the viral titre was decreased by more than 4 log10 TCID50/mL when treated with 80 ppm of each chemical for 10 s regardless of presence or absence of FBS. It should be emphasized that treatment with 24 ppm of ClO2 inactivated more than 99.99% SARS-CoV-2 within 10 s or 99.99% SARS-CoV-2 in 1 min in the presence of 0.5% or 1.0% FBS, respectively. By contrast, 24 ppm of sodium hypochlorite inactivated only 99% or 90% SARS-CoV-2 in 3 min under similar conditions. Notably, except for ClO2, the other components of Cleverin such as sodium chlorite, decaglycerol monolaurate, and silicone showed no significant antiviral activity. CONCLUSION: Altogether, the results strongly suggest that although ClO2 and sodium hypochlorite are strong antiviral agents in absence of organic matter but in presence of organic matter, ClO2 is a more potent antiviral agent against SARS-CoV-2 than sodium hypochlorite.


Subject(s)
COVID-19 , Chlorine Compounds , Disinfectants , Antiviral Agents/pharmacology , Chlorine , Chlorine Compounds/pharmacology , Disinfectants/pharmacology , Humans , Oxides/pharmacology , Pandemics , SARS-CoV-2 , Sodium Hypochlorite/pharmacology
5.
Viruses ; 13(3)2021 03 23.
Article in English | MEDLINE | ID: covidwho-1154525

ABSTRACT

The emergent human coronavirus SARS-CoV-2 and its high infectivity rate has highlighted the strong need for new disinfection systems. Evidence has proven that airborne transmission is an important route of spreading for this virus. Therefore, this short communication introduces CLODOS Technology®, a novel strategy to disinfect contaminated surfaces. It is a product based on stable and 99% pure chlorine dioxide, already certified as a bactericide, fungicide and virucide against different pathogens. In this study, CLODOS Technology®, by direct contact or thermonebulization, showed virucidal activity against the human coronavirus HCoV-229E at non-cytotoxic doses. Different conditions such as nebulization, exposure time and product concentration have been tested to standardize and optimize this new feasible method for disinfection.


Subject(s)
Coronavirus 229E, Human/drug effects , Disinfectants/pharmacology , Disinfection/methods , Cell Line , Chlorine Compounds/analysis , Chlorine Compounds/pharmacology , Coronavirus Infections/prevention & control , Coronavirus Infections/virology , Disinfectants/analysis , Disinfection/instrumentation , Humans , Nebulizers and Vaporizers , Oxides/analysis , Oxides/pharmacology
6.
Adv Mater ; 33(8): e2005477, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1039151

ABSTRACT

Besides the pandemic caused by the coronavirus outbreak, many other pathogenic microbes also pose a devastating threat to human health, for instance, pathogenic bacteria. Due to the lack of broad-spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized "capture and killing" action of bacteriophages, a virus-like peroxidase-mimic (V-POD-M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metal-organic-framework-derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO3 , can serve as a peroxo-complex-intermediate to reduce the free energy for catalyzing H2 O2 , which mainly benefits the generation of •OH radicals. The unique virus-like spikes endow the V-POD-M with fast bacterial capture and killing abilities (nearly 100% at 16 µg mL-1 ). Furthermore, the in vivo experiments show that V-POD-M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V-POD-M provides a promising broad-spectrum therapy for nonantibiotic disinfection.


Subject(s)
Anti-Bacterial Agents/chemical synthesis , Biomimetic Materials/chemical synthesis , Oxides/chemical synthesis , Peroxidase/chemistry , Anti-Bacterial Agents/pharmacology , Biocompatible Materials/chemistry , Biomimetic Materials/pharmacology , Catalysis , Humans , Hydrogen Peroxide/metabolism , Metal-Organic Frameworks/chemistry , Metal-Organic Frameworks/pharmacology , Molecular Dynamics Simulation , Molybdenum/pharmacology , Oxides/pharmacology , Peroxidase/metabolism , Sterilization , Vancomycin/pharmacology
7.
Physiol Int ; 107(1): 1-11, 2020 03 01.
Article in English | MEDLINE | ID: covidwho-18420

ABSTRACT

Motivation: Viruses have caused many epidemics throughout human history. The novel coronavirus [10] is just the latest example. A new viral outbreak can be unpredictable, and development of specific defense tools and countermeasures against the new virus remains time-consuming even in today's era of modern medical science and technology. In the lack of effective and specific medication or vaccination, it would be desirable to have a nonspecific protocol or substance to render the virus inactive, a substance/protocol, which could be applied whenever a new viral outbreak occurs. This is especially important in cases when the emerging new virus is as infectious as SARS-CoV-2 [4]. Aims and structure of the present communication: In this editorial, we propose to consider the possibility of developing and implementing antiviral protocols by applying high purity aqueous chlorine dioxide (ClO2) solutions. The aim of this proposal is to initiate research that could lead to the introduction of practical and effective antiviral protocols. To this end, we first discuss some important properties of the ClO2 molecule, which make it an advantageous antiviral agent, then some earlier results of ClO2 gas application against viruses will be reviewed. Finally, we hypothesize on methods to control the spread of viral infections using aqueous ClO2 solutions.


Subject(s)
Betacoronavirus , Chlorine Compounds/pharmacology , Communicable Diseases, Emerging , Coronavirus Infections , Disease Transmission, Infectious/prevention & control , Oxides/pharmacology , Pandemics , Pneumonia, Viral , Antiviral Agents/pharmacology , Betacoronavirus/drug effects , Betacoronavirus/pathogenicity , Betacoronavirus/physiology , COVID-19 , Clinical Protocols , Communicable Diseases, Emerging/prevention & control , Communicable Diseases, Emerging/virology , Coronavirus Infections/epidemiology , Coronavirus Infections/prevention & control , Coronavirus Infections/transmission , Coronavirus Infections/virology , Disinfectants/pharmacology , Humans , Pandemics/prevention & control , Pharmaceutical Solutions/pharmacology , Pneumonia, Viral/epidemiology , Pneumonia, Viral/prevention & control , Pneumonia, Viral/transmission , Pneumonia, Viral/virology , Research Design , SARS-CoV-2
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