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Int J Mol Sci ; 22(16)2021 Aug 05.
Article in English | MEDLINE | ID: covidwho-1341694


The current coronavirus disease-19 (COVID-19) pandemic has strongly revived the pressing need to incorporate new therapeutic alternatives to deal with medical situations that result in a dramatic breakdown in the body's normal homeostasis [...].

Acute Disease/therapy , COVID-19/therapy , Emergency Treatment/methods , Mesenchymal Stem Cell Transplantation/methods , Regenerative Medicine/methods , Acute Disease/mortality , COVID-19/mortality , Clinical Trials as Topic , Emergency Service, Hospital , Emergency Treatment/trends , Humans , Mesenchymal Stem Cell Transplantation/trends , Regenerative Medicine/trends , Survival Rate , Treatment Outcome
J Biol Regul Homeost Agents ; 34(4 Suppl. 1): 1-13. SPECIAL ISSUE: OZONE THERAPY, 2020.
Article in English | MEDLINE | ID: covidwho-919947


Despite various opinions and healthy controversy on Ozone Therapy (OT), the practices of this therapy have increased worldwide. Main areas of study with consistent scientific outcomes are the topical treatment of both disk herniation and periodontal disease. On the other hand, there is a net dissociation of the scientific resonance concerning systemic oxygen/ozone treatments. It is our intention to discuss in logical terms the numerous papers that commendably reported adverse reactions attributable to OT, focusing our attention mainly to the techniques of administration and not to the simple contact of ozone with biological material. The case reports on OT treatments safety concerns discussed on international journals, make it possible to state that most safety issues are secondary to infections or traumatic reactions due to malpractice. Commonly, the molecule of ozone itself is not responsible of severe reactions at the therapeutic modalities. The millions of patients treated so far from the thousands of physicians correctly practicing OT world widely in the last 40 years demonstrate the safety of this simple and cost-effective regenerative medicine tool. The promising therapeutic implications also for the current COVID-19 emergency are a further stimulus to the standardization of this therapeutic resource with multiple application specificities.

Ozone/therapeutic use , Regenerative Medicine/trends , Betacoronavirus , COVID-19 , Coronavirus Infections/therapy , Humans , Pandemics , Pneumonia, Viral/therapy , SARS-CoV-2
Stem Cells Transl Med ; 10(1): 5-13, 2021 01.
Article in English | MEDLINE | ID: covidwho-734123


This perspective from a Regenerative Medicine Manufacturing Society working group highlights regenerative medicine therapeutic opportunities for fighting COVID-19. This article addresses why SARS-CoV-2 is so different from other viruses and how regenerative medicine is poised to deliver new therapeutic opportunities to battle COVID-19. We describe animal models that depict the mechanism of action for COVID-19 and that may help identify new treatments. Additionally, organoid platforms that can recapitulate some of the physiological properties of human organ systems, such as the lungs and the heart, are discussed as potential platforms that may prove useful in rapidly screening new drugs and identifying at-risk patients. This article critically evaluates some of the promising regenerative medicine-based therapies for treating COVID-19 and presents some of the collective technologies and resources that the scientific community currently has available to confront this pandemic.

COVID-19/therapy , Regenerative Medicine/methods , Regenerative Medicine/trends , Animals , Humans , SARS-CoV-2