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Tohoku J Exp Med ; 258(1): 63-68, 2022 Aug 10.
Article in English | MEDLINE | ID: covidwho-1938489


The detailed clinical course of coronavirus disease 2019 (COVID-19) in patients with hairy cell leukemia (HCL) is rarely reported. We report the first case of HCL diagnosed with prolonged pancytopenia after COVID-19 infection in Japan. We describe the case of a 56-year-old man who was diagnosed with COVID-19. Computed tomography revealed ground-glass opacities in the bilateral lung lobes as well as splenomegaly. Remdesivir and dexamethasone were administered for the treatment of COVID-19. Since the pancytopenia persisted, bone marrow examination was performed, and he was diagnosed with HCL. Although pancytopenia can occur with COVID-19 alone, clinicians should be alerted regarding the presence of hematologic malignancies in patients in whom pancytopenia persists after COVID-19 treatment or in those with splenomegaly. Further, the condition of all previously reported patients with COVID-19 associated with HCL was severe enough to require mechanical ventilation. This is the first case in which the disease was not severe. The interleukin-6 (IL-6) level was lower in this case than in previous cases, suggesting that racial differences in IL-6 production may have contributed to COVID-19 severity.

COVID-19 , Coronavirus , Leukemia, Hairy Cell , Pancytopenia , COVID-19/complications , COVID-19/drug therapy , Humans , Interleukin-6 , Leukemia, Hairy Cell/complications , Leukemia, Hairy Cell/drug therapy , Leukemia, Hairy Cell/pathology , Male , Middle Aged , Pancytopenia/complications , Splenomegaly/complications , Splenomegaly/pathology
Int J Legal Med ; 134(6): 2205-2208, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-621065


"Severe acute respiratory syndrome" (SARS) due to coronavirus (SARS-CoV-2) infection is a well-known cause of death. Sometimes, demise can occur unexpectedly in apparently previous healthy individual after a brief period of trivial flu-like symptoms. In these doubtful cases, the forensic pathologist could be requested to define the cause of death occurred outside the hospital. In this report, the authors describe two autopsied cases of SARS-CoV-2-related deaths which occurred suddenly at home and were not preceded by hospitalization, highlighting associated histopathologic patterns and correlating them to pathophysiology of viral infection.

Betacoronavirus/pathogenicity , Coronavirus Infections/pathology , Lung/pathology , Pneumonia, Viral/pathology , Adrenal Cortex/pathology , Aged , Alveolar Epithelial Cells/pathology , Autopsy , COVID-19 , Cell Aggregation , Eosinophils/pathology , Female , Humans , Hyperplasia , Intranuclear Inclusion Bodies/pathology , Megakaryocytes/pathology , Microscopy , Middle Aged , Multimorbidity , Pandemics , Pulmonary Embolism/pathology , SARS-CoV-2 , Splenomegaly/pathology