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Adv Anat Pathol ; 27(6): 355-362, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-638434


Pathology Autopsy and Mortuary Services have been front and center in the severe acute respiratory syndrome coronavirus 2 (SARS-Co-V-2) pandemic. The sheer number of fatalities from the pandemic have been unlike any other in recent memory and needed the rapid creation of new protocols and paradigms to manage the situation. This required rapidly escalating mortuary capacity to manage the increased fatalities from the pandemic with the establishment of lines of communication and networking with governmental entities, institution of new policies for patient flow, and implementation of worker infection control and well-being plans. Autopsies also assumed a crucial role, both to provide insight into the pathomechanisms of a novel disease and to allow tissue retrieval necessary to power research directed towards finding a vaccine. We here outline the plan adopted by the Yale Autopsy and Mortuary Services, in alignment with the institutional mission of high-quality patient care, education, research and health care worker safety and well-being, as the Corona Virus Disease of 2019 (COVID-19) pandemic surged in Connecticut. In the early response phase, ensuring sufficient mortuary capacity necessarily took center stage. As we enter the recovery and plateau phase of the pandemic, setting up a process for a rapid and safe autopsy, that will meet educational and research needs while ensuring the safety of our workforce is being implemented.

Autopsy/methods , Coronavirus Infections , Emergencies , Mortuary Practice/methods , Pandemics , Pathology, Clinical/methods , Pneumonia, Viral , Autopsy/standards , Betacoronavirus , Humans , Mortuary Practice/standards , Occupational Exposure/prevention & control , Occupational Health/standards , Pathology, Clinical/standards , Public Health/methods , Public Health/standards
J Histotechnol ; 43(2): 102-104, 2020 06.
Article in English | MEDLINE | ID: covidwho-2831


The 2019 Coronavirus epidemic, provisionally called 2019-nCoV, was first identified in Wuhan, China, in persons exposed to a seafood or wet market. There is an international push to contain the virus and prevent its spread. It is feasible that potentially infectious samples may be received in histopathology laboratories for diagnosis. This technical note presents disinfection procedures and histotechnology processes that should alleviate the risk of infection to laboratory staff. Using data obtained from similar coronaviruses, e.g. severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), experts are confident that 70% ethanol and 0.1% sodium hypochlorite should inactivate the virus. Formalin fixation and heating samples to 56oC, as used in routine tissue processing, were found to inactivate several coronaviruses and it is believed that 2019-nCoV would be similarly affected.

Betacoronavirus , Containment of Biohazards/methods , Coronavirus Infections , Disinfection/methods , Pandemics , Pathology, Clinical/methods , Pneumonia, Viral , Containment of Biohazards/standards , Disinfection/standards , Histological Techniques/standards , Humans , Laboratories/standards , Pathology, Clinical/standards